DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment spg and dock4b

DIOPT Version :9

Sequence 1:NP_733258.4 Gene:spg / 43404 FlyBaseID:FBgn0264324 Length:2187 Species:Drosophila melanogaster
Sequence 2:NP_001159700.1 Gene:dock4b / 654774 ZFINID:ZDB-GENE-060130-74 Length:1977 Species:Danio rerio


Alignment Length:2213 Identity:780/2213 - (35%)
Similarity:1169/2213 - (52%) Gaps:386/2213 - (17%)


- Green bases have known domain annotations that are detailed below.


  Fly    16 WHGDVRFGLALDVGDSVDIVEECKHWYRGSCPRKSRAVGLFPKTYIHIKD------------LSK 68
            :.|.|:.||.|::||:|.|:|:|:.||||...:...|.|:||..|||:|:            :..
Zfish    43 FRGTVQHGLPLEIGDTVQILEKCEGWYRGFVLKNPNAKGIFPCCYIHLK
NAHIKNKGQFETVVPS 107

  Fly    69 IDPVVAECTQVLREWSEIWKRLYVDREAYKFQTLRKVMFSILESRRELLSATMTQDQTLELQMVV 133
            .|.|:.|.|..||:|..:||:|:|..|...|..|..||..||:.||::|...:|.|:..:::..:
Zfish   108 EDSVITEMTSTLRDWGAMWKQLFVKNEGDLFNRLWHVMNEILDLRRQVLVGHLTHDRMRDVKQHI 172

  Fly   134 VSKIDWGNRKLGLDLVPREGPLAVDPHGIGIVKLYNVHVSSADNAKASSSRGTLRRKTQRKILTH 198
            .:::||||.:||||||||.....|||..|.:.:||.:           ......:::|...:.||
Zfish   173 TARLDWGNEQLGLDLVPRREFSMVDPDDISVTELYRL-----------MEHRHRKKETPAPVSTH 226

  Fly   199 HLYFCMRDFGHRIGGDDAEVYFFLYDGSHMRPLSERFLVKISKDGFSNYIERLHSNCTVFTDLGA 263
            ||:..::.......|::.||:||:||....|||||||.||::|:|...:.|:....||:|.|||:
Zfish   227 HLFVHLKSLMSSNLGEELEVFFFIYDSRENRPLSERFFVKLNKNGLPKFPEKTERQCTLFVDLGS 291

  Fly   264 ADLNEELHLVAVVMRVGKIIQSDSIKKIEKSGTLGHGP-------TFRRPFGVGVLSLGDIAHFD 321
            :||.:::::|..::|:|:               :|.|.       .:|||||..|:|:.|:...|
Zfish   292 SDLRKDVYIVVHIIRIGR---------------MGAGEKKNLCNVQYRRPFGCAVVSIADLLTAD 341

  Fly   322 SSLEQSSDEREYNFKLFQCE-EKDFHLLPELIIKKSSGKYSPIQASQGTQGIVVSLKLLHGGLGQ 385
            |       :.::..|::.|. |.|:..:.:.||||.:.:|:   .|....|:.|:|:||||.:.|
Zfish   342 S-------KDDHLLKVYACNTESDWSQIHDNIIKKVNSRYN---LSGSNTGLAVALQLLHGDIEQ 396

  Fly   386 ARQEQPMLF-QGSTITRKMGFPDVIMPGDVRNDLFLNLERGEFERGGKNTGKNILVTVVVLDVAG 449
            .|:|..:|| :|.:||:|:||.||||||::||||::.||:||||:|||:..:|:.:|:..||..|
Zfish   397 LRREYMVLFTRGVSITKKLGFS
DVIMPGEMRNDLYMTLEKGEFEKGGKSVARNVEITIYALDADG 461

  Fly   450 NVLTDCLWGASGMESQPQYRSMILYHQNAPSWNEMLRLSVPIDKFSTAHVRFEFRHCSTRDKTEP 514
            .:|...:...||.....:|.:.:|||.|:|.|.|.::|.:|:|.|..:|||||||||||:||.|.
Zfish   462 QILKGFVAVGSGEPGGDEYHTFVLYHNNSPRWAEQIKLPIPVDMFRGSHVRFEFRHCSTKDKGEK 526

