DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment spg and Dock2

DIOPT Version :9

Sequence 1:NP_733258.4 Gene:spg / 43404 FlyBaseID:FBgn0264324 Length:2187 Species:Drosophila melanogaster
Sequence 2:NP_203538.2 Gene:Dock2 / 94176 MGIID:2149010 Length:1828 Species:Mus musculus


Alignment Length:1974 Identity:701/1974 - (35%)
Similarity:1048/1974 - (53%) Gaps:263/1974 - (13%)


- Green bases have known domain annotations that are detailed below.


  Fly     8 KYGVAIHNWHGDVRFGLALDVGDSVDIVEECKHWYRGSCPRKSRAVGLFPKTYIHIKDLS----- 67
            ::||||:|:.|.....|.|.:||.|.|.|.|..||||...:...:.|:||.::||:|:::     
Mouse    11 RHGVAIYNFQGSEAQHLTLQIGDVVRIQETCGDWYRGYLIKHKLSQGIFPTSFIHLKEVTVEKRR 75

  Fly    68 KID-------PVVAECTQVLREWSEIWKRLYVDREAYKFQTLRKVMFSILESRRELLSATMTQDQ 125
            .|:       |:..|.|..|.||..|||:|||..:..:|..::.:|:.::|.|.:|||.|:.:|:
Mouse    76 NIENIIPAEIPLAQEVTTTLWEWGSIWKQLYVASKKERFLQVQSMMYDLMEWRSQLLSGTLPKDE 140

  Fly   126 TLELQMVVVSKIDWGNRKLGLDLVPR-EGPLAVDPHGIGIVKLYNVHVSSA---------DNAKA 180
            ..||:..|.||||:||:.|.|||:.| |....:||....::.|::.|..:.         :.:|.
Mouse   141 LKELKQKVTSKIDYGNKILELDLIVRDEDGNILDPDKTSVISLFHAHEEATYKITERIKEEMSKD 205

  Fly   181 SSSRGTLRRKTQRKILTHHLYFCMRDFGHRIGGDDAEVYFFLYDGSHMRPLSERFLVKISKDGFS 245
            ....|...|.:...  ||.||..:|:|..|| |:|||::..|||......:||.:||:....||.
Mouse   206 QPDYGVYSRISSSP--THSLYVFVRNFVCRI-GEDAELFMSLYDPHKQTVISENYLVRWGSKGFP 267

  Fly   246 NYIERLHSNCTVFTDLGAADLN-EELHLVAVVMRVGKIIQSDSIKKIE-KSGTLGHGPTFRRPFG 308
            ..||.|::...||||||..||| :::.|:..::|:||:    .:|.|. |..|.|    .|||||
Mouse   268 KEIEMLNNLKVVFTDLGNKDLNRDKIFLICQIVRIGKM----DLKDINAKKCTQG----LRRPFG 324

  Fly   309 VGVLSLGDIAHFDSSLEQSSDEREYNFKLFQ--CEEKDFHLLPELIIKKSSGKYSPIQASQGTQG 371
            |.|:.:.||.    ..:..|||.:.:|..|.  ..|.||  |..|:     ||....:...|.||
Mouse   325 VAVMDITDII----KGKAESDEEKQHFIPFHPVSAENDF--LHSLL-----GKVIASKGDSGGQG 378

  Fly   372 IVVSLKLLHGGLGQARQEQPMLFQGST-ITRKMGFPDVIMPGDVRNDLFLNLERGEFERGGKNTG 435
            :.|::|:|.|.:.|.|::.|.|...:| :.||:|||::|||||||||:::.|.:|:|::..|.|.
Mouse   379 LWVTMKMLVGDIIQIRKDYPHLVDRTTVVARKLGFPEIIMPGDVRNDIYITLLQGDFDKYTKTTQ 443

  Fly   436 KNILVTVVVLDVAGNVLTDCLWGASGMESQPQYRSMILYHQNAPSWNEMLRLSVPIDKFSTAHVR 500
            :|:.|.:.|....|.||.:.:...:|.::..:|.|::.|....|.|.|.::::|||:.....|:|
Mouse   444 RNVEVIMCVCTEDGKVLPNAICVGAGDKAMNEYHSVVYYQVKQPRWMETVKVAVPIEDMQRIHLR 508

  Fly   501 FEFRHCS---TRDKTEPKLFAFSFARLMDTGGATLGDGLHELYVYKCEDPAKLQVAN-YLRLQCR 561
            |.|||.|   ::||.| |.||.|:.:||...|.||.||.|||.|.| .|..|::.|: ||.|...
Mouse   509 FMFRHRSSLESKDKGE-KNFAMSYVKLMKEDGTTLHDGYHELVVLK-GDSKKMEDASAYLTLPSY 571

  Fly   562 PRDAQAKMDCGGCFSR----------SSKEVFVLRSLLCSTKLTQNADLLSLLQWRTYPETIQDS 616
            ....:.|   |...||          ||::||.:.:|:||||||||..||.||:||..|:.:|::
Mouse   572 RHPVENK---GATLSRSSSSVGGLSVSSRDVFSISTLVCSTKLTQNVGLLGLLKWRMKPQLLQEN 633

