DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment spg and Dock1

DIOPT Version :9

Sequence 1:NP_733258.4 Gene:spg / 43404 FlyBaseID:FBgn0264324 Length:2187 Species:Drosophila melanogaster
Sequence 2:NP_001137330.1 Gene:Dock1 / 309081 RGDID:1566072 Length:1864 Species:Rattus norvegicus


Alignment Length:2120 Identity:735/2120 - (34%)
Similarity:1082/2120 - (51%) Gaps:338/2120 - (15%)


- Green bases have known domain annotations that are detailed below.


  Fly     2 WIPS--NNKYGVAIHNWHGDVRFGLALDVGDSVDIVEECKHWYRGSCPRKSRAVGLFPKTYIHIK 64
            |:|:  ..|||||.:|:.......|:|.:||:|.|:|..:.||||...||....|:||.:|||:|
  Rat     4 WVPTKREEKYGVAFYNYDARGADELSLQIGDTVHILETYEGWYRGYTLRKKSKKGIFPASYIHLK 68

  Fly    65 ----------------DLSKIDPVVAECTQVLREWSEIWKRLYVDREAYKFQTLRKVMFSILESR 113
                            ||    |::.|.|..|||||.||::|||......|:::|.:::.::|.|
  Rat    69 EAIVEGKGQHETVIPGDL----PLIQEVTTTLREWSTIWRQLYVQDNREMFRSVRHMIYDLIEWR 129

  Fly   114 RELLSATMTQDQTLELQMVVVSKIDWGNRKLGLDLVPR-EGPLAVDPHGIGIVKLYNVHVSSADN 177
            .::||.|:.||:..||:..|.:|||:|||.|.||||.| |....:||.....:.|:..|..::..
  Rat   130 SQILSGTLPQDELKELKKKVTAKIDYGNRILDLDLVVRDEDGNILDPELTSTISLFRAHEVASKQ 194

  Fly   178 A-----KASSSRGTLRRKTQRKIL---THHLYFCMRDFGHRIGGDDAEVYFFLYDGSHMRPLSER 234
            .     :..|.:..:....|.|..   :..|:..:::...:| |:||||...|||....:.:||.
  Rat   195 VEERLQEEKSQKQNMDINRQAKFAATPSLALFVNLKNVVCKI-GEDAEVLMSLYDPVESKFISEN 258

  Fly   235 FLVKISKDGFSNYIERLHSNCTVFTDLGAADL-NEELHLVAVVMRVGKIIQSDSIKKIEKSGTLG 298
            :||:.|..|....|:|||:...||||||:.|| .|::..|..::|||::...||..:...||   
  Rat   259 YLVRWSSSGLPKDIDRLHNLRAVFTDLGSKDLKREKISFVCQIVRVGRMELRDSNTRKLTSG--- 320

  Fly   299 HGPTFRRPFGVGVLSLGDIAHFDSSLEQSSDEREYNFKLFQ--CEEKDFHLLPELIIKKSSGKYS 361
                .||||||.|:.:.||.:     .:..||.:.:|..||  ..|.||  |..:|.|..:.|  
  Rat   321 ----LRRPFGVAVMDVTDIIN-----GKVDDEDKQHFIPFQPVAGENDF--LQTVINKVIAAK-- 372

  Fly   362 PIQASQGTQGIVVSLKLLHGGLGQARQEQPMLFQGST-ITRKMGFPDVIMPGDVRNDLFLNLERG 425
              :.:...||:.|:||||.|.:.|.|:|.|.|...:| :.||.|||::|||||||||:::.|.:|
  Rat   373 --EVNHKGQGLWVTLKLLPGDIHQIRKEFPHLVDRTTAVARKTGFPEIIMPGDVRNDIYVTLVQG 435

  Fly   426 EFERGGKNTGKNILVTVVVLDVAGNVLTDCLWGASGMESQPQYRSMILYHQNAPSWNEMLRLSVP 490
            :|::|.|.|.||:.|||.|.|..|..|...::..:|.|:..:|:|:|.|....|.|.|.|::::|
  Rat   436 DFDKGSKTTAKNVEVTVSVYDEDGKRLEHVIFPGAGDEAISEYKSVIYYQVKQPRWFETLKVAIP 500