  Fly   515 KLFAFSFARLMDTGGATLGDGLHELYVYKCEDPAKLQ-VANYLRLQCRPRDAQAKMDCGGCFSRS 578
            |||.|||..||...|.||.||.|||.|:|||:.|.|| .:.||:|.               ||:|
Zfish   527 KLFGFSFVPLMQEDGRTLPDGTHELIVHKCEENANLQDCSRYLKLP---------------FSKS 576

  Fly   579 -----------SKEVFVLRSLLCSTKLTQNADLLSLLQWRTYPETIQDSLTGVLRLNDEELVKFL 632
                       :||...:.|.|||||||||.|:|.||:||.:||.|.|||:.:..::..|:||||
Zfish   577 NLPGNNQTVKGTKESLWITSFLCSTKLTQNGDMLDLLKWRAHPERISDSLSKLKEIDGSEIVKFL 641

  Fly   633 QDVLDALFAMFSNEEGNSTQHSGLVFHVLVSIFSLLQSNKFQHFRPVMNEYIENHFAAALVYKGL 697
            ||.||.||.:.   :.:|.:::..||..||.|.:|||.:|||||:|||:.|||:|||.||.|:.|
Zfish   642 QDTLDTLFGIL---DESSQRYALKVFDCLVHIINLLQDSKFQHFKPVMDTYIESHFAGALSYRDL 703

  Fly   698 ITSVEHMAVFMTKAEHPDPFQKCFGSLEYIFKLLIQSRKLFARATGGQYEDSFKRDLHSLFTALN 762
            |..::.....:..|:..:..|:...:.|||||.::|||:|||.|||||.|:.|:..:|.||.::.
Zfish   704 IKVLKWYVDRIIDADRQEHIQQVLKATEYIFKYIVQSRRLFALATGGQNEEEFRCCMHELFMSIR 768

  Fly   763 GMLAVPSYDV--IIPTQEALLNSTGVVLEQLKDTLPAPELGMLARNMLDAIPRGA----PIRLIQ 821
            ..|:..:..:  |..||...|.|...|..:|.......|:....|..|.::|..:    |:..: 
Zfish   769 FFLSQENKSMRPITHTQAVFLQSFPAVYNELLKLFTVREVATFVRETLGSLPTASQPDCPLEAV- 832

  Fly   822 AKLHAVKDLVSGELFHEDDSRTVVLSVACKHLRMHLSRRDELRLCAEILSEILSQLYDLQKEQRE 886
             |||.:...|..:|:...|||.|:|.|..:.|:.|:..:.:|.:||.||:.:||.|      :::
Zfish   833 -KLHCIAKTVDSQLYTNPDSRCVLLPVVLRLLQAHMQEQRDLVMCAHILTCMLSLL------KKD 890

  Fly   887 KVTNTLQHDLDSLCKNILGILIRTISIIMEGSNAVLP--------------QLVSCLLGLLQLLD 937
            ...::...::|.:.:::|.:|:||   |:|.:|...|              :.|||||.||:.:.
Zfish   891 DTDSSSSEEVDLIVESVLAVLLRT---ILEVANRPQPAGPTLRPQVQDVTGEFVSCLLALLRHMK 952

  Fly   938 ETHYKRYWDELSPNKDPRDLKEFLSKSLLVYEELLTQDWHVFPNDWLVMKLAANDVLRMSLEEFA 1002
            :.||::.....:..:   ||::||.....|:..|:..:  :||.||.||:|..|:::..::...:
Zfish   953 DKHYQQLLQRFTSKE---DLRDFLLHIFTVFRILIRPE--MFPKDWTVMRLVTNNIIITTVLYLS 1012

  Fly  1003 KPLVYRFLGPQAFDSQLWWSYFSLAVAFLTQPSLQLEQYREPKRLKILHSHGDMRVLMGFQILSM 1067
            ..|...||. :.||.::|.|||.|:|.|:.|..||||.:...|:.|||..:|||||:||.:|.||
Zfish  1013 DALRKNFLS-EKFDYKVWDSYFCLSVIFINQTCLQLETFSASKKKKILEKYGDMRVMMGCEIFSM 1076

  Fly  1068 WSQLGEQKLHFIPSMVGPFLEVTLVPEPALRKATLSVFYDMMQCEQAARGSFRLVESELIDKLDL 1132
            |..|||.||:|||:|:||||||||||:|.||...:.:|:|||..||...|:|:.||::||||||.
Zfish  1077 WQNLGEHKLNFIPAMIGPFLEVTLVPQPDLRNVMIPIFHDMMDWEQRRSGNFKQVEAKLIDKLDS 1141

