Protein Alignment spg and DOCK4

DIOPT Version :9

• Sequence 1: NP_733258.4
• Gene: spg / 43404
• FlyBaseID: FBgn0264324
• Length: 2187
• Species: Drosophila melanogaster
• Sequence 2: XP_016868308.1
• Gene: DOCK4 / 9732
• HGNCID: 19192
• Length: 2006
• Species: Homo sapiens
• Alignment Length: 2237
• Identity: 775/2237 - (34%)
• Similarity: 1162/2237 - (51%)
• Gaps: 394/2237 - (17%)

  Fly    13 IHNWHGDVRFGLALDVGDSVDIVEECKHWYRGSCPRKSRAVGLFPKTYIHIKD------------ 65
            |.::.|.|.:||:|::||:|.|:|:|..||||...:.....|:||.:|:|:|:
Human    45 IASFRGTVPYGLSLEIGDTVQILEKCDGWYRGFALKNPNIKGIFPSSYVHLKNACVKNKGQFEMV 109

  Fly    66 LSKIDPVVAECTQVLREWSEIWKRLYVDREAYKFQTLRKVMFSILESRRELLSATMTQDQTLELQ 130
            :...|.|:.|.|..||:|..:||:|||..|...|..|..:|..||:.||::|...:|.|:..:::
Human   110 IPTEDSVITEMTSTLRDWGTMWKQLYVRNEGDLFHRLWHIMNEILDLRRQVLVGHLTHDRMKDVK 174

  Fly   131 MVVVSKIDWGNRKLGLDLVPREGPLAVDPHGIGIVKLYNV----HVSSADNAKASSSRGTLRRKT 191
            ..:.:::||||.:||||||||:....|||..|.|.:||.:    |.......:|||
Human   175 RHITARLDWGNEQLGLDLVPRKEYAMVDPEDISITELYRLMEHRHRKKDTPVQASS--------- 230

  Fly   192 QRKILTHHLYFCMRDFGHRIGGDDAEVYFFLYDGSHMRPLSERFLVKISKDGFSNYIERLHSNCT 256
                  |||:..|:.......|::.||.|.|:|....||:||||.::::::|.....::...:|:
Human   231 ------HHLFVQMKSLMCSNLGEELEVIFSLFDSKENRPISERFFLRLNRNGLPKAPDKPERHCS 289

  Fly   257 VFTDLGAADLNEELHLVAVVMRVGKIIQSDSIKKIEKSGTLGHGP-------TFRRPFGVGVLSL 314
            :|.|||:::|.:::::...::|:|:               :|.|.       .:|||||..|||:
Human   290 LFVDLGSSELRKDIYITVHIIRIGR---------------MGAGEKKNACSVQYRRPFGCAVLSI 339

  Fly   315 GDIAHFDSSLEQSSDEREYNFKLFQCE-EKDFHLLPELIIKKSSGKYSPIQASQGTQGIVVSLKL 378
            .|       |.....:.:...|::.|. |.:::.:.|.||||.:.:|:   .:....|:.|||:|
Human   340 AD-------LLTGETKDDLILKVYMCNTESEWYQIHENIIKKLNARYN---LTGSNAGLAVSLQL 394

  Fly   379 LHGGLGQARQEQPMLF-QGSTITRKMGFPDVIMPGDVRNDLFLNLERGEFERGGKNTGKNILVTV 442
            |||.:.|.|:|...:| .|.:||||:||.::||||::||||::.:||||||:|||:..:|:.||:
Human   395 LHGDIEQIRREYSSVFSHGVSITRKLGFSNIIMPGEMRNDLYITIERGEFEKGGKSVARNVEVTM 459

  Fly   443 VVLDVAGNVLTDCLWGASGMESQPQYRSMILYHQNAPSWNEMLRLSVPIDKFSTAHVRFEFRHCS 507
            .::|.:|..|.|.:...||.....:|.|.:|||.|:|.|:|:|:|.:|:|||..||:||||||||
Human   460 FIVDSSGQTLKDFISFGSGEPPASEYHSFVLYHNNSPRWSELLKLPIPVDKFRGAHIRFEFRHCS 524

