DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment spg and DOCK8

DIOPT Version :9

Sequence 1:NP_733258.4 Gene:spg / 43404 FlyBaseID:FBgn0264324 Length:2187 Species:Drosophila melanogaster
Sequence 2:NP_982272.2 Gene:DOCK8 / 81704 HGNCID:19191 Length:2099 Species:Homo sapiens


Alignment Length:2140 Identity:410/2140 - (19%)
Similarity:712/2140 - (33%) Gaps:700/2140 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly    19 DVRFGLALDVG----DSVDIV---EECKHWYRGSCPRKSRAVGLFPKTYIHIKDLSKIDPVVAEC 76
            ||:  ||.::|    |.:|:|   :||: ..:.|.|.:.                .::||.|.:|
Human    76 DVQ--LAQELGDFTDDDLDVVFTPKECR-TLQPSLPEEG----------------VELDPHVRDC 121

  Fly    77 TQV-LREWSEIWKRLYVDREAYKFQTLRKVM-FSILESRREL---LSATMTQDQTLELQMVVVSK 136
            .|. :|||      |.|:|   |.|...::. |....||::.   |.....:.:|||........
Human   122 VQTYIREW------LIVNR---KNQGSPEICGFKKTGSRKDFHKTLPKQTFESETLECSEPAAQA 177

  Fly   137 IDWGNRKLG-LDLVPREGPLAVDPHGIGIV----KLYNV--HVSSADNAKASSSRGTLRRKTQRK 194
               |.|.|. |..|..:||:......:..:    :|.|:  .||:.|..|.:..    .|:|.|:
Human   178 ---GPRHLNVLCDVSGKGPVTACDFDLRSLQPDKRLENLLQQVSAEDFEKQNEE----ARRTNRQ 235

  Fly   195 ILTHHLY---------------FCMRD-FGHRI--------GGDDAEVYF---FLYDGSHMRPLS 232
            .....||               .|.:: .|:||        ...:.|..|   .|||....:.:|
Human   236 AELFALYPSVDEEDAVEIRPVPECPKEHLGNRILVKLLTLKFEIEIEPLFASIALYDVKERKKIS 300

  Fly   233 ERFLVKISKDGFSNYIERLHSNCTVFTDLGAADL------NEELHLVAVVMRVGKIIQSDSI--- 288
            |.|...::.|.|..:: |.|:.....:....:.:      :.:::|   |:::.|::|...|   
Human   301 ENFHCDLNSDQFKGFL-RAHTPSVAASSQARSAVFSVTYPSSDIYL---VVKIEKVLQQGEIGDC 361

  Fly   289 ----------------KKIEK--------SGTLGHGPTFRRPFGVGVLSLG----------DIAH 319
                            :||||        ...||   .:|.||....:||.          ::..
Human   362 AEPYTVIKESDGGKSKEKIEKLKLQAESFCQRLG---KYRMPFAWAPISLSSFFNVSTLEREVTD 423

  Fly   320 FDSSLEQSS-------------DEREY---------NFKL-------FQCEEKD-------FHLL 348
            .||.:.:||             .||..         |||.       |..:|.|       |..|
Human   424 VDSVVGRSSVGERRTLAQSRRLSERALSLEENGVGSNFKTSTLSVSSFFKQEGDRLSDEDLFKFL 488

  Fly   349 PELIIKKSSGKYSPIQASQGTQGIVVSL--KLLHGGLGQARQEQPMLFQGSTITRK--MGFP--D 407
            .:  .|:||.....:::..|...:.:|.  ::::..|...........:..|...|  :.||  :
Human   489 AD--YKRSSSLQRRVKSIPGLLRLEISTAPEIINCCLTPEMLPVKPFPENRTRPHKEILEFPTRE 551

  Fly   408 VIMPGDV-RNDLFLNLERGEFERGGKNTGKNILVTVVVL--DVAGNVLTDCLWGASGMESQPQYR 469
            |.:|..| ||.|::..:|..|. ....:.:||.:.:..:  :.|.|.:......:||.|...:..
Human   552 VYVPHTVYRNLLYVYPQRLNFV-NKLASARNITIKIQFMCGEDASNAMPVIFGKSSGPEFLQEVY 615

  Fly   470 SMILYHQNAPSWNEMLRLSVPIDKFSTAHVRFEFRHCSTRDK---TEPKLFAFSFARL-----MD 526
            :.:.||..:|.:.|.:::.:|.......|:.|.|.|.|.:.|   :...|..:|:..:     :.
Human   616 TAVTYHNKSPDFYEEVKIKLPAKLTVNHHLLFTFYHISCQQKQGASVETLLGYSWLPILLNERLQ 680

