Protein Alignment spg and dock8

DIOPT Version :9

• Sequence 1: NP_733258.4
• Gene: spg / 43404
• FlyBaseID: FBgn0264324
• Length: 2187
• Species: Drosophila melanogaster
• Sequence 2: XP_001920107.4
• Gene: dock8 / 403040
• ZFINID: ZDB-GENE-060503-743
• Length: 2090
• Species: Danio rerio
• Alignment Length: 2176
• Identity: 399/2176 - (18%)
• Similarity: 718/2176 - (32%)
• Gaps: 701/2176 - (32%)

  Fly     5 SNNKYGVAIHNWH-----GDVRFGL--ALDVGDSVDIVEECKHWYRGSCPRKSRAVGLFPKTYIH 62
            |...:|...|:.|     |...|.:  :.:..:.||:.|......|.......:.:|.||...:.
Zfish    29 SGVSHGSLPHHRHSYNASGSFCFNVPQSYEAVEPVDLDEFLMSQLRSGDAEVMQELGEFPDDDLD 93

  Fly    63 I----KDLSKIDPVVAE-----------CTQVLREWSEIWKRLYVDREAYKFQTLRKVMFSILES 112
            :    ::...|.|.:||           |.|   .:::.|  |.|.|.:   |....:.:|....
Zfish    94 VELVERECRTIRPTIAEEGVELDSHVRDCVQ---SYTQPW--LVVSRRS---QGYGWISYSDRTD 150

  Fly   113 RRELLSATMTQDQTLELQMVVVSKIDWGNRKLGLDLVPREGPLAVDPHGIGIVKL-YNVHVSSAD 176
            ..::|     |.||.|..:       ..:::..||..|....|..|.....:... :|:.....|
Zfish   151 SNKIL-----QRQTFESDV-------QPDKQEQLDKSPSLTALCDDSARTTLTSSDFNLRALQPD 203

  Fly   177 NAKAS----SSRGTLRRKTQRKILTHH------LY---------------FCMRD-FGHRIGGDD 215
            ....|    ||...|.|..|....::.      ||               .|.:: ||.||....
Zfish   204 QRVESVLRFSSPEELDRFNQESRQSNRYGELFGLYPPIDEEDAVAIRPIPDCPKEHFGQRILVRC 268

  Fly   216 AEVYF-----------FLYDGSHMRPLSERFLVKISKDGFSNYIERLHSNCTVFTDLGAADL--- 266
            ..|.|           .|||....:.:||.|...::.|....:: |.|:.....:.|..:.:
Zfish   269 QTVKFEIEIEPLFATMALYDLKEKKKISENFNFDLNSDQMKGFL-RTHTPQVDTSTLSRSAIFSI 332

  Fly   267 ---NEELHLVAVVMRVGKIIQ----------------SDSIK---KIEKSGTLGHG-----PTFR 304
               :.:::|   |:::.|::|                ||:.|   |:||......|     ..:|
Zfish   333 SYPSPDIYL---VIKIEKVLQQGEIGDCAEPYMVLKESDTTKNRDKLEKLRNQAEGFCQRLGRYR 394

  Fly   305 RPFGVGVLSLGDIAHFDSSLE-QSSDEREYN-----------------FKLFQ------------ 339
            .|.....:::..:  .:|:|| ::||....|                 |.|.:
Zfish   395 MPLAFATVNIMSV--INSTLERETSDTDSINGRGSMDKKGLPRRNSDRFSLMEDNYILSGFKPAV 457

  Fly   340 --C-----------EEKDFHLLPELIIKKSSG-----------KYSPIQASQGTQGIVVSLKLLH 380
              |           :|..|..|.:  ||:||.           |...:.|.....| .:|.:|:.
Zfish   458 TMCTFIKQEGERLSDEDLFKFLAD--IKRSSSQRRVKIIPGYLKLEVLPAPDTVPG-CLSPELIP 519

  Fly   381 GGLGQARQEQPMLFQGSTITRKMGFP--DVIMPGDV-RNDLF-----LNLERGEFERGGKNTGKN 437
            ......:.::|       |...:.||  :|.:|.:: ||.|:     |||      .....:.:|
Zfish   520 VKPVSEKNQRP-------IKEVLEFPSKEVYVPHNIYRNLLYVYPLRLNL------TNRLTSARN 571

  Fly   438 ILVTVVVLDVAGNVLTDC----LWG-ASGMESQPQYRSMILYHQNAPSWNEMLRLSVPIDKFSTA 497
            |  ||.:..::|.. :.|    ::| :||.|...:..:.:.||..:|.:.:.:::.:|.......
Zfish   572 I--TVKIQFMSGED-SSCAMPVIFGKSSGPEFLTEVYTPVTYHNRSPDFYDEIKILLPARLTDKH 633

  Fly   498 HVRFEFRHCSTRDK-----TEPKLFAFSFARLMD-----TGGATLGDGLHELYV-YKCEDPAKLQ 551
            |:.|.|.|.|.:.|     :...|..:|:..:::     |....|...|.:|.: |....|.||.
Zfish   634 HLLFTFFHISCQQKQNQTGSVEALIGYSWLPMLNNDRLQTSQQCLPIVLDKLPINYSLHTPEKLP 698

