Protein Alignment spg and Dock7

DIOPT Version :9

• Sequence 1: NP_733258.4
• Gene: spg / 43404
• FlyBaseID: FBgn0264324
• Length: 2187
• Species: Drosophila melanogaster
• Sequence 2: XP_006503371.1
• Gene: Dock7 / 67299
• MGIID: 1914549
• Length: 2142
• Species: Mus musculus
• Alignment Length: 2204
• Identity: 430/2204 - (19%)
• Similarity: 732/2204 - (33%)
• Gaps: 753/2204 - (34%)

  Fly    30 DSVDIVEECKHWYRGSCPRKSRA-VGLFPKTYIHIKDLSKIDPVVAECTQVLREWSEIWKRLYVD 93
            |.:::|..         ||..|. |...|:.       |::||.|.:|   :|.::|.|  ..|.
Mouse    85 DDIEVVYS---------PRDCRTLVSAVPEE-------SEMDPHVRDC---IRSYTEDW--AVVV 128

  Fly    94 REAYKF------QTLRKVMFSILESRRELLSATMTQDQTLELQMVVVSKIDWGNRKLGLDLVPRE 152
            |:.:|.      .||.|..    |.::.|.......|:..:.......:.|...|.:.:|..||
Mouse   129 RKYHKLGTGFNPNTLDKQK----ERQKGLPRQVFESDEAPDGSSYQDEQDDLKRRSMSIDDTPR- 188

  Fly   153 GPLAVDPHGIGIVKLYNVHVSSADNA------KASSSRGTLRRKTQRKILTHHLYFCM------- 204
                    |.....::::..|..|..      :..:.....:...|||...|...|.:
Mouse   189 --------GSWACSIFDLKNSLPDALLPNLLDRTPNEEIDHQNDDQRKSNRHKELFALHPSPDEE 245

  Fly   205 -------------RDFGHRIGGDDAEVYF-----------FLYDGSHMRPLSERFLVKISKDGFS 245
                         ..||.|:......:.|           .|||....:.:||.|...::.:...
Mouse   246 EPIERLSVPDVPKEHFGQRLLVKCLSLKFEIEIEPIFASLALYDVKEKKKISENFYFDLNSEQMK 310

  Fly   246 NYIERLHSNCTVFTDLGAADL------NEELHLVAVVMRVGKIIQSDSI---------------- 288
            ..: |.|......|.|..:.:      ::::.|   |:::.|::|...|
Mouse   311 GLL-RPHVPPAAITTLARSAIFSITYPSQDVFL---VIKLEKVLQQGDIGECAEPYMIFKEADAT 371

  Fly   289 ---KKIEKSGT--------LGHGPTFRRPFGVGVLSLGDIAHFDSSLEQSSDEREY--------- 333
               :|:||..:        ||   .:|.||....:.|.:|.....|||:.|.|.|.
Mouse   372 KNKEKLEKLKSQADQFCQRLG---KYRMPFAWTAIHLMNIVSSAGSLERDSTEVEISTGERKGSW 433

  Fly   334 ----NFKL------------------------------FQCEEKDFHLLPELIIKKSSGKYSPIQ 364
                |..|                              |..:|.| .|..|.:.|..:....|..
Mouse   434 SERRNSSLVGRRSLERTTSGDDACNLTSFRPATLTVANFFKQEGD-RLSDEDLYKFLADMRRPSS 497

  Fly   365 ASQGTQGIVVSLKLLHGGLGQARQE----------QPMLFQGSTI--TRK-MGFP--DVIMPGDV 414
            ..:..:.|...||:   .:..|.:.          |..|:..|.:  ||: :.||  ||.:|...
Mouse   498 VLRRLRPITAQLKI---DISPAPENPHYCLTPELLQVKLYPDSRVRPTREILEFPARDVYVPNTT 559

  Fly   415 -RNDLFLNLERGEF-ERGGKNTGKNILVTVVVL--DVAGNVLTDCLWGASGMESQPQYRSMILYH 475
             ||.|::..:...| .|.|  :.:||.|.|..:  :...|.:......:|..|...:..:.::||
Mouse   560 YRNLLYIYPQSLNFANRQG--SARNITVKVQFMYGEDPSNAMPVIFGKSSCSEFSKEAYTAVVYH 622

  Fly   476 QNAPSWNEMLRLSVPIDKFSTAHVRFEFRHCSTRDKTEPKL---FAFSFARLMDTGGATLGDGLH 537
            ..:|.::|.:::.:|.......|:.|.|.|.|.:.|....|   ..:::..::..|....|.
Mouse   623 NRSPDFHEEIKVKLPATLTDHHHLLFTFYHVSCQQKQNTPLETPVGYTWIPMLQNGRLKTGQ--- 684

  Fly   538 ELYVYKCEDPAKLQVANYLRLQCRPRDAQAKMD-----CGGCFSRSSKEVFVLRSLLCSTKLTQN 597
                 .|. |..|:         :|..|.:.:.     .|..:..:.|.||.:..:..|:..||:
Mouse   685 -----FCL-PVSLE---------KPPQAYSVLSPEVPLPGMKWVDNHKGVFNVEVVAVSSIHTQD 734