  Fly   527 TGGATLGDGLHELYVYKCEDPA--KLQVANYLRLQCRPRDAQAKMDCGGCFSRSSKEVFVLRSLL 589
            ||...|...|.:|       |.  .:..|..:.||..|..          ::...|.||.:....
Human   681 TGSYCLPVALEKL-------PPNYSMHSAEKVPLQNPPIK----------WAEGHKGVFNIEVQA 728

  Fly   590 CSTKLTQNADL-------LSLLQWRTYPETIQDS-----------LTGVLRLND---EELVKFLQ 633
            .|:..||:..|       .||....|:|..:.|.           ...::.||.   |.||.||.
Human   729 VSSVHTQDNHLEKFFTLCHSLESQVTFPIRVLDQKISEMALEHELKLSIICLNSSRLEPLVLFLH 793

  Fly   634 DVLDALFAMFSNE---EGNSTQHSGLVFHVLVSIFSLLQS----NKFQHFRP-VMNEYIE----- 685
            .|||.||.:....   .|.:...|...|..:|:|.:.|.:    :|.||.|. ::..|:.     
Human   794 LVLDKLFQLSVQPMVIAGQTANFSQFAFESVVAIANSLHNSKDLSKDQHGRNCLLASYVHYVFRL 858

  Fly   686 ----------------------------------------------------NHFAAALVYKGLI 698
                                                                .|.||....|.::
Human   859 PEVQRDVPKSGAPTALLDPRSYHTYGRTSAAAVSSKLLQARVMSSSNPDLAGTHSAADEEVKNIM 923

  Fly   699 TS------VEHMAVFMTKAEH-------PDPFQK---------------------CFGSLEYIFK 729
            :|      ...|:.:.:.:..       |.|..|                     .|....:.|:
Human   924 SSKIADRNCSRMSYYCSGSSDAPSSPAAPRPASKKHFHEELALQMVVSTGMVRETVFKYAWFFFE 988

  Fly   730 LLIQS----------RKLFARATGGQYEDSFKRDLHSLFTALNGMLAVPSYDVIIPTQEALLNST 784
            ||::|          |..|.|.   ::.|.|..|:.::...:...:|            |||   
Human   989 LLVKSMAQHVHNMDKRDSFRRT---RFSDRFMDDITTIVNVVTSEIA------------ALL--- 1035

  Fly   785 GVVLEQLKDTLPAPE----LGMLARNMLDAIPRGAPIRLIQ-------AKLHAVKDLVSGELFHE 838
               ::..|:...|.:    |.....::|..:.||....||:       |||..:..|:|      
Human  1036 ---VKPQKENEQAEKMNISLAFFLYDLLSLMDRGFVFNLIRHYCSQLSAKLSNLPTLIS------ 1091

  Fly   839 DDSRTVVLSVACKH-----LRMHLSRRD-------------ELRLCAEILSEILSQLYDLQKEQR 885
              .|...|.:.|.|     |.:.....|             ....|:....:.::.::||..|.|
Human  1092 --MRLEFLRILCSHEHYLNLNLFFMNADTAPTSPCPSISSQNSSSCSSFQDQKIASMFDLTSEYR 1154

  Fly   886 EK--VTNTL-------------------------------QHDLDSLCKN-------------IL 904
            ::  :|..|                               .||||..|..             ::
Human  1155 QQHFLTGLLFTELAAALDAEGEGISKVQRKAVSAIHSLLSSHDLDPRCVKPEVKVKIAALYLPLV 1219

  Fly   905 GILI---------------------------------RTISIIMEGSN----------AVLP--- 923
            ||::                                 :.:::.:.|:|          :.||   
Human  1220 GIILDALPQLCDFTVADTRRYRTSGSDEEQEGAGAINQNVALAIAGNNFNLKTSGIVLSSLPYKQ 1284

  Fly   924 ----------QLVSCLLGLLQLLDETHYKRYW-------------------------------DE 947
                      .|:.|.|.:::..|::..:: |                               |:
Human  1285 YNMLNADTTRNLMICFLWIMKNADQSLIRK-WIADLPSTQLNRILDLLFICVLCFEYKGKQSSDK 1348

  Fly   948 LSPN--KDPRDLKEFLSKSLLVYE----ELLTQ---------------DWHVFPNDWLVMKLAAN 991
            :|..  :..||:|..|.::||..|    |::.:               .|......|    ..||
Human  1349 VSTQVLQKSRDVKARLEEALLRGEGARGEMMRRRAPGNDRFPGLNENLRWKKEQTHW----RQAN 1409

  Fly   992 DVLRMSLEEF-AKPLVYRFLGPQAFDSQLWWSYFSLAVAFLTQPSLQLEQYREPKR------LKI 1049
            :.|..:..|. .:.|:...|..:|          .|.:..:.:..:|.....:.|.      |::
Human  1410 EKLDKTKAELDQEALISGNLATEA----------HLIILDMQENIIQASSALDCKDSLLGGVLRV 1464