  Fly   491 IDKFSTAHVRFEFRHCS---TRDKTEPKLFAFSFARLMDTGGATLGDGLHELYVYKCEDPAKLQV 552
            |:..:.:|:||.|||.|   ::||:| |:||.:|.:||...|.||.||.|:|.|||.|.......
  Rat   501 IEDVNRSHLRFTFRHRSSQDSKDKSE-KIFALAFVKLMRYDGTTLRDGEHDLIVYKAEAKKLEDA 564

  Fly   553 ANYLRLQCRPRDAQAK---------MDCGGCFSRSSKEVFVLRSLLCSTKLTQNADLLSLLQWRT 608
            |.||.|.....:.:.|         ...|.|  ..||:.|.:.:|:||||||||.|||.||:||:
  Rat   565 ATYLSLPSTKGELEEKGHSATGKGMQSLGSC--TISKDSFQISTLVCSTKLTQNVDLLGLLKWRS 627

  Fly   609 YPETIQDSLTGVLRLNDEELVKFLQDVLDALF-AMFSNEEGNSTQHSGLVFHVLVSIFSLLQSNK 672
            ....:|.:|..:::::..|:||||||.||||| .|..|.|  |.....|||..||.|..|:...|
  Rat   628 NTNLLQQNLRQLMKVDGGEVVKFLQDTLDALFNIMMENSE--SETFDTLVFDALVFIIGLIADRK 690

  Fly   673 FQHFRPVMNEYIENHFAAALVYKGLITSVEHMAVFMTKAEHP---DPFQKCFGSLEYIFKLLIQS 734
            ||||.||:..||:.||:|.|.|..| |.|  :..::..||.|   :...|...:||||||.:::|
  Rat   691 FQHFNPVLETYIKKHFSATLAYTKL-TKV--LRTYVASAEKPGINEQLYKAIKALEYIFKFIVRS 752

  Fly   735 RKLFARATGGQYEDSFKRDLHSLFTALNGMLAVPSYDVIIPTQEALLNSTGVVLEQLKDTLPAPE 799
            |.||.:....:.|..|...|..||.::|.|::..| ::.:..:.|.|.....::..:|......|
  Rat   753 RVLFNQLYENKGEADFVESLLQLFRSINDMMSSMS-ELTVRVKGAALKYLPTIVNDVKLVFDPKE 816

  Fly   800 LGMLARNMLDAIPRGAPIRLIQAKLHAVKDLVSGELFHEDDSRTVVLSVACKHLRMHLSRRDELR 864
            |..:....:..:|.|.   |...||:.:.::|..:||.:.|.|.::|.:....|:.||.|:::|.
  Rat   817 LSKMFTEFILNVPVGL---LTVQKLYCLIEIVHSDLFTQHDCREILLPMMTDQLKYHLERQEDLE 878

  Fly   865 LCAEILSEILSQLYDLQKEQREKVTNTLQHDLDSLCKNILGILIRTISIIMEGSNAVLPQLVSCL 929
            .|.::||.||..||      |:.|..|.:| :..:.:.:|..:.||: |.|...:.::...|:|:
  Rat   879 ACCQLLSNILEVLY------RKDVGPTQRH-VQIIMEELLRTVNRTV-ISMGRDSELIGNFVACM 935

  Fly   930 LGLLQLLDETHY----KRYWDELSPNKDPRDLKEFLSKSLLVYEELLTQDWHVFPNDWLVMKLAA 990
            ..:|:.:::.||    |.:      .|...|:.:||.::.::::.|:.:  :|:|.||::|....
  Rat   936 TAILRQMEDFHYAHLIKTF------GKMRTDVVDFLMETFIMFKNLIGK--NVYPFDWVIMNTMQ 992

