DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment spg and Dock11

DIOPT Version :9

Sequence 1:NP_733258.4 Gene:spg / 43404 FlyBaseID:FBgn0264324 Length:2187 Species:Drosophila melanogaster
Sequence 2:XP_006257515.1 Gene:Dock11 / 313438 RGDID:1564707 Length:2086 Species:Rattus norvegicus


Alignment Length:1992 Identity:364/1992 - (18%)
Similarity:692/1992 - (34%) Gaps:589/1992 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly    32 VDIVEECKHWYRGSCPRKSRAVGLFPKTYIHIKDLSKIDP----VVAECTQVLREWSEIWKRLYV 92
            :|:|:         ||:..|          |..:|..:|.    :.||..|.:.||         
  Rat   227 IDVVQ---------CPKMRR----------HAFELKMLDKYSHYLAAETEQEMEEW--------- 263

  Fly    93 DREAYKFQTLRKVM----FSILESRRELLSATMTQDQTLE--LQMVVVS--------KIDWGNRK 143
                  ..||:|::    .|:::.::|.:.|...::.:.:  .:.::.|        .:.:|...
  Rat   264 ------LITLKKIIQINTDSLVQEKKETVEAIQEEETSSQGKAENIMASLERSMHPELMKYGRET 322

  Fly   144 LGLDLVPREGPLAVDPHGIGIVKLYNV--HVSSADNAKASSSRGTLRRKTQRKILT--HHLYFCM 204
            ..|:.:.|         |.|...|::.  .|...|.:...........|..::.|.  |.|.|.:
  Rat   323 EQLNKLSR---------GDGRQNLFSFDSEVQRLDFSGIEPDVKPFEEKCNKRFLVNCHDLTFNI 378

  Fly   205 RDFGHRIGGDDA-------EVYFF---LYDGSHMRPLSERFLV----------------KISKDG 243
              .||.  ||:|       |.:|.   |:|..:...:|..|.|                :::.||
  Rat   379 --LGHI--GDNAKGPPTNVEPFFITLALFDVKNNCKISADFHVDLNPPSVREMLWGMSTQLANDG 439

  Fly   244 FS------NYIERLHSNCTVFTDLGAADLNEELHLVAVVMRVGKIIQ-------------SDSIK 289
            .:      :.|..:..:...:...|...:......:.:|:|:.|::|             ||.||
  Rat   440 NTKGSSPESLIHGIAESRLCYIRQGIFSVTNPHPEIFLVVRIEKVLQGNITHCAEPYIKNSDPIK 504

  Fly   290 KIEK--------SGTLGHGPTFRRPFG----------VGVLSL----GDIAHFDSSLEQSSD--- 329
            ..:|        ...||.   :|.||.          .|.|.|    ..:...|||...:.|   
  Rat   505 TAQKVHRTAKQVCSRLGQ---YRMPFAWAARPIFKDLQGSLDLDGKFSPLYKQDSSKLSNEDILK 566

  Fly   330 -----EREYNFKL----------FQCEEKDFHLLPELIIKKSSGKYSPIQA-SQGTQGIVVSLKL 378
                 ::....||          .:|...|   ||..|    :..|.|::. .:..|.|.|    
  Rat   567 LLSEYKKPEKTKLQIIPGQLNITVECVPVD---LPNCI----TSSYVPLKPFEKNCQNITV---- 620

  Fly   379 LHGGLGQARQEQPMLFQGSTITRKMGFPDVIMPGDVRNDLF---LNLERGEFERGGKNTGKNILV 440
                  :..:..|.:       .|..:|..|    .:|.|:   |.|:....:...|  .:||.|
  Rat   621 ------EVEEFVPEM-------TKYCYPFTI----YKNHLYVYPLQLKYDSQKSFAK--ARNIAV 666

  Fly   441 TVVV--LDVAGNVLTDCLWG--ASGMESQPQYRSMILYHQNAPSWNEMLRLSVPIDKFSTAHVRF 501
            .|..  .|.:......|::|  |..:.:...| :::.:|...|.:.:.:::.:||......|:.|
  Rat   667 CVEFRDSDESDTSALKCIYGKPAGSVFTTNAY-AVVSHHNQNPEFYDEIKIELPIHLHQKHHLLF 730

  Fly   502 EFRHCS----------TRDKTEPKLFAFSFARLMDTGGATLGDGLHELYVYKCEDPAKLQVANYL 556
            .|.|.|          .:|..|..: .|::..|:..|..|..:  .:|.|.....|..|.|    
  Rat   731 TFYHVSCEINTKGTTKKQDTVETPV-GFAWVPLLKDGRVTTLE--QQLPVSANLPPGYLNV---- 788

