DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment spg and Dock7

DIOPT Version :9

Sequence 1:	NP_733258.4	Gene:	spg / 43404	FlyBaseID:	FBgn0264324	Length:	2187	Species:	Drosophila melanogaster
Sequence 2:	XP_038965832.1	Gene:	Dock7 / 313388	RGDID:	1309790	Length:	2146	Species:	Rattus norvegicus

Alignment Length:	2215	Identity:	434/2215 - (19%)
Similarity:	738/2215 - (33%)	Gaps:	752/2215 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 LALDVGDSVDIV----EECKHWYRGSCPRKSRA-VGLFPKTYIHIKDLSKIDPVVAECTQVLREW 83
            ||:|.|...|:|    ::.:..|   .||..|. |...|:.       |::||.|.:|   :|.:
  Rat    72 LAVDSGPLRDLVDFPPDDIEVVY---SPRDCRTLVSAVPEE-------SEMDPHVRDC---IRSY 123

  Fly    84 SEIWKRLYVDREAYKF------QTLRKVMFSILESRRELLSATMTQDQTLELQMVVVSKIDWGNR 142
            :|.|  ..|.|:.:|.      .||.|..    |.::.|.......|:..:.......:.|...|
  Rat   124 TEDW--AIVVRKYHKLGTGFNPNTLDKQK----ERQKGLPRQVFESDEAPDGNSYPDEQDDLKRR 182

  Fly   143 KLGLDLVPREGPLAVDPHGIGIVKLYNVHVSSADNA------KASSSRGTLRRKTQRKILTHHLY 201
            .:.:|..||         |.....::::..|..|..      :..:.....:...|||...|...
  Rat   183 SMSIDDTPR---------GSWACSIFDLKNSLPDALLPNLLDRTPNEEIDHQNDDQRKSNRHKEL 238

  Fly   202 FCM--------------------RDFGHRIGGDDAEVYF-----------FLYDGSHMRPLSERF 235
            |.:                    ..||.|:......:.|           .|||....:.:||.|
  Rat   239 FALHPSPDEEEPIERLSVPDVPKEHFGQRLLVKCLSLKFEIEIEPIFASLALYDVKEKKKISENF 303

  Fly   236 LVKISKDGFSNYIERLHSNCTVFTDLGAADL------NEELHLVAVVMRVGKIIQSDSI------ 288
            ...::.:.....: |.|......|.|..:.:      ::::.|   |:::.|::|...|
  Rat   304 YFDLNSEQMKGLL-RPHVPPAAITTLARSAIFSITYPSQDVFL---VIKLEKVLQQGDIGECAEP 364

  Fly   289 -------------KKIEKSGT--------LGHGPTFRRPFGVGVLSLGDIAHFDSSLEQSSDERE 332
                         :|:||..:        ||   .:|.||....:.|.:|.....|||:.|.|.|
  Rat   365 YMIFKEADATKNKEKLEKLKSQADQFCQRLG---KYRMPFAWTAIHLMNIVSSAGSLERDSTEVE 426

  Fly   333 Y-------------NFKL------------------------------FQCEEKDFHLLPELIIK 354
            .             |..|                              |..:|.| .|..|.:.|
  Rat   427 ISTGERKGSWSERRNSSLVGRRSLERTASGDDACNLTSFRPATLTVANFFKQEGD-RLSDEDLYK 490

  Fly   355 KSSGKYSPIQASQGTQGIVVSLKLLHGGLGQARQE----------QPMLFQGSTI--TRK-MGFP 406
            ..:....|....:..:.|...||:   .:..|.:.          |..|:..|.:  ||: :.||
  Rat   491 FLADMRRPSSVLRRLRPITAQLKI---DISPAPENPHYCLTPELLQVKLYPDSRVRPTREILEFP 552

  Fly   407 --DVIMPGDV-RNDLFLNLERGEF-ERGGKNTGKNILVTVVVL--DVAGNVLTDCLWGASGMESQ 465
              ||.:|... ||.|::..:...| .|.|  :.:||.|.|..:  :...|.:......:|..|..
  Rat   553 ARDVYVPNTTYRNLLYIYPQSLNFANRQG--SARNITVKVQFMYGEDPSNAMPVIFGKSSCSEFS 615

  Fly   466 PQYRSMILYHQNAPSWNEMLRLSVPIDKFSTAHVRFEFRHCSTRDKTEPKL---FAFSFARLMDT 527
            .:..:.::||..:|.::|.:::.:|.......|:.|.|.|.|.:.|....|   ..:::..::..
  Rat   616 KEAYTAVVYHNRSPDFHEEVKVKLPATLTDHHHLLFTFYHVSCQQKQNTPLETPVGYTWIPMLQN 680

  Fly   528 GGATLGDGLHELYVYKCEDPAKLQVANYLRLQCRPRDAQAKMD-----CGGCFSRSSKEVFVLRS 587
            |....|.        .|. |..|:         :|..|.:.:.     .|..:..:.|.||.:..
  Rat   681 GRLKTGQ--------FCL-PVSLE---------KPPQAYSVLSPEVPLPGMKWVDNHKGVFNVEV 727

