DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment spg and DOCK5

DIOPT Version :9

Sequence 1:NP_733258.4 Gene:spg / 43404 FlyBaseID:FBgn0264324 Length:2187 Species:Drosophila melanogaster
Sequence 2:NP_079216.4 Gene:DOCK5 / 80005 HGNCID:23476 Length:1870 Species:Homo sapiens


Alignment Length:2102 Identity:711/2102 - (33%)
Similarity:1081/2102 - (51%) Gaps:357/2102 - (16%)


- Green bases have known domain annotations that are detailed below.


  Fly     2 WIPS-NNKYGVAIHNWHGDVRFGLALDVGDSVDIVEECKHWYRGSCPRKSRAVGLFPKTYIHIKD 65
            |||: ..||||||:|::......|:|.:||:|.|:|..:.||||...:.....|:||:||||:|:
Human     4 WIPTKRQKYGVAIYNYNASQDVELSLQIGDTVHILEMYEGWYRGYTLQNKSKKGIFPETYIHLKE 68

  Fly    66 LSKID------------PVVAECTQVLREWSEIWKRLYVDREAYKFQTLRKVMFSILESRRELLS 118
            .:..|            |:|.|.|..||||:.||::|||:.:...|:.|:::.:|::|.|.::||
Human    69 ATVEDLGQHETVIPGELPLVQELTSTLREWAVIWRKLYVNNKLTLFRQLQQMTYSLIEWRSQILS 133

  Fly   119 ATMTQDQTLELQMVVVSKIDWGNRKLGLDLVPRE--GPLAVDPHGIGIVKLYNVH--VSSADNAK 179
            .|:.:|:..||:..|.:|||.|||.||||||.|:  |.: :||.....:.|:..|  .|.....|
Human   134 GTLPKDELAELKKKVTAKIDHGNRMLGLDLVVRDDNGNI-LDPDETSTIALFKAHEVASKRIEEK 197

  Fly   180 ASSSRGTLRRKTQR------KILTHHLYFCMRDFGHRIGGDDAEVYFFLYDGSHMRPLSERFLVK 238
            ....:..|:....|      .|.|:.||...::|...| |:|||::..|||......:||.:|::
Human   198 IQEEKSILQNLDLRGQSIFSTIHTYGLYVNFKNFVCNI-GEDAELFMALYDPDQSTFISENYLIR 261

  Fly   239 ISKDGFSNYIERLHSNCTVFTDLGAADL-NEELHLVAVVMRVGKIIQSDSIKKIEKSGTLGHGPT 302
            ...:|....||:|::...|||||.:.|| ...:.||..::|||.:    .:|:.:|     |...
Human   262 WGSNGMPKEIEKLNNLQAVFTDLSSMDLIRPRVSLVCQIVRVGHM----ELKEGKK-----HTCG 317

  Fly   303 FRRPFGVGVLSLGDIAHFDSSLEQSSDEREYNFKLFQ-------CEEKDFHLLPELIIKKSSGKY 360
            .||||||.|:.:.||.|     .:..||.:.:|..||       ..::...:.| ||.....|:.
Human   318 LRRPFGVAVMDITDIIH-----GKVDDEEKQHFIPFQQIAMETYIRQRQLIMSP-LITSHVIGEN 376

  Fly   361 SPI-----------QASQGTQGIVVSLKLLHGGLGQARQEQPMLFQGST-ITRKMGFPDVIMPGD 413
            .|:           :.:...||:.||||||.|.|.|.::....|...|| |.||||||::|:|||
Human   377 EPLTSVLNKVIAAKEVNHKGQGLWVSLKLLPGDLTQVQKNFSHLVDRSTAIARKMGFPEIILPGD 441

  Fly   414 VRNDLFLNLERGEFERGGKNTGKNILVTVVVLDVAGNVLTDCLWGASGMESQPQYRSMILYHQNA 478
            ||||:::.|..|||::|.|.|.||:.||:.|.|..|.:|...:...:|.|...:|:|::.|....
Human   442 VRNDIYVTLIHGEFDKGKKKTPKNVEVTMSVHDEEGKLLEKAIHPGAGYEGISEYKSVVYYQVKQ 506

