DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment spg and DCK1

DIOPT Version :9

Sequence 1:	NP_733258.4	Gene:	spg / 43404	FlyBaseID:	FBgn0264324	Length:	2187	Species:	Drosophila melanogaster
Sequence 2:	NP_013526.1	Gene:	DCK1 / 851141	SGDID:	S000004414	Length:	1932	Species:	Saccharomyces cerevisiae

Alignment Length:	2005	Identity:	393/2005 - (19%)
Similarity:	683/2005 - (34%)	Gaps:	604/2005 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 WIPSNNK-YGVAIHNWHGDVRF-GLALD--------VGDSVDIVEEC--KHWYRG-SCPR----- 48
            |:|::.. |||.:.::....|: .|..:        ||..|.:.||.  |.|.|. .|.|
Yeast     9 WLPTDRLIYGVLVKSFLPLQRYPELVYENSNYANVYVGAEVYVFEESVDKKWCRAYQCLRPFPEE 73

  Fly    49 ---------------KSRAVGLFPKTYIHIK--------------DLSKIDPVVA-ECTQVLREW 83
                           |.:.| :||:.|:|.:              ......|::: ||     |.
Yeast    74 FISNMNSANDVLPDVKPKVV-IFPRKYVHFEAEKAVSTMPFFKAPSAEDFKPLISKEC-----ES 132

  Fly    84 SEIWKRLYV------------------------DREAYK----------------------FQTL 102
            ......|||                        .:.::|                      |...
Yeast   133 RSFCDSLYVSSTDDISTGKPRKTPRPPFPFFRYQKRSFKDEMGPILSLISSHVYSMYSIGEFSIY 197

  Fly   103 RKV--MFSILESRRELLSATMTQD----------QTLELQMVVVSKIDWGNRKLGLDLVPREGPL 155
            ||:  ::..|::.|..||..:|.:          .:|..::.......:...||..:..||.
Yeast   198 RKMIKLYYDLDTIRFRLSMNLTTEAEKINLIRAATSLRTKIAKFLSSTYRKNKLIANSTPRN--- 259

  Fly   156 AVDPHGI----------GIVKLYNVH-----------------------VSSADNAKASSSRGTL 187
             .||:|.          |.:..|.:.                       |.|.|.:.::...||:
Yeast   260 -PDPYGFEGIFARDIDTGELLSYEIDKLRTLVSSSMLCGLTNNFPTVPVVESDDESSSNGLFGTV 323

  Fly   188 RR-----------------------------KTQRKILTHHLYFCMRDFGHRIGGDDAEVYFFLY 223
            |.                             :|:.::||..                    |.:.
Yeast   324 RSSILVNLKDLAWDPSISDPKYQDLSICVYLRTKDEVLTES--------------------FTMT 368

  Fly   224 DGSHMRPLSERFLVKISKDGFSNYIERL-HSNCTVFTDLGAADLNEELHLVAVVMRVGKI----- 282
            ..|:|    |..|.:|....|.|.:|.: |.|              :::||.|:.....|
Yeast   369 KSSNM----ESALDEIPAMLFKNILETIVHKN--------------KVYLVVVLKETIAITTETA 415

  Fly   283 --IQSDSIKKIEKSGTLGHGP-------------TFRRPFGVGVLSLGDIAHFDSSLEQSSDERE 332
              |.|.:|...|.|   .|.|             ..::....||:::..:..|.:.|..::..:.
Yeast   416 PEISSYNISTEESS---SHSPFSPFNSSTENKIDHVKKGLAAGVINISPVFKFYNGLSVANKAQR 477

  Fly   333 YNFKLFQCEEKDFH--------------LLPELIIKKSSGKYSPIQASQGTQGIVVSLKLLHGGL 383
            :|..|:..:..|..              |:.::|...|.|    :..:.....:.|::|.:.|
Yeast   478 FNLYLYSSDSSDSQNFNSSKDADLGWGGLINKIIKDSSEG----VSVNPRAVSLSVTVKEIIG-- 536

  Fly   384 GQARQEQPMLFQGSTITRK---MGFPDVIMPGDVRNDLFLNLERGEFERGGKNTGKNILVTVVVL 445
               :||...:...|.:..:   ..|.|.:.....|  ::|||.|... .|......||....|.:
Yeast   537 ---KQEAEKVLSTSLVPIRSIPTYFYDTMFSQAER--IYLNLGRVSL-YGLPAADTNIENVTVQI 595

  Fly   446 DVAGNVLTDCL---------W-----------GAS----GMESQPQYRSMILYHQNAPSWNEMLR 486
            ......:..|.         |           |.|    |:|:..:              :|.||
Yeast   596 SCRNKAVKFCKNKLEERSGDWKFVSVRPNESIGESIRIEGVENMNE--------------DETLR 646

