DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment spg and Dock2

DIOPT Version :9

Sequence 1:	NP_733258.4	Gene:	spg / 43404	FlyBaseID:	FBgn0264324	Length:	2187	Species:	Drosophila melanogaster
Sequence 2:	XP_038943067.1	Gene:	Dock2 / 360509	RGDID:	1564189	Length:	1829	Species:	Rattus norvegicus

Alignment Length:	1876	Identity:	675/1876 - (35%)
Similarity:	1035/1876 - (55%)	Gaps:	149/1876 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 KYGVAIHNWHGDVRFGLALDVGDSVDIVEECKHWYRGSCPRKSRAVGLFPKTYIHIKDLS----- 67
            ::||||:|:.|.....|.|.:||.|.|.|.|..||||...:...:.|:||.::||:|:::
  Rat    11 RHGVAIYNFQGSGAQHLTLQIGDVVRIQETCGDWYRGYLIKHKMSQGIFPTSFIHLKEVTVEKRR 75

  Fly    68 KID-------PVVAECTQVLREWSEIWKRLYVDREAYKFQTLRKVMFSILESRRELLSATMTQDQ 125
            .|:       |:..|....|.||..|||:|||..:..:|..::.:|:.::|.|.:|||.|:.:|:
  Rat    76 NIENIIPAEIPLAQEVATTLWEWGSIWKQLYVASKKERFLQVQSMMYDLMEWRSQLLSGTLPKDE 140

  Fly   126 TLELQMVVVSKIDWGNRKLGLDLVPR-EGPLAVDPHGIGIVKLYNVHVSSA---------DNAKA 180
            ..||:..|.||||:||:.|.|||:.| |....:||....::.|::.|..:.         :..|.
  Rat   141 LKELKQKVTSKIDFGNKILELDLIVRDEDGNILDPDNTSVISLFHAHEEATHKITERIKEETCKD 205

  Fly   181 SSSRGTLRRKTQRKILTHHLYFCMRDFGHRIGGDDAEVYFFLYDGSHMRPLSERFLVKISKDGFS 245
            ....|...|.:...  ||.||..:|:|..|| |:|||::..|||......:||.:||:....||.
  Rat   206 QPDYGIYSRISSSP--THSLYVFVRNFVCRI-GEDAELFMSLYDPHKQMVISENYLVRWGSKGFP 267

  Fly   246 NYIERLHSNCTVFTDLGAADLN-EELHLVAVVMRVGKIIQSD-SIKKIEKSGTLGHGPTFRRPFG 308
            ..||.|::...||||||..||| :::.|:..::|:||:...| ::||..:.        .|||||
  Rat   268 KEIEMLNNLKVVFTDLGNKDLNRDKIFLICQIVRIGKMDLKDINVKKCTQG--------LRRPFG 324

  Fly   309 VGVLSLGDIAHFDSSLEQSSDEREYNFKLFQ--CEEKDFHLLPELIIKKSSGKYSPIQASQGTQG 371
            |.|:.:.||.    ..:..|||.:.:|..|.  ..|.||  |..|:     ||....:...|.||
  Rat   325 VAVMDITDII----KGKAESDEEKQHFIPFHPVSAENDF--LHSLL-----GKVIASKGDSGGQG 378

  Fly   372 IVVSLKLLHGGLGQARQEQPMLFQGST-ITRKMGFPDVIMPGDVRNDLFLNLERGEFERGGKNTG 435
            :.|::|:|.|.:.|.|::.|.|...:| :.||:|||::|||||||||:::.|.:|:|::..|.|.
  Rat   379 LWVTMKMLVGDIIQIRKDYPHLVDRTTVVARKLGFPEIIMPGDVRNDIYITLLQGDFDKYTKTTQ 443

  Fly   436 KNILVTVVVLDVAGNVLTDCLWGASGMESQPQYRSMILYHQNAPSWNEMLRLSVPIDKFSTAHVR 500
            :|:.|.:.|....||||.:.:...:|.::..:|.|::.|....|.|.|.::::|||:.....|:|
  Rat   444 RNVEVIMCVCTEDGNVLPNAICVGAGDKAMNEYHSVVYYQVKQPRWMETVKVAVPIEDMQRIHLR 508

  Fly   501 FEFRHCS---TRDKTEPKLFAFSFARLMDTGGATLGDGLHELYVYKCEDPAKLQVAN-YLRLQCR 561
            |.|||.|   ::||.| |.||.|:.:||...|.||.||.|||.|.| .|..|::.|: ||.|...
  Rat   509 FMFRHRSSLESKDKGE-KNFAMSYVKLMKEDGTTLQDGYHELVVLK-GDSKKMEDASAYLTLPSY 571

  Fly   562 PRDAQAKMDCGGCFSR----------SSKEVFVLRSLLCSTKLTQNADLLSLLQWRTYPETIQDS 616
            ....:.|   |...||          ||::||.:..|:||||||||..||.||:||..|:.:|::
  Rat   572 RYHVENK---GATLSRSSSSVGGLSVSSRDVFSISILVCSTKLTQNVGLLGLLKWRMRPQLLQEN 633

