DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment spg and Dock6

DIOPT Version :9

Sequence 1:	NP_733258.4	Gene:	spg / 43404	FlyBaseID:	FBgn0264324	Length:	2187	Species:	Drosophila melanogaster
Sequence 2:	XP_038937778.1	Gene:	Dock6 / 367039	RGDID:	1306517	Length:	2123	Species:	Rattus norvegicus

Alignment Length:	1968	Identity:	370/1968 - (18%)
Similarity:	632/1968 - (32%)	Gaps:	671/1968 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   222 LYDGSHMRPLSERFLVKISKDGFSNYIERLHSNCTVFTDLGAADLNEELHL---VAVVMRVGKII 283
            |||....:.:||.|...::.|.....: |.|......:.|..:.:....:.   :.:|:::.|::
  Rat   283 LYDVREKKKISENFYFDLNSDSVKGLL-RAHGTHPAISTLARSAIFSVTYPSPDIFLVVKLEKVL 346

  Fly   284 Q----------------SDSIK---KIEK--------SGTLGHGPTFRRPFGVGVLSLGDIAHFD 321
            |                :|::|   |:||        ...||.   :|.||....:.|.:|....
  Rat   347 QQGDISECCEPYMVMKEADTVKNKEKLEKLRLAAEQFCTRLGR---YRMPFAWTAVHLANIVSSV 408

  Fly   322 SSLEQSSD------------------EREY------NFKLFQ---------CEEKDFHLLPELII 353
            ...::.||                  :|.|      :|..|:         .:::...|..|.:.
  Rat   409 GPQDRDSDSEGERRPTWAERRRRGPQDRSYSGDDACSFSSFRPATLTVTNFFKQEAERLSDEDLF 473

  Fly   354 KKSSGKYSPIQASQGTQGIVVSLKL--------LHGGLGQARQEQPMLF--------QGSTITRK 402
            |..:....|....:..:.:...||:        ||..|      .|.|.        :|......
  Rat   474 KFLADMRRPSSLLRRLRPVTAQLKIDISPAPENLHFCL------SPELLHVKPYPDPRGRPTKEI 532

  Fly   403 MGFP--DVIMPGD-VRNDLFLNLERGEFERGGKNTGKNILVTVVVLDVAGNVLTDCLWGASGMES 464
            :.||  :|..|.. .||.||:......|. ..:.:.:|:.|.:..:  ||...:..|....|..|
  Rat   533 LEFPAREVYAPHTCYRNLLFVYPHSLNFS-SRQGSVRNLAVRIQYM--AGEDQSQALPVIFGKSS 594

  Fly   465 QPQYR----SMILYHQNAPSWNEMLRLSVPIDKFSTAHVRFEFRHCSTRDKTEPKL---FAFSFA 522
            ..::.    :.::||..:|.:.|..:|.:|.......|:.|.|.|.|.:.:....|   ..|::.
  Rat   595 CSEFTREAFTPVVYHNKSPEFYEEFKLRLPACVTENHHLFFTFYHVSCQPRPGTALETPVGFTWI 659

  Fly   523 RLMDTGGATLG------------------------------DGLHELYVYKCEDPAKLQVANYLR 557
            .|:..|....|                              || |: .|:..|..|...|
  Rat   660 PLLQHGRLRTGPFCLPVSVDQPPPSYSVLTPDVALPGMRWVDG-HK-GVFSVELTAVSSV----- 717

  Fly   558 LQCRPRDAQAKMDCGGCFSRSSKEVFVLRSLLCSTKLTQNADLLSLLQWRTYPETIQDSLTGVLR 622
               .|:|..        ..:....|.||...:...:|.:     ::|...|..:.::.||..:..
  Rat   718 ---HPQDPH--------LDKFFTLVHVLEEGIFPFRLKE-----TVLSEGTMEQELRASLAALRL 766

  Fly   623 LNDEELVKFLQDVLDALFAMFSNEE---GNSTQHSGLVFHVLVSIFSLLQSN--KFQHFR---PV 679
            .:.|.||.|...|||.|..:.....   |.........|..:..:.||:..|  ..|..|   |:
  Rat   767 ASPEPLVAFSHHVLDKLVRLVVRPPVICGQMVNLGRGAFEAMAHVASLVHRNLEAVQDSRGHCPL 831

  Fly   680 MNEYIENHFA--------------------AALVYKGLITSVEHMAVFMTKAE-----HPD---- 715
            :..|:  |:|                    ||.:.:|   |....::::.:::     :||
  Rat   832 LAAYV--HYAFRLPGGDLGLPGEVPPATVQAATLARG---SGRPASLYLARSKSISSSNPDLAVV 891

