Protein Alignment spg and Dock8

DIOPT Version :9

• Sequence 1: NP_733258.4
• Gene: spg / 43404
• FlyBaseID: FBgn0264324
• Length: 2187
• Species: Drosophila melanogaster
• Sequence 2: NP_083061.2
• Gene: Dock8 / 76088
• MGIID: 1921396
• Length: 2100
• Species: Mus musculus
• Alignment Length: 2162
• Identity: 405/2162 - (18%)
• Similarity: 720/2162 - (33%)
• Gaps: 751/2162 - (34%)

  Fly    24 LALDVGDSVD-------IVEECKHWYRGSCPRKSRAVGLFPKTYIHIKDLSKIDPVVAECTQV-L 80
            ||.::||..|       ..:||: ..:.|.|.:.                .::||.|.:|.|. :
Mouse    79 LAQELGDLTDDDLHVAFTPKECR-TLQHSLPEEG----------------VELDPHVRDCVQTYI 126

  Fly    81 REWSEIWKRLYVDRE---AYKFQTLRKVMFSILESRRELLSATMTQDQTLELQMVVVSKIDWGNR 142
            |||      |.|:|:   :.:|.:.:|.     .|||:....  .|.||.|.:.:..|:.|   .
Mouse   127 REW------LIVNRKNQGSSEFCSFKKT-----GSRRDFQKT--LQKQTFESETLECSEPD---T 175

  Fly   143 KLGLDLVPREGPLAV--DPHGIGIV--------------KLYNV--HVSSADNAKASSSRGTLRR 189
            :.|    ||. ||.|  |..|.|.:              :|.|:  .||:.|..|....    .|
Mouse   176 QTG----PRH-PLNVLCDVSGKGPLTSCDFDLRSLQPDERLENLLQLVSAEDFEKEKEE----AR 231

  Fly   190 KTQRKILTHHLY---------------FCMRD-FGHRIGGDDAEVYF-----------FLYDGSH 227
            ||.|......||               .|.:: .|:||......:.|           .|||...
Mouse   232 KTNRPAELFALYPPVDEEDAVEIRPVPECPKEHLGNRILVKVLTLKFEIEIEPLFASIALYDVKE 296

  Fly   228 MRPLSERFLVKISKDGFSNYIERLH---------SNCTVFT-DLGAADLNEELHLVAVVMRVGKI 282
            .:.:||.|...::.|.|..:: |.|         :...||: ...::|       :.:|:::.|:
Mouse   297 RKKISENFHCDLNSDQFKGFL-RAHTPSIDPSSQARSAVFSVTYPSSD-------IYLVVKIEKV 353

  Fly   283 IQSDSI-------------------KKIEK--------SGTLGHGPTFRRPFGVGVLSLGDIAHF 320
            :|...|                   :|:||        ...||   .:|.||....:||....:.
Mouse   354 LQQGEIADCAEPYMIIKESDGGKSKEKVEKLKLQAESFCQRLG---KYRMPFAWAPISLASFFNI 415

  Fly   321 DSSLEQSSDERE---------------------------------YNFK-------LFQCEEKD- 344
             |:||:.|.:.|                                 .|||       :|..:|.|
Mouse   416 -STLERESTDVEPGVGRNSVGEKRSLSQSRRPSERTLSLEENGVGSNFKATTLATNIFFKQEGDR 479

  Fly   345 ------FHLLPELIIKKSSGKYSPIQASQGTQGIVVS--------------LKLLHGGLGQARQE 389
                  |..|.:  .|:||.....:::..|:..:.:|              |.:......:.|..
Mouse   480 LSDEDLFKFLAD--YKRSSSLQRRVKSIPGSLRLEISPAPDVMNCCLTPEMLPVKPFPENRTRPH 542

  Fly   390 QPMLFQGSTITRKMGFP--DVIMPGDV-RNDLFLNLERGEFERGGKNTGKNILVTVVVL--DVAG 449
            :.:|          .||  :|.:|..| ||.|::..:|..| .....:.:||.:.:..:  :...
Mouse   543 KEIL----------EFPIREVYVPHTVYRNLLYVYPQRLNF-ASKLASARNITIKIQFMCGEDPS 596

  Fly   450 NVLTDCLWGASGMESQPQYRSMILYHQNAPSWNEMLRLSVPIDKFSTAHVRFEFRHCSTRDK--- 511
            |.:......:||.|...:..:.|.||..:|.:.|.:::.:|.......|:.|.|.|.|.:.|
Mouse   597 NAMPVIFGKSSGPEFLQEVYTAITYHNKSPDFYEEVKIKLPAKLTVNHHLLFTFYHISCQQKQGA 661

  Fly   512 TEPKLFAFSFARL-----MDTGGATLGDGLHELYV-YKCEDPAKLQVAN-------------YLR 557
            :...|..:|:..:     :.||...|...|.:|.. |......|:.:.|             .:.
Mouse   662 SGESLLGYSWLPILLNERLQTGSYCLPVALEKLPPNYSIHSAEKVPLQNPPIKWAEGHKGVFNIE 726

