DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment spg and Dock3

DIOPT Version :9

Sequence 1:	NP_733258.4	Gene:	spg / 43404	FlyBaseID:	FBgn0264324	Length:	2187	Species:	Drosophila melanogaster
Sequence 2:	XP_038937508.1	Gene:	Dock3 / 315992	RGDID:	1306677	Length:	2077	Species:	Rattus norvegicus

Alignment Length:	2268	Identity:	832/2268 - (36%)
Similarity:	1214/2268 - (53%)	Gaps:	343/2268 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MWIPS-NNKYGVAIHNWHGDVRFGLALDVGDSVDIVEECKHWYRGSCPRKSRAVGLFPKTYIHIK 64
            ||.|: ..||||.|.::.|.|..||.|::|::|.|:|:|:.||||...:|....||||..|||:|
  Rat     1 MWTPTEEEKYGVVICSFRGSVPQGLVLEIGETVQILEKCEGWYRGVSTKKPNVKGLFPANYIHLK 65

  Fly    65 D------------LSKIDPVVAECTQVLREWSEIWKRLYVDREAYKFQTLRKVMFSILESRRELL 117
            .            :...|.:|.|.|..|:||:.:||:|||..:...|..||.||..:::.||:||
  Rat    66 KAIVSNRGQYETVVPLEDSIVTEVTATLQEWASLWKQLYVKHKVDLFYKLRHVMNELIDLRRQLL 130

  Fly   118 SATMTQDQTLELQMVVVSKIDWGNRKLGLDLVPREGPLAVDPHGIGIVKLYNVHVSSADNAKASS 182
            |..:||||..|::..:..::||||..||||||||:....||...|.:..||.:|:||..:.:.|:
  Rat   131 SGHLTQDQVREVKRHITVRLDWGNEHLGLDLVPRKDFEVVDSDQISVSDLYKMHLSSRQSVQQST 195

  Fly   183 SR-GTLRRK---TQRKILTHHLYFCMRDFGHRIGGDDAEVYFFLYDGSHMRPLSERFLVKISKDG 243
            |: .|:|.:   |.|..:.||.:|.::.|.:...|:|::|:|.|||....:.:||||||:::|:|
  Rat   196 SQVDTMRPRHGETCRMPVPHHFFFSLKSFTYNTIGEDSDVFFSLYDMREGKQISERFLVRLNKNG 260

  Fly   244 FSNYIERLHSNCTVFTDLGAADLNEELHLVAVVMRVGKIIQSDSIKKIEKSGTLGHGPT---FRR 305
            .....|::...|.:||||.:.|:..:|::||.|:|:|:::.:||.|          ||.   :||
  Rat   261 GPRNPEKIERMCALFTDLSSKDMKRDLYIVAHVIRIGRMLLNDSKK----------GPAHLHYRR 315

  Fly   306 PFGVGVLSLGDIAHFDSSLEQSSDEREYNFKLFQC-EEKDFHLLPELIIKKSSGKYSPIQASQGT 369
            |:|..|||:.|:.   .||.:..:|:::..|::.| .|.::..:.|.||:|||.|||   |...:
  Rat   316 PYGCAVLSILDVL---QSLTELKEEKDFVLKVYTCNNESEWTQIHENIIRKSSTKYS---APSAS 374

  Fly   370 QGIVVSLKLLHGGLGQARQEQPMLF-QGSTITRKMGFPDVIMPG------DVRNDLFLNLERGEF 427
            .|:::||:|..|.:.|.|:|.||:| :|..||||:||||||||.      |:||||:|.||:|:|
  Rat   375 HGLIISLQLFRGDMEQIRRENPMIFNRGLAITRKLGFPDVIMPEMKIVGCDIRNDLYLTLEKGDF 439

  Fly   428 ERGGKNTGKNILVTVVVLDVAGNVLTDCLWGASGMESQPQYRSMILYHQNAPSWNEMLRLSVPID 492
            |||||:..|||.||:.||...|.:|.||:...||..::..|.|.:|||.|:|.|.|:::|.:|||
  Rat   440 ERGGKSVQKNIEVTMYVLYADGEILKDCISLGSGEPNRSSYHSFVLYHSNSPRWGEIIKLPIPID 504