  Fly   557 RLQCRPRDAQAKMDCGGCFS--RSSKEVFVLRSLLCSTKLTQNADL------LSLLQ--WRTYPE 611
                  .||:::........  ..:|.:..:::.|.||..||:..:      ..|:|  .:..|.
  Rat   789 ------NDAESRRQSNADIKWVDGAKPLLKIKTHLESTIYTQDLHVHKFFHHCQLIQSGSKEVPG 847

  Fly   612 TIQDSLTGVLRLNDEELVKFLQDVLDALFAMFSN---EEGNSTQHSGLVFHVL-----VSIFSLL 668
            .:...|..:..:..:.:::||..:|..||.:.:|   |:......:.::.|::     ..:.|.|
  Rat   848 ELIKYLKCLHAMEIQVMIQFLPVILMQLFRVLTNMTHEDDVPINCTMVLLHIVSKCHEEGLESYL 912

  Fly   669 QSNKFQHFRPVMNEYIENHFAAALVYKGLITSVEHMAVFMTKAEHPDPFQKCFGSLEY---IFKL 730
            :|.....|||.....::    |.|:::.|.|::  :|:....|:    |......|:|   .|::
  Rat   913 RSFIKYSFRPEKPSTLQ----AQLIHETLATTM--IAILKQSAD----FLAINKLLKYSWFFFEI 967

  Fly   731 LIQSRKLF-------ARATGGQYEDSFKRDLHSLFTALNGMLAVPSYDV---IIPTQEALLNSTG 785
            :.:|...:       ....|.::.:::...||||..|:     :|...:   .||.:...:|.: 
  Rat   968 IAKSMATYLLEENKIKLPRGQRFPEAYHHILHSLLLAI-----IPHVTIRYAEIPDESRNVNYS- 1026

  Fly   786 VVLEQLKDTLPAPELGMLARNMLDAIPRGAPIRLIQAKLHAVKDLVSGELFHEDDSRTVV----- 845
                          |....:..|..:.||....||       .|.:||  |...|.:.:.     
  Rat  1027 --------------LASFLKRCLTLMDRGFVFNLI-------NDYISG--FSPKDPKVLAEYKFE 1068

  Fly   846 -LSVACKH-----LRMHLS-RRDELRLCAEILSEILSQLYDLQKEQREKVTNTLQHDL-DSLCKN 902
             |...|.|     |.:.:: .:.:|:...:..|..:.:|        ..|.:.|::.| |..||:
  Rat  1069 FLQTICNHEHYIPLNLPMAFAKPKLQRVQDFFSFAVDRL--------TSVDSNLEYSLSDEYCKH 1125

  Fly   903 --ILGILIRTISIIMEGSNAVLPQLVSCLLGLL-QLLDETHYKR--------------------- 943
              ::|:|:|..||.::.:..:....:|.:..|| :...:|.|:.                     
  Rat  1126 HFLVGLLLRETSIALQDNYEIRYTAISVIKNLLIKHAFDTRYQHKNQQAKIAQLYLPFVGLLLEN 1190

  Fly   944 ----------YWDELSPNKDPRDLKEF-------LSKSLLVYEE--------------------- 970
                      |.....||...||  ||       .|:..|..::                     
  Rat  1191 IQRLAGRDTLYSCAAMPNSASRD--EFPCGFVSPTSRGSLATDKEPAYGSFQNGHGIKREDSRGS 1253

  Fly   971 LLTQDWHVFPND----------------------------------WLVMKLAANDVL-----RM 996
            |:.:....||:.                                  ..::|:.:.|.|     ::
  Rat  1254 LIPEGATGFPDPGSTGENTRQSSSRTSVSQYNRLDQYEIRNLLMCYLYIVKMISEDTLLTYWNKV 1318

  Fly   997 SLEEFAKPLV--------YRFLGPQ--AFDSQLWWS-YFSLAVAFLTQPSLQLEQYREPKRLKIL 1050
            |.:|....||        :|::|.:  |.....|.| :|.:.....|.|:|:........||:.|
  Rat  1319 SPQELINILVLLEVCLFHFRYMGKRNIARVHDAWLSKHFGIDRKSQTMPALRNRSGVMQARLQHL 1383

  Fly  1051 HS------------------------HGDMRVLMGFQIL---SMWSQLGEQKL-----HFIPSMV 1083
            .|                        .|:....:...:|   |.::|..:.:|     | .|.|.
  Rat  1384 SSLESSFTLNHSSATTEADIFHQALLEGNTATEVSLTVLDTISFFTQCFKSQLLNNDGH-NPLMK 1447

  Fly  1084 GPF-----------LEVTLVPEPALRKATLSVF----------------YDMMQC---------- 1111
            ..|           .||:|....|..::.:|.|                |::::|          
  Rat  1448 KVFDIHLAFLKNGQSEVSLKHVFASLRSFISKFPSAFFKGRVNMCAAFCYEVLKCCTSKISSTRN 1512