  Fly   479 PSWNEMLRLSVPIDKFSTAHVRFEFRHCS---TRDKTEPKLFAFSFARLMDTGGATLGDGLHELY 540
            |.|.|.:::|:.|::.:..|:||.|||.|   ||||:| :.|..:|.:||:..|.||.||.|:|.
Human   507 PCWYETVKVSIAIEEVTRCHIRFTFRHRSSQETRDKSE-RAFGVAFVKLMNPDGTTLQDGRHDLV 570

  Fly   541 VYKCEDPAKLQVANY------LRLQCRPRDAQAKMDCGGCFS---RSSKEVFVLRSLLCSTKLTQ 596
            ||| .|..|::.|.:      .:::...::.||..:. ..|:   .|:|:.|.:.:|:|||||||
Human   571 VYK-GDNKKMEDAKFYLTLPGTKMEMEEKELQASKNL-VTFTPSKDSTKDSFQIATLICSTKLTQ 633

  Fly   597 NADLLSLLQWRTYPETIQDSLTGVLRLNDEELVKFLQDVLDALFAMFSNEEGNSTQHSGLVFHVL 661
            |.|||.||.||:..:.|:.:|..::.::..|:||||||.|||||.:.. |..:|..:..|||..|
Human   634 NVDLLGLLNWRSNSQNIKHNLKKLMEVDGGEIVKFLQDTLDALFNIMM-EMSDSETYDFLVFDAL 697

  Fly   662 VSIFSLLQSNKFQHFRPVMNEYIENHFAAALVYKGLITSVEHMAVFMTKAEHPDPFQKCFG---S 723
            |.|.||:...|||||.||:..||..||:|.|.|   :...:.:..::..|:.....:..|.   :
Human   698 VFIISLIGDIKFQHFNPVLETYIYKHFSATLAY---VKLSKVLNFYVANADDSSKTELLFAALKA 759

  Fly   724 LEYIFKLLIQSRKLFARATGGQYE-DSFKRDLHSLFTALNGMLAVPSYDVIIPTQEALLNSTGVV 787
            |:|:|:.:||||.|:.|..|...: |.|...:..||.|.|.::..| .:..:..:.|.|.....:
Human   760 LKYLFRFIIQSRVLYLRFYGQSKDGDEFNNSIRQLFLAFNMLMDRP-LEEAVKIKGAALKYLPSI 823

  Fly   788 LEQLKDTLPAPELGMLARNMLDAIPRGAPIRLIQAKLHAVKDLVSGELFHEDDSRTVVLSVACKH 852
            :..:|......||.:|....:.:||..   :|::.||:.:..:|...||.:.:.|.|:|.:....
Human   824 INDVKLVFDPVELSVLFCKFIQSIPDN---QLVRQKLNCMTKIVESTLFRQSECREVLLPLLTDQ 885

  Fly   853 LRMHL---SRRDELRLCAEILSEILSQLYDLQKEQREKVTNTLQHDLDSLCKNILGILIRTISII 914
            |...|   |.:.:....:::||.||..|      .|:.|..|..|     .:.|:..|:|.|:..
Human   886 LSGQLDDNSNKPDHEASSQLLSNILEVL------DRKDVGATAVH-----IQLIMERLLRRINRT 939

  Fly   915 MEGSNAVLPQL---VSCLLGLLQLLDETHYKRYWDELSPNKDPRDLKEFLSKSLLVYEELLTQDW 976
            :.|.|...|.:   |:|::.|||.:|::||..|   :|..|..:|:.:||.::.:::::|:.:  
Human   940 VIGMNRQSPHIGSFVACMIALLQQMDDSHYSHY---ISTFKTRQDIIDFLMETFIMFKDLIGK-- 999