  Fly   598 A------DLLSLLQWRTYPETIQD------SLTGVLR-----LNDEEL---VKFLQDVLDALF-- 640
            .      .|::.|....:|..|.|      :|...|:     ||..:|   |:||..:||.|.
Mouse   735 PYLDKFFALVNALDEHMFPVRIGDMRIMENNLESELKSSISALNSSQLEPVVRFLHLLLDKLILL 799

  Fly   641 --------------------AMFS-------NEEGNSTQH------SGLVFHV------------ 660
                                ||.|       |.|||..||      :..:::|
Mouse   800 VVRPPVIAGQIVNLGQASFEAMASIINRLHKNLEGNHDQHGRNNLLASYIYYVFRLPNTYPNSPS 864

  Fly   661 -----------------------------------------------------LVSIFSLLQSNK 672
                                                                 ::....|.:||.
Mouse   865 PGPGGLGGSVHYATMARSAVRPASLNLNRSRSLSNSNPDISGTPTSPDDEVRSIIGSKGLDRSNS 929

  Fly   673 FQHFRPVMNEYIENHFAAALVYKGLITSVEHM------AVFM--------TKAEHPDPFQK---- 719
            :.:..|....:..|...:|...:.:..|...|      :.|:        ||....|..:|
Mouse   930 WVNTGPKAAPWGSNPSPSAESTQAMDRSCNRMSSHTETSSFLQTLTGRLPTKKGKEDELEKLSLL 994

  Fly   720 ------------CFGSLE--------YIFKLLIQSR--------KLFARATGGQYEDSFKRDLHS 756
                        |.||:.        :.|:|:::|.        ||.| ....::.:.|..|:.:
Mouse   995 LFHEELALQWVVCSGSVRESALQQAWFFFELMVKSMVHHLYFNDKLDA-PRKSRFPERFMDDIAA 1058

  Fly   757 LFTALNGMLAVPSYDVIIPTQEALLNSTGVVLEQLKDTLPAPELGMLARNMLDAIPRGAPIRLIQ 821
            |.:.:.|       ||:...|:    .|.:| |:|..:     |.....::|..:.||....||:
Mouse  1059 LVSTIAG-------DVVSRFQK----DTEMV-ERLNTS-----LAFFLNDLLSVMDRGFVFSLIK 1106

  Fly   822 -------AKLHAVKD---LVSGEL-------FHEDDSRTVVLSVACKHL---------------- 853
                   |||:::.:   |||..|       .||   ..|.|::.|..|
Mouse  1107 SCYKQVSAKLYSLPNPSVLVSLRLDFLRIICSHE---HYVTLNLPCSLLTPPASPSPSVSSATSQ 1168

  Fly   854 -----------------RMHLSRRDELRLCAEILSEI-------LSQLYDLQKEQREKVTNTLQ- 893
                             .:.|..|.:..|...:|:|:       ...|:.|.|:....|.|.|.
Mouse  1169 SSGFSTSVQDQKIANMFELSLPFRQQHYLAGLVLTELALILDPDAEGLFGLHKKVINMVHNLLST 1233

  Fly   894 HDLD-------------SLCKNILGILIRTI---------------------------------- 911
            ||.|             .|...::||::.|:
Mouse  1234 HDSDPRYSDPQIKARVAMLYLPLIGIIMETVPQLYDFTESHNQRGRPICIAPDDYDSESGSMISQ 1298

  Fly   912 SIIMEGSNAVLPQ---------------------------LVSCLLGLLQLLDETHYKRYWDELS 949
            ::.|..:...:||                           |:.|||.:|:..|||..::::.:||
Mouse  1299 TVAMAIAGTSVPQLTRPGSFLLTSTSGRQHTTFSAESSRSLLICLLWVLKNADETVLQKWFTDLS 1363

  Fly   950 PNKDPR--DL-----KEFLSKSLLVYEELLTQDWHVFPNDWLVMKLAANDVLRMSLEE------- 1000
            ..:..|  ||     ..|..|...|:|.:          :.|..|.:.:  :|..|||
Mouse  1364 VLQLNRLLDLLYLCVSCFEYKGKKVFERM----------NSLTFKKSKD--MRAKLEEAILGSIG 1416

  Fly  1001 FAKPLVYRFLGP-------QAFDSQ--LWWSYFSLAVAFLTQPSLQLEQYREPKRLKILH----- 1051
            ..:.:|.|..|.       .||.||  |.|   ...:....|.|.:|::    .|.:|.|
Mouse  1417 ARQEMVRRSRGQLERSPSGSAFGSQENLRW---RKDMTHWRQNSEKLDK----SRAEIEHEALID 1474

  Fly  1052 ----SHGDMRVLMGFQILSMWSQLGEQKLHFIPSMVGPFLEVTLVPEP------------ALRKA 1100
                :..::.:|...:|:.....:.|.|    .|::|..|:|.|....            |.::|
Mouse  1475 GNLATEANLIILDTLEIIVQTVSVTESK----ESILGGVLKVLLQSMACNQSAVYLQHCFATQRA 1535

