DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment spg and Dock8

DIOPT Version :9

Sequence 1:	NP_733258.4	Gene:	spg / 43404	FlyBaseID:	FBgn0264324	Length:	2187	Species:	Drosophila melanogaster
Sequence 2:	NP_001032882.2	Gene:	Dock8 / 499337	RGDID:	1561588	Length:	2099	Species:	Rattus norvegicus

Alignment Length:	2165	Identity:	397/2165 - (18%)
Similarity:	720/2165 - (33%)	Gaps:	758/2165 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 LALDVGDSVD-------IVEECKHWYRGSCPRKSRAVGLFPKTYIHIKDLSKIDPVVAECTQV-L 80
            ||.::||..|       ..:||: ..:.|.|.:.                .::||.|.:|.|. :
  Rat    79 LAQELGDLTDDDLHVAFTPKECR-TLQHSLPEEG----------------VELDPHVRDCVQTYI 126

  Fly    81 REWSEIWKRLYVDRE---AYKFQTLRKVMFSILESRRELLSATMTQDQTLELQMVVVSKIDWGNR 142
            |||      |.|:|:   :.:|.:.||.     .|||:....  .|.||.|.:.:..|
  Rat   127 REW------LIVNRKNQGSPEFCSFRKT-----GSRRDFHKT--LQKQTFESETLECS------- 171

  Fly   143 KLGLDLVPREGP-----LAVDPHGIGIV--------------KLYNVHVSSADNAKASSSRGTLR 188
                :...:.||     :..|..|.|.:              :|.|:...||::.:......
  Rat   172 ----EPATQTGPRHRFNVLCDVSGKGPITSCDFDLRSLQPDERLENLLQLSAEDFEKEKEEA--- 229

  Fly   189 RKTQRKILTHHLY---------------FCMRD-FGHRIGGDDAEVYF-----------FLYDGS 226
            |||.|......||               .|.:: .|:||......:.|           .|||..
  Rat   230 RKTNRTAELFALYPSVDEEDAVEIRPVPECPKEHLGNRILVKVLTLKFEIEIEPLFASIALYDVK 294

  Fly   227 HMRPLSERFLVKISKDGFSNYIERLH---------SNCTVFT-DLGAADLNEELHLVAVVMRVGK 281
            ..:.:||.|...::.|.|..:: |.|         :...||: ...::|       :.:|:::.|
  Rat   295 ERKKISENFHCDLNSDQFKGFL-RAHTPSVDPSSQARSAVFSVTYPSSD-------IYLVVKIEK 351

  Fly   282 IIQSDSI-------------------KKIEK--------SGTLGHGPTFRRPFGVGVLSLGDIAH 319
            ::|...|                   :|:||        ...||   .:|.||....:||....:
  Rat   352 VLQQGEIADCAEPYMIIKESDGGKSKEKVEKLKLQAESFCQRLG---KYRMPFAWAPISLASFFN 413

  Fly   320 FDSSLEQSSDERE---------------------------------YNFK-------LFQCEEKD 344
            . |:||:.|.:.|                                 .|||       :|..:|.|
  Rat   414 V-STLERESTDLEPGAGRNSVGERRSLSQSRRPSERTLSFEENGVGSNFKTTTLATNIFFKQEGD 477

  Fly   345 -------FHLLPELIIKKSSGKYSPIQASQGTQGIVVS--------------LKLLHGGLGQARQ 388
                   |..|.:  .|:||.....:::..|:..:.::              |.:......:.|.
  Rat   478 RLSDEDLFKFLAD--YKRSSSLQRRVKSIPGSLRLEIAPAPDVMNCCLTPEMLPVKPFPENRTRP 540

  Fly   389 EQPMLFQGSTITRKMGFP--DVIMPGDV-RNDLFLNLERGEFERGGKNTGKNILVTVVVL--DVA 448
            .:.:|          .||  :|.:|..| ||.|::..:|..| .....:.:||.:.:..:  :..
  Rat   541 HKEIL----------EFPIREVYVPHTVYRNLLYVYPQRLNF-ANKLASARNITIKIQFMCGEDP 594

  Fly   449 GNVLTDCLWGASGMESQPQYRSMILYHQNAPSWNEMLRLSVPIDKFSTAHVRFEFRHCSTRDK-- 511
            .|.:......:||.|...:..:.|.||..:|.:.|.:::.:|.......|:.|.|.|.|.:.|
  Rat   595 SNAMPVIFGKSSGPEFLQEVYTAITYHNKSPDFYEEVKIKLPAKLTVNHHLLFTFYHISCQQKQG 659

  Fly   512 -TEPKLFAFSFARL-----MDTGGATLGDGLHELYV-YKCEDPAKLQVAN-------------YL 556
             :...|..:|:..:     :.||...|...|.:|.. |......|:.:.|             .:
  Rat   660 ASGESLLGYSWLPILLNERLQTGSYCLPVALEKLPPNYSIHSAEKVPLQNPPIKWAEGHKGVFNI 724