  Fly   493 KFSTAHVRFEFRHCSTRDKTEPKLFAFSFARLMDTGGATLGDGLHELYVYKCEDPAKL-QVANYL 556
            :|..:|:|||||||||:||.|.|||.|||:.||...|.||.|.:||||||||::.:.. ..|.||
  Rat   505 RFRGSHLRFEFRHCSTKDKGEKKLFGFSFSPLMRDDGTTLSDDIHELYVYKCDENSTFNNHALYL 569

  Fly   557 RLQCRPRDAQAKMDCGGC--------FSRSSKEVFVLRSLLCSTKLTQNADLLSLLQWRTYPETI 613
            .|.|      .|.|..||        |.||:||.|.:.:.|.|||||||.|||:||:|:.:|:.|
  Rat   570 GLPC------CKEDYNGCPNIPSSLIFQRSTKESFFISTQLSSTKLTQNVDLLALLKWKAFPDRI 628

  Fly   614 QDSLTGVLRLNDEELVKFLQDVLDALFAMFSNEEGNSTQHSGLVFHVLVSIFSLLQSNKFQHFRP 678
            .|.|..:..::.||:||||||:||.||.:.   :.|:.::..|||..||.|.:||:..|:.||||
  Rat   629 MDILGRLRHVSGEEIVKFLQDILDTLFVIL---DDNTEKYGLLVFQSLVFIINLLRDIKYFHFRP 690

  Fly   679 VMNEYIENHFAAALVYKGLITSVEHMAVFMTKAEHPDPFQKCFGSLEYIFKLLIQSRKLFARATG 743
            ||:.||:.|||.||.||.||..::.......:....|..|:...:|||:||.::|||.|::|||.
  Rat   691 VMDTYIQKHFAGALAYKELIRCLKWYMDCSAELIRQDHIQEAMRALEYLFKFIVQSRILYSRATC 755

  Fly   744 GQYEDSFKRDLHSLFTALNGMLAVPS--YDVIIPTQEALLNSTGVVLEQLKDTLPAPELGMLARN 806
            |..|:.|:..:..||.::..:|::.|  .:.::.||.|||||...:.::|.......|:....|.
  Rat   756 GMEEEQFRSSIQELFQSIRFVLSLDSRNSETLLFTQAALLNSFPTIFDELLQMFTVQEVAEFVRG 820

  Fly   807 MLDAIPRGAPIRLIQA----KLHAVKDLVSGELFHEDDSRTVVLSVACKHLRMHLSRRDELRLCA 867
            .|.::|  :.:.:.|:    ||.::...|...||...:||.::|.|...|:.:||.::.||.:|:
  Rat   821 TLGSMP--STVHIGQSMDVVKLQSIARTVDSRLFSFSESRRILLPVVLHHIHLHLRQQKELLICS 883

  Fly   868 EILSEILSQLYDLQKEQREKVTNTLQHD----LDSLCKNILGILIRTISIIMEGSNA-------- 920
            .||..|.|.:          .|::|:.|    ::.:.:::|.:|::|:..||..|:|
  Rat   884 GILGSIFSIV----------KTSSLEADVMEEVEMMVESLLDVLLQTLLTIMSKSHAQEAVRGQR 938

  Fly   921 -------VLPQLVSCLLGLLQLLDETHYKRYWDELSPNKDPRDLKEFLSKSLLVYEELLTQDWHV 978
                   :..:.|||||.||:.:.:|||:...|... :||  :|||||.|...|:..|:...  |
  Rat   939 CPQCTAEITGEYVSCLLSLLRQMCDTHYQHLLDNFQ-SKD--ELKEFLLKIFCVFRNLMKMS--V 998

  Fly   979 FPNDWLVMKLAANDVLRMSLEEFAKPLVYRFLGPQAFDSQLWWSYFSLAVAFLTQPSLQLEQYRE 1043
            ||.||:||:|..::::..:::..:..|...|.... ||.::|.|||||||.|:.|||||||....
  Rat   999 FPRDWMVMRLLTSNIIVTTVQYLSSALHKNFTETD-FDFKVWNSYFSLAVLFINQPSLQLEIITS 1062

  Fly  1044 PKRLKILHSHGDMRVLMGFQILSMWSQLGEQKLHFIPSMVGPFLEVTLVPEPALRKATLSVFYDM 1108
            .||.|||..:|||||:|.:::.|||..|||.|:||||.|:||||.|||||:|.:|...:.:|:||
  Rat  1063 AKRKKILDKYGDMRVMMAYELFSMWQNLGEHKIHFIPGMIGPFLGVTLVPQPEVRNIMIPIFHDM 1127

