Protein Alignment spg and DOCK7

DIOPT Version :9

• Sequence 1: NP_733258.4
• Gene: spg / 43404
• FlyBaseID: FBgn0264324
• Length: 2187
• Species: Drosophila melanogaster
• Sequence 2: NP_001354490.1
• Gene: DOCK7 / 85440
• HGNCID: 19190
• Length: 2140
• Species: Homo sapiens
• Alignment Length: 2211
• Identity: 430/2211 - (19%)
• Similarity: 737/2211 - (33%)
• Gaps: 747/2211 - (33%)

  Fly    24 LALDVGDSVDIVE----ECKHWYRGSCPRKSRA-VGLFPKTYIHIKDLSKIDPVVAECTQVLREW 83
            ||:|.|...|::|    :.:..|   .||..|. |...|:.       |::||.|.:|   :|.:
Human    69 LAVDSGPLRDLIEFPPDDIEVVY---SPRDCRTLVSAVPEE-------SEMDPHVRDC---IRSY 120

  Fly    84 SEIWKRLYVDREAYKF------QTLRKVMFSILESRRELLSATMTQDQTLELQMVVVSKIDWGNR 142
            :|.|  ..|.|:.:|.      .||.|..    |.::.|.......|:..:.......:.|...|
Human   121 TEDW--AIVIRKYHKLGTGFNPNTLDKQK----ERQKGLPKQVFESDEAPDGNSYQDDQDDLKRR 179

  Fly   143 KLGLDLVPREGPLAVDPHGIGIVKLYNVHVSSAD----NAKASSSRGTLRRKT--QRKILTHHLY 201
            .:.:|..||         |.....::::..|..|    |....:....:.|:.  |||...|...
Human   180 SMSIDDTPR---------GSWACSIFDLKNSLPDALLPNLLDRTPNEEIDRQNDDQRKSNRHKEL 235

  Fly   202 FCM--------------------RDFGHRIGGDDAEVYF-----------FLYDGSHMRPLSERF 235
            |.:                    ..||.|:......:.|           .|||....:.:||.|
Human   236 FALHPSPDEEEPIERLSVPDIPKEHFGQRLLVKCLSLKFEIEIEPIFASLALYDVKEKKKISENF 300

  Fly   236 LVKISKDGFSNYIERLHSNCTVFTDLGAADL------NEELHLVAVVMRVGKIIQSDSI------ 288
            ...::.:.....: |.|......|.|..:.:      ::::.|   |:::.|::|...|
Human   301 YFDLNSEQMKGLL-RPHVPPAAITTLARSAIFSITYPSQDVFL---VIKLEKVLQQGDIGECAEP 361

  Fly   289 -------------KKIEKSGT--------LGHGPTFRRPFGVGVLSLGDIAHFDSSLEQSSDERE 332
                         :|:||..:        ||   .:|.||....:.|.:|.....|||:.|.|.|
Human   362 YMIFKEADATKNKEKLEKLKSQADQFCQRLG---KYRMPFAWTAIHLMNIVSSAGSLERDSTEVE 423

  Fly   333 YN-----------------------------------------------FKLFQCEEKDFHLLPE 350
            .:                                               ||    :|.| .|..|
Human   424 ISTGERKGSWSERRNSSIVGRRSLERTTSGDDACNLTSFRPATLTVTNFFK----QEGD-RLSDE 483

  Fly   351 LIIKKSSGKYSPIQASQGTQGIVVSLKLLHGGLGQARQE----------QPMLFQGSTI--TRK- 402
            .:.|..:....|....:..:.|...||:   .:..|.:.          |..|:..|.:  ||:
Human   484 DLYKFLADMRRPSSVLRRLRPITAQLKI---DISPAPENPHYCLTPELLQVKLYPDSRVRPTREI 545

  Fly   403 MGFP--DVIMPGDV-RNDLFLNLERGEF-ERGGKNTGKNILVTVVVL--DVAGNVLTDCLWGASG 461
            :.||  ||.:|... ||.|::..:...| .|.|  :.:||.|.|..:  :...|.:......:|.
Human   546 LEFPARDVYVPNTTYRNLLYIYPQSLNFANRQG--SARNITVKVQFMYGEDPSNAMPVIFGKSSC 608

  Fly   462 MESQPQYRSMILYHQNAPSWNEMLRLSVPIDKFSTAHVRFEFRHCSTRDKTEPKL---FAFSFAR 523
            .|...:..:.::||..:|.::|.:::.:|.......|:.|.|.|.|.:.|....|   ..:::..
Human   609 SEFSKEAYTAVVYHNRSPDFHEEIKVKLPATLTDHHHLLFTFYHVSCQQKQNTPLETPVGYTWIP 673

  Fly   524 LMDTGGATLGDGLHELYVYKCEDPAKLQVANYLRLQCRPRDAQAKMD-----CGGCFSRSSKEVF 583
            ::..|....|.        .|. |..|:         :|..|.:.:.     .|..:..:.|.||
Human   674 MLQNGRLKTGQ--------FCL-PVSLE---------KPPQAYSVLSPEVPLPGMKWVDNHKGVF 720