  Fly  1101 TLSVFYDMM---QCEQAARGSFRL----------VESELIDKLDLLISEN--KGDDEYR-ELFST 1149
            .:|.|.:::   :.||.|....||          :.|.....|.||:.:|  .|::..| ::..|
Mouse  1536 LVSKFPELLFEEETEQCADLCLRLLRHCSSSISTIRSHASASLYLLMRQNFEIGNNFARVKMQVT 1600

  Fly  1150 ILLEKVQVENPNWKEAGIAFIASVTRLLERLLDYRSVMQGEENRDKRMT--------CTVNLLNF 1206
            :.|..:...:.|:.|      ..:.|.|:.:|.|     .||:.:.|.|        ...||...
Mouse  1601 MSLSSLVGTSQNFNE------EFLRRSLKTILTY-----AEEDLELRETTFPDQVQDLVFNLHMI 1654

  Fly  1207 YKNEINRKE-----------MY-------------LRYIYKLHNLHLQAENYTEAGFTL------ 1241
            ..:.:..||           ||             |.::..:...|.:..|:.||...|
Mouse  1655 LSDTVKMKEHQEDPEMLIDLMYRIAKGYQTSPDLRLTWLQNMAGKHSERSNHAEAAQCLVHSAAL 1719

  Fly  1242 -KLYASMLSWDRETQSFAP-----FDNSGQPEWQRKERLYHEILKYFDKGKC-----WEKGI--- 1292
             ..|.|||    |.:.:.|     |.|......: :..:..:::...::|.|     .|.|:
Mouse  1720 VAEYLSML----EDRKYLPVGCVTFQNISSNVLE-ESAVSDDVVSPDEEGICSGKYFTESGLVGL 1779

  Fly  1293 ------------------PLCKELAHLYETRRFDYNKLSEI--LIQEAKFFQNILTQL----RPE 1333
                              .:.|.|..::|..| |..|||.|  .:|||  |..|:.|.    |..
Mouse  1780 LEQAAASFSMAGMYEAVNEVYKVLIPIHEANR-DAKKLSTIHGKLQEA--FSKIVHQSTGWERMF 1841

  Fly  1334 PEYFRVGFYGMGLPLFVRNKQFVYRGLEYERIGAFTQRLQTEFPS------AQILGNNSPPDNAI 1392
            ..||||||||.... .:..::|||:.....::...:.||:..:..      .:::.:::|.|...
Mouse  1842 GTYFRVGFYGTKFG-DLDEQEFVYKEPAITKLAEISHRLEGFYGERFGEDVLEVIKDSNPVDKCK 1905

  Fly  1393 LNAPDQYIQISNVRPVGDAQALKTAMVPVPEKIARFYEVNDVTRFIYDRPMYKGTVD--KDNEFK 1455
            |:....||||:.|.|..|...:|       ::|..|.:..::.||:|..|.   |:|  ...|..
Mouse  1906 LDPNKAYIQITYVEPFFDTYEMK-------DRITYFDKNYNLRRFMYCTPF---TLDGRAHGELH 1960

  Fly  1456 SLWIERTILEIASPLPGILRWYEVKQKTMQELTPVEYACEIISNAGKELSELIVQYKRDPKRNIN 1520
            ..:..:|||..:...|.|.....|..|....|||:|.|.|.:....:||:....|...|||.
Mouse  1961 EQFKRKTILTTSHAFPYIKTRVNVTHKEEIILTPIEVAIEDMQKKTQELAFATHQDPADPKM--- 2022

  Fly  1521 PFSMRLQGTIDANVMGGISKYQEAFFSEQFLKSPQGAGQQANVQRLKVLILEQIQILEQALELHG 1585
             ..|.|||::...|..|..:..:.|.||    .|.......:..:|::...:..:..|.||..:.
Mouse  2023 -LQMVLQGSVGTTVNQGPLEVAQVFLSE----IPGDPKLFRHHNKLRLCFKDFTKRCEDALRKNK 2082

  Fly  1586 QL-APSGVQPLHNRLLER-FSQLKQSLSGMGRLKRQHSESIVNTPLPPLPTEQRVAPAT 1642
            .| .|.  |..:.|.||| :.:||::|           :.::|..:|.|  .:.|.|.|
Mouse  2083 SLIGPD--QKEYQRELERNYHRLKEAL-----------QPLINRKIPQL--YKAVLPVT 2126

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
spg	NP_733258.4	SH3_DOCK_AB	9..64	CDD:212805	7/34 (21%)
		DOCK_N	67..406	CDD:292790	83/470 (18%)
		C2_Dock-B	414..600	CDD:176077	39/203 (19%)
		DHR2_DOCK	1215..1610	CDD:297424	112/472 (24%)
Dock7	XP_006503371.1	DUF3398	52..161	CDD:371776	23/100 (23%)
		C2_Dock-C	560..737	CDD:176078	39/196 (20%)
		DHR2_DOCK7	1646..2120	CDD:212576	119/515 (23%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1997
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810