  Fly   558 LQC----RPRDAQAKMDCGGCFSRSSKEVFVLRSLLCSTKLTQNADLLSLLQWRTYPETIQDSL- 617
            :|.    ..:|...:.....|.|..|:..|.:|.|  ..|:|::              |::..|
Mouse   727 VQAVSSVHTQDNHLEKFFTLCHSLESQVSFPIRVL--DQKITES--------------TLEHELK 775

  Fly   618 TGVLRLND---EELVKFLQDVLDALFAMFSNE---EGNSTQHSGLVFHVLVSIFSLLQSN----K 672
            ..::.||.   |.||.||..|||.||.:....   .|.:...|...|..:|:|.:.|.::    |
Mouse   776 LSIICLNSSRLEPLVLFLHLVLDKLFQLSVQPMVIAGQTANFSQFAFESVVAIANSLHNSKDLRK 840

  Fly   673 FQHFRP-VMNEYIE--------------------------------------------------- 685
            .||.|. ::..|:.
Mouse   841 DQHGRNCLLASYVHYVFRLPELHRDTSKSGGPTTVVPDPRYHTYGRTSAAAVSSKLMQARVMSSS 905

  Fly   686 ------NHFAAALVYKGLITS------VEHMAVFMT-------KAEHPDPFQK------------ 719
                  :|.||....|.:::|      ...|:.:.:       ....|.|..|
Mouse   906 NPDLTGSHCAADEEVKNIMSSKIADRNCSRMSYYCSGNSDAPGSTAAPRPVSKKHFHEELALQMV 970

  Fly   720 ---------CFGSLEYIFKLLIQS----------RKLFARATGGQYEDSFKRDLHSLFTALNGML 765
                     .|....:.|:||::|          |..|.|.   ::.|.||.|:.::...:...:
Mouse   971 VSTGVVRETVFKYAWFFFELLVKSMAQYVHNLDKRDSFRRT---RFSDRFKDDITTIVNVVTSEI 1032

  Fly   766 AVPSYDVIIPTQEALLNSTGVVLEQLKDTLPAPE----LGMLARNMLDAIPRGAPIRLIQ----- 821
            |            |||      ::..|::..|.:    |.....::|..:.||....||:
Mouse  1033 A------------ALL------VKPQKESEQAEKINISLAFFLYDLLSIMDRGFVFNLIKHYCSQ 1079

  Fly   822 --AKLHAVKDLVSGELFHEDDSRTVVLSVACKH---LRMHL----------------SRRDELRL 865
              |||:.:..|:|        .|...|.:.|.|   |.::|                |.::. ..
Mouse  1080 LSAKLNILPTLIS--------MRLEFLRILCSHEHYLNLNLLFMNTDTAPASPCPSISSQNS-SS 1135

  Fly   866 CAEILSEILSQLYDLQKEQREK--VTNTL-------------------------------QHDLD 897
            |:....:.::.::||..|.|::  :|..|                               .||||
Mouse  1136 CSSFQDQKIASMFDLTPEYRQQHFLTGLLFTELAVALDAEGDGISRVQRKAVSAIHSLLCSHDLD 1200

  Fly   898 SLCKN-------------ILGILI---------------------------------RTISIIME 916
            ..|:.             ::||::                                 :.:::.:.
Mouse  1201 PRCRKPEVKVKIAALYLPLVGIILDALPQLYDFTDARSGRSRASGSYEEQDVANGINQNVALAIA 1265

  Fly   917 GSN----------AVLP-------------QLVSCLLGLLQLLDETHYKRYWDEL---------- 948
            |::          :.||             .|:.|.|.:::..|::..:::..:|
Mouse  1266 GNHFNLKTSGAMLSSLPYKQYNMLNADTTRHLMICFLWIMKNADQSLIRKWIADLPSMQLNRILD 1330

  Fly   949 ---------------SPNK-------DPRDLKEFLSKSLLVYE----ELLTQ------------- 974
                           |.:|       ..||:|..|.::||..|    |::.:
Mouse  1331 LLFICVSCFEYKGKQSSDKVSNQVLQKSRDVKAKLEEALLRGEGARGEMMRRRIPGTDRFPGINE 1395

  Fly   975 --DWHVFPNDWLVMKLAANDVLRMSLEEF-AKPLVYRFLGPQAFDSQLWWSYFSLAVAFLTQPSL 1036
              .|......|    ..||:.|..:..|. .:.|:...|..:|          :|.:..:.:..:
Mouse  1396 NLRWRKEQTQW----RQANEKLDKTKAELDQEALISGNLATEA----------NLIILDMQENII 1446

  Fly  1037 QLEQYREPKR------LKIL--------------HSHGDMRVLMG-------FQILSMWSQLGEQ 1074
            |.....:.|.      |::|              |....:|.|:.       .:.:...:.|.::
Mouse  1447 QASSALDCKDSLLGGVLRVLVNSLSCDQSTTYLTHCFATLRALIAKFGDLLFEEEMEQCADLCQR 1511