  Fly   617 LTGVLRLNDEELVKFLQDVLDALFAMFSNEEGNSTQHSGLVFHVLVSIFSLLQSNKFQHFRPVMN 681
            |..:..::.||:||||||.|||||.:.. |...|.::..|||..|:.|..|:...|||||..|:.
Mouse   634 LEKLKIVDGEEVVKFLQDTLDALFNIMM-EHSQSNEYDILVFDALIYIIGLIADRKFQHFNTVLE 697

  Fly   682 EYIENHFAAALVYKGLITSVEHMAVFMTKAEHPDPFQKCFGSLEYIFKLLIQSRKLFARATGGQY 746
            .||:.||:|.|.||.|:|.::......::.|..:|..:...:|||:||.:::||.||::...|:.
Mouse   698 AYIQQHFSATLAYKKLMTVLKTYLDTSSRGEQCEPILRTLKALEYVFKFIVRSRTLFSQLYEGKE 762

  Fly   747 EDSFKRDLHSLFTALNGMLAVPSYDVIIPTQEALLNSTGVVLEQLKDTLPAPELGMLARNMLDAI 811
            :..|:..:..||.::|.::. ..|...|..|.|.|.....||..::....|..|..|.......|
Mouse   763 QMEFEESMRRLFESINNLMK-SQYKTTILLQVAALKYIPSVLHDVETVFDAKLLSQLLYEFYTCI 826

  Fly   812 PRGAPIRLIQAKLHAVKDLVSGELFHEDDSRTVVLSVACKHLRMHLSRRD------ELRLCAEIL 870
            |   |::|.:.|:.::.::|...||.:.:.|.::|.|..|.|:..|.:||      |.:.|.|:|
Mouse   827 P---PVKLQKQKVQSMNEIVQSNLFKKQECRDILLPVITKELKELLEQRDDGQHQAEKKHCVELL 888

  Fly   871 SEILSQLYDLQKEQREKVTNTLQHDLDSLCKNILGILIRTIS---IIMEGSNAVLPQLVSCLLGL 932
            :.||..|      ..:....|..|     .:.|:..|:||::   |.|...:|::...|:|:..:
Mouse   889 NSILEVL------SCQDAAFTYDH-----IQEIMVQLLRTVNRTVITMGRDHALISHFVACMTAI 942

  Fly   933 LQLLDETHYKRYWDELSPNKDPRDLKEFLSKSLLVYEELLTQDWHVFPNDWLVMKLAANDVLRMS 997
            |..:.:.||..|.:....:.   ||.:||.::.:::::|:.:  :|:|.||:.|.:..|.|...:
Mouse   943 LDQMGDQHYSFYIETFQTSS---DLVDFLMETFIMFKDLIGK--NVYPGDWMAMSMVQNRVFLRA 1002

  Fly   998 LEEFAKPLVYRFLGPQAFDSQLWWSYFSLAVAFLTQPSLQLEQYREPKRLKILHSHGDMRVLMGF 1062
            :.:||:.:..:||...:|:.|||.:||.|||||:||.||||||:...|..|||:.:||||.|:||
Mouse  1003 INKFAETMNQKFLEHTSFEFQLWNNYFHLAVAFITQDSLQLEQFTHAKYNKILNKYGDMRRLIGF 1067

  Fly  1063 QILSMWSQLGEQKLHFIPSMVGPFLEVTLVPEPALRKATLSVFYDMMQCEQAARGSFRLVESELI 1127
            .|..||.:||:.|:.|||.||||.||:||:||..|||||:.:|:|||.||....|:|:..|:|:|
Mouse  1068 SIRDMWYKLGQNKICFIPGMVGPILEMTLIPEAELRKATIPIFFDMMLCEYQRTGAFKKFENEII 1132

  Fly  1128 DKLDLLISENKGDDEYRELFSTILLEKVQVENPNWKEAGIAFIASVTRLLERLLDYRSVMQGEEN 1192
            .|||..:...:||::|.:|..:||:| ...|:|...::...|::.|..|||:|||||.||. :|:
Mouse  1133 LKLDHEVEGGRGDEQYMQLLESILME-CTAEHPTIAKSVENFVSLVKGLLEKLLDYRGVMT-DES 1195

  Fly  1193 RDKRMTCTVNLLNFYKNEINRKEMYLRYIYKLHNLHLQAENYTEAGFTLKLYASMLSWDRETQSF 1257
            :|.||:||||||||||:. ||:|||:||:|||.:|||..||||||.:||.|:..:|.|..| |..
Mouse  1196 KDNRMSCTVNLLNFYKDN-NREEMYIRYLYKLRDLHLDCENYTEAAYTLLLHTWLLKWSDE-QCA 1258

  Fly  1258 APFDNSGQ--PEWQR--KERLYHEILKYFDKGKCWEKGIPLCKELAHLYETRRFDYNKLSEILIQ 1318
            :....:||  |:..|  ||.||..|:.||||||.||:.|.||||||..||...|||..||:.|.|
Mouse  1259 SQVMQTGQQHPQTHRQLKETLYETIIGYFDKGKMWEEAISLCKELAEQYEMEIFDYELLSQNLTQ 1323