  Fly   508 TRDKTEPKLFAFSFARLMDTGGATLGDGLHELYVYKCEDPAKLQ-VANYLRLQCRPRDAQAKMDC 571
            |::|.|.|||.|||..||...|.||.||.|||.|:|||:...|| ...||:|   |......:..
Human   525 TKEKGEKKLFGFSFVPLMQEDGRTLPDGTHELIVHKCEENTNLQDTTRYLKL---PFSKGIFLGN 586

  Fly   572 GGCFSRSSKEVFVLRSLLCSTKLTQNADLLSLLQWRTYPETIQDSLTGVLRLNDEELVKFLQDVL 636
            .....:::||.|.:.|.|||||||||.|:|.||:|||:|:.|...|:.:..::..|:||||||.|
Human   587 NNQAMKATKESFCITSFLCSTKLTQNGDMLDLLKWRTHPDKITGCLSKLKEIDGSEIVKFLQDTL 651

  Fly   637 DALFAMFSNEEGNSTQHSGLVFHVLVSIFSLLQSNKFQHFRPVMNEYIENHFAAALVYKGLITSV 701
            |.||.:.   :.||.::...||..||.|.:|||.:||.||:|||:.|||:|||.||.|:.||..:
Human   652 DTLFGIL---DENSQKYGSKVFDSLVHIINLLQDSKFHHFKPVMDTYIESHFAGALAYRDLIKVL 713

  Fly   702 EHMAVFMTKAEHPDPFQKCFGSLEYIFKLLIQSRKLFARATGGQYEDSFKRDLHSLFTALNGMLA 766
            :.....:|:||..:..|:...:.|||||.::|||:||:.|||||.|:.|:..:..|..::...|:
Human   714 KWYVDRITEAERQEHIQEVLKAQEYIFKYIVQSRRLFSLATGGQNEEEFRCCIQELLMSVRFFLS 778

  Fly   767 VPS--YDVIIPTQEALLNSTGVVLEQLKDTLPAPELGMLARNMLDAIPRGAPI--RLIQAKLHAV 827
            ..|  ...:..:|...|:|...|..:|.......|:..|.::.|.::|....:  .|...||..:
Human   779 QESKGSGALSQSQAVFLSSFPAVYSELLKLFDVREVANLVQDTLGSLPTILHVDDSLQAIKLQCI 843

  Fly   828 KDLVSGELFHEDDSRTVVLSVACKHLRMHLSRRDELRLCAEILSEILSQLYDLQKEQREKVTNTL 892
            ...|..:|:...|||.::|.|...||.:||..:.:|.:||.|||.:...   ::|...||   ::
Human   844 GKTVESQLYTNPDSRYILLPVVLHHLHIHLQEQKDLIMCARILSNVFCL---IKKNSSEK---SV 902

  Fly   893 QHDLDSLCKNILGILIRTISII----MEGSNA-------VLPQLVSCLLGLLQLLDETHYKRYWD 946
            ..::|.:..::|.||:|||..|    ...|:|       |..:.|:|||.||:.:.:.||::..|
Human   903 LEEIDVIVASLLDILLRTILEITSRPQPSSSAMRFQFQDVTGEFVACLLSLLRQMTDRHYQQLLD 967

  Fly   947 ELSPNKDPRDLKEFLSKSLLVYEELLTQDWHVFPNDWLVMKLAANDVLRMSLEEFAKPLVYRFLG 1011
            ..:..:   :|::||.:...|:..|:..:  :||.||.||:|.||:|:..::...:..|...||.
Human   968 SFNTKE---ELRDFLLQIFTVFRILIRPE--MFPKDWTVMRLVANNVIITTVLYLSDALRKNFLN 1027

  Fly  1012 PQAFDSQLWWSYFSLAVAFLTQPSLQLEQYREPKRLKILHSHGDMRVLMGFQILSMWSQLGEQKL 1076
             :.||.::|.|||.|||.|:.|..||||.:...|:.|:|..:|||||.||.:|.|||..|||.||
Human  1028 -ENFDYKIWDSYFYLAVIFINQLCLQLEMFTPSKKKKVLEKYGDMRVTMGCEIFSMWQNLGEHKL 1091

