DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nepl17 and nep-13

DIOPT Version :9

Sequence 1:	NP_651641.1	Gene:	Nepl17 / 43408	FlyBaseID:	FBgn0039609	Length:	681	Species:	Drosophila melanogaster
Sequence 2:	NP_001342017.1	Gene:	nep-13 / 173672	WormBaseID:	WBGene00018196	Length:	732	Species:	Caenorhabditis elegans

Alignment Length:	749	Identity:	167/749 - (22%)
Similarity:	318/749 - (42%)	Gaps:	140/749 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 CLIFVTLAVGSLAIQGGVFKELTTPLGQQIMR--------IAKSAE-------MCSFMDTSVSPC 58
            ||:.:.:.:|::.:   .::..:.|  |.|.:        :.|:||       :.::.:|::.||
Worm    48 CLVIIAICMGAVIV---FWRMDSAP--QAICKTDHNKTRDVCKTAECITLSSTLLNWQNTNIDPC 107

  Fly    59 DDFYGYACGNYA--TIN--AATSQKDTNIRQLMFANYLRRVRQVLNEPRISTDRPMEVRVKYFYE 119
            :|||.|:||.|.  |:|  ...::|||.:.:|        :||.:.:.: ||....|..:...||
Worm   108 EDFYEYSCGRYQEHTLNDGIRANEKDTIVMKL--------IRQFVLKNQ-STTSNSENALMLLYE 163

  Fly   120 SCLDTAALRTKQRS----------HLLSVLREFGGMPAVEGKSWDYVGFDAIEMMAQL----LRR 170
            .|    :||.:..:          .:...:|:.|..| :..|:|:...|:...|::.:    :..
Worm   164 KC----SLRYRMENRHQETEVIQREVFENIRKIGSWP-IADKNWNSSHFNLNNMLSNMASIHMLP 223

  Fly   171 YGKLTLLGVYVVPDHFNSQIKRLQL-GQRLDLAESDEFASLWKKYALKMRLRNLLGLS--EELAR 232
            :|......:.:.|  .|:..|:|.: ..:|..:...|        .|...:|:||.::  ..:.:
Worm   224 FGLFETRVIELYP--MNTTAKQLVIRPTKLKFSIPQE--------ELVRAIRDLLSVNGITSIMK 278

  Fly   233 KTAEEIIE---LELELSRSAFDHRMNRDPRLMRHLTMLSNMSDAYGPILNVTRFVTSWLG----- 289
            |..|::.|   |:.|:.      .::.||:  .....||.:..|. |.::..|.:.|:|.
Worm   279 KVKEDVAESFALDKEIG------NIHIDPQ--PKPATLSELQKAV-PDIDFERIIKSYLNPKTGN 334

  Fly   290 -SEYNLPVFESVPSYLF----QVKKILLSTPNHVVANYMLSSLLTDFEITANEEQQKV-----IC 344
             |.....:|.:.....|    .:..|:..|...::|||:....: ::......:..||     .|
Worm   335 WSSLRTKIFSARFELFFGKNNNLSSIIARTKPRILANYLFLKYI-EYAYFFFFDNTKVFSDDDFC 398

  Fly   345 HERITELFPDV-VDHMVYHSLEQQNPYIANEMRSLWVE-LKSSFREMLSSPDIEWLEKQTREELL 407
            .|.:|...|.. :...|.:..:::|..:|:|:    || :|:::.|::::.  .||...|||..:
Worm   399 TEVVTTSLPRASLRVFVRNHFKKENMAVASEI----VEVVKTAYVEIINNS--TWLHNSTRESAI 457

  Fly   408 EKLNGM--------SFEIAGGQAVNFEEQFGDLVVSSADYY---------GNIQRLLEVKARILR 455
            ||:..|        .:|..|.    .:|.|..|.:|.:|.:         ..|::|::.   :..
Worm   458 EKVVKMKKVIGYTEEYERTGA----LDEMFETLQLSRSDSFFVLMTKVNRFKIEQLMDF---VSS 515

  Fly   456 TDLLRESSSVYYYHGVTATPIYETETNLVVLPVSYMQHRYLWDDIYPAALKYGTLGFTMAHEMAH 520
            ..||.....:     |.|...|....||:.:.|.::. :.|:|..||..:....:|..:|||:.|
Worm   516 DSLLNPIEPL-----VMANAFYFPTKNLLNVLVPFLD-KPLFDFKYPRYVAMAGVGRVLAHEIGH 574

  Fly   521 GFDDLNRLYDSRGNLNDNWSTQTKVGFELVKNCLADQFSGMLYGNLRLRRLKSQ--AESIADNVG 583
            .||...|..|..|...|.|:.:....::....|.|:||:.....:.:.::..::  ||.|||.:|
Worm   575 AFDINGRQTDEIGRTRDWWTREDTEEYDRRSECFAEQFTNFKDPSFKGKQNGTEVLAEIIADALG 639

  Fly   584 IRIAQSAYWKWLDQVEMEETESLPHMTQSP-EQLFFLSAAQFMCSDIYPERRANFVRNNFHPPYE 647
            :    .|.|....::.:.|.:.|....... .:|:|..||...|:....|.|  :.....||..:
Worm   640 M----EASWIAFKKINLTEEQGLIQFEDHDFGKLYFQVAALDFCAPSRIEER--YSDQLSHPTNK 698

  Fly   648 ARVFAMMINSPAFAEAFQCSNSSKMNPPNKCLMY 681
            .|:.....||.|||:.::|...|||||..:|.|:
Worm   699 FRINGAFSNSRAFADTYKCPVGSKMNPVQRCDMF 732

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl17	NP_651641.1	PepO	49..672	CDD:226118	152/683 (22%)
Nepl17	NP_651641.1	M13	55..678	CDD:189000	155/683 (23%)
nep-13	NP_001342017.1	M13	104..729	CDD:189000	155/683 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.920