DRSC/TRiP Functional Genomics Resources

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Protein Alignment spg and Dock6

DIOPT Version :9

Sequence 1:NP_733258.4 Gene:spg / 43404 FlyBaseID:FBgn0264324 Length:2187 Species:Drosophila melanogaster
Sequence 2:XP_017168915.1 Gene:Dock6 / 319899 MGIID:1914789 Length:2181 Species:Mus musculus


Alignment Length:1943 Identity:357/1943 - (18%)
Similarity:614/1943 - (31%) Gaps:649/1943 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly   222 LYDGSHMRPLSERFLVKISKDGFSNYIERLHSNCTVFTDLGAADLNEELHL---VAVVMRVGKII 283
            |||....:.:||.|...::.|.....: |.|......:.|..:.:....:.   :.:|:::.|::
Mouse   283 LYDVREKKKISENFYFDLNSDSVKGLL-RAHGTHPAISTLARSAIFSVTYPSPDIFLVVKLEKVL 346

  Fly   284 QSDSI-------------------KKIEK--------SGTLGHGPTFRRPFGVGVLSLGDIAHFD 321
            |...|                   :|:||        ...||.   :|.||....:.|.:|....
Mouse   347 QQGDISECCEPYMVMKEADTAKNKEKLEKLRLAAEQFCTRLGR---YRMPFAWTAVHLANIVSRP 408

  Fly   322 SSLEQSSD----------------EREY------NFKLFQ---------CEEKDFHLLPELIIKK 355
            ...:..|:                :|.|      :|..|:         .:::...|..|.:.|.
Mouse   409 QDRDSDSEGERRPTWAERRRRGPQDRGYSGDDACSFSSFRPATLTVTNFFKQEAERLSDEDLFKF 473

  Fly   356 SSGKYSPIQASQGTQGIVVSLKL--------LHGGLGQARQEQPMLF--------QGSTITRKMG 404
            .:....|....:..:.:...|||        ||..|      .|.|.        :|......:.
Mouse   474 LADMRRPSSLLRRLRPVTAQLKLDISPAPENLHFCL------SPDLLHVKPYPDPRGRPTKEILE 532

  Fly   405 FP--DVIMPGD-VRNDLFLNLERGEFERGGKNTGKNILVTVVVLDVAGNVLTDCLWGASGMESQP 466
            ||  :|..|.. .||.||:......|. ..:.:.:|:.|.:..:  ||...:..|....|..|..
Mouse   533 FPAREVYAPHSCYRNLLFVYPHSLNFS-SRQGSVRNLAVRIQYM--AGEDQSQALPVIFGKSSCS 594

  Fly   467 QYR----SMILYHQNAPSWNEMLRLSVPIDKFSTAHVRFEFRHCSTRDKTEPKL---FAFSFARL 524
            ::.    :.::||..:|.:.|..:|.:|.......|:.|.|.|.|.:.:....|   ..|::..|
Mouse   595 EFTREAFTPVVYHNKSPEFYEEFKLRLPACVTENHHLFFTFYHVSCQPRPGTALETPVGFTWIPL 659

  Fly   525 MDTGGATLG------------------------------DGLHELYVYKCEDPAKLQVANYLRLQ 559
            :..|....|                              || |: .|:..|..|...|       
Mouse   660 LQHGRLRTGPFCLPVSVDQPPPSYSVLTPDVALPGMRWVDG-HK-GVFSVELTAVSSV------- 715

  Fly   560 CRPRDAQAKMDCGGCFSRSSKEVFVLRSLLCSTKLTQNADLLSLLQWRTYPETIQDSLTGVLRLN 624
             .|:|..        ..:....|.||...:...:|.:     ::|...|..:.::.||..:...:
Mouse   716 -HPQDPH--------LDKFFTLVHVLEEGIFPFRLKE-----TVLSEGTMEQELRASLAALRLAS 766

  Fly   625 DEELVKFLQDVLDALFAMFSNEE---GNSTQHSGLVFHVLVSIFSLLQSN--KFQHFR---PVMN 681
            .|.||.|...|||.|..:.....   |.........|..:..:.||:..|  ..|..|   |::.
Mouse   767 PEPLVAFSHLVLDKLVRLVVRPPIICGQMVNLGRGAFEAMAHVASLVHRNLEAVQDSRGHCPLLA 831