  Fly   487 LSVPIDKF----STAHVR-----FEFRHCST----RDKTEP----KLFAFSFARLMDTGGATLGD 534
            :.|.::.|    |..|::     .|:|..:.    ..|:.|    :|.|..|.|..:.
Yeast   647 VLVYLNGFLMAKSNIHIKKKNEIIEYRKGTVFQIMSSKSVPLIHLELEASYFGRRYNI------- 704

  Fly   535 GLHELYVYKCEDPAKLQVANYLRLQCRPRDAQAKMDCGGCFSRSSKEVFVLRSLLCSTKLTQNAD 599
                       :||   :.|:|.||.:..:          |.:..||.:.:     :.|...|..
Yeast   705 -----------NPA---ITNFLVLQTKNVE----------FDQQLKEHYSV-----TLKQLNNVS 740

  Fly   600 LLSLLQWRTYPETIQDSLTGVLRLNDEELVKFLQDVLDALFAMFSNEEGNSTQHSGLVFHVLVSI 664
            ...||:   :.:||   |...|.|        |:.|.:|     ::::|.|:....:||...|..
Yeast   741 FKDLLK---HFDTI---LAHYLLL--------LESVNEA-----TDKKGPSSSLPNIVFSEFVKF 786

  Fly   665 FSLL---QSNKFQHF----RPVMNEYIENHFAAALVYKGLITSVEHMAVFMTKAEHPDPFQKCFG 722
            .:|:   |.|....|    :.||::.:|....|.::.|.:.|..:......|:.          |
Yeast   787 LNLMLTHQENSRYWFNRLYKKVMSKELECPNVAPILIKHMTTIFDRSHSSWTRT----------G 841

  Fly   723 -----SLEYIFKLLIQSRKLFARATGGQYEDS------FKRDLHSLFTALNGMLAVPSYDVIIPT 776
                 ::.||..|          |.|..:.|.      |.|.||...     |||   .:.|:..
Yeast   842 TAICRTILYIIVL----------AIGSSHSDEMPNFSHFFRSLHKFL-----MLA---DEPIMAD 888

  Fly   777 QEALLNSTGVVLEQLKDTLPAPELGMLARNMLDA----------IPRGAPIR---LIQAKLHAVK 828
            |..|:.|...:||.:.:.....:|...|..:.:.          ..|...:|   .:..|.:.:.
Yeast   889 QILLIESIPSMLETMTNHCKVEDLVRFAIGLFECCQEKEMNQKMYSRPLSVREEEYLNTKFNCLL 953

  Fly   829 DLVSGELFHE--------DDSRTVVLSVACKHLRMHLSRRDE-------LRLCAEILSEILSQLY 878
            .|::.::...        |..|...||...:.|....:..|:       |||...:...|:.. |
Yeast   954 KLINKKVLQNYLTNTESVDKLRLQFLSKTLEWLLTPYTPGDDKCFHVESLRLVNSVFITIIED-Y 1017

  Fly   879 DLQKEQREKVTNTLQHDLDSLCKNILGI--------LIRTISIIMEGSNAVLPQLVSC------- 928
            .....||     .|...|..|||:.:.:        |:|...:.    ..:.|:.:.|
Yeast  1018 KFDMLQR-----NLIRLLPYLCKSFVHLRRYCKKARLMRPRRVF----TMLFPREIPCNYIPVDS 1073

  Fly   929 ----------LLGLLQLLDE---------THYKRYWDELS-PNKDPRDLKEFLSKSLL---VYEE 970
                      ||.|..::.|         ..|:.:.:.:: .:||......|.|:.:.   ||..
Yeast  1074 IVNDEVVVEVLLELAIIICEITKIASSRFPSYQSFSEIINLCDKDTLFQSNFYSRQITNENVYTI 1138

  Fly   971 LLT------QDWHVFPN-DWLVMK--LAANDVLRMSLEEFAKPLVYRFLGP-------QAFDSQL 1019
            ..|      |||  ||. .||.:.  |..:.::.:||   .|..:.....|       :..|.:|
Yeast  1139 TKTVFLFFKQDW--FPGMKWLGVSALLGRSSLILLSL---CKDYIIENNSPSPSKESEKRVDMRL 1198

  Fly  1020 WWSYFSLAVAFLTQPSLQLEQYREPKRLKILHSHGDMRVLMGFQILSMWSQLGE-------QKLH 1077
            |..|..:.:......|..|.:.....|..:....||::.:..:.:...|..|..       .|.:
Yeast  1199 WAEYVKVILLVSNHKSASLTKLAITPRKAVYLISGDLKKISAYILNECWDALATGHYNITYAKKY 1263