  Fly   991 NDVLRMSLEEFAKPLVYRFLGPQAFDSQLWWSYFSLAVAFLTQPSLQLEQYREPKRLKILHSHGD 1055
            |.|...::.::|..|..:||....|:.|||.:||.||||||||.|||||.:...||.|||:.:||
  Rat   993 NKVFLRAINQYADMLNKKFLDQANFELQLWNNYFHLAVAFLTQESLQLENFSSAKRAKILNKYGD 1057

  Fly  1056 MRVLMGFQILSMWSQLGEQKLHFIPSMVGPFLEVTLVPEPALRKATLSVFYDMMQCEQAARGSFR 1120
            ||..:||:|..||..||:.|:.|||.||||.||:||:||..||||||.:|:||||||..:..||:
  Rat  1058 MRRQIGFEIRDMWYNLGQHKIKFIPEMVGPILEMTLIPETELRKATLPIFFDMMQCEFHSTRSFQ 1122

  Fly  1121 LVESELIDKLDLLISENKGDDEYRELFSTILLEKVQVENPNWKEAGIAFIASVTRLLERLLDYRS 1185
            :.|:|:|.|||..:...:||::|:.||..||||..: ::....:.|..|:..|.||:|||||||:
  Rat  1123 MFENEIITKLDHEVEGGRGDEQYKVLFDKILLEHCR-KHKYLAKTGETFVKLVVRLMERLLDYRT 1186

  Fly  1186 VMQGEENRDKRMTCTVNLLNFYKNEINRKEMYLRYIYKLHNLHLQAENYTEAGFTLKLYASMLSW 1250
            :|. :||:|.||:||||:||||| ||.|:|||:||:|||.:||.:.:|||||.:||.|:|.:|.|
  Rat  1187 IMH-DENKDNRMSCTVNVLNFYK-EIEREEMYIRYLYKLCDLHKECDNYTEAAYTLLLHAKLLKW 1249

  Fly  1251 DRETQSFAPFDNSG---QPEWQRKERLYHEILKYFDKGKCWEKGIPLCKELAHLYETRRFDYNKL 1312
            ..:..:.......|   ..:.|.||:||.||:.||||||.||:.|.|.||||..|||..|||.:|
  Rat  1250 SEDACAAHLIQRDGFQATTQGQLKEQLYQEIIHYFDKGKMWEEAIALGKELAEQYETELFDYEQL 1314

  Fly  1313 SEILIQEAKFFQNILTQLRPEPEYFRVGFYGMGLPLFVRNKQFVYRGLEYERIGAFTQRLQTEFP 1377
            ||:|.::|:|::||:..:||:|:||.||:||.|.|.|:|.|.|:|||.||||...|..||.|:||
  Rat  1315 SELLKKQAQFYENIVKVIRPKPDYFAVGYYGQGFPSFLRGKVFIYRGKEYERREDFEARLLTQFP 1379

  Fly  1378 SAQILGNNSPPDNAILNAPDQYIQISNVRPVGDAQALKTAMVPVPEKIARFYEVNDVTRFIYDRP 1442
            :|:.:...|||.:.|..:|.||||...|:|..|..  .....||.|:|..||.||:|.||.|.||
  Rat  1380 NAEKMKTTSPPGDDIKTSPGQYIQCFTVKPKLDLP--PKFHRPVSEQIVSFYRVNEVQRFEYSRP 1442

  Fly  1443 MYKGTVDKDNEFKSLWIERTILEIASPLPGILRWYEVKQKTMQELTPVEYACEIISNAGKELSEL 1507
            :.||..:.||||.::||||||...|..|||||||:|||...|.|::|:|.|.|.:.....::|.:
  Rat  1443 IRKGEKNPDNEFANMWIERTIYTTAYKLPGILRWFEVKSVFMVEISPLENAIETMQLTNDKISSM 1507

  Fly  1508 IVQYKRDPKRNINPFSMRLQGTIDANVMGGISKYQEAFFSEQFLKS-PQGAGQQANVQRLKVLIL 1571
            |.|:..||...|||.||.|.|.:|..||||.:.|::|||::::|:. |:..||   :::||.||.
  Rat  1508 IQQHLDDPGLPINPLSMLLNGIVDPAVMGGFANYEKAFFTDRYLQEHPEAHGQ---IEKLKDLIA 1569