  Fly   682 EYIENHFA--------------------AALVYKGLITSVEHMAVFMTKAE-----HPD----PF 717
            .|:  |:|                    ||.:.:|   |....::::.:::     :||    | 
Mouse   832 SYV--HYAFRLPGGDLSLPGEAPPATVQAATLARG---SGRPASLYLARSKSISSSNPDLAVVP- 890

  Fly   718 QKCFGSLEYIFKLLIQSRKL--------FARATGGQYEDSFKRDLHSLFTALNGMLAVPSYDVII 774
                ||::.....::.|:.:        .|.|.||.     |..|.          .||.|....
Mouse   891 ----GSVDDEVSRILASKGVDRSHSWVNSAYAPGGS-----KAVLR----------RVPPYCGAD 936

  Fly   775 PTQEALLNST--GVVLEQLKDTLPAPELGMLARNMLDAIPRGAPIRLIQAKLH---AVKDLVSGE 834
            |.|....||:  ...||.....||||:    :|:            .:|..||   |::.:|||.
Mouse   937 PRQAIDRNSSRASSYLEASSSALPAPQ----SRH------------TVQKLLHEELALQWVVSGS 985

  Fly   835 LFHE----------------------------------------DDSRTVVLSVACK-----HLR 854
            ...|                                        ||...:|.||..:     |..
Mouse   986 AVRELVLQHAWFFFQLMVKSMELHLLLGQRLDTPRKLRFPGRFLDDIAALVASVGLEVITRVHKD 1050

  Fly   855 MHLSRRDELRLCAEILSEILS-----QLYDLQKEQREKVTN------------TLQHDLDS-LCK 901
            |.|:.|....| |..||::||     .::.|.:...::|..            ||:.|... ||.
Mouse  1051 MKLAERLNASL-AFFLSDLLSIADRGYIFSLVRAHYKQVATRLQSAPNPTALLTLRMDFTRILCS 1114

  Fly   902 N---------------------------------------------------------ILGILIR 909
            :                                                         :.|:|:.
Mouse  1115 HEHYVTLNLPCCPLSPPASPSPSVSSTTSQSSTFSSQAPDPKVTSMFELSGPFRQQHFLSGLLLT 1179

  Fly   910 TISIIM----EGSNAVLPQLVSCLLGLLQLLD-ETHY----------KRYWDELSPNKD--PR-- 955
            .:::.:    ||::.:..:.:|.:..||...| ::.|          :.|...||..:|  |:  
Mouse  1180 ELALALDPEAEGASLLHKKAISAVHSLLCSHDVDSRYAEATVKAKVAELYLPLLSLARDTLPQLH 1244

  Fly   956 ---------------------------------------------------------------DL 957
                                                                           .|
Mouse  1245 GFAEGSGQRSRLASMLDSDTEGEGDIGSTINPSVAMAIAGGPLAPGSRTSISQGPSTAARSGCPL 1309

  Fly   958 KEFLSKSLLV--------YEELLTQDWH---VFPN-----DWLVMKLAANDV------------- 993
            ....|::|||        .|..|.|.|.   ..|.     |.|.:.|||.:.             
Mouse  1310 SAESSRTLLVCVLWVLKNAEPTLLQRWAADLALPQLGRLLDLLYLCLAAFEYKGKKAFERINSLT 1374

  Fly   994 ------LRMSLEE-------FAKPLVYRFLGPQAFDSQ---LW------WSYFSLAV-------- 1028
                  ::..|||       ..:.:|.|......|.:|   .|      |...|..|        
Mouse  1375 FKKSLDMKARLEEAILGTIGARQEMVRRSRERSPFGNQENVRWRKSATHWRQTSDRVDKTKDEME 1439

  Fly  1029 -------AFLTQPSLQLEQYREPKRLKILHSHGDMRVLMGFQILSMWSQLGEQKLHFIP------ 1080
                   ...|:.||.:....|.....::.|.....:|.....:.::|....|...|:.      
Mouse  1440 HEALVDGNLATEASLVVLDTLETIVQTVMLSEARESILSAVLKVVLYSLGSAQSALFLQHGLATQ 1504

  Fly  1081 -SMVGPFLEVTLVPEPAL--------------RKATLSV-----FYDMMQCEQAARGSFRLVESE 1125
             ::|..|.|:....:..|              |.:|:.:     .|.:|:.......:|..|:..
Mouse  1505 RALVSKFPELLFEEDTELCADLCLRLLRHCGSRISTIRMHASASLYLLMRQNFEIGHNFARVKML 1569