  Fly  1112 --------------EQAARGSFRLVESELIDKLDLLISE--NKGDDEYRELFSTILLEKVQVENP 1160
                          |...|.:|.....::|..:..||::  ..|...::|  |..::.  ...|.
  Rat  1513 EASALLYLLMRNNFEYTKRKTFLRTHLQIIIAVSQLIADVALSGGSRFQE--SLFIIN--NFANS 1573

  Fly  1161 NWKEAGIAFIASVTRLLERLLDYRSVMQG-----EENRDKRMTCTVNLLNFYKNEINRKEMYLRY 1220
            :......||...|..|.:|:   |:|:..     |..:|..|...:. .:..|:..:..|:...:
  Rat  1574 DRPMKATAFPTEVKDLTKRI---RTVLMATAQMKEHEKDPEMLIDLQ-YSLAKSYASTPELRKTW 1634

  Fly  1221 IYKLHNLHLQAENYTEAGFTL--------------KLYASMLSWDRE-----TQSFAPFDNSGQP 1266
            :..:..:|::..:::||....              ||:.|..|..::     .:..|..:::|..
  Rat  1635 LDSMAKIHIKNGDFSEAAMCYVHVAALVAEFLHRKKLFPSGCSAFKKITPNIDEEGAMKEDAGMM 1699

  Fly  1267 EWQRKERLYHEILKY----FDKGKCWEKGIPLCKELAHLYETRRFDYNKLSEILIQEAKFFQNIL 1327
            :....|.:..|:|:.    ..|.:.:|....:.|.:..:||.|| ::.||:::.......:..||
  Rat  1700 DVHYSEEVLLELLEQCVDGLWKAERYEVISEISKLIIPIYEKRR-EFEKLTQVYRTLHGAYTKIL 1763

  Fly  1328 ----TQLRPEPEYFRVGFYGMGLPLFVRNKQFVYR-----GL---EYERIGAFTQRLQTEFPSAQ 1380
                |:.|....:|||.|||.........|:::|:     ||   .:..:..:.::..||  :.:
  Rat  1764 EVMHTKKRLLGTFFRVAFYGQSFFEEEDGKEYIYKEPKLTGLSEISFRLVKLYGEKFGTE--NIK 1826

  Fly  1381 ILGNNSPPDNAILNAPDQYIQISNVRPVGDAQALKTAMVPVPEKIARFYEVNDVTRFIYDRPMYK 1445
            |:.::...:...|:....:||::.|:|..|.:.|       .|:...|...:::.||:::.| |.
  Rat  1827 IIQDSDKVNAKELDPKFAHIQVTYVKPYFDDKEL-------TERKTEFERNHNINRFVFEAP-YT 1883

  Fly  1446 GTVDKDNEFKSLWIERTILEIASPLPGILRWYEVKQKTMQELTPVEYACEIISNAGKELSELIVQ 1510
            .:..|....:.....||||..::..|.:.:...:..:....|.|::.|.:.|.:...||.:|...
  Rat  1884 LSGKKQGCIEEQCKRRTILTTSNSFPYVKKRIPITCEQQVNLKPIDVATDEIKDKTAELHKLCSS 1948

  Fly  1511 YKRDPKRNINPFSMRLQGTIDANVMGGISKYQEAFFSEQFLKSPQGAGQQAN------VQRLKVL 1569
            ...|    :....::|||.:...|..|...|..||.:|          .|||      |..||.:
  Rat  1949 ADVD----MIQLQLKLQGCVSVQVNAGPLAYARAFLNE----------SQANKYPPKKVNELKDM 1999

  Fly  1570 ILEQIQILEQALELHGQLAPSGVQPLHNRLLERFSQLKQSLS 1611
            ..:.||....||||:.:|........|..|...|..:.:.||
  Rat  2000 FRKFIQACSIALELNERLIKEDQIEYHEGLKSNFRDMVKELS 2041

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
spgNP_733258.4 SH3_DOCK_AB 9..64 CDD:212805 6/31 (19%)
DOCK_N 67..406 CDD:292790 77/446 (17%)
C2_Dock-B 414..600 CDD:176077 42/204 (21%)
DHR2_DOCK 1215..1610 CDD:297424 91/435 (21%)
Dock11XP_006257515.1 DUF3398 54..145 CDD:288711
PH_DOCK-D 161..284 CDD:270087 17/90 (19%)
PH 166..271 CDD:278594 16/77 (21%)
C2_Dock-D 639..828 CDD:176079 42/204 (21%)
DHR2_DOCK11 1628..2040 CDD:212573 91/436 (21%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1997
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.810

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