  Fly  1319 EAKFFQNILTQLRPEPEYFRVGFYGMGLPLFVRNKQFVYRGLEYERIGAFTQRLQTEFPSAQILG 1383
            :|||::||:..||.:|:||.||:||.|.|.|:|||.|:|||.||||...|..:|.::||:|:.:.
Mouse  1324 QAKFYENIMKILRTKPDYFAVGYYGQGFPSFLRNKVFIYRGKEYERREDFQMQLLSQFPNAEKMN 1388

  Fly  1384 NNSPPDNAILNAPDQYIQISNVRPVGDAQALKTAMVPVPEKIARFYEVNDVTRFIYDRPMYKGTV 1448
            ..|.|.:.:.|||.||||...|:||.|... :....|||::|..||:.|.|.:|.|.||:.:|.|
Mouse  1389 TTSAPGDDVRNAPGQYIQCFTVQPVLDEHP-RFKNKPVPDQIINFYKSNYVQKFHYSRPVRRGKV 1452

  Fly  1449 DKDNEFKSLWIERTILEIASPLPGILRWYEVKQKTMQELTPVEYACEIISNAGKELSELIVQYKR 1513
            |.:|||.|:|||||....|..|||||||:||...:...::|:|.|.|.:|...:::..:|.||:.
Mouse  1453 DPENEFASMWIERTSFLTAYKLPGILRWFEVVHMSQTTISPLENAIETMSTVNEKILMMINQYQS 1517

  Fly  1514 DPKRNINPFSMRLQGTIDANVMGGISKYQEAFFSEQFLKSPQGAGQQANVQRLKVLILEQIQILE 1578
            |....|||.||.|.|.:|..||||.:||::|||:|::  |.:....|..:..||.||..||..|.
Mouse  1518 DESLPINPLSMLLNGIVDPAVMGGFAKYEKAFFTEEY--SREHPEDQDKLSHLKDLIAWQIPFLG 1580

  Fly  1579 QALELHGQLAPSGVQPLHNRLLERFSQLKQSLSGMGRLKRQHSESIVNTPLPPLPTEQRVAPATA 1643
            ..:::|.:.....::|.|:|:.|.|..||        :|.:....:...|               
Mouse  1581 AGIKIHEKRVSDNLRPFHDRMEECFKNLK--------MKVEKEYGVREMP--------------- 1622

  Fly  1644 SSSLNANAHSNYVYDLDEIYTRPGDTVRPVDPLSSYQTLSKESLSIPLEDTAAP-PVPNRPRSQN 1707
                          |.::  .|.|   ||...|.||:.:|..||:....|.:.| .||..     
Mouse  1623 --------------DFED--RRVG---RPRSMLRSYRQMSVISLASMHSDCSTPSKVPAE----- 1663

  Fly  1708 FIGNGSMDSPEVPPKRQPTLNSPNAPPLPPRGITPDKRASNPLIFNDFGSGDAVGRRHSQQQQQH 1772
                 |.|....||| .|.:..   .|:.|....|:                 |..|.|:::.  
Mouse  1664 -----SFDLESAPPK-TPKVEE---EPISPGSTLPE-----------------VKLRRSKKRT-- 1700

  Fly  1773 GQKYSVVDISYDDPEADQQPHSLPPNFQDGSGGHLSVCFAPNDFRDSGISTTS-----SRELNHM 1832
             ::.|||                                    |.|...:|.|     ||:...|
Mouse  1701 -KRSSVV------------------------------------FADEKAATESDLKRLSRKQEFM 1728

  Fly  1833 NLNNLSEDSSSISTITVQHREHCRISSNGSLDYNAAASMNITQRESSTSSFDVEDFPVPPPPIPP 1897
            :..|||              ||..|.:..|:         ::|...::.|.         |.||.
Mouse  1729 SDTNLS--------------EHAAIPARVSI---------LSQMSFASQSM---------PTIPA 1761

  Fly  1898 KSLAVSSNGVNFSLDEAH-SPHPS 1920
            .:|:|:  ||. .||||: ||..|
Mouse  1762 LTLSVA--GVP-GLDEANTSPRLS 1782

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
spgNP_733258.4 SH3_DOCK_AB 9..64 CDD:212805 23/54 (43%)
DOCK_N 67..406 CDD:292790 122/365 (33%)
C2_Dock-B 414..600 CDD:176077 74/199 (37%)
DHR2_DOCK 1215..1610 CDD:297424 181/398 (45%)
Dock2NP_203538.2 SH3 12..67 CDD:302595 23/54 (43%)
DOCK_N 78..414 CDD:292790 121/357 (34%)
C2 422..617 CDD:301316 74/199 (37%)
DHR2_DOCK2 1199..1619 CDD:212579 196/432 (45%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1652..1703 16/84 (19%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1997
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG54452
OrthoDB 1 1.010 - - D102580at2759
OrthoFinder 1 1.000 - - FOG0000433
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100636
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X372
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
87.730

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