  Fly   977 HVFPNDWLVMKLAANDVLRMSLEEFAKPLVYRFLGPQAFDSQLWWSYFSLAVAFLTQPSLQLEQY 1041
            :|:..||:||.:..|.|...::.:||:.|...|:...:|:.|||.:||.|||||||..|||||.:
Human  1000 NVYAKDWMVMNMTQNRVFLRAINQFAEVLTRFFMDQASFELQLWNNYFHLAVAFLTHESLQLETF 1064

  Fly  1042 REPKRLKILHSHGDMRVLMGFQILSMWSQLGEQKLHFIPSMVGPFLEVTLVPEPALRKATLSVFY 1106
            .:.||.||:..:||||..:||:|..||..||..|:.||||||||.|||||.||..|||||:.:|:
Human  1065 SQAKRNKIVKKYGDMRKEIGFRIRDMWYNLGPHKIKFIPSMVGPILEVTLTPEVELRKATIPIFF 1129

  Fly  1107 DMMQCE--QAARGSFRLVESELIDKLDLLISENKGDDEYRELFSTILLEKVQVENPNWKEAGIAF 1169
            ||||||  .:..|:|.:.|:|||.|||..:...:||::|:.|...:|||..: ::.....:|..|
Human  1130 DMMQCEFNFSGNGNFHMFENELITKLDQEVEGGRGDEQYKVLLEKLLLEHCR-KHKYLSSSGEVF 1193

  Fly  1170 IASVTRLLERLLDYRSVMQGEENRDKRMTCTVNLLNFYKNEINRKEMYLRYIYKLHNLHLQAENY 1234
            ...|:.|||.|||||:::..:|:::.||:||||:||||| |..|:::|:||:|||.:||...|||
Human  1194 ALLVSSLLENLLDYRTIIMQDESKENRMSCTVNVLNFYK-EKKREDIYIRYLYKLRDLHRDCENY 1257

  Fly  1235 TEAGFTLKLYASMLSW-DR-------ETQSFAPFDNSGQPEWQRKERLYHEILKYFDKGKCWEKG 1291
            |||.:||.|:|.:|.| |:       :..|:..:     .:.:.||:||.||:.||||||.|||.
Human  1258 TEAAYTLLLHAELLQWSDKPCVPHLLQKDSYYVY-----TQQELKEKLYQEIISYFDKGKMWEKA 1317

  Fly  1292 IPLCKELAHLYETRRFDYNKLSEILIQEAKFFQNILTQLRPEPEYFRVGFYGMGLPLFVRNKQFV 1356
            |.|.||||..||::.|||..|..:|.:.|.|::||:..:||:||||.||:||.|.|.|:|||.|:
Human  1318 IKLSKELAETYESKVFDYEGLGNLLKKRASFYENIIKAMRPQPEYFAVGYYGQGFPSFLRNKIFI 1382

  Fly  1357 YRGLEYERIGAFTQRLQTEFPSAQILGNNSPPDNAILNAPDQYIQISNVRPVGDAQALKTAM--V 1419
            |||.||||...|:.||.|:||:|:.:.:.:||...|.::|.||:|...|:||   .:|..:.  .
Human  1383 YRGKEYERREDFSLRLLTQFPNAEKMTSTTPPGEDIKSSPKQYMQCFTVKPV---MSLPPSYKDK 1444

  Fly  1420 PVPEKIARFYEVNDVTRFIYDRPMYKGTVDKDNEFKSLWIERTILEIASPLPGILRWYEVKQKTM 1484
            ||||:|..:|..|:|.:|.|.||..||..|.||||.::|||||....|...||||:|:||||.:.
Human  1445 PVPEQILNYYRANEVQQFRYSRPFRKGEKDPDNEFATMWIERTTYTTAYTFPGILKWFEVKQIST 1509

  Fly  1485 QELTPVEYACEIISNAGKELSELIVQYKRDPKRNINPFSMRLQGTIDANVMGGISKYQEAFFSEQ 1549
            :|::|:|.|.|.:....:.:|..:.|:..|...:::|.||.|.|.:|..||||.|.|::|||:|:
Human  1510 EEISPLENAIETMELTNERISNCVQQHAWDRSLSVHPLSMLLSGIVDPAVMGGFSNYEKAFFTEK 1574