  Fly   588 LLCSTKLTQNA------DLLSLLQWRTYPETIQD------SLTGVLR-----LNDEEL---VKFL 632
            :..|:..||:.      .|::.|....:|..|.|      :|...|:     ||..:|   |:||
  Rat   728 VAVSSIHTQDPYLDKFFALVNALDEHMFPVRIGDMRIMENNLESELKSSISALNSSQLEPVVRFL 792

  Fly   633 QDVLDALF----------------------AMFS-------NEEGNSTQH------SGLVFHV-- 660
            ..:||.|.                      ||.|       |.|||..||      :..:::|
  Rat   793 HLLLDKLILLVVRPPVIAGQIVNLGQASFEAMASIINRLHKNLEGNHDQHGRNNLLASYIYYVFR 857

  Fly   661 ---------------------------------------------------------------LV 662
                                                                           ::
  Rat   858 LPNTYPNSPSPGPGGLGGSVHYATMARSAVRPASLNLNRSRSLSNSNPDISGTPTSPDDEVRSII 922

  Fly   663 SIFSLLQSNKFQHFRPVMNEYIENHFAAALVYKGLITSVEHM------AVFM--------TKAEH 713
            ....|.:||.:.:..|....:..|...:|...:.:..|...|      :.|:        ||...
  Rat   923 GSKGLDRSNSWVNTGPKAAPWGSNPSPSAESTQAVDRSCNRMSSHTETSSFLQTLTGRLPTKKGK 987

  Fly   714 PDPFQK----------------CFGSLE--------YIFKLLIQSR--------KLFARATGGQY 746
            .|...|                |.||:.        :.|:|:::|.        ||.| ....::
  Rat   988 EDELGKLSLLLFHEELALQWVVCSGSVRESALQQAWFFFELMVKSMVHHLYFNDKLDA-PRKSRF 1051

  Fly   747 EDSFKRDLHSLFTALNGMLAVPSYDVIIPTQEALLNSTGVVLEQLKDTLPAPELGMLARNMLDAI 811
            .:.|..|:.:|.:.:.|       ||:...|:    .|.:| |:|..:     |.....::|..:
  Rat  1052 PERFMDDIAALVSTIAG-------DVVSRFQK----DTEMV-ERLNTS-----LAFFLNDLLSVM 1099

  Fly   812 PRGAPIRLIQ-------AKLHAVKD---LVSGEL-------FHEDDSRTVVLSVACKHL------ 853
            .||....||:       |||:::.:   |||..|       .||   ..|.|::.|..|
  Rat  1100 DRGFVFTLIKSCYKQVSAKLYSLPNPSVLVSLRLDFLRIICSHE---HYVTLNLPCSLLTPPASP 1161

  Fly   854 ---------------------------RMHLSRRDELRLCAEILSEI-------LSQLYDLQKEQ 884
                                       .:.|..|.:..|...:|:|:       ...|:.|.|:.
  Rat  1162 SPSVSSATSQSSGFSTNVQDQKIANMFELSLPFRQQHYLAGLVLTELALILDPDAEGLFGLHKKV 1226

  Fly   885 REKVTNTL-QHDLD-------------SLCKNILGILIRTI------------------------ 911
            ...|.|.| .||.|             .|...::||::.|:
  Rat  1227 INMVHNLLSSHDSDPRYSDPQIKARVAMLYLPLIGIIMETVPQLYDFTETHNQRGRPICIAPDDY 1291

  Fly   912 ----------SIIMEGSNAVLPQ----------------------------LVSCLLGLLQLLDE 938
                      ::.|..:...:||                            |:.|||.:|:..||
  Rat  1292 DSESGSMISQTVAMAIAGTSVPQLTRPGSFLLTSTSGRQHTVTFSAESSRSLLICLLWVLKNADE 1356

  Fly   939 THYKRYWDELSPNKDPR--DL-----KEFLSKSLLVYEELLTQDWHVFPNDWLVMKLAANDVLRM 996
            |..::::.:||..:..|  ||     ..|..|...|:|.:          :.|..|.:.:  :|.
  Rat  1357 TVLQKWFTDLSVLQLNRLLDLLYLCVSCFEYKGKKVFERM----------NSLTFKKSKD--MRA 1409

  Fly   997 SLEE-------FAKPLVYRFLGP-------QAFDSQ--LWWSYFSLAVAFLTQPSLQLEQYREPK 1045
            .|||       ..:.:|.|..|.       .||.||  |.|   ...:....|.:.:|::    .
  Rat  1410 KLEEAILGSIGARQEMVRRSRGQLERSPSGSAFGSQENLRW---RKDMTHWRQNTEKLDK----S 1467

  Fly  1046 RLKILH---------SHGDMRVLMGFQILSMWSQLGEQKLHFIPSMVGPFLEVTLVPEP------ 1095
            |.:|.|         :..::.:|...:|:.....:.|.|    .|::|..|:|.|....
  Rat  1468 RAEIEHEALIDGNLATEANLIILDTLEIIVQTVSVTESK----ESILGGVLKVLLQSMACNQSAV 1528