  Fly  1109 MQCEQAARGSFRLVESELIDKLDLLISENKGDDEYRELFSTI---------LLEKVQVENPNWKE 1164
            |..||...|:|:.||||||||||.::||.|||:.||||||.:         |||||:.|  .|:|
  Rat  1128 MDWEQRKNGNFKQVESELIDKLDSMVSEGKGDESYRELFSLLTQLFGPYPSLLEKVEQE--TWRE 1190

  Fly  1165 AGIAFIASVTRLLERLLDYRSVMQGEENRDKRMTCTVNLLNFYKNEINRKEMYLRYIYKLHNLHL 1229
            .||:|:.|||||:|||||||..|:|||..:|::.|||||:||||:|||::|||:|||:||.::||
  Rat  1191 TGISFVTSVTRLMERLLDYRDCMKGEETENKKVGCTVNLMNFYKSEINKEEMYIRYIHKLCDMHL 1255

  Fly  1230 QAENYTEAGFTLKLYASMLSW-DRETQSFAPFDNSGQPEWQRKERLYHEILKYFDKGKCWEKGIP 1293
            ||||||||.|||.||..:|.| ||..:.|..:.:  |.||||||.|..:|:.||:|||.||.|||
  Rat  1256 QAENYTEAAFTLLLYCELLQWEDRPLREFLHYPS--QTEWQRKEGLCRKIIHYFNKGKSWEFGIP 1318

  Fly  1294 LCKELAHLYETRRFDYNKLSEILIQEAKFFQNILTQLRPEPEYFRVGFYGMGLPLFVRNKQFVYR 1358
            ||:|||..||: .:||..||.|...||.::.||:.|.|.|||:|||||||...|.|:|||::|.|
  Rat  1319 LCRELACQYES-LYDYQSLSWIRKMEASYYDNIIEQQRLEPEFFRVGFYGRKFPFFLRNKEYVCR 1382

  Fly  1359 GLEYERIGAFTQRLQTEFPSAQILGNNSPPDNAILNAPDQYIQISNVRPVGD-AQALKTAMVPVP 1422
            |.:|||:.||.||:.:|||.|..:.:.:.||:|||....||:||..|.|:.| ...|:  |..||
  Rat  1383 GHDYERLEAFQQRMLSEFPQAVAMQHPNHPDDAILQCDAQYLQIYAVTPIPDYVDVLQ--MDRVP 1445

  Fly  1423 EKIARFYEVNDVTRFIYDRPMYKGTVDKDNEFKSLWIERTILEIASPLPGILRWYEVKQKTMQEL 1487
            :::..||.||:|.:|.||||.:||..||||||||||||||.|.:...||||.||:||:::.:.|:
  Rat  1446 DRVKSFYRVNNVRKFRYDRPFHKGPKDKDNEFKSLWIERTTLTLTHSLPGISRWFEVERRELVEV 1510

  Fly  1488 TPVEYACEIISNAGKELSELIVQYK-RDPKRNINPFSMRLQGTIDANVMGGISKYQEAFFSEQFL 1551
            :|:|.|.:::.|..:||..||.||: :....|||..||.|.|.|||.|.|||::||||||.:.::
  Rat  1511 SPLENAIQVVENKNQELRALISQYQHKQVHGNINLLSMCLNGVIDAAVNGGIARYQEAFFDKDYI 1575

  Fly  1552 -KSPQGAGQQANVQRLKVLILEQIQILEQALELHGQLAPSGVQPLHNRLLERFSQLKQSLSGMGR 1615
             |.|   |....:.:||.|:.||:.:|...|.:|.:.....::|||.:|:::|..::.||
  Rat  1576 TKHP---GDAEKISQLKELMQEQVHVLGVGLAVHEKFVHPEMRPLHKKLIDQFQMMRASL----- 1632

  Fly  1616 LKRQHSESIVNTPLPPLPTEQRVAPATASSSLNANAHSNYVYDLDEIYTRPGDTVRPVDPLSSYQ 1680
               .|.          .|...:::||.:.:|                 |..|:.      |:|:.
  Rat  1633 ---YHE----------FPCLDKLSPACSGTS-----------------TPRGNV------LASHS 1661

  Fly  1681 TLSKESLSIPLEDTAAPPVPNRPRSQNFIGNGSMDSPEVPPKRQPTLNSPNAPPLPPRGITPDKR 1745
            .:|.|::.          :.:|....|.:|.|...|..:         |.:|          ...
  Rat  1662 PMSPENIK----------MSHRHSPMNLMGTGRHSSSSL---------SSHA----------SSE 1697