  Fly   584 VLRSLLCSTKLTQNA------DLLSLLQWRTYPETIQD------SLTGVLR-----LNDEEL--- 628
            .:..:..|:..||:.      .|::.|....:|..|.|      :|...|:     ||..:|
Human   721 NVEVVAVSSIHTQDPYLDKFFALVNALDEHLFPVRIGDMRIMENNLENELKSSISALNSSQLEPV 785

  Fly   629 VKFLQDVLDALFAM------FSNEEGNSTQHSGLVFHVLVSIFSL----LQSNKFQHFR-PVMNE 682
            |:||..:||.|..:      .:.:..|..|.|   |..:.||.:.    |:.|..||.| .::..
Human   786 VRFLHLLLDKLILLVIRPPVIAGQIVNLGQAS---FEAMASIINRLHKNLEGNHDQHGRNSLLAS 847

  Fly   683 YIENHFAAALVYK--------GLITSVEHMAVFMTKA----------------EHPD-------- 715
            ||...|.....|.        ||..|| |.|.....|                .:||
Human   848 YIHYVFRLPNTYPNSSSPGPGGLGGSV-HYATMARSAVRPASLNLNRSRSLSNSNPDISGTPTSP 911

  Fly   716 ----------------------------------------------------------------- 715
                                                                             
Human   912 DDEVRSIIGSKGLDRSNSWVNTGGPKAAPWGSNPSPSAESTQAMDRSCNRMSSHTETSSFLQTLT 976

  Fly   716 ---PFQK------------CFGSLE--------YIFKLLIQSR--------KLFARATGGQYEDS 749
               |.:|            |.||:.        :.|:|:::|.        ||.| ....::.:.
Human   977 GRLPTKKLFHEELALQWVVCSGSVRESALQQAWFFFELMVKSMVHHLYFNDKLEA-PRKSRFPER 1040

  Fly   750 FKRDLHSLFTALNGMLAVPSYDVIIPTQEALLNSTGVVLEQLKDTLPAPELGMLARNMLDAIPRG 814
            |..|:.:|.:.:       :.|::...|:    .|.:| |:|..:     |.....::|..:.||
Human  1041 FMDDIAALVSTI-------ASDIVSRFQK----DTEMV-ERLNTS-----LAFFLNDLLSVMDRG 1088

  Fly   815 APIRLIQ-------AKLHAVKD---LVSGEL-------FHEDDSRTVVLSVACKHL--------- 853
            ....||:       :||:::.:   |||..|       .||   ..|.|::.|..|
Human  1089 FVFSLIKSCYKQVSSKLYSLPNPSVLVSLRLDFLRIICSHE---HYVTLNLPCSLLTPPASPSPS 1150

  Fly   854 ------------------------RMHLSRRDELRLCAEILSEI-------LSQLYDLQKEQREK 887
                                    .:.:..|.:..|...:|:|:       ...|:.|.|:....
Human  1151 VSSATSQSSGFSTNVQDQKIANMFELSVPFRQQHYLAGLVLTELAVILDPDAEGLFGLHKKVINM 1215

  Fly   888 VTNTL-QHDLD-------------SLCKNILGILIRTI--------------------------- 911
            |.|.| .||.|             .|...::||::.|:
Human  1216 VHNLLSSHDSDPRYSDPQIKARVAMLYLPLIGIIMETVPQLYDFTETHNQRGRPICIATDDYESE 1280

  Fly   912 -------SIIMEGSNAVLPQ---------------------------LVSCLLGLLQLLDETHYK 942
                   ::.|..:...:||                           |:.|||.:|:..|||..:
Human  1281 SGSMISQTVAMAIAGTSVPQLTRPGSFLLTSTSGRQHTTFSAESSRSLLICLLWVLKNADETVLQ 1345

  Fly   943 RYWDELSPNKDPRDLK---------EFLSKSLLVYEELLT----QDWHVFPNDWLVMKLAA-NDV 993
            :::.:||..:..|.|.         |:..|.:......||    :|......:.::..:.| .::
Human  1346 KWFTDLSVLQLNRLLDLLYLCVSCFEYKGKKVFERMNSLTFKKSKDMRAKLEEAILGSIGARQEM 1410

  Fly   994 LRMSLEEFAKPLVYRFLGP-------QAFDSQ--LWWSYFSLAVAFLTQPSLQLEQYREPKRLKI 1049
            :|.|..:..   .|....|       .||.||  |.|   ...:....|.:.:|::    .|.:|
Human  1411 VRRSRGQLG---TYTIASPPERSPSGSAFGSQENLRW---RKDMTHWRQNTEKLDK----SRAEI 1465

  Fly  1050 LH---------SHGDMRVLMGFQILSMWSQLGEQKLHFIPSMVGPFLEVTLVPEP---------- 1095
            .|         :..::.:|...:|:.....:.|.|    .|::|..|:|.|....
Human  1466 EHEALIDGNLATEANLIILDTLEIVVQTVSVTESK----ESILGGVLKVLLHSMACNQSAVYLQH 1526