  Fly   716 PFQKCFGSLEYIFKLLIQSRKL--------FARATGGQYEDSFKRDLHSLFTALNGMLAVPSYDV 772
            |     ||::.....::.|:.:        .|.|.||.     |..|.          .||.|..
  Rat   892 P-----GSVDDEVSRILASKGVDRSHSWVNSAYAPGGS-----KAVLR----------RVPPYCG 936

  Fly   773 IIPTQEALLNST--GVVLEQLKDTLPAPELGMLARNMLDA------IPRGAPIRLIQAKLHA--- 826
            ..|.|....||:  ...||.....||||:|....:.:|..      :..|:.:|.:..: ||
  Rat   937 ADPRQAIDRNSSRASSYLEASSSALPAPQLRHTVQKLLHEELALQWVVSGSAVRELVLQ-HAWFF 1000

  Fly   827 ----VKD----LVSGELFHE-----------DDSRTVVLSVACK-----HLRMHLSRRDELRLCA 867
                ||.    |:.|:....           ||...:|.||..:     |..|.|:.|....| |
  Rat  1001 FQLMVKSMELHLLLGQRLDTPRKLRFPGRFLDDIAALVASVGLEVITRVHKDMELAERLNASL-A 1064

  Fly   868 EILSEILS-----QLYDLQKEQREKVTN------------TLQHDLDS-LCKN------------ 902
            ..||::||     .::.|.:...::|..            ||:.|... ||.:
  Rat  1065 FFLSDLLSIADRGYIFSLVRAHYKQVATRLQSAPNPAALLTLRMDFTRILCSHEHYVTLNLPCCP 1129

  Fly   903 ---------------------------------------------ILGILIRTISIIM----EGS 918
                                                         :.|:|:..:::.:    ||:
  Rat  1130 LSPPASPSPSVSSTTSQSSTFSSQAPDPKVISMFELSGPFRQQHFLSGLLLTELALALDPEAEGA 1194

  Fly   919 NAVLPQLVSCLLGLLQLLD-ETHY----------KRYWDELSPNKD--PRDLKEFL----SKSLL 966
            :.:..:.::.:..||...| ::.|          :.|...||..:|  || |..|.    .:|.|
  Rat  1195 SLLHKKAITAVHNLLCSHDVDSRYTDATVKAKVAELYLPLLSLARDTLPR-LHGFAEGSGQRSRL 1258

  Fly   967 VYEELLTQD---------------------------------------WHVFPND---------- 982
            .  .:|..|                                       |.:||..
  Rat  1259 A--SMLDSDTEGEGDIGGTINPSVAMAIAGGPLAPGSRTSISQGPSTKWILFPLCTQAARSGCPL 1321

  Fly   983 -------------WLVMKLAANDVLRMSLEEFAKPLVYRFL-------------GPQAF------ 1015
                         | |:|.|...:|:....:.|.|.:.|.|             |.:||
  Rat  1322 SAESSRTLLVCVLW-VLKNAEPALLQRWAADLALPQLGRLLDLLYLCLAAFEYKGKKAFERINSL 1385

  Fly  1016 ------DSQLWWSYFSLAVAFLTQPSLQLEQYREP--------KRLKILH--------------- 1051
                  |.:.......|......|..::..:.|.|        .|..:.|
  Rat  1386 TFKKSLDMKARLEEAILGTIGARQEMVRRSRERSPFGNQENVRWRKSVTHWRQTSDRVDKTKDEV 1450

  Fly  1052 -----------SHGDMRVLMGFQILSMWSQLGEQKLHFIPSMVGPFLEVTLV----PEPAL---- 1097
                       :...:.||...:|:.....|.|.:    .|::|..|:|.|.    .:.||
  Rat  1451 EHEALVDGNLATEASLVVLDMLEIIVQTVMLSEAR----ESILGAVLKVVLYSLGSAQSALFLQH 1511

  Fly  1098 ----RKATLSVFYDMM---QCEQAARGSFRL----------VESELIDKLDLLISEN--KGDDEY 1143
                ::|.:|.|.:::   ..|..|....||          :.:.....|.||:.:|  .|.:..
  Rat  1512 GLATQRALVSKFPELLFEEDTELCADLCLRLLRHCGSRISTIRTHASASLYLLMRQNFEIGHNFA 1576