  Fly  1133 LISENKGDDEYRELFSTILLEKVQVENPNWKEAGIAFIASVTRLLERLLDYRSVMQGEENRDKRM 1197
            |:||.|||:.|||||::|||:|  :|...|:|:||:.||:||||:|||||||..|:..|...|::
Zfish  1142 LMSEGKGDETYRELFNSILLKK--IERETWRESGISLIATVTRLMERLLDYRDCMKLGEVDGKKI 1204

  Fly  1198 TCTVNLLNFYKNEINRKEMYLRYIYKLHNLHLQAENYTEAGFTLKLYASMLSW-DRETQSFAPFD 1261
            .|||:||||||.|:|::|||:|||:||::|||:|:|||||.:||.||..:|.| :|..:.|..:.
Zfish  1205 GCTVSLLNFYKTELNKEEMYIRYIHKLYDLHLKAQNYTEASYTLLLYDELLEWSERPLREFLSYP 1269

  Fly  1262 NSGQPEWQRKERLYHEILKYFDKGKCWEKGIPLCKELAHLYETRRFDYNKLSEILIQEAKFFQNI 1326
            .  |.||||||.|:..|::.||:|||||.||.||:|||..||: .:||..||::.:.||.|:..|
Zfish  1270 M--QSEWQRKEYLHLTIIQNFDRGKCWENGILLCRELADQYES-YYDYRNLSKMRMMEASFYDKI 1331

  Fly  1327 LTQLRPEPEYFRVGFYGMGLPLFVRNKQFVYRGLEYERIGAFTQRLQTEFPSAQILGNNSPPDNA 1391
            :.|.|.|||:|||||||...|.|:|||:||.||.:|||:.||.||:..|||.|..:.:.:.||..
Zfish  1332 MDQQRLEPEFFRVGFYGKKFPFFLRNKEFVCRGHDYERLEAFQQRMLNEFPHAIAMQHANQPDQT 1396

  Fly  1392 ILNAPDQYIQISNVRPVGDAQALKTAMVPVPEKIARFYEVNDVTRFIYDRPMYKGTVDKDNEFKS 1456
            |..|..||:||..|.|:.|:|.: .....||:.|..||:||.:.||.||||.:|||.||:|||||
Zfish  1397 IYQAEAQYLQIYAVTPIPDSQDV-LQRDGVPDNIKSFYKVNHIWRFRYDRPFHKGTKDKENEFKS 1460

  Fly  1457 LWIERTILEIASPLPGILRWYEVKQKTMQELTPVEYACEIISNAGKELSELIVQYKRDPKRNINP 1521
            ||:|||.|.:...||||.||:||:::.:.|::|:|.|.|:|.|...:|..||.|.:....:||||
Zfish  1461 LWVERTTLTLVQSLPGISRWFEVERRELVEVSPLENAIEVIENKNLQLRTLITQCQTRQMQNINP 1525

  Fly  1522 FSMRLQGTIDANVMGGISKYQEAFFSEQFLKSPQGAGQQANVQRLKVLILEQIQILEQALELHGQ 1586
            .:|.|.|.|||.|.||:::||||||.:.::.:....|.:  :.||:.|:.||..|||..|.:|.:
Zfish  1526 LTMCLNGVIDAAVNGGLARYQEAFFVKDYIMNHPEDGDK--IGRLRELMFEQAHILEFGLTVHEK 1588

  Fly  1587 LAPSGVQPLHNRLLERFSQLKQSL-----------------SGMGRLKRQHSESIVN-------- 1626
            ..|..::|||.:|:::|..:|.||                 :|..|:.|..:.:|::        
Zfish  1589 FVPQDMRPLHKKLVDQFHLMKSSLGIQEFPAYVRASPIHFTNGSPRVGRNSAPNIMSPDGGARVV 1653

  Fly  1627 ---TPLPPLPTEQRVAPATASSSLNANAHSNYVYDLDEIYTRPGDTVRPVDPLSSYQTLSKESLS 1688
               :|| ..|...|.    :||||::.| ||.|.::.. ::...|.|..:.|..|..:||....:
Zfish  1654 SRRSPL-SYPAVNRY----SSSSLSSQA-SNEVSNITG-HSESSDEVFNMQPSPSTSSLSSNHSA 1711