  Fly   617 LTGVLRLNDEELVKFLQDVLDALFAMFSNEEGNSTQHSGLVFHVLVSIFSLLQSNKFQHFRPVMN 681
            |..:..::.||:||||||.|||||.:.. |...|.::..|||..|:.|..|:...|||||..|:.
  Rat   634 LEKLKIVDGEEVVKFLQDTLDALFNIMM-EHAQSNEYDILVFDALIYIIGLIADRKFQHFNTVLE 697

  Fly   682 EYIENHFAAALVYKGLITSVEHMAVFMTKAEHPDPFQKCFGSLEYIFKLLIQSRKLFARATGGQY 746
            .||:.||:|.|.||.|:|.::......::.|..:|..:...:|||:||.:::||:||::...|:.
  Rat   698 AYIQQHFSATLAYKKLMTVLKTYLDTSSRGEQCEPILRTLKALEYVFKFIVRSRRLFSQLYEGKE 762

  Fly   747 EDSFKRDLHSLFTALNGMLAVPSYDVIIPTQEALLNSTGVVLEQLKDTLPAPELGMLARNMLDAI 811
            :..|:..:..||.::|.::. ..:...|..|.|.|.....||..::....|..|..|.......|
  Rat   763 QMEFEESMRRLFESINNLMK-SQHKTTILLQVAALKYIPSVLHDVETVFDAKLLSQLLYEFYTCI 826

  Fly   812 PRGAPIRLIQAKLHAVKDLVSGELFHEDDSRTVVLSVACKHLRMHLSRRD-------ELRLCAEI 869
            |   |::|.:.|:.::.::|...||.:.:.|.::|.|..|.|:..|.:||       |.:.|.|:
  Rat   827 P---PVKLQKQKVQSMNEIVQSNLFKKQECRDILLPVITKELKELLEQRDDGQHQALEKKYCVEL 888

  Fly   870 LSEILSQLYDLQKEQREKVTNTLQHDLDSLCKNILGILIRTIS---IIMEGSNAVLPQLVSCLLG 931
            |:.||..|      ..:....|..|     .:.|:..|:||::   |.|...::::...|:|:..
  Rat   889 LNSILEVL------SCQDAAFTYDH-----IQEIMVQLLRTVNRTVITMGRDHSLISHFVACMTA 942

  Fly   932 LLQLLDETHYKRYWDELSPNKDPRDLKEFLSKSLLVYEELLTQDWHVFPNDWLVMKLAANDVLRM 996
            :|..:.:.||..|.:....:.   ||.:||.::.:::::|:.:  :|:|.||:.|.:..|.|...
  Rat   943 ILDQMGDQHYSFYIETFQTSS---DLVDFLMETFIMFKDLIGK--NVYPGDWIAMSMVQNRVFLR 1002

  Fly   997 SLEEFAKPLVYRFLGPQAFDSQLWWSYFSLAVAFLTQPSLQLEQYREPKRLKILHSHGDMRVLMG 1061
            ::.:||:.:..:||...:|:.|||.:||.|||||:||.||||||:...|..|||:.:||||.|:|
  Rat  1003 AINKFAETMNQKFLEHTSFEFQLWNNYFHLAVAFITQDSLQLEQFTHAKYNKILNKYGDMRRLVG 1067

  Fly  1062 FQILSMWSQLGEQKLHFIPSMVGPFLEVTLVPEPALRKATLSVFYDMMQCEQAARGSFRLVESEL 1126
            |.|..||.:||:.|:.|||.||||.||:||:||..|||||:.:|:|||.||....|:|:..|:|:
  Rat  1068 FSIRDMWYKLGQNKICFIPGMVGPILEMTLIPEAELRKATIPIFFDMMLCEYQRTGAFKKFENEI 1132

  Fly  1127 IDKLDLLISENKGDDEYRELFSTILLEKVQVENPNWKEAGIAFIASVTRLLERLLDYRSVMQGEE 1191
            |.|||..:...:||::|.:|..:||:| ...|:|...::...|::.|..|||:|||||.||. :|
  Rat  1133 ILKLDHEVEGGRGDEQYMQLLESILME-CAAEHPTIAKSVENFVSLVKGLLEKLLDYRGVMT-DE 1195

  Fly  1192 NRDKRMTCTVNLLNFYKNEINRKEMYLRYIYKLHNLHLQAENYTEAGFTLKLYASMLSWDRETQS 1256
            ::|.||:||||||||||:. ||:|||:||:|||.:|||..:|||||.:||.|:..:|.|..| |.
  Rat  1196 SKDNRMSCTVNLLNFYKDH-NREEMYIRYLYKLRDLHLDCDNYTEAAYTLLLHTWLLKWSDE-QC 1258