  Fly  1096 ------ALRKATLSVFYDMM---QCEQAARGSFRL----------VESELIDKLDLLISEN--KG 1139
                  |.::|.:|.|.:::   :.||.|....||          :.|.....|.||:.:|  .|
  Rat  1529 YLQHCFATQRALVSKFPELLFEEETEQCADLCLRLLRHCSSSISTIRSHASASLYLLMRQNFEIG 1593

  Fly  1140 DDEYR-ELFSTILLEKVQVENPNWKEAGIAFIASVTRLLERLLDYRSVMQGEENRDKRMT----- 1198
            ::..| ::..|:.|..:...:.|:.|      ..:.|.|:.:|.|     .||:.:.|.|
  Rat  1594 NNFARVKMQVTMSLSSLVGTSQNFNE------EFLRRSLKTILTY-----AEEDLELRETTFPDQ 1647

  Fly  1199 ---CTVNLLNFYKNEINRKE-----------MY-------------LRYIYKLHNLHLQAENYTE 1236
               ...||.....:.:..||           ||             |.::..:...|.:..|:.|
  Rat  1648 VQDLVFNLHMILSDTVKMKEHQEDPEMLIDLMYRIAKGYQTSPDLRLTWLQNMAGKHSERSNHAE 1712

  Fly  1237 AGFTL-------KLYASMLSWDRETQSFAP-----FDNSGQPEWQRKERLYHEILKYFDKGKC-- 1287
            |...|       ..|.|||    |.:.:.|     |.|......: :..:..:::...::|.|
  Rat  1713 AAQCLVHSAALVAEYLSML----EDRKYLPVGCVTFQNISSNVLE-ESAVSDDVVSPDEEGICSG 1772

  Fly  1288 ---WEKGI---------------------PLCKELAHLYETRRFDYNKLSEI--LIQEAKFFQNI 1326
               .|.|:                     .:.|.|..::|..| |..|||.|  .:|||  |..|
  Rat  1773 KYFTESGLVGLLEQAAASFSMAGMYEAVNEVYKVLIPIHEANR-DAKKLSTIHGKLQEA--FSKI 1834

  Fly  1327 LTQL----RPEPEYFRVGFYGMGLPLFVRNKQFVYRGLEYERIGAFTQRLQTEFPS------AQI 1381
            :.|.    |....||||||||.... .:..::|||:.....::...:.||:..:..      .::
  Rat  1835 VHQSTGWERMFGTYFRVGFYGTKFG-DLDEQEFVYKEPAITKLAEISHRLEGFYGERFGEDVLEV 1898

  Fly  1382 LGNNSPPDNAILNAPDQYIQISNVRPVGDAQALKTAMVPVPEKIARFYEVNDVTRFIYDRPMYKG 1446
            :.:::|.|...|:....||||:.|.|..|...:|       ::|..|.:..::.||:|..|.
  Rat  1899 IKDSNPVDKCKLDPNKAYIQITYVEPFFDTYEMK-------DRITYFDKNYNLRRFMYCTPF--- 1953

  Fly  1447 TVD--KDNEFKSLWIERTILEIASPLPGILRWYEVKQKTMQELTPVEYACEIISNAGKELSELIV 1509
            |:|  ...|....:..:|||..:...|.|.....|..|....|||:|.|.|.:....:||:....
  Rat  1954 TLDGRAHGELHEQFKRKTILTTSHAFPYIKTRVNVTHKEEIILTPIEVAIEDMQKKTQELAFATH 2018

  Fly  1510 QYKRDPKRNINPFSMRLQGTIDANVMGGISKYQEAFFSEQFLKSPQGAGQQANVQRLKVLILEQI 1574
            |...|||.    ..|.|||::...|..|..:..:.|.||    .|.......:..:|::...:..
  Rat  2019 QDPADPKM----LQMVLQGSVGTTVNQGPLEVAQVFLSE----IPGDPKLFRHHNKLRLCFKDFT 2075

  Fly  1575 QILEQALELHGQL-APSGVQPLHNRLLER-FSQLKQSLSGMGRLKRQHSESIVNTPLPPLPTEQR 1637
            :..|.||..:..| .|.  |..:.|.||| :.:||::|           :.::|..:|.|  .:.
  Rat  2076 KRCEDALRKNKSLIGPD--QKEYQRELERNYHRLKEAL-----------QPLINRKIPQL--YKA 2125

  Fly  1638 VAPAT 1642
            |.|.|
  Rat  2126 VLPVT 2130

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
spg	NP_733258.4	SH3_DOCK_AB	9..64	CDD:212805	12/44 (27%)
		DOCK_N	67..406	CDD:292790	83/470 (18%)
		C2_Dock-B	414..600	CDD:176077	39/203 (19%)
		DHR2_DOCK	1215..1610	CDD:297424	112/472 (24%)
Dock7	XP_038965832.1	DUF3398	55..164	CDD:403173	28/110 (25%)
		C2_Dock-C	563..740	CDD:176078	39/196 (20%)
		DHR2_DOCK7	1650..2124	CDD:212576	119/515 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1997
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810