  Fly  1689 IPLEDTAAPPVPNRPRSQNFIGNGSMDSPEVPPKRQPTLNSPNAPPLPPRGITPDKRASNPLIFN 1753
            .|...::||             :.:..||::..|.:    .|....|.||    |:..|      
Zfish  1712 SPNVSSSAP-------------SSARGSPQLSDKHK----HPRENCLSPR----DRPCS------ 1749

  Fly  1754 DFGSGDAVGRRHSQQQQQHGQKYSVVDISYDDP-EADQQPHSLPPNFQDGSGGHLSVCFAPNDFR 1817
                  ||                     |.:| |..|:|                   .|:...
Zfish  1750 ------AV---------------------YPNPMEPTQRP-------------------VPHPAG 1768

  Fly  1818 DSGISTTSSRELNHMNLNNLSEDSSSISTITVQHREHCRISSNGSLDYNAAASMNITQRESSTSS 1882
            ||.:..:                                       |.|.::...:.:...|:.|
Zfish  1769 DSSLPRS---------------------------------------DPNISSPDKVVKPAPSSWS 1794

  Fly  1883 FD--VEDFPVPPPPIPPKSLAVSSNGVNFSLDEAHSPHPSTQANTTQLNHIQNPNQNHSTNSHHH 1945
            .|  :.:|....||:||:                 .|:..:.|.||:   .|:|           
Zfish  1795 LDMPLSEFNGKCPPVPPR-----------------PPYSGSPARTTR---SQSP----------- 1828

  Fly  1946 LQQQQNGDGDGYSTLQHPMNGLGLPTLPPPPSAVE-------SPMPASAIASSTSSHQHDGGTFX 2003
                       .||.:.|.. ..:|...|.|:..:       ||:.:.:.:|..||         
Zfish  1829 -----------VSTSRSPQK-TSVPPFTPSPTECQSTGLVSNSPVLSGSYSSGISS--------- 1872

  Fly  2004 VTICRCHHPPDQPHQPHKPSSSTSTSDSTATDTASESTESSSSTHSMTPPPPPPPPPSSFTHLHH 2068
              :.||            ..|..|.:::|.||....::.||.|...:......|||.|    :|.
Zfish  1873 --LSRC------------SVSEASGTENTPTDHVLPNSASSGSDELIRRENKTPPPYS----IHE 1919

  Fly  2069 QMAATTHYCQDCLSSPSPPPTIITEQAQVHPTPGSTSAQPH-IEHCSCGLSFSVVQDQQ----EQ 2128
            :.......       |.||...:.......|.|    .:|| |..          ||.:    ||
Zfish  1920 RNNPRRQV-------PLPPSLSLPPNVDAPPIP----PKPHQIRR----------QDTEPRRPEQ 1963

  Fly  2129 FPR 2131
            |||
Zfish  1964 FPR 1966

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
spgNP_733258.4 SH3_DOCK_AB 9..64 CDD:212805 22/47 (47%)
DOCK_N 67..406 CDD:292790 115/347 (33%)
C2_Dock-B 414..600 CDD:176077 88/197 (45%)
DHR2_DOCK 1215..1610 CDD:297424 187/395 (47%)
dock4bNP_001159700.1 SH3_DOCK4_B 38..91 CDD:212982 22/47 (47%)
DOCK_N 95..418 CDD:292790 115/358 (32%)
C2_Dock-B 426..609 CDD:176077 88/197 (45%)
DHR2_DOCK4 1222..1612 CDD:212578 187/395 (47%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 484 1.000 Domainoid score I385
eggNOG 1 0.900 - - E1_KOG1997
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 1242 1.000 Inparanoid score I173
OMA 1 1.010 - - QHG54452
OrthoDB 1 1.010 - - D102580at2759
OrthoFinder 1 1.000 - - FOG0000433
OrthoInspector 1 1.000 - - otm24913
orthoMCL 1 0.900 - - OOG6_100636
Panther 1 1.100 - - O PTHR45653
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R2355
SonicParanoid 1 1.000 - - X372
SwiftOrtho 1 1.000 - -
TreeFam 1 0.960 - -
ZFIN 00.000 Not matched by this tool.
1413.870

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