  Fly  1572 EQIQILEQALELHGQLAPSGVQPLHNRLLERFSQLKQSLSGMGRLKRQHSESIVNTPLPPLPTEQ 1636
            .||..|.:.:.:||......::|.|.|:...|.|||:.:                        |:
  Rat  1570 WQIPFLAEGIRIHGDKVTEALRPFHERMEACFKQLKEKV------------------------EK 1610

  Fly  1637 RVAPATASSSLNANAHSNYVYDLDEIYTRPGDTVRPVDPLSSYQTLSKESLSIPLEDTAAPPVPN 1701
            :....|..|.|:           |...:||...||.....||.:.||..|:|....|:    .|:
  Rat  1611 QYGVRTMPSGLD-----------DRRGSRPRSMVRSFTMPSSSRPLSVASVSSFSSDS----TPS 1660

  Fly  1702 RPRSQNFIGNGSMDSPEVPPKRQPTLNSPNAPPLPPRGITPDKRASNPLIFNDFGSGDAVGRRHS 1766
            ||.|..|.                      ..||.|:                        :.||
  Rat  1661 RPGSDGFA----------------------LEPLLPK------------------------KMHS 1679

  Fly  1767 QQQQQHGQKYSVVDISYDDPEADQQPHSLPPNFQDGSGGHLSVC---FAPNDFRDSGISTTSSRE 1828
            :.|.:         :..|||:.:::....    :..:..|..:.   |.|   .||.:..:.:..
  Rat  1680 RSQDK---------LDKDDPDKEKKDKKK----EKRNSKHQEIFDKEFKP---ADSSLQQSEAVI 1728

  Fly  1829 LNHMNLNNLSEDSSSISTITVQHREHCRISSNGSLDYNAAASMNITQRESSTSSFDVEDFPVPPP 1893
            |           |.:||.:..|..:...|:..||            :|..|.|.......|.|||
  Rat  1729 L-----------SETISPLRPQRPKSQVINVIGS------------ERRFSVSPASPCSQPTPPP 1770

  Fly  1894 PIPPKSLAVS------SNGVNFSLDEAHSPHPSTQANTTQLNHIQNPNQNHSTNSHHHLQQQQNG 1952
            ..|...|:.|      .||: ..:|.|..|.|                            ....|
  Rat  1771 VTPRAKLSFSIQPNLELNGM-MGMDVADVPPP----------------------------LPLKG 1806

  Fly  1953 DGDGYSTLQHPMNGLGLPTLPPPPSAVESPMPASAIASSTSSHQHDGGTFXVTICRCHHPPDQPH 2017
            :...|..|....:.:|.||.|||                                    ||.:..
  Rat  1807 NMADYGNLMENQDLMGSPTSPPP------------------------------------PPQRQQ 1835

  Fly  2018 QPHKPSSSTSTSDSTATDTASESTESSSSTHSMTPPPPPP 2057
            .|..||.                          |||||||
  Rat  1836 PPPLPSK--------------------------TPPPPPP 1849

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
spgNP_733258.4 SH3_DOCK_AB 9..64 CDD:212805 24/54 (44%)
DOCK_N 67..406 CDD:292790 120/351 (34%)
C2_Dock-B 414..600 CDD:176077 77/197 (39%)
DHR2_DOCK 1215..1610 CDD:297424 182/398 (46%)
Dock1NP_001137330.1 SH3_DOCK1_5_A 13..68 CDD:212984 24/54 (44%)
DOCK_N 72..416 CDD:292790 122/366 (33%)
C2_Dock-A 424..619 CDD:176076 77/197 (39%)
DHR2_DOCK 1214..1612 CDD:297424 183/426 (43%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1997
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG54452
OrthoDB 1 1.010 - - D102580at2759
OrthoFinder 1 1.000 - - FOG0000433
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100636
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 1 1.000 - - X372
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
98.730

Return to query results.
Submit another query.