  Fly   552 --------VANY-----LRLQC----RPRDAQAKMDCGGCFSRSSKEVFVLRSLLCSTKLTQNAD 599
                    :.|:     |.||.    :.:|:..:.....|.:...|..|.:|  :...|:.:|
Zfish   699 AQVPPVKWLENHKGLFNLELQAVSSVQTQDSHLERFFTLCHALEGKSTFPIR--VRDEKIQEN-- 759

  Fly   600 LLSLLQWRTYPETIQDSLTGVLRLNDEELVKFLQDVLDALFAMFSNE---EGNSTQHSGLVFHVL 661
                    .:...::.|:..:.....|.||.||..|||.||.:....   .|.:...:.:.|..:
Zfish   760 --------MFEHELKLSIISLSSAGLEPLVLFLHQVLDKLFRLIMQPMVIAGQTANLAQIAFESV 816

  Fly   662 VSIFSLLQSNK-----------------FQHFRPVMNEY-IENHFAAALV------YKGLITSVE 702
            ||:.:.|.:::                 :..||....:| |.......|:      |..|..:..
Zfish   817 VSVINSLHNSQELAKDHQGRNCLLATYLYFVFRLPDTQYEIHTSGTGGLMAHPEGRYSTLTRTTA 881

  Fly   703 HMAVFM------TKAEHPD---PF--------------------------------QKCFGSLE- 725
            ....||      ..:.:||   |.                                |...||..
Zfish   882 TTVGFMLLQSRIRSSSNPDIPAPLSPEDTEVNNILGKVLNHPGSRMSTAANASNSPQSSTGSTRP 946

  Fly   726 ------------------------------YIFKLLIQS---------RKLFARATGGQYEDSFK 751
                                          :.|::|::|         :|..:|.  .::.|.||
Zfish   947 TNKKLFHEELALQMVVSTGVCRENVYKYAWFFFEVLVKSMSQHVSQLDKKTVSRR--NRFSDRFK 1009

  Fly   752 RDLHSLFTALNGMLAVPSYDVIIPTQEALLNSTGVVLEQLKDTLPAPELGMLARNMLDAIPRGAP 816
            .|:.::...:...:.    ::::..|:.|..:..|.:          .|.....:::..:.||..
Zfish  1010 DDITTIVNVVTAEIG----NILVKQQKELEQAEKVNI----------SLAFFLYDLMSLMDRGFV 1060

  Fly   817 IRLIQ-------AKLHAVKDLVSGELFHEDDSRTVVLSVACKH---------------------- 852
            .:|::       ||...:..|:|        .|...|.|.|.|
Zfish  1061 FQLVKNYCNQMAAKSVNMATLIS--------MRLEFLRVLCSHEHYLNLSLFFSSPSSAPASPSP 1117

  Fly   853 ------------------LRMHLSRRDELR--LCAEILSEILSQLYDLQKE----QREKVTNTLQ 893
                              ....||:..:.|  |...:|:| ||...|::.|    |::.:..|..
Zfish  1118 SVSSQTSSSCSFQDNKIAAMFDLSQDFKQRHYLTGLLLTE-LSTALDIESEGGRVQQKAINATYS 1181

  Fly   894 ----HDLDSLCKN-------------ILGILIRTI------------------------------ 911
                ||||..|..             ::||:|.:|
Zfish  1182 LLCAHDLDQRCSRSEVKAKIAALYLPLVGIIIDSINYLDFTVSDSRSGKGKSGGPEEDPDNIATI 1246

  Fly   912 -------------------------SIIMEGSNAVLPQ----LVSCLLGLLQLLDETHYKRYWDE 947
                                     |:.::.:|.:..:    |:.|.|.:::..|:...:| |..
Zfish  1247 NQSVAMAIAGNPFNTLTRNALVSMASVSVKTTNMLTAETSRNLLMCFLWIIKNADQNLIQR-WTV 1310

  Fly   948 LSPNKDPRDLKEFLSKSLLVYE--------ELLTQDWHVFPNDWLVMKLAANDVLRMSLEEF--- 1001
            ..|:.....|.|.|:.....:|        ::.||            .|..:...:..|||.
Zfish  1311 DMPSSQLSRLLELLAICTSCFEYRGKQSSDKVSTQ------------ALQKSQQAKARLEEALLG 1363

  Fly  1002 ---AKPLVYRFLGPQAFDSQL-------W------W-------------------------SYFS 1025
               |:..:.:.:|.|..|..|       |      |                         :..:
Zfish  1364 GIGARGEMMKRVGVQGNDRTLGLRENLRWRKDLTQWRQTNDRQDKSKAELDQEAIISGNLATETN 1428

  Fly  1026 LAVAFLTQPSLQLEQYREPKR------LKIL--------------HSHGDMRVLMGFQILSMWSQ 1070
            |.|..|.:..:|.....:.|.      ||:|              |....:|.|    |:.....
Zfish  1429 LIVLDLLEMIVQAVPLADCKDNVVGGVLKVLLHSLTCNQSTTYLSHCFSTLRAL----IVKFGDL 1489