  Fly  1077 HFIPSMVGPFLEVTLVPEPALRKATLSVFYDMMQCEQAARGSFRLVESELIDKLDLLISENKGDD 1141
            ||||:::||||||||:|:|.||...:.:|:|||..||...|:|:.||::||||||.|:||.|||:
Human  1092 HFIPALIGPFLEVTLIPQPDLRNVMIPIFHDMMDWEQRRSGNFKQVEAKLIDKLDSLMSEGKGDE 1156

  Fly  1142 EYRELFSTI---------LLEKVQVENPNWKEAGIAFIASVTRLLERLLDYRSVMQGEENRDKRM 1197
            .|||||::|         ||:|  :|...|:|:|::.||:||||:|||||||..|:..|...|::
Human  1157 TYRELFNSIIPLFGPYPSLLKK--IERETWRESGVSLIATVTRLMERLLDYRDCMKMGEVDGKKI 1219

  Fly  1198 TCTVNLLNFYKNEINRKEMYLRYIYKLHNLHLQAENYTEAGFTLKLYASMLSW-DRETQSFAPFD 1261
            .|||:||||||.|:|::|||:|||:||::|||:|:|:|||.:||.||..:|.| ||..:.|..:.
Human  1220 GCTVSLLNFYKTELNKEEMYIRYIHKLYDLHLKAQNFTEAAYTLLLYDELLEWSDRPLREFLTYP 1284

  Fly  1262 NSGQPEWQRKERLYHEILKYFDKGKCWEKGIPLCKELAHLYETRRFDYNKLSEILIQEAKFFQNI 1326
            .  |.||||||.|:..|::.||:|||||.||.||:::|..||: .:||..||::.:.||..:..|
Human  1285 M--QTEWQRKEHLHLTIIQNFDRGKCWENGIILCRKIAEQYES-YYDYRNLSKMRMMEASLYDKI 1346

  Fly  1327 LTQLRPEPEYFRVGFYGMGLPLFVRNKQFVYRGLEYERIGAFTQRLQTEFPSAQILGNNSPPDNA 1391
            :.|.|.|||:|||||||...|.|:|||:||.||.:|||:.||.||:..|||.|..:.:.:.||..
Human  1347 MDQQRLEPEFFRVGFYGKKFPFFLRNKEFVCRGHDYERLEAFQQRMLNEFPHAIAMQHANQPDET 1411

  Fly  1392 ILNAPDQYIQISNVRPVGDAQALKTAMVPVPEKIARFYEVNDVTRFIYDRPMYKGTVDKDNEFKS 1456
            |..|..||:||..|.|:.::|.: .....||:.|..||:||.:.:|.||||.:|||.||:|||||
Human  1412 IFQAEAQYLQIYAVTPIPESQEV-LQREGVPDNIKSFYKVNHIWKFRYDRPFHKGTKDKENEFKS 1475

  Fly  1457 LWIERTILEIASPLPGILRWYEVKQKTMQELTPVEYACEIISNAGKELSELIVQYKRDPKRNINP 1521
            ||:|||.|.:...||||.||:||:::.:.|::|:|.|.|::.|..::|..||.|.:....:||||
Human  1476 LWVERTSLYLVQSLPGISRWFEVEKREVVEMSPLENAIEVLENKNQQLKTLISQCQTRQMQNINP 1540

  Fly  1522 FSMRLQGTIDANVMGGISKYQEAFFSEQFLKSPQGAGQQANVQRLKVLILEQIQILEQALELHGQ 1586
            .:|.|.|.|||.|.||:|:||||||.::::.|....|::  :.||:.|:|||.||||..|.:|.:
Human  1541 LTMCLNGVIDAAVNGGVSRYQEAFFVKEYILSHPEDGEK--IARLRELMLEQAQILEFGLAVHEK 1603

  Fly  1587 LAPSGVQPLHNRLLERFSQLKQSL-----------------SGMGRLKRQHSESIVNTPLPPLPT 1634
            ..|..::|||.:|:::|..:|.||                 :|..|:.|..:.:.|:      |.
Human  1604 FVPQDMRPLHKKLVDQFFVMKSSLGIQEFSACMQASPVHFPNGSPRVCRNSAPASVS------PD 1662