  Fly   557 RLQC----RPRDAQAKMDCGGCFSRSSKEVFVLRSLLCSTKLTQNADLLSLLQWRTYPETIQDSL 617
            .:|.    ..:|...:.....|.|..|:..|.:|.|  ..|:|:|              |::..|
  Rat   725 EVQAVSSVHTQDNHLEKFFTLCHSLESQVTFPIRVL--DQKITEN--------------TLEHEL 773

  Fly   618 -TGVLRLND---EELVKFLQDVLDALFAMFSNE---EGNSTQHSGLVFHVLVSIFSLLQSN---- 671
             ..::.||.   |.||.||..|||.||.:....   .|.:...|...|..:|:|.:.|.::
  Rat   774 KLSIICLNSSRLEPLVLFLHLVLDKLFQLSVQPMVIAGQTANFSQFAFESVVAIANSLHNSKDLR 838

  Fly   672 KFQHFRP-VMNEYIE-------------------------------------------------- 685
            |.||.|. ::..|:.
  Rat   839 KDQHGRNCLLASYVHYVFRLPELHRDAPKSGGPTAVVPDPRYHTYGRTSAAAVSSKLMQARVMSS 903

  Fly   686 -------NHFAAALVYKGLITS------VEHMAVFMT-------KAEHPDPFQK----------- 719
                   .|.||....|.:::|      ...|:.:.:       ....|.|..|
  Rat   904 SNPDLAGTHCAADEEVKNIMSSKIADRNCSRMSYYCSGNSDVPGSTAAPRPVSKKHFHEELALQM 968

  Fly   720 ----------CFGSLEYIFKLLIQS----------RKLFARATGGQYEDSFKRDLHSLFTALNGM 764
                      .|....:.|:||::|          |..|.|.   ::.|.||.|:.::...:...
  Rat   969 VVSTGLVRETVFKYAWFFFELLVKSMAQYVHNLDKRDSFRRT---RFSDRFKDDITTIVNVVTSE 1030

  Fly   765 LAVPSYDVIIPTQEALLNSTGVVLEQLKDTLPAPE----LGMLARNMLDAIPRGAPIRLIQ---- 821
            :|            |||      ::..|::..|.:    |.....::|..:.||....||:
  Rat  1031 IA------------ALL------VKPQKESEQAEKINISLAFFLYDLLSIMDRGFVFNLIKHYCT 1077

  Fly   822 ---AKLHAVKDLVSGELFHEDDSRTVVLSVACKH---LRMHL----------------SRRDELR 864
               |||:.:..|:|        .|...|.:.|.|   |.::|                |.::. .
  Rat  1078 QLSAKLNTLPTLIS--------MRLEFLRILCSHEHYLNLNLLFMNPDTAPASPCPSISSQNS-S 1133

  Fly   865 LCAEILSEILSQLYDLQKEQREK--VTNTL-------------------------------QHDL 896
            .|:....:.::.::||..|.|::  :|..|                               .|||
  Rat  1134 SCSSFQDQKIASMFDLTPEYRQQHFLTGLLFTELAVALDAEGDGISRVQRKAVSAIHSLLSSHDL 1198

  Fly   897 DSLCKN-------------ILGILI---------------------------------RTISIIM 915
            |..|..             ::||::                                 :.:::.:
  Rat  1199 DPRCLKPEVKVKIAALYLPLVGIILDALPQLYDFTDARSGRSRASGSYEEQDVANGINQNVALAI 1263

  Fly   916 EGSN----------AVLP-------------QLVSCLLGLLQLLDETHYKRYWDEL--------- 948
            .|::          :.||             .|:.|.|.:::..|::..:::..:|
  Rat  1264 AGNHFNLKTSGAMLSSLPYKQYNMLNADTTRHLMVCFLWIMKNADQSLIRKWIADLPSMQLNRIL 1328

  Fly   949 ----------------SPNK-------DPRDLKEFLSKSLLVYE----ELLTQ------------ 974
                            |.:|       ..||:|..|.::||..|    |::.:
  Rat  1329 DLLFICVSCFEYKGKQSSDKVSNQVLQKSRDVKAKLEEALLRGEGARGEMMRRRIPGTDRFPGLN 1393

  Fly   975 ---DWHVFPNDWLVMKLAANDVLRMSLEEF-AKPLVYRFLGPQAFDSQLWWSYFSLAVAFLTQPS 1035
               .|......|    ..||:.|..:..|. .:.|:...|..:|          :|.:..:.:..
  Rat  1394 ENLRWRKEQTQW----RQANEKLDKTKAELDQEALISGNLATEA----------NLIILDMQENI 1444

  Fly  1036 LQLEQYREPKR------LKIL--------------HSHGDMRVLMG-------FQILSMWSQLGE 1073
            :|.....:.|.      |::|              |....:|.|:.       .:.:...:.|.:
  Rat  1445 IQASSSLDCKDSLLGGVLRVLVNSLSCDQSTTYLTHCFATLRALIAKFGDLLFEEEMEQCADLCQ 1509