  Fly  1746 ASNPLIFNDFGSGDA-VGRRHSQQQQQHGQKY-------SVVDISYDDPEAD--QQPHSLPPNFQ 1800
            |.|.::..|...|:. ....|..|...|..:|       ||:..|...|.:.  ...||.|...
  Rat  1698 AGNMMMMGDNSMGETPEDLYHHMQLAYHNPRYQGSVTNVSVLSSSQASPSSSSLSSTHSAPSQM- 1761

  Fly  1801 DGSGGHLSVCFAPNDFRDSGISTTSSRELNHMNLNNLSEDSSSISTITVQHREHCRISSNGSLDY 1865
                    :..||:..|.|.......|....|.|            :...||:.     ..|..|
  Rat  1762 --------ITSAPSSTRGSPSLPDKYRHAREMML------------LLPTHRDR-----PSSAMY 1801

  Fly  1866 NAAASMNITQRESSTSSFDVEDF--------PVPPPPIPPKSLAVSSNGVNFSLDE-AHSPHPST 1921
            .||...|     ...::|....|        |...|.:.....||.:...::|||. |....|..
  Rat  1802 PAAILEN-----GQPANFQRALFQQVVGACKPCSDPNLSMAEKAVPAAPSSWSLDSGAQEAQPFL 1861

  Fly  1922 QANTTQLNHIQNPNQNHSTNSHHHLQQQQNGDGDGYSTLQHPMNGLGLPTLPPPPSAVESPMPAS 1986
            .|   .:.||..|.....:..|.|....       :....||:.       ..||:     :||.
  Rat  1862 SA---LMGHIMVPPVPPRSLLHGHYSLH-------FDAFHHPLG-------DTPPA-----LPAR 1904

  Fly  1987 AIASSTSSHQHDGGTFXVTICRCHHPPDQPHQPHKPSSSTSTSDSTATDTASESTESSSST---H 2048
            .:..|..                 ||  .|..|..|.|....|:||.:.:||....|.|.:   |
  Rat  1905 TLRKSPL-----------------HP--IPASPTSPQSGLDGSNSTLSGSASSGVSSLSESNFGH 1950

  Fly  2049 SMTPPP-------------------PPPPPPSSFTHLHHQMAAT------------THYCQDCL- 2081
            |...||                   .||..|     :|:.::.:            :|....|:
  Rat  1951 SSEAPPRTDTMDSMPSQAWNGDEDLEPPYLP-----VHYSLSESAVLDSIKSQPCRSHSAPGCVI 2010

  Fly  2082 -SSPSPPPTIITEQAQVHPTPGSTSAQPHIEHCSCGLSFSVVQDQQEQFPRLLSTRFS 2138
             ..|..||.:  .....||      ..|.:||     ...|:..::.:.||.|..:.|
  Rat  2011 PQDPMDPPAL--PPKPYHP------RLPALEH-----DEGVLLREEAERPRGLHRKAS 2055

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
spg	NP_733258.4	SH3_DOCK_AB	9..64	CDD:212805	26/54 (48%)
		DOCK_N	67..406	CDD:292790	131/347 (38%)
		C2_Dock-B	414..600	CDD:176077	97/194 (50%)
		DHR2_DOCK	1215..1610	CDD:297424	192/398 (48%)
Dock3	XP_038937508.1	SH3_DOCK3_B	10..65	CDD:212981	26/54 (48%)
		DOCK_N	69..412	CDD:406558	131/358 (37%)
		C2_Dock-B	426..615	CDD:176077	97/194 (50%)
		DHR2_DOCK3	1241..1632	CDD:212577	192/398 (48%)
		Atrophin-1	1757..>2064	CDD:397323	75/389 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	492	1.000	Domainoid score	I354
eggNOG	1	0.900	-	-		E1_KOG1997
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H21030
Inparanoid	1	1.050	1341	1.000	Inparanoid score	I131
OMA	1	1.010	-	-		QHG54452
OrthoDB	1	1.010	-	-		D102580at2759
OrthoFinder	1	1.000	-	-		FOG0000433
OrthoInspector	1	1.000	-	-		otm44464
orthoMCL	1	0.900	-	-		OOG6_100636
Panther	1	1.100	-	-	LDO	PTHR45653
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X372
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	14	13.840