  Fly  1075 KLHFIPSMVGPFLEVTLVPEPALRKATLSVFYDMMQCEQAARGSFRLVESELIDKLDLLISE--N 1137
            .||...|.    ::||       |....:..|.:|:....|..:|..|:.::...|..|:.:  :
Mouse  1512 VLHHCSSS----MDVT-------RSQACATLYLLMRFSFGATSNFARVKMQVTMALASLVGKAPD 1565

  Fly  1138 KGDDEYRELFSTILLEKVQVENPNWKEAGIA-----FIASVTRLLERL--LDYRSVMQGEENRDK 1195
            ..::..|....|||.         :.|...|     |...|..||..|  :.|.:|...|...|.
Mouse  1566 FNEEHLRRSLRTILA---------YSEEDTAMQTTPFPMQVEELLCNLNSILYDTVKMREFQEDP 1621

  Fly  1196 RMTCTVNLLNFYKNEINRKEMYLRYIYKLHNLHLQAENYTEAGFTL-------KLYASMLSWDRE 1253
            .|...: :....|:.....::.|.::..:...|.:.:.:|||...|       ..|.|||    |
Mouse  1622 EMLMDL-MYRIAKSYQASPDLRLTWLQNMAEKHTKKKCFTEAAMCLVHAAALVAEYLSML----E 1681

  Fly  1254 TQSFAPFDNSGQPEWQ-------RKERLYHEILKYFDKGKC-----WEKG-IPLCKELAHLYET- 1304
            ..|:.|.   |...:|       .:..:..:.|...:.|.|     .|.| :.|.::.|.|:.|
Mouse  1682 DHSYLPV---GSVSFQNISSNVLEESAVSDDTLSPDEDGVCSGRYFTESGLVGLLEQAAELFSTG 1743

  Fly  1305 ------------------RRFDYNKLSEILIQEAKFFQNILTQ--LRPEPEYFRVGFYGMGLPLF 1349
                              ...|:.||:....:..|.|.||:.:  .|....||||||||.... .
Mouse  1744 GLYETVNEVYKLVIPILEAHRDFRKLTSTHDKLQKAFDNIINKDHKRMFGTYFRVGFYGSRFG-D 1807

  Fly  1350 VRNKQFVYRGLEYERIGAFTQRLQ--------TEFPSAQILGNNSPPDNAILNAPDQYIQISNVR 1406
            :..::|||:.....::...:.||:        .||  .:::.:::|.|...|:....||||:.|.
Mouse  1808 LDEQEFVYKEPAITKLPEISHRLEGFYGQCFGAEF--VEVIKDSTPVDKTKLDPNKAYIQITFVE 1870

  Fly  1407 PVGDAQALKTAMVPVPEKIARFYEVNDVTRFIYDRPMY-----KGTVDKDNEFKSLWIERTILEI 1466
            |..|...:|       :::..|.:..::.||:|..|..     :|.:.:.:.      ..|:|..
Mouse  1871 PYFDEYEMK-------DRVTYFEKNFNLRRFMYTTPFTLEGRPRGELHEQHR------RNTVLTT 1922

  Fly  1467 ASPLPGILRWYEVKQKTMQELTPVEYACEIISNAGKELSELIVQYKRDPKRNINPFSMRLQGTID 1531
            ....|.|.....|.||....|||:|.|   |.:..|:..:|.|...::|. :.....|.|||::.
Mouse  1923 MHAFPYIKTRIRVSQKEEFVLTPIEVA---IEDMKKKTLQLAVATHQEPP-DAKMLQMVLQGSVG 1983

  Fly  1532 ANVMGGISKYQEAFFSEQFLKSPQGAGQQANVQRLKVLILEQIQILEQALELHGQLAPSGVQPLH 1596
            |.|..|..:..:.|.:|    .|.......:..:|::...|.|....:|:|.:.:|..:..:...
Mouse  1984 ATVNQGPLEVAQVFLAE----IPADPKLYRHHNKLRLCFKEFIMRCGEAVEKNRRLITAEQREYQ 2044

  Fly  1597 NRLLERFSQLKQSLSGM 1613
            ..|.:.:::|:.||..|
Mouse  2045 QELKKNYNKLRDSLRPM 2061

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
spg	NP_733258.4	SH3_DOCK_AB	9..64	CDD:212805	9/46 (20%)
		DOCK_N	67..406	CDD:292790	96/485 (20%)
		C2_Dock-B	414..600	CDD:176077	44/214 (21%)
		DHR2_DOCK	1215..1610	CDD:297424	99/448 (22%)
Dock8	NP_083061.2	DUF3398	73..164	CDD:288711	28/114 (25%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	424..453		1/28 (4%)
		C2_Dock-C	560..740	CDD:176078	35/180 (19%)
		DHR2_DOCK8	1637..2058	CDD:212574	99/451 (22%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1997
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810