  Fly  1050 L--------------HSHGDMRVLMG-------FQILSMWSQLGEQKLHFIPSMVGPFLEVTLVP 1093
            |              |....:|.|:.       .:.:.....|..|.||...|.    ::||   
Human  1465 LVNSLNCDQSTTYLTHCFATLRALIAKFGDLLFEEEVEQCFDLCHQVLHHCSSS----MDVT--- 1522

  Fly  1094 EPALRKATLSVFYDMMQCEQAARGSFRLVESELIDKLDLLI--SENKGDDEYRELFSTILLEKVQ 1156
                |....:..|.:|:....|..:|..|:.::...|..|:  :.:..::..|....|||.    
Human  1523 ----RSQACATLYLLMRFSFGATSNFARVKMQVTMSLASLVGRAPDFNEEHLRRSLRTILA---- 1579

  Fly  1157 VENPNWKEAGIA-----FIASVTRLLERL--LDYRSVMQGEENRDKRMTCTVNLLNFYKNEINRK 1214
                 :.|...|     |...|..||..|  :.|.:|...|...|..|...: :....|:.....
Human  1580 -----YSEEDTAMQMTPFPTQVEELLCNLNSILYDTVKMREFQEDPEMLMDL-MYRIAKSYQASP 1638

  Fly  1215 EMYLRYIYKLHNLHLQAENYTEAGFTL-------KLYASMLSWDRETQSFAPFDNSGQPEWQR-- 1270
            ::.|.::..:...|.:.:.||||...|       ..|.|||    |..|:.|.   |...:|.  
Human  1639 DLRLTWLQNMAEKHTKKKCYTEAAMCLVHAAALVAEYLSML----EDHSYLPV---GSVSFQNIS 1696

  Fly  1271 ----KERLYHE-ILKYFDKGKC-----WEKG-IPLCKELAH------LYETRRFDYNKLSEILIQ 1318
                :|.:..| .|...:.|.|     .|.| :.|.::.|.      ||||....|..:..||..
Human  1697 SNVLEESVVSEDTLSPDEDGVCAGQYFTESGLVGLLEQAAELFSTGGLYETVNEVYKLVIPILEA 1761

  Fly  1319 EAKFFQNILTQLRPE---------------PEYFRVGFYGMGLPLFVRNKQFVYRGLEYERIGAF 1368
            ..:|.:..||..:.:               ..||||||:|.... .:..::|||:.....::...
Human  1762 HREFRKLTLTHSKLQRAFDSIVNKDHKRMFGTYFRVGFFGSKFG-DLDEQEFVYKEPAITKLPEI 1825

  Fly  1369 TQRLQ--------TEFPSAQILGNNSPPDNAILNAPDQYIQISNVRPVGDAQALKTAMVPVPEKI 1425
            :.||:        .||  .:::.:::|.|...|:....||||:.|.|..|...:|       :::
Human  1826 SHRLEAFYGQCFGAEF--VEVIKDSTPVDKTKLDPNKAYIQITFVEPYFDEYEMK-------DRV 1881

  Fly  1426 ARFYEVNDVTRFIYDRPMYKGTVD--KDNEFKSLWIERTILEIASPLPGILRWYEVKQKTMQELT 1488
            ..|.:..::.||:|..|.   |::  ...|....:...|:|......|.|.....|.||....||
Human  1882 TYFEKNFNLRRFMYTTPF---TLEGRPRGELHEQYRRNTVLTTMHAFPYIKTRISVIQKEEFVLT 1943

  Fly  1489 PVEYACEIISNAGKELSELIVQYKRDPKRNINPFSMRLQGTIDANVMGGISKYQEAFFSEQFLKS 1553
            |:|.|.|.:.....:|:..|.|...|.|.    ..|.|||::.|.|..|..:..:.|.:|    .
Human  1944 PIEVAIEDMKKKTLQLAVAINQEPPDAKM----LQMVLQGSVGATVNQGPLEVAQVFLAE----I 2000

  Fly  1554 PQGAGQQANVQRLKVLILEQIQILEQALELHGQLAPSGVQPLHNRLLERFSQLKQSLSGM 1613
            |.......:..:|::...|.|....:|:|.:.:|..:..:.....|.:.:::||::|..|
Human  2001 PADPKLYRHHNKLRLCFKEFIMRCGEAVEKNKRLITADQREYQQELKKNYNKLKENLRPM 2060

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
spgNP_733258.4 SH3_DOCK_AB 9..64 CDD:212805 12/51 (24%)
DOCK_N 67..406 CDD:292790 92/460 (20%)
C2_Dock-B 414..600 CDD:176077 42/198 (21%)
DHR2_DOCK 1215..1610 CDD:297424 104/445 (23%)
DOCK8NP_982272.2 DUF3398 73..164 CDD:288711 29/115 (25%)
C2_Dock-C 559..739 CDD:176078 41/197 (21%)
DHR2_DOCK8 1636..2057 CDD:212574 104/448 (23%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1997
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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