  Fly  1126 LIDKLDLLI--SENKGDDEYRELFSTILL---EKVQVENPNWKEAGIAFIASVTRLL-------- 1177
            :...|..|:  ::|..::..|:...|||.   |.:.:.:..:.|.....:.::..:|        
Mouse  1570 VTMSLSSLVGTTQNFSEEHLRKSLKTILTYAEEDIGLRDSTFAEQVQDLMFNLHMILTDTVKMKE 1634

  Fly  1178 -----ERLLD--YRSVMQGEENRDKRMTCTVNLLNFYKNEINRKEM-------------YLRYIY 1222
                 |.|:|  ||.....:.:.|.|:|...|:...:....|..|.             ||..:.
Mouse  1635 HQEDPEMLMDLMYRIARGYQGSPDLRLTWLQNMAGKHAELGNHAEAAQCMVHAAALVAEYLALLE 1699

  Fly  1223 KLHNLHLQAENYTEAGFTL----KLYASMLSWDRE----TQSFAPFDNSGQPEWQRKERLYHEIL 1279
            ...:|.:...::......:    .:...:||.|.|    .::|......|         |..:..
Mouse  1700 DSRHLPVGCVSFQNVSSNVLEESAISDDILSPDEEGFCSGKNFTELGLVG---------LLEQAA 1755

  Fly  1280 KYFDKGKCWEKGIPLCKELAHLYETRRFDYNKLSEI--LIQEAKFFQNILTQL----RPEPEYFR 1338
            .||..|..:|....:.|.|..:.|..| ||.||:.:  .:|||  |..|:.|.    |....|||
Mouse  1756 GYFTMGGLYEAVNEVYKNLIPILEAHR-DYKKLAAVHGKLQEA--FTKIMHQSSGWERVFGTYFR 1817

  Fly  1339 VGFYGMGLPLFVRNKQFVYRGLEYERIGAFTQRLQTEFPS-------AQILGNNSPPDNAILNAP 1396
            |||||.... .:..::|||:.....::...:.||: ||.:       .:|:.:::|.|.:.|:..
Mouse  1818 VGFYGTRFG-DLDEQEFVYKEPSITKLAEISHRLE-EFYTERFGDDVVEIIKDSNPVDKSKLDPQ 1880

  Fly  1397 DQYIQISNVRPVGDAQALKTAMVPVPEKIARFYEVNDVTRFIYDRPMYKGTVD--KDNEFKSLWI 1459
            ..||||:.|.|..|...||       :::..|.....:..|::..|.   |.|  ...|......
Mouse  1881 KAYIQITYVEPHFDTYELK-------DRVTYFDRNYGLRAFLFCTPF---TPDGRAHGELAEQHK 1935

  Fly  1460 ERTILEIASPLPGILRWYEVKQKTMQELTPVEYACEIISNAGKELSELIVQYKRDPKRNINPFSM 1524
            .:|:|......|.|.....|..:....|||||.|   |.:..|:..||....::||. :.....|
Mouse  1936 RKTLLSTEHAFPYIKTRIRVCHREETVLTPVEVA---IEDMQKKTRELAFATEQDPP-DAKMLQM 1996

  Fly  1525 RLQGTIDANVMGGISKYQEAFFSEQFLKSPQGAGQQANVQRLKVLILEQIQILEQALELHGQLAP 1589
            .|||::...|..|..:..:.|.||    .|:......:..:|::...:..:..|.||..:..|..
Mouse  1997 VLQGSVGPTVNQGPLEVAQVFLSE----IPEDPKLFRHHNKLRLCFKDFCKKCEDALRKNKALIG 2057

  Fly  1590 SGVQPLHNRLLERFSQLKQSLSGMGRLKRQHSESIVNTPLPPLPTE---QRVAPATAS 1644
            ...:..|..|...:|:|:::|.                   ||.|:   |.:||::.|
Mouse  2058 PDQKEYHRELERHYSRLREALQ-------------------PLLTQRLPQLLAPSSTS 2096

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
spgNP_733258.4 SH3_DOCK_AB 9..64 CDD:212805
DOCK_N 67..406 CDD:292790 42/260 (16%)
C2_Dock-B 414..600 CDD:176077 41/222 (18%)
DHR2_DOCK 1215..1610 CDD:297424 100/430 (23%)
Dock6XP_017168915.1 DUF3398 48..157 CDD:371776
C2_Dock-C 545..722 CDD:176078 37/197 (19%)
DHR2_DOCK 1656..2078 CDD:384404 105/453 (23%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1997
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.810

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