Protein Alignment Nepl17 and EEF1AKMT4-ECE2

DIOPT Version :10

• Sequence 1: NP_651641.1
• Gene: Nepl17 / 43408
• FlyBaseID: FBgn0039609
• Length: 681
• Species: Drosophila melanogaster
• Sequence 2: NP_055508.3
• Gene: EEF1AKMT4-ECE2 / 110599583
• HGNCID: 53615
• Length: 883
• Species: Homo sapiens
• Alignment Length: 740
• Identity: 180/740 - (24%)
• Similarity: 312/740 - (42%)
• Gaps: 98/740 - (13%)

  Fly     1 MERLPASACLIFVTLAVGSLAIQGGVF---KELTTPLGQQIMRIAKSAEMCSFMDTSVSPCDDFY 62
            :|.:.|.|.|:...|.:|.|...|..:   ...:|.|.:..:|:|  .::...:|..||||:|||
Human   177 LELVLAGASLLLAALLLGCLVALGVQYHRDPSHSTCLTEACIRVA--GKILESLDRGVSPCEDFY 239

  Fly    63 GYACGNYA-------------TINAATSQKDTNIRQLMFANYLRRVRQVLNEPRISTDRPMEVRV 114
            .::||.:.             |.|:...|....::.|            |.....::....|.:.
Human   240 QFSCGGWIRRNPLPDGRSRWNTFNSLWDQNQAILKHL------------LENTTFNSSSEAEQKT 292

  Fly   115 KYFYESCLDTAALRTKQRSHLLSVLREFGGMPAVEGKSWDYVGFDAIEMMAQLLRRYGKLTLLGV 179
            :.||.|||....:.......|..::.:.||. .:.| .||...|  :|::..:...|.......|
Human   293 QRFYLSCLQVERIEELGAQPLRDLIEKIGGW-NITG-PWDQDNF--MEVLKAVAGTYRATPFFTV 353

  Fly   180 YVVPDHFNSQIKRLQLGQR----------LDLAESDEFASLWKKYALKMRLRNLLGLSEELARKT 234
            |:..|..:|....:|:.|.          |:...:::..:.:..|..::.:  |||......|:.
Human   354 YISADSKSSNSNVIQVDQSGLFLPSRDYYLNRTANEKVLTAYLDYMEELGM--LLGGRPTSTREQ 416

  Fly   235 AEEIIELELELSRSAFDHRMNRDPRLMRHLTMLSNMSDAYGPILNVTRFVTSWLGSEYNL----P 295
            .::::|||::|:.........||...:.|...:|.: .|..|.::...|: |:|.|...|    |
Human   417 MQQVLELEIQLANITVPQDQRRDEEKIYHKMSISEL-QALAPSMDWLEFL-SFLLSPLELSDSEP 479

  Fly   296 VFESVPSYLFQVKKILLSTPNHVVANYML--------SSLLTDFEITANEEQQKVI--------- 343
            |......||.||.:::..|...::.||::        |||...||    ..|:|::
Human   480 VVVYGMDYLQQVSELINRTEPSILNNYLIWNLVQKTTSSLDRRFE----SAQEKLLETLYGTKKS 540

  Fly   344 CHERITELFPDVVDHM--------VYHSLEQQNPYIANEMRSLWVELKSSFREMLSSPDIEWLEK 400
            |..|......:..|.:        |..:.::|:..||..|.|   |::::|.|.|.  .:.|:::
Human   541 CVPRWQTCISNTDDALGFALGSLFVKATFDRQSKEIAEGMIS---EIRTAFEEALG--QLVWMDE 600

  Fly   401 QTREELLEKLNGMSFEIAGG-----QAVNFEEQFGDLVVSSADYYGNIQRLLEVKARILRTDLLR 460
            :||:...||.:.: :::.|.     :....::.:....:|...::.|:..|....|::: .|.||
Human   601 KTRQAAKEKADAI-YDMIGFPDFILEPKELDDVYDGYEISEDSFFQNMLNLYNFSAKVM-ADQLR 663

  Fly   461 E--SSSVYYYHGVTATPIYETETNLVVLPVSYMQHRYLWDDIYPAALKYGTLGFTMAHEMAHGFD 523
            :  |...:.....|....|....|.:|.|...:|..: :...:|.||.:|.:|..|.||:.|.||
Human   664 KPPSRDQWSMTPQTVNAYYLPTKNEIVFPAGILQAPF-YARNHPKALNFGGIGVVMGHELTHAFD 727

  Fly   524 DLNRLYDSRGNLNDNWSTQTKVGFELVKNCLADQFSGMLYGNLRLRRLKSQAESIADNVGIRIAQ 588
            |..|.||..|||...|..::...|.....|:.:|::.......||...::..|:||||.|::.|.
Human   728 DQGREYDKEGNLRPWWQNESLAAFRNHTACMEEQYNQYQVNGERLNGRQTLGENIADNGGLKAAY 792

  Fly   589 SAYWKWLDQVEMEETESLPHMTQSPEQLFFLSAAQFMCSDIYPERRANFVRNNFHPPYEARVFAM 653
            :||..||.  :..|.:.||.:..:..||||:..||..||...||.....:..:.|.|...||...
Human   793 NAYKAWLR--KHGEEQQLPAVGLTNHQLFFVGFAQVWCSVRTPESSHEGLVTDPHSPARFRVLGT 855

  Fly   654 MINSPAFAEAFQCSNSSKMNPPNKC 678
            :.||..|...|.|...|.|||...|
Human   856 LSNSRDFLRHFGCPVGSPMNPGQLC 880

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nepl17	NP_651641.1	M13	55..678	CDD:341056	166/681 (24%)
EEF1AKMT4-ECE2	NP_055508.3	Methyltransferase-like region. /evidence=ECO:0000305	1..160
		UbiG	48..>128	CDD:441829
		M13	232..881	CDD:341056	167/683 (24%)