  Fly  1144 R-ELFSTILLEKVQVENPNWKEAGIAFIASVTRLLERLLDYRSVMQGEEN---RDKRMTCTV--- 1201
            | ::..|:.|..:.....|:.|      ..:.|.|:.:|.|     .||:   ||......|
  Rat  1577 RVKMLVTMSLSSLVGTTQNFSE------EHLRRSLKTILTY-----AEEDLGLRDSTFAEQVQDL 1630

  Fly  1202 --NLLNFYKNEINRKE-----------MY-------------LRYIYKLHNLHLQAENYTEAGFT 1240
              ||.....:.:..||           ||             |.::..:.:.|.:..|:.||...
  Rat  1631 MFNLHMILTDTVKMKEHQEDPEMLMDLMYRIARGYQGSPDLRLTWLQNMASKHAELGNHAEAAQC 1695

  Fly  1241 LKLYASM--------------------------------------LSWDRE----TQSFAPFDNS 1263
            :...|::                                      ||.|.|    .::|......
  Rat  1696 MVHAAALVAEYLALLEDSRHLPVGCVSFQNVSSNVLEESAISDDILSPDEEGFCSGKNFTDLGLV 1760

  Fly  1264 GQPEWQRKERLYHEILKYFDKGKCWEKGIPLCKELAHLYETRRFDYNKLSEI--LIQEAKFFQNI 1326
            |         |..:...||..|..:|....:.|.|..:.|..| ||.||:.:  .:|||  |..|
  Rat  1761 G---------LLEQAAAYFTMGGLYEAVNEVYKNLIPILEAHR-DYKKLAAVHGKLQEA--FTKI 1813

  Fly  1327 LTQL----RPEPEYFRVGFYGMGLPLFVRNKQFVYRGLEYERIGAFTQRLQTEFPS-------AQ 1380
            :.|.    |....||||||||.... .:..::|||:.....::...:.||: ||.:       .:
  Rat  1814 MHQSSGWERVFGTYFRVGFYGARFG-DLDEQEFVYKEPSITKLAEISHRLE-EFYTERFGDDVVE 1876

  Fly  1381 ILGNNSPPDNAILNAPDQYIQISNVRPVGDAQALKTAMVPVPEKIARFYEVNDVTRFIYDRPMYK 1445
            |:.:::|.|...|:....||||:.|.|..|...||       :::..|.....:..|::..|.
  Rat  1877 IIKDSNPVDKLKLDPQKAYIQITYVEPHFDTYELK-------DRVTYFDRNYGLRAFLFCTPF-- 1932

  Fly  1446 GTVD--KDNEFKSLWIERTILEIASPLPGILRWYEVKQKTMQELTPVEYACEIISNAGKELSELI 1508
             |.|  ...|.......:|:|......|.|.....|..:....|||||.|   |.:..|:..||.
  Rat  1933 -TPDGRAHGELAEQHKRKTLLSTEHAFPYIKTRIRVCHREETVLTPVEVA---IEDMQKKTRELA 1993

  Fly  1509 VQYKRDPKRNINPFSMRLQGTIDANVMGGISKYQEAFFSEQFLKSPQGAGQQANVQRLKVLILEQ 1573
            ...::||. :.....|.|||::...|..|..:..:.|.||    .|:......:..:|::...:.
  Rat  1994 FATEQDPP-DAKMLQMVLQGSVGPTVNQGPLEVAQVFLSE----IPEDPKLFRHHNKLRLCFKDF 2053

  Fly  1574 IQILEQALELHGQLAPSGVQPLHNRLLERFSQLKQSLSGMGRLKRQHSESIVNTPLPPLPTE--- 1635
            .:..|.||..:..|.....:..|..|...:|:|:::|.                   ||.|:
  Rat  2054 CKKCEDALRKNKALIGPDQKEYHRELERHYSRLREALQ-------------------PLLTQRLP 2099

  Fly  1636 QRVAPATAS--SSLNANA 1651
            |.:||::.|  :|:|.::
  Rat  2100 QLLAPSSTSLRNSINRSS 2117

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
spg	NP_733258.4	SH3_DOCK_AB	9..64	CDD:212805
		DOCK_N	67..406	CDD:292790	43/262 (16%)
		C2_Dock-B	414..600	CDD:176077	41/222 (18%)
		DHR2_DOCK	1215..1610	CDD:297424	105/475 (22%)
Dock6	XP_038937778.1	DUF3398	48..157	CDD:403173
		C2_Dock-C	547..724	CDD:176078	37/197 (19%)
		DHR2_DOCK	1668..2090	CDD:414667	102/453 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910