  Fly  1550 FLKS-PQGAGQQANVQRLKVLILEQIQILEQALELHGQLAPSGVQPLHNRLLERFSQLKQSLSGM 1613
            :|:. |:   .|..|:.||.||..|:.:|.:.:.:||:.....::|||.||...|.:||:.:   
Human  1575 YLQEHPE---DQEKVELLKRLIALQMPLLTEGIRIHGEKLTEQLKPLHERLSSCFRELKEKV--- 1633

  Fly  1614 GRLKRQHSESIVNTPLPPLPTEQR-------VAPATASSSLN-----------ANAHSNYVYDLD 1660
                .:|...|.   |||..||::       |.|...||:|.           .:..||   ..|
Human  1634 ----EKHYGVIT---LPPNLTERKQSRTGSIVLPYIMSSTLRRLSITSVTSSVVSTSSN---SSD 1688

  Fly  1661 EIYTRPGDTVRPVDPLSSYQTLS---KESLSIPLEDTAAPPVPNRPRSQNFIG-----NGSMDSP 1717
            ...:|||.....::||...:..|   .|.||:..|:           |:|.|.     :.|:...
Human  1689 NAPSRPGSDGSILEPLLERRASSGARVEDLSLREEN-----------SENRISKFKRKDWSLSKS 1742

  Fly  1718 EVPPKR--QPTLNSPNAPPLPPRGI-TPDKRASNPLIFNDFGSGDAVGRRHSQQQQQHGQKYSVV 1779
            :|..::  :|.|.||......|:.: ..|.|.| |.                     ||.     
Human  1743 QVIAEKAPEPDLMSPTRKAQRPKSLQLMDNRLS-PF---------------------HGS----- 1780

  Fly  1780 DISYDDPEADQQPHSLPPNFQDGSGGHLSVCFAPNDFRDSGISTTSSRELNHMNLNNLSEDSSSI 1844
                ..|::  .|.|.||                       ::..::|.|:          |.|:
Human  1781 ----SPPQS--TPLSPPP-----------------------LTPKATRTLS----------SPSL 1806

  Fly  1845 STITVQHREHCRISSNGSLDYNAAASMNITQRESSTSSFDVEDFPVPPPPIPPKSLAVSSNGVNF 1909
            .|                 |..||.                   |||||| ||||          
Human  1807 QT-----------------DGIAAT-------------------PVPPPP-PPKS---------- 1824

  Fly  1910 SLDEAHSPHPSTQANTTQLNHIQNPNQNHSTNSHHHLQQQQNGDGDGYSTLQHPMNGLGLPTL-- 1972
                  .|:..:|.|:|:|                                        .|.|  
Human  1825 ------KPYEGSQRNSTEL----------------------------------------APPLPV 1843

  Fly  1973 --------PPPPSAVESPMPAS 1986
                    ||||.|.:|.:|.|
Human  1844 RREAKAPPPPPPKARKSGIPTS 1865

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
spgNP_733258.4 SH3_DOCK_AB 9..64 CDD:212805 24/54 (44%)
DOCK_N 67..406 CDD:292790 122/380 (32%)
C2_Dock-B 414..600 CDD:176077 73/197 (37%)
DHR2_DOCK 1215..1610 CDD:297424 174/405 (43%)
DOCK5NP_079216.4 SH3_DOCK1_5_A 12..67 CDD:212984 24/54 (44%)
DOCK_N 75..434 CDD:292790 121/375 (32%)
C2 442..637 CDD:301316 73/197 (37%)
DHR2_DOCK5 1238..1637 CDD:212581 174/416 (42%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1679..1702 6/25 (24%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1772..1870 43/253 (17%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1997
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG54452
OrthoDB 1 1.010 - - D102580at2759
OrthoFinder 1 1.000 - - FOG0000433
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100636
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X372
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
98.730

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