  Fly  1635 EQRVAPAT-----------ASSSLNANAHSNYVYDLDEI--YTRPGDTVRPVDPLSSYQTLSKES 1686
            ..||.|..           :||||::.|.:    ::..|  .:...|.|..:.|..|..:||...
Human  1663 GTRVIPRRSPLSYPAVNRYSSSSLSSQASA----EVSNITGQSESSDEVFNMQPSPSTSSLSSTH 1723

  Fly  1687 LSIPLEDTAAPPVPNRPRSQNFIGNGSMDSPEVPPK----RQPTLNSPNAPP---LPPRGITPDK 1744
            .:.|...::||             :.:..||.:..|    |:.:..||...|   :.|..:.|.:
Human  1724 SASPNVTSSAP-------------SSARASPLLSDKHKHSRENSCLSPRERPCSAIYPTPVEPSQ 1775

  Fly  1745 RASNPLIFNDFGSGDAVGRRHSQQQQQHGQKYSVVDISYDDPEADQQPHSLPPNFQDGSGGHLSV 1809
            |    ::||..|.| |:.|                    .||.......::.|.
Human  1776 R----MLFNHIGDG-ALPR--------------------SDPNLSAPEKAVNPT----------- 1804

  Fly  1810 CFAPNDFRDSGISTTSSRELNHMNLNNLSEDSSSISTITVQHREHCRISSNGSLDYNAAASMNIT 1874
                    .|..|..|.:|     ..|:|:....||
Human  1805 --------PSSWSLDSGKE-----AKNMSDSGKLIS----------------------------- 1827

  Fly  1875 QRESSTSSFDVEDFPVPPPPIPPKSLAVSSNGVNFSLDEAHSPHPSTQANTTQLNHIQNPNQNHS 1939
                              ||:||:                                   |.|..|
Human  1828 ------------------PPVPPR-----------------------------------PTQTAS 1839

  Fly  1940 TNSHHHLQQQQNGDGDGYSTLQHPMNGLGLPTLPPPPSAVESPMPASAIASSTSSHQHDGGTFXV 2004
            ...|                          .|...|..|..||:..| :.|.|.|
Human  1840 PARH--------------------------TTSVSPSPAGRSPLKGS-VQSFTPS---------- 1867

  Fly  2005 TICRCHHPPDQPHQPHKPSSSTSTSDSTATDTASESTESSSSTHSM----------TPPPPPPPP 2059
                    |.:.|.|...|:|...|.|.::..:|.|..|:|.|...          .|.|.|.|.
Human  1868 --------PVEYHSPGLISNSPVLSGSYSSGISSLSRCSTSETSGFENQVNEQSAPLPVPVPVPV 1924

  Fly  2060 PSSFTHLHHQMAATTHYCQD---CLSSPSPPPTIITEQAQVHPTPGSTSAQPHIEHCSCGLSFSV 2121
            ||              |..:   ...|.:|||..:.|:....|.|     .||      .||..|
Human  1925 PS--------------YGGEEPVRKESKTPPPYSVYERTLRRPVP-----LPH------SLSIPV 1964

  Fly  2122 VQDQQEQFPRLLSTRFSTLE---RQTD 2145
            ..:.....|:.|:.|.|.||   |:||
Human  1965 TSEPPALPPKPLAARSSHLENGARRTD 1991

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
spg	NP_733258.4	SH3_DOCK_AB	9..64	CDD:212805	21/50 (42%)
		DOCK_N	67..406	CDD:292790	110/351 (31%)
		C2_Dock-B	414..600	CDD:176077	89/186 (48%)
		DHR2_DOCK	1215..1610	CDD:297424	185/395 (47%)
DOCK4	XP_016868308.1	None

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	490	1.000	Domainoid score	I376
eggNOG	1	0.900	-	-		E1_KOG1997
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1308	1.000	Inparanoid score	I154
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54452
OrthoDB	1	1.010	-	-		D102580at2759
OrthoFinder	1	1.000	-	-		FOG0000433
OrthoInspector	1	1.000	-	-		otm40333
orthoMCL	1	0.900	-	-		OOG6_100636
Panther	1	1.100	-	-	O	PTHR45653
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2355
SonicParanoid	1	1.000	-	-		X372
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	13	12.870