DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nepl17 and ece2

DIOPT Version :9

Sequence 1:	NP_651641.1	Gene:	Nepl17 / 43408	FlyBaseID:	FBgn0039609	Length:	681	Species:	Drosophila melanogaster
Sequence 2:	XP_002935189.1	Gene:	ece2 / 100488407	XenbaseID:	XB-GENE-1011916	Length:	766	Species:	Xenopus tropicalis

Alignment Length:	740	Identity:	170/740 - (22%)
Similarity:	300/740 - (40%)	Gaps:	100/740 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 ERLPASACLIFVTLAVGS---LAIQGGVFKELTTPLGQQIMRIAKSAEMCSFMDTSVSPCDDFYG 63
            |.|..:...:...|.:||   |.:|....:..:..|.:..:.:|  ..:...:|..:.||.|||.
Frog    61 EVLLGALSAVLGVLLLGSLIALGVQQMTDRSRSLCLSEACVSVA--GRILDSLDRGIDPCQDFYQ 123

  Fly    64 YACGNYA-------------TINAATSQKDTNIRQLMFANYLRRVRQVLNEPRISTDRPMEVRVK 115
            |:||.:.             |.|:...|....:            :.:|.....::....|::.:
Frog   124 YSCGGWMRRNPLPDGRSRWNTFNSIWDQNQAIL------------KHILENATFNSSSEAEMKTQ 176

  Fly   116 YFYESCLDTAALRTKQRSHLLSVLREFGGMPAVEGKSWDYVGFDAIEMMAQLLRRYGKLTLLGVY 180
            .||.|||....:...::..|..::.:.||.    ..|.::.|.:.:.::..:...|.......|:
Frog   177 RFYLSCLKEQRIEELRQKPLTDLIEKIGGW----NISGNWRGENFMSVLKTVSGTYRATPFFSVF 237

  Fly   181 VVPDHFNSQIKRLQLGQR----------LDLAESDEFASLWKKYALKMRLRNLLGLSEELARKTA 235
            |..|..:|....:|:.|.          |:...:.:....:.:|.:.  :..|||.|........
Frog   238 VSADSKSSNSNIIQVDQSGLFLPSRDYYLNKTANGKVLDAYLQYMVS--VGELLGGSPGSVDMQM 300

  Fly   236 EEIIELELELSRSAFDHRMNRD-PRLMRHLTM--LSNMSDAYGPILNVTRFVTSWLGSEYNLPVF 297
            .:|:|.|..|:.........|| .::...:|:  |.:::.|: ..::...|..|.|......||.
Frog   301 TQILEFETLLANLTVPQDERRDEEKIYNRMTISELQSLAPAF-DWMDYLTFALSPLDLNDTEPVV 364

  Fly   298 ESVPSYLFQVKKILLSTPNHVVANY--------MLSSLLTDFEITANEEQQKVI---------CH 345
            .....||.||.:::.:|...::.||        |.|||.:.||    :.|.|::         |.
Frog   365 VYGKEYLQQVSELVNNTDPMLLNNYLVWNLVQKMSSSLDSRFE----KAQDKLLESLYGAKKSCT 425

  Fly   346 ERITELFPDVVDHM--------VYHSLEQQNPYIANEMRSLWVELKSSFREMLSSPDIEWLEKQT 402
            .|......:..|.:        |..:.::.:..||.:|.|   |::.:|.  |:...:.|::::|
Frog   426 PRWQTCLSNTDDTLGFALGSLFVKSTFDKNSKNIAEQMIS---EIRDAFE--LTLGGLTWMDEKT 485

  Fly   403 REELLEKLNGMSFEIAGG-----QAVNFEEQFGDLVVSSADYYGNIQRLLEVKARILRTDLL--- 459
            |....||.:.: :::.|.     .....:|.:....||...::.|:.......|:::...|.
Frog   486 RRAAKEKADAI-YDMIGFPDFILDTKELDEVYDGFEVSEDAFFQNMLNFYNFSAKLMAEQLRKPP 549

  Fly   460 -RESSSVYYYHGVTATPIYETETNLVVLPVSYMQHRYLWDDIYPAALKYGTLGFTMAHEMAHGFD 523
             ||..|:   ...|....|....|.:|.|...:|..: :...:|.||.:|.:|..|.||:.|.||
Frog   550 NREQWSM---TPQTVNAYYLPNKNEIVFPAGILQAPF-YAPTHPKALNFGGIGVVMGHELTHAFD 610

  Fly   524 DLNRLYDSRGNLNDNWSTQTKVGFELVKNCLADQFSGMLYGNLRLRRLKSQAESIADNVGIRIAQ 588
            |..|.||..|||...|...:...|:....|:.:|::.......|:...::..|:||||.|::.|.
Frog   611 DQGREYDEDGNLRPWWQNSSLEAFKNRTECMVNQYNSYTVNGERVNGRQTLGENIADNGGLKAAY 675

  Fly   589 SAYWKWLDQVEMEETESLPHMTQSPEQLFFLSAAQFMCSDIYPERRANFVRNNFHPPYEARVFAM 653
            .||..||  |:..|.:.||.:..:..||||:..||..||...||.....:..:.|.|.:.||...
Frog   676 HAYKSWL--VKHGEEKQLPGVGLTNNQLFFVGFAQVWCSVRTPESSHEGLVTDPHSPAKFRVIGT 738

  Fly   654 MINSPAFAEAFQCSNSSKMNPPNKC 678
            :.||..|||.|.|...:.|||...|
Frog   739 LSNSKDFAEHFNCPKGTPMNPGKHC 763

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl17	NP_651641.1	PepO	49..672	CDD:226118	157/682 (23%)
Nepl17	NP_651641.1	M13	55..678	CDD:189000	159/682 (23%)
ece2	XP_002935189.1	M13	115..763	CDD:341056	159/682 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.020