DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment spg and DOCK6

DIOPT Version :9

Sequence 1:	NP_733258.4	Gene:	spg / 43404	FlyBaseID:	FBgn0264324	Length:	2187	Species:	Drosophila melanogaster
Sequence 2:	XP_005260057.1	Gene:	DOCK6 / 57572	HGNCID:	19189	Length:	2113	Species:	Homo sapiens

Alignment Length:	1237	Identity:	251/1237 - (20%)
Similarity:	443/1237 - (35%)	Gaps:	308/1237 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   584 VLRSLLCSTKLTQNADLLSLLQWRTYPETIQDSLTGVL-RLNDEELVKFLQDV-----LDALFAM 642
            :::|:.....|.|..|....|:   :|....|.:|.:: .:..|.:.:..:||     |:|..|.
Human  1004 MVKSMALHLLLGQRLDTPRKLR---FPGRFLDDITALVGSVGLEVITRVHKDVELAEHLNASLAF 1065

  Fly   643 FSNEEGNSTQHSGLVFHVLVS------IFSLLQSNKFQHFRPVMNEYIENHFAAALV-----YKG 696
            |.::              |:|      :|||:::    |::.|......:...|||:     :..
Human  1066 FLSD--------------LLSLVDRGFVFSLVRA----HYKQVATRLQSSPNPAALLTLRMEFTR 1112

  Fly   697 LITSVEH---------------------------MAVFMTKAEHPDP-----FQKC--FGSLEYI 727
            ::.|.||                           .:.|.::|  |||     |:..  |....::
Human  1113 ILCSHEHYVTLNLPCCPLSPPASPSPSVSSTTSQSSTFSSQA--PDPKVTSMFELSGPFRQQHFL 1175

  Fly   728 FKLLIQSRKLFARATGGQYEDSF---KRDLHSLFTALNGMLAVPSY----------DVIIPTQEA 779
            ..||:..   .|.|...:.|.:|   |:.:.::.:.|.|....|.|          ::.:|
Human  1176 AGLLLTE---LALALEPEAEGAFLLHKKAISAVHSLLCGHDTDPRYAEATVKARVAELYLP---- 1233

  Fly   780 LLNSTGVVLEQLKDTLPAPELGMLARNMLDA------------------------IPRGAPIRLI 820
            ||:.....|.:|.|....|.......:|||:                        :..|:...:.
Human  1234 LLSIARDTLPRLHDFAEGPGQRSRLASMLDSDTEGEGDIAGTINPSVAMAIAGGPLAPGSRASIS 1298

  Fly   821 QAKLHAVKDLVSGELFHEDDSRTVVLSV--ACKHLRMHLSRRDELRLCAEILSEILSQLY----- 878
            |....|.:   :|.....:.|||::..|  ..|:....|.:|....|....|..:|..||
Human  1299 QGPPTASR---AGCALSAESSRTLLACVLWVLKNTEPALLQRWATDLTLPQLGRLLDLLYLCLAA 1360

  Fly   879 --DLQKEQREKVTN-TLQHDLD---SLCKNILGILIRTISII---MEGSNAVLPQLVSCLLGLLQ 934
              ...|:..|::.: |.:..||   .|.:.|||.:.....::   .|.|....|:.|.....:
Human  1361 FEYKGKKAFERINSLTFKKSLDMKARLEEAILGTIGARQEMVRRSRERSPFGNPENVRWRKSV-- 1423

  Fly   935 LLDETHYKRYWDELSPNKDPRDLKEFLSKSLLVYEELLTQDWHVFPNDWLVMKLAANDVLRMSLE 999
                ||:|:..|.:...||..:.:..:..:|.....|:..|    ..:.:|..:..::.....|.
Human  1424 ----THWKQTSDRVDKTKDEMEHEALVEGNLATEASLVVLD----TLEIIVQTVMLSEARESVLG 1480

  Fly  1000 EFAKPLVYRFLGPQAFDSQLWWSYFSLAVAFLTQ-------PSLQLEQYRE-------------P 1044
            ...|.::|.....|        |...|.....||       |.|..|:..|             .
Human  1481 AVLKVVLYSLGSAQ--------SALFLQHGLATQRALVSKFPELLFEEDTELCADLCLRLLRHCG 1537

  Fly  1045 KRLKILHSH--GDMRVLM--GFQILSMWSQLGEQKLHFIPSMVGPFLEVTLVPEPALRKATLSVF 1105
            .|:..:.:|  ..:.:||  .|:|...::::..|....:.|:||.....:   |..||: :|...
Human  1538 SRISTIRTHASASLYLLMRQNFEIGHNFARVKMQVTMSLSSLVGTTQNFS---EEHLRR-SLKTI 1598