  Fly  1071 LGEQK-----------LHFIPSMVGPFLEVTLVPEPALRKATLSVFYDMMQCEQAARGSFRLVES 1124
            |.|::           ||:..|.|           ...|....:..|.:|:...::..:|..|:.
Zfish  1490 LFEEEAEQCADLCQKVLHYCSSCV-----------DGNRSQACATLYLIMRYSYSSASNFSRVKM 1543

  Fly  1125 ELIDKLDLLISENKG-DDEY-RELFSTILL---EKVQVENPNWKEAGIAFIASVTRLLERLLDYR 1184
            ::...|..|:.::.. .:|| |..|.|||.   |..::::..       ..:.|..||..|....
Zfish  1544 QVTMSLASLVGKSSDIHEEYLRRSFRTILAYAEEDTEMQSTQ-------LPSQVDELLRNLNSIL 1601

  Fly  1185 S--VMQGEENRDKRMTCTVNLLNFYKNEINRKEMYLRYIYKLHNLHLQAENYTEAGFTL------ 1241
            |  |...|..:|..|...: :....|......::.|.::..:...|...:.:||:...|
Zfish  1602 SDTVKMKEFQKDPEMLMDL-MYRIAKGYQTSPDLRLTWLQNMAEKHNGRKCFTESAMCLVHAAAL 1665

  Fly  1242 -KLYASMLSWDRETQSFAP-----FDNSGQPEWQRKERLYHEILKYFDKGKC-----WEKG-IPL 1294
             ..|.|||    |...:.|     |.|. .|....:..:..:||...:.|.|     .|.| :.|
Zfish  1666 VAEYLSML----EDHKYLPVGSVTFQNI-SPNVLEESAVSDDILSPDEDGVCSGRYFTENGLVGL 1725

  Fly  1295 CKELAHLY--------------------ETRRFDYNKLSEILIQEAKFFQNILTQ--LRPEPEYF 1337
            .::.|.|:                    |..| |:.||:....:..:.|.||:.:  .|....||
Zfish  1726 LEQAAELFSNGGLFEAVNEVYKVIVPILEAHR-DFRKLASTHDKLQRAFDNIIQKGHKRMFGTYF 1789

  Fly  1338 RVGFYGMGLPLFVRNKQFVYRGLEYERIGAFTQRLQTEFPSA------QILGNNSPPDNAILNAP 1396
            ||||||.... .:..::|:|:......:...:.||:..:...      :::.:::|.|...|:..
Zfish  1790 RVGFYGSKFG-DLDEQEFIYKEPGITHLPEISHRLENFYSQCFGDGVLEMIKDSTPVDRNKLSPN 1853

  Fly  1397 DQYIQISNVRPVGDAQALKTAMVPVPEKIARFYEVNDVTRFIYDRPMYKGTVDKDNEFKSLWIER 1461
            ..||||:.|.|..|...:|       :::..|.:..::.||:|..|..|....: .|....:..:
Zfish  1854 KAYIQITFVEPYFDDYEMK-------DRLTNFEKNFNLRRFMYTTPFTKSGRPR-GELNEQYKRK 1910

  Fly  1462 TILEIASPLPGILRWYEVKQKTMQELTPVEYACEIISNAGKELSELIVQYKRDPKRNINPFSMRL 1526
            |||......|.|.....|.||...:|||:|.|.|.:....:||:|...:.|.|...    ..|.|
Zfish  1911 TILTTMHAFPYIKTRINVIQKEEFDLTPIEVAIEDMQKKTRELAEATHREKPDAVM----LQMVL 1971

  Fly  1527 QGTIDANVMGGISKYQEAFFSEQFLKSPQGAGQQANVQRLKVLILEQIQILEQALELHGQLAPSG 1591
            ||::.|.|..|..:..:.|.:|    .|.......:..:|::...|.|....:|:|.:.||....
Zfish  1972 QGSVTATVNQGPLEVAQVFLNE----IPADPKLFRHHNKLRLCFKEFILRCGEAIEKNKQLITPD 2032

  Fly  1592 VQPLHNRLLERFSQLKQSLSGMGRLKRQHSE 1622
            .:.....:.:.:::|:::|..|  |:|:..|
Zfish  2033 QKEYQQEMKKNYNKLRENLRPM--LERKIPE 2061

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
spg	NP_733258.4	SH3_DOCK_AB	9..64	CDD:212805	12/65 (18%)
		DOCK_N	67..406	CDD:292790	85/471 (18%)
		C2_Dock-B	414..600	CDD:176077	47/224 (21%)
		DHR2_DOCK	1215..1610	CDD:297424	99/440 (23%)
dock8	XP_001920107.4	DUF3398	75..161	CDD:288711	19/98 (19%)
		C2_Dock-C	549..731	CDD:176078	41/190 (22%)
		DHR2_DOCK8	1630..2051	CDD:212574	99/443 (22%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1997
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810