  Fly  1078 FIPSMVGPFLEVTLVPEPALRKATLSVFYDMMQCEQAAR-----------------GSFR----- 1120
            .:.::.....|:.:..:..:|:..:..|:..:   .|.|                 ||.:
Yeast  1264 GLGALSDCQFELFVHNQFLIREIFIFAFHRHI---DATRICCKILWGLGLNFWRIFGSLQPAVNA 1325

  Fly  1121 ----LVESELIDKLDLLISENKGDDEYRELFSTILLEKVQV-ENPNWKEAGIAFIASVTRLLERL 1180
                |..:..|.||.|       :|...|.|.:.|...:.| ::..:..|.:.|:..:...|..:
Yeast  1326 CIPELFSAYQIGKLRL-------NDYELERFVSCLFFMMHVPDSDTFFPACMDFLRDLLGFLHIV 1383

  Fly  1181 LDYRSVMQGEENRDKRMTCTVNLLNFYKNEINRKEMYLRYIYKLHNLHLQAENYTEAGFTLKLYA 1245
            .:...:...||..|.|....:.:.. |..|.||.|::.:.||.|....:|.:::.:|..:|:|.|
Yeast  1384 NEIYKIPNQEEFDDDRTARHIEMFE-YLLEANRPELFHKMIYDLFIHFIQKKDFVQAALSLELLA 1447

  Fly  1246 SMLSWDR----ETQSFAPFDNSGQPEWQRKERLYHEILKYFDKGKCWEKGIPLCKELAHLYETRR 1306
            ...:||.    |..||.|...  |..::|||.|..|..:.|.:|:..||.:.:.|:|...|:...
Yeast  1448 GTYAWDSNDTLEAISFPPLPE--QSSFERKEYLLKESARNFSRGQKPEKALAVYKDLIKAYDEIN 1510

  Fly  1307 FDYNKLSEILIQEAKFFQNILTQLRPEPEYFRVGFYGMGLPLFVRNKQFVYRGLEYERIGAFTQR 1371
            :|.|.|:.:..|.|..:..:.:..|..|.||:|.|.|.|.|..:|||.||:.||.:|.|.:...|
Yeast  1511 YDLNGLAFVHDQIAGIYTRLQSIDRLVPTYFKVSFMGFGFPKSLRNKSFVFEGLPFEHITSMHDR 1575

  Fly  1372 LQTEFPSAQILGNNSPPDNAILNAP-DQYIQISNVRP---VGDAQALKTAMVPVPEKIARFYEVN 1432
            |...:..:.|:.:....|..::|.| .:||.:::|.|   :.|..........:..|:..:.|..
Yeast  1576 LLRSYHGSNIVHSQEEVDMLLMNPPMGKYIHVASVEPCLSISDNYNSSDKKSSINNKVRMYIENR 1640

  Fly  1433 DVTRFIYDR--PMYKGTVDKDNEFKSLWIERTILEIASPLPGILRWYEVKQKTMQELTPVEYACE 1495
            |:..|...|  |..||..|       ||:|.......:..|.::...|:.:.|..:|:|:|.|..
Yeast  1641 DLRTFSNSRRLPGAKGVTD-------LWVEEYTYHTMNTFPTLMNRSEIVKVTKSKLSPLENAIR 1698

  Fly  1496 IISNAGKELSEL------IVQYKRDPKRNINPFSMRLQGTIDANVMGGISKYQ---EAFFSEQFL 1551
            .:....:||..|      .::...|........|..:.|||.|.|.||||:|:   |...|:||.
Yeast  1699 SLQVKIQELYGLENMCNKTLKDHGDVNDLFTELSTNITGTISAPVNGGISQYKAFLEPSTSKQFS 1763

  Fly  1552 KSPQGAGQQANVQRLKVLILEQIQILEQALELHGQLAPS-GVQPLHNRLLERFSQ 1605
            ....|        ||.:...|.:.:|.:.|.||.:|.|| .::|.|:.|:..|.:
Yeast  1764 TDDLG--------RLTLAFDELVAVLGRCLTLHAELLPSKDLKPSHDLLVRLFEE 1810

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
spg	NP_733258.4	SH3_DOCK_AB	9..64	CDD:212805	21/86 (24%)
		DOCK_N	67..406	CDD:292790	74/497 (15%)
		C2_Dock-B	414..600	CDD:176077	41/226 (18%)
		DHR2_DOCK	1215..1610	CDD:297424	115/411 (28%)
DCK1	NP_013526.1	DHR2_DOCK	1417..1815	CDD:212566	115/411 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	119	1.000	Domainoid score	I1269
eggNOG	1	0.900	-	-		E1_KOG1997
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000433
OrthoInspector	1	1.000	-	-		otm46498
orthoMCL	1	0.900	-	-		OOG6_100636
Panther	1	1.100	-	-	O	PTHR45653
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2355
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	8.840