  Fly  1096 --ALRKATLSVFYDMM---QCEQAARGSFRL----------VESELIDKLDLLISEN--KGDDEY 1143
              |.::|.:|.|.:::   :.||.|....||          :.|.....|.||:.:|  .|::..
Human  1527 CFATQRALVSKFPELLFEEETEQCADLCLRLLRHCSSSIGTIRSHASASLYLLMRQNFEIGNNFA 1591

  Fly  1144 R-ELFSTILLEKVQVENPNWKEAGIAFIASVTRLLERLLDYRSVMQGEENRDKRMT--------C 1199
            | ::..|:.|..:...:.|:.|      ..:.|.|:.:|.|     .||:.:.|.|        .
Human  1592 RVKMQVTMSLSSLVGTSQNFNE------EFLRRSLKTILTY-----AEEDLELRETTFPDQVQDL 1645

  Fly  1200 TVNLLNFYKNEINRKE-----------MY-------------LRYIYKLHNLHLQAENYTEAGFT 1240
            ..||.....:.:..||           ||             |.::..:...|.:..|:.||...
Human  1646 VFNLHMILSDTVKMKEHQEDPEMLIDLMYRIAKGYQTSPDLRLTWLQNMAGKHSERSNHAEAAQC 1710

  Fly  1241 L-------KLYASMLSWDRETQSFAP-----FDNSGQPEWQRKERLYHEILKYFDKGKC-----W 1288
            |       ..|.|||    |.:.:.|     |.|......: :..:..:::...::|.|     .
Human  1711 LVHSAALVAEYLSML----EDRKYLPVGCVTFQNISSNVLE-ESAVSDDVVSPDEEGICSGKYFT 1770

  Fly  1289 EKGI---------------------PLCKELAHLYETRRFDYNKLSEI--LIQEAKFFQNILTQL 1330
            |.|:                     .:.|.|..::|..| |..|||.|  .:|||  |..|:.|.
Human  1771 ESGLVGLLEQAAASFSMAGMYEAVNEVYKVLIPIHEANR-DAKKLSTIHGKLQEA--FSKIVHQS 1832

  Fly  1331 ----RPEPEYFRVGFYGMGLPLFVRNKQFVYRGLEYERIGAFTQRLQTEFPS------AQILGNN 1385
                |....||||||||.... .:..::|||:.....::...:.||:..:..      .:::.::
Human  1833 TGWERMFGTYFRVGFYGTKFG-DLDEQEFVYKEPAITKLAEISHRLEGFYGERFGEDVVEVIKDS 1896

  Fly  1386 SPPDNAILNAPDQYIQISNVRPVGDAQALKTAMVPVPEKIARFYEVNDVTRFIYDRPMYKGTVD- 1449
            :|.|...|:....||||:.|.|..|...:|       ::|..|.:..::.||:|..|.   |:|
Human  1897 NPVDKCKLDPNKAYIQITYVEPYFDTYEMK-------DRITYFDKNYNLRRFMYCTPF---TLDG 1951

  Fly  1450 -KDNEFKSLWIERTILEIASPLPGILRWYEVKQKTMQELTPVEYACEIISNAGKELSELIVQYKR 1513
             ...|....:..:|||..:...|.|.....|..|....|||:|.|.|.:....:||:....|...
Human  1952 RAHGELHEQFKRKTILTTSHAFPYIKTRVNVTHKEEIILTPIEVAIEDMQKKTQELAFATHQDPA 2016

  Fly  1514 DPKRNINPFSMRLQGTIDANVMGGISKYQEAFFSEQFLKSPQGAGQQANVQRLKVLILEQIQILE 1578
            |||.    ..|.|||::...|..|..:..:.|.||    .|.......:..:|::...:..:..|
Human  2017 DPKM----LQMVLQGSVGTTVNQGPLEVAQVFLSE----IPSDPKLFRHHNKLRLCFKDFTKRCE 2073

  Fly  1579 QALELHGQL-APSGVQPLHNRLLER-FSQLKQSLSGMGRLKRQHSESIVNTPLPPLPTEQRVAPA 1641
            .||..:..| .|.  |..:.|.||| :.:||::|           :.::|..:|.|  .:.|.|.
Human  2074 DALRKNKSLIGPD--QKEYQRELERNYHRLKEAL-----------QPLINRKIPQL--YKAVLPV 2123

  Fly  1642 T 1642
            |
Human  2124 T 2124

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
spg	NP_733258.4	SH3_DOCK_AB	9..64	CDD:212805	12/44 (27%)
		DOCK_N	67..406	CDD:292790	84/474 (18%)
		C2_Dock-B	414..600	CDD:176077	39/203 (19%)
		DHR2_DOCK	1215..1610	CDD:297424	112/472 (24%)
DOCK7	NP_001354490.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	138..183		8/48 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	888..971		2/82 (2%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1997
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810