  Fly  1106 YDMMQCEQAARGS-FRLVESELIDKLDLLISENKGDDEYRELFSTILLEKVQVENPNWKEAGIAF 1169
            ....:.:...|.| |.....:|:..|.:::::            |:.:::.| |:|
Human  1599 LTYAEEDMGLRDSTFAEQVQDLMFNLHMILTD------------TVKMKEHQ-EDP--------- 1641

  Fly  1170 IASVTRLLERLLD--YRSVMQGEENRDKRMTCTVNLLNFYKNEINRKE----------MYLRYIY 1222
                    |.|:|  ||.....:.:.|.|:|...|:...:....|..|          :...|:.
Human  1642 --------EMLIDLMYRIARGYQGSPDLRLTWLQNMAGKHAELGNHAEAAQCMVHAAALVAEYLA 1698

  Fly  1223 KLH-NLHLQ---------AENYTEAGFTLKLYASMLSWDRE----TQSFAPFDNSGQPEWQRKER 1273
            .|. :.||.         :.|..|..   .:...:||.|.|    .:.|......|
Human  1699 LLEDHRHLPVGCVSFQNISSNVLEES---AISDDILSPDEEGFCSGKHFTELGLVG--------- 1751

  Fly  1274 LYHEILKYFDKGKCWEKGIPLCKELAHLYETRRFDYNKLSEI--LIQEAKFFQNILTQL----RP 1332
            |..:...||..|..:|....:.|.|..:.|..| ||.||:.:  .:|||  |..|:.|.    |.
Human  1752 LLEQAAGYFTMGGLYEAVNEVYKNLIPILEAHR-DYKKLAAVHGKLQEA--FTKIMHQSSGWERV 1813

  Fly  1333 EPEYFRVGFYGMGLPLFVRNKQFVYRGLEYERIGAFTQRLQTEFPS-------AQILGNNSPPDN 1390
            ...||||||||.... .:..::|||:.....::...:.||: ||.:       .:|:.:::|.|.
Human  1814 FGTYFRVGFYGAHFG-DLDEQEFVYKEPSITKLAEISHRLE-EFYTERFGDDVVEIIKDSNPVDK 1876

  Fly  1391 AILNAPDQYIQISNVRPVGDAQALKTAMVPVPEKIARFYEVNDVTRFIYDRPMYKGTVD--KDNE 1453
            :.|::...||||:.|.|..|...||       :::..|.....:..|::..|.   |.|  ...|
Human  1877 SKLDSQKAYIQITYVEPYFDTYELK-------DRVTYFDRNYGLRTFLFCTPF---TPDGRAHGE 1931

  Fly  1454 FKSLWIERTILEIASPLPGILRWYEVKQKTMQELTPVEYACEIISNAGKELSELIVQYKRDPKRN 1518
            .......:|:|......|.|.....|..:....|||||.|   |.:..|:..||....::||. :
Human  1932 LPEQHKRKTLLSTDHAFPYIKTRIRVCHREETVLTPVEVA---IEDMQKKTRELAFATEQDPP-D 1992

  Fly  1519 INPFSMRLQGTIDANVMGGISKYQEAFFSEQFLKSPQGAGQQANVQRLKVLILEQIQILEQALEL 1583
            .....|.|||::...|..|..:..:.|.:|    .|:......:..:|::...:..:..|.||..
Human  1993 AKMLQMVLQGSVGPTVNQGPLEVAQVFLAE----IPEDPKLFRHHNKLRLCFKDFCKKCEDALRK 2053

  Fly  1584 HGQLAPSGVQPLHNRLLERFSQLKQSLSGMGRLKRQHSESIVNTPLPPL--PTEQRVAPATASSS 1646
            :..|.....:..|..|...:.:|:::|           :.::...||.|  ||     |....:|
Human  2054 NKALIGPDQKEYHRELERNYCRLREAL-----------QPLLTQRLPQLMAPT-----PPGLRNS 2102

  Fly  1647 LN 1648
            ||
Human  2103 LN 2104

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
spg	NP_733258.4	SH3_DOCK_AB	9..64	CDD:212805
		DOCK_N	67..406	CDD:292790
		C2_Dock-B	414..600	CDD:176077	3/15 (20%)
		DHR2_DOCK	1215..1610	CDD:297424	101/433 (23%)
DOCK6	XP_005260057.1	DUF3398	65..155	CDD:288711
		C2_Dock-C	547..724	CDD:176078
		DHR2_DOCK6	1658..2080	CDD:212575	106/456 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1997
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810