  Fly  1074 QKLHFIPSMVGPFLEVTLVPEPALRKATLSVFYDMMQCEQAARGSFRLVESELIDKLDLLISE-- 1136
            :.||...|.    ::||       |....:..|.:|:....|..:|..|:.::...|..|:.:
  Rat  1510 RVLHHCSSS----MDVT-------RSQACATLYLLMRFSFGATSNFARVKMQVTMALASLVGKAP 1563

  Fly  1137 NKGDDEYRELFSTILLEKVQVENPNWKEAGIAFIASV--TRLLERLLDYRSVM-------QGEEN 1192
            :..::..|:...|||.         :.|...|..|::  |::.|.|.:..|::       :.:|:
  Rat  1564 DFNEEHLRKSLRTILA---------YSEEDTAMRATLFPTQVEELLCNLNSILYDTVKMREFQED 1619

  Fly  1193 RDKRMTCTVNLLNFYKNEINRKEMYLRYIYKLHNLHLQAENYTEAGFTL-------KLYASMLSW 1250
            .:..|.....:...|:..   .::.|.::..:...|.:.:.:|||...|       ..|.|||
  Rat  1620 PEMLMDLMYRIAKSYQAS---PDLRLTWLQNMAEKHTKRKCFTEAAMCLVHAAALVAEYLSML-- 1679

  Fly  1251 DRETQSFAPFDNSGQPEWQ-------RKERLYHEILKYFDKGKC-----WEKG-IPLCKELAHLY 1302
              |..|:.|.   |...:|       .:..:..:.|...:.|.|     .|.| :.|.::.|.|:
  Rat  1680 --EDHSYLPV---GSVSFQNISSNVLEESAVSDDTLSPDEDGVCSGRYFTESGLVGLLEQAAELF 1739

  Fly  1303 ET-------------------RRFDYNKLSEILIQEAKFFQNILTQ--LRPEPEYFRVGFYGMGL 1346
            .|                   ...|:.||:....:..|.|.||:.:  .|....||||||||...
  Rat  1740 STGGLYETVNEVYKLVIPILEAHRDFRKLTSTHDKLQKAFDNIINKDHKRMFGTYFRVGFYGSKF 1804

  Fly  1347 PLFVRNKQFVYRGLEYERIGAFTQRLQ--------TEFPSAQILGNNSPPDNAILNAPDQYIQIS 1403
            . .:..::|||:.....::...:.||:        .||  .:::.:::|.|...|:....||||:
  Rat  1805 G-DLDEQEFVYKEPAITKLPEISHRLEGFYGQCFGAEF--VEVIKDSTPVDKTKLDPNKAYIQIT 1866

  Fly  1404 NVRPVGDAQALKTAMVPVPEKIARFYEVNDVTRFIYDRPMY-----KGTVDKDNEFKSLWIERTI 1463
            .|.|..|...:|       :::..|.:..::.||:|..|..     :|.:.:.:.      ..|:
  Rat  1867 FVEPYFDEYEMK-------DRVTYFEKNFNLRRFMYTTPFTLEGRPRGELHEQHR------RNTV 1918

  Fly  1464 LEIASPLPGILRWYEVKQKTMQELTPVEYACEIISNAGKELSELIVQYKRDPKRNINPFSMRLQG 1528
            |......|.|.....|.||....|||:|.|   |.:..|:..:|.|...::|. :.....|.|||
  Rat  1919 LTTMHAFPYIKTRIRVSQKEEFVLTPIEVA---IEDMKKKTLQLAVATHQEPP-DAKMLQMVLQG 1979

  Fly  1529 TIDANVMGGISKYQEAFFSEQFLKSPQGAGQQANVQRLKVLILEQIQILEQALELHGQLAPSGVQ 1593
            ::.|.|..|..:..:.|.:|    .|.......:..:|::...|.|....:|:|.:.:|..:..:
  Rat  1980 SVGATVNQGPLEVAQVFLAE----IPADPKLYRHHNKLRLCFKEFIMRCGEAVEKNRRLITAEQR 2040

  Fly  1594 PLHNRLLERFSQLKQSLSGM 1613
            .....|.:.:::||.||..|
  Rat  2041 EYQQELKKNYNRLKDSLRPM 2060

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
spg	NP_733258.4	SH3_DOCK_AB	9..64	CDD:212805	9/46 (20%)
		DOCK_N	67..406	CDD:292790	89/486 (18%)
		C2_Dock-B	414..600	CDD:176077	45/214 (21%)
		DHR2_DOCK	1215..1610	CDD:297424	100/448 (22%)
Dock8	NP_001032882.2	DUF3398	73..164	CDD:288711	29/114 (25%)
		C2_Dock-C	559..739	CDD:176078	35/180 (19%)
		DHR2_DOCK8	1636..2057	CDD:212574	100/454 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1997
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810