  Fly  1257 FAPFDNSGQ--PEWQR--KERLYHEILKYFDKGKCWEKGIPLCKELAHLYETRRFDYNKLSEILI 1317
            .:....:||  |:..|  ||.||..|:.||||||.||:.|.||||||..||...|||..||:.|.
  Rat  1259 ASQVMQTGQQHPQTHRQLKETLYETIIGYFDKGKMWEEAISLCKELAEQYEMEVFDYELLSQNLT 1323

  Fly  1318 QEAKFFQNILTQLRPEPEYFRVGFYGMGLPLFVRNKQFVYRGLEYERIGAFTQRLQTEFPSAQIL 1382
            |:|||::||:..|||:|:||.||:||.|.|.|:|||.|:|||.||||...|..:|.::||:|:.:
  Rat  1324 QQAKFYENIMKILRPKPDYFAVGYYGQGFPSFLRNKVFIYRGKEYERREDFQMQLLSQFPNAEKM 1388

  Fly  1383 GNNSPPDNAILNAPDQYIQISNVRPVGDAQALKTAMVPVPEKIARFYEVNDVTRFIYDRPMYKGT 1447
            ...|.|.:.:.|||.||||...|:||.|... :....|||::|..||:.|.|..|.|.||:.:||
  Rat  1389 NTTSAPGDDVKNAPGQYIQCFTVQPVLDEHP-RFKNKPVPDQIINFYKSNYVQTFHYSRPVRRGT 1452

  Fly  1448 VDKDNEFKSLWIERTILEIASPLPGILRWYEVKQKTMQELTPVEYACEIISNAGKELSELIVQYK 1512
            ||.:|||.|:|||||....|..|||||||:||...:...::|:|.|.|.:|.|.:::..:|.||:
  Rat  1453 VDPENEFASMWIERTSFLTAYKLPGILRWFEVVHMSQTTISPLENAIETMSTANEKILMMINQYQ 1517

  Fly  1513 RDPKRNINPFSMRLQGTIDANVMGGISKYQEAFFSEQFLKSPQGAGQQANVQRLKVLILEQIQIL 1577
            .|....|||.||.|.|.:|..||||.:||::|||:|::  |.:....|..:.|||.||..||..|
  Rat  1518 SDESLPINPLSMLLNGIVDPAVMGGFAKYEKAFFTEEY--SREHPEDQDKLSRLKDLIAWQIPFL 1580

  Fly  1578 EQALELHGQLAPSGVQPLHNRLLERFSQLKQSLS--------------GMGR----LKRQHSESI 1624
            ...:::|.:.....::|.|:|:.|.|..||..:.              .:||    |:.....||
  Rat  1581 GAGIKIHEKRVSDNLRPFHDRMEECFKNLKMKVEKEYGVREMPDFDDRRLGRPRSMLRSYRQMSI 1645

  Fly  1625 VNTPLPPLPTEQRVAPATASSSLNANAHSNYVYDLDEIYTRPGDTVRPVDPLSSYQTLSKESLSI 1689
            ::  |..:.::........|.|.:..:.:.....::|....||.|:..|....|.:...:.|:..
  Rat  1646 IS--LASMNSDCSTPSKVVSESFDLESVTPKTPKVEEEPISPGSTLPEVKLRRSKKRTKRSSVVF 1708

  Fly  1690 PLEDTAAPPVPNR-PRSQNFIGNGSMDSPEVPPKR-----QPTLNSPNAPPLPPRGITP------ 1742
            ..|..||.....| .|...|:.:.::......|.|     |.:..|.:.|.:|...::.
  Rat  1709 ADEKAAAESELKRLSRKHEFMSDTNLSEHATVPTRVSVLSQMSFASQSMPTIPALTLSVAGVPGL 1773

  Fly  1743 DKRASNPLIFNDF---GSGDAVGRRHSQQQQQHGQKYSVVDISYDDPEADQQPHSL 1795
            |:.:::|.:...|   ...|    :.:.::::..|.:..:..|....|:.|.|..|
  Rat  1774 DEASTSPRLSQTFFQVSDSD----KKTLKKKKVNQFFKTMLASKSGEESKQIPDIL 1825

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
spg	NP_733258.4	SH3_DOCK_AB	9..64	CDD:212805	23/54 (43%)
		DOCK_N	67..406	CDD:292790	119/365 (33%)
		C2_Dock-B	414..600	CDD:176077	75/199 (38%)
		DHR2_DOCK	1215..1610	CDD:297424	184/398 (46%)
Dock2	XP_038943067.1	SH3_DOCK2_A	12..67	CDD:212983	23/54 (43%)
		DOCK_N	71..414	CDD:406558	119/364 (33%)
		C2	422..617	CDD:417471	75/199 (38%)
		DHR2_DOCK2	1200..1620	CDD:212579	198/424 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D102580at2759
OrthoFinder	1	1.000	-	-		FOG0000433
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100636
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.820