DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nepl17 and EEF1AKMT4-ECE2

DIOPT Version :9

Sequence 1:	NP_651641.1	Gene:	Nepl17 / 43408	FlyBaseID:	FBgn0039609	Length:	681	Species:	Drosophila melanogaster
Sequence 2:	NP_055508.3	Gene:	EEF1AKMT4-ECE2 / 110599583	HGNCID:	53615	Length:	883	Species:	Homo sapiens

Alignment Length:	740	Identity:	180/740 - (24%)
Similarity:	312/740 - (42%)	Gaps:	98/740 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MERLPASACLIFVTLAVGSLAIQGGVF---KELTTPLGQQIMRIAKSAEMCSFMDTSVSPCDDFY 62
            :|.:.|.|.|:...|.:|.|...|..:   ...:|.|.:..:|:|  .::...:|..||||:|||
Human   177 LELVLAGASLLLAALLLGCLVALGVQYHRDPSHSTCLTEACIRVA--GKILESLDRGVSPCEDFY 239

  Fly    63 GYACGNYA-------------TINAATSQKDTNIRQLMFANYLRRVRQVLNEPRISTDRPMEVRV 114
            .::||.:.             |.|:...|....::.|            |.....::....|.:.
Human   240 QFSCGGWIRRNPLPDGRSRWNTFNSLWDQNQAILKHL------------LENTTFNSSSEAEQKT 292

  Fly   115 KYFYESCLDTAALRTKQRSHLLSVLREFGGMPAVEGKSWDYVGFDAIEMMAQLLRRYGKLTLLGV 179
            :.||.|||....:.......|..::.:.||. .:.| .||...|  :|::..:...|.......|
Human   293 QRFYLSCLQVERIEELGAQPLRDLIEKIGGW-NITG-PWDQDNF--MEVLKAVAGTYRATPFFTV 353

  Fly   180 YVVPDHFNSQIKRLQLGQR----------LDLAESDEFASLWKKYALKMRLRNLLGLSEELARKT 234
            |:..|..:|....:|:.|.          |:...:::..:.:..|..::.:  |||......|:.
Human   354 YISADSKSSNSNVIQVDQSGLFLPSRDYYLNRTANEKVLTAYLDYMEELGM--LLGGRPTSTREQ 416

  Fly   235 AEEIIELELELSRSAFDHRMNRDPRLMRHLTMLSNMSDAYGPILNVTRFVTSWLGSEYNL----P 295
            .::::|||::|:.........||...:.|...:|.: .|..|.::...|: |:|.|...|    |
Human   417 MQQVLELEIQLANITVPQDQRRDEEKIYHKMSISEL-QALAPSMDWLEFL-SFLLSPLELSDSEP 479

  Fly   296 VFESVPSYLFQVKKILLSTPNHVVANYML--------SSLLTDFEITANEEQQKVI--------- 343
            |......||.||.:::..|...::.||::        |||...||    ..|:|::
Human   480 VVVYGMDYLQQVSELINRTEPSILNNYLIWNLVQKTTSSLDRRFE----SAQEKLLETLYGTKKS 540

  Fly   344 CHERITELFPDVVDHM--------VYHSLEQQNPYIANEMRSLWVELKSSFREMLSSPDIEWLEK 400
            |..|......:..|.:        |..:.::|:..||..|.|   |::::|.|.|.  .:.|:::
Human   541 CVPRWQTCISNTDDALGFALGSLFVKATFDRQSKEIAEGMIS---EIRTAFEEALG--QLVWMDE 600

  Fly   401 QTREELLEKLNGMSFEIAGG-----QAVNFEEQFGDLVVSSADYYGNIQRLLEVKARILRTDLLR 460
            :||:...||.:.: :::.|.     :....::.:....:|...::.|:..|....|::: .|.||
Human   601 KTRQAAKEKADAI-YDMIGFPDFILEPKELDDVYDGYEISEDSFFQNMLNLYNFSAKVM-ADQLR 663

  Fly   461 E--SSSVYYYHGVTATPIYETETNLVVLPVSYMQHRYLWDDIYPAALKYGTLGFTMAHEMAHGFD 523
            :  |...:.....|....|....|.:|.|...:|..: :...:|.||.:|.:|..|.||:.|.||
Human   664 KPPSRDQWSMTPQTVNAYYLPTKNEIVFPAGILQAPF-YARNHPKALNFGGIGVVMGHELTHAFD 727

  Fly   524 DLNRLYDSRGNLNDNWSTQTKVGFELVKNCLADQFSGMLYGNLRLRRLKSQAESIADNVGIRIAQ 588
            |..|.||..|||...|..::...|.....|:.:|::.......||...::..|:||||.|::.|.
Human   728 DQGREYDKEGNLRPWWQNESLAAFRNHTACMEEQYNQYQVNGERLNGRQTLGENIADNGGLKAAY 792

  Fly   589 SAYWKWLDQVEMEETESLPHMTQSPEQLFFLSAAQFMCSDIYPERRANFVRNNFHPPYEARVFAM 653
            :||..||.  :..|.:.||.:..:..||||:..||..||...||.....:..:.|.|...||...
Human   793 NAYKAWLR--KHGEEQQLPAVGLTNHQLFFVGFAQVWCSVRTPESSHEGLVTDPHSPARFRVLGT 855

  Fly   654 MINSPAFAEAFQCSNSSKMNPPNKC 678
            :.||..|...|.|...|.|||...|
Human   856 LSNSRDFLRHFGCPVGSPMNPGQLC 880

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl17	NP_651641.1	PepO	49..672	CDD:226118	164/681 (24%)
Nepl17	NP_651641.1	M13	55..678	CDD:189000	166/681 (24%)
EEF1AKMT4-ECE2	NP_055508.3	Methyltransferase-like region. /evidence=ECO:0000305	1..160
		Methyltransf_25	62..>128	CDD:316196
		S-adenosyl-L-methionine binding. /evidence=ECO:0000250\|UniProtKB:P0DPD7	88..89
		S-adenosyl-L-methionine binding. /evidence=ECO:0000250\|UniProtKB:P0DPD7	113..114
		M13	232..881	CDD:189000	167/683 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.920