DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment spg and Dock9

DIOPT Version :9

Sequence 1:	NP_733258.4	Gene:	spg / 43404	FlyBaseID:	FBgn0264324	Length:	2187	Species:	Drosophila melanogaster
Sequence 2:	XP_006252543.1	Gene:	Dock9 / 259237	RGDID:	629617	Length:	2143	Species:	Rattus norvegicus

Alignment Length:	1614	Identity:	298/1614 - (18%)
Similarity:	514/1614 - (31%)	Gaps:	584/1614 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   455 CLWGASGMESQPQYR----SMILYHQNAPSWNEMLRLSVPIDKFSTAHVRFEFRH--C--STRDK 511
            |::|..|   .|.:.    :.:|:||.:|.:.:.:::.:|.......|:.|.|.|  |  ||:..
  Rat   692 CIYGRPG---GPVFTRSALAAVLHHQQSPEFYDEIKIELPAQLHEKHHLLFTFFHVSCDNSTKGS 753

  Fly   512 TEPK-----LFAFSFARLMDTGGATLGDGLHELYVYKCEDPAKLQV-ANYLRLQ----CRPRDAQ 566
            |:.|     ...||:..|:..|...    .:|.::     |....: :.||..|    .|....:
  Rat   754 TKKKDAVETQVGFSWLPLLKDGRVL----TNEQHI-----PVSANLPSGYLGYQELSMGRHYGPE 809

  Fly   567 AKMDCGGCFSRSSKEVFVLRSLLCSTKLTQNADLLSLLQWRTYPETIQDSLTGVLRLNDEELVK- 630
            .|...||      |.:..:.:.|.||..||:..|.:..|:      .|.:.:|. :.:..||||
  Rat   810 VKWVEGG------KPLLKISTHLVSTVYTQDQHLHNFFQY------CQKTESGA-QASGSELVKY 861

  Fly   631 --------------FLQDVLDALFAMFS----------------------NEEG----------- 648
                          ||..:|:.||.:.:                      :|||
  Rat   862 LKSLHAMEGHVMIAFLPTILNQLFRVLTRATQEEVAVNVTRVIIHVVAQCHEEGLESHLRSYVKF 926

  Fly   649 -----------NSTQHSGL---VFHVLVSIFSLLQSNKFQHF---------RPVMNEYIENH--- 687
                       ..|.|..|   :..:|......|.|||...:         :.:....|||:
  Rat   927 AYKAEPYIASEYKTVHEELTKSMTTILKPSADFLTSNKLLKYSWFFFDVLIKSMAQHLIENNKVK 991

  Fly   688 ------FAAALVYKGLITSVEHMAV-FMTKAEHPDP-------------FQKCFGSLE--YIFKL 730
                  |.|:  |...:.:|.:|.: .:|:....:|             .::||..::  ::||.
  Rat   992 LLRNQRFPAS--YHHAVETVVNMLMPHITQKFRDNPEASKNANHSLAVFIKRCFTFMDRGFVFKQ 1054

  Fly   731 LIQSRKLFARA---TGGQYEDSFKRDL--HSLFTALNGMLAVP--------------SYDVIIPT 776
            :......||..   |..:|:..|.|.:  |..:..||  |.:|              .|.:   |
  Rat  1055 INNYISCFAPGDPKTLFEYKFEFLRVVCNHEHYIPLN--LPMPFGKGRIQRYQDLQLDYSL---T 1114

  Fly   777 QE---------ALLNSTGVVLEQLKD--------------------------------TLPAPEL 800
            .|         .||...|..|::.::                                ||..|..
  Rat  1115 DEFCRNHFLVGLLLREVGTALQEFREVRVIAVSVLKNLLIKHSFDDRYTSRSHQARIATLYLPLF 1179

  Fly   801 GMLARNMLD-----------------------AIPRGAPI------RLIQAKLHAVKDL---VSG 833
            |:|..|:..                       |:|.|.|:      ..:...||  |||   :||
  Rat  1180 GLLIENVQRINVRDVSPFPVNPGSQISKDEALAVPTGNPLMTPQKGNTLDHSLH--KDLLGAISG 1242

  Fly   834 ELFHEDDSRTVVLSVACKHLRMHLSRRDELRLCAEILSEILSQLYDLQKEQREKVTNTLQHDLDS 898
            .......|...:.||.....|..|           |.::..:.|.|...|:    :|:|.....|
  Rat  1243 IASPYTASTPNINSVRNADSRGSL-----------ISTDSGNSLPDRNPEK----SNSLDKQQQS 1292

  Fly   899 LCKNILGILIRTISIIMEGSNAVLPQLVSCLLGLLQLLDETHYKRYWDELSPNKDPRDLKEFLSK 963
                  |:|..::....:...:.:..|:.|.|.:|:.:.:.....||::.|    ..:|.:|.:.
  Rat  1293 ------GMLGNSVVRCDKLDQSEIKSLLMCFLYVLKSMSDDALFTYWNKAS----TAELMDFFTI 1347

  Fly   964 SLLVYEELLTQDWHVFPNDWLVMKLAANDVLRMSLEEFAKPLVYRF---LGPQAFD--SQLWWSY 1023
            |                           :|.....:...|..:.|.   |||...|  ||
  Rat  1348 S---------------------------EVCLHQFQYMGKRYIARSQEGLGPIGHDRKSQ----- 1380

  Fly  1024 FSLAVAFLTQPSLQLEQYREPKRLKIL----------HSHGDMRVLMGFQILSMWSQLGEQKLHF 1078
                    |.|..:........||:.|          ||:|.....:..|.|
  Rat  1381 --------TLPVSRNRAGMAHARLQQLGSLDNSVTFNHSYGHSEADVAHQSL------------- 1424

  Fly  1079 IPSMVGPFLEVTLVPEPALRKA-TLSVF---------------------YDMMQC-------EQA 1114
                    ||..:..|..|... |||:|                     :|:..|       |.|
  Rat  1425 --------LEANIATEVCLTALDTLSLFTLAFKNQLLADHGHNPLMKKVFDVYLCFLQKHQSEMA 1481

  Fly  1115 ARGSFRLVESELIDKLDLLISENKGDD----EYREL------FSTILLEKVQ----VENPNWKEA 1165
            .:..|..:.| ||.|......|.:.|.    .|..|      .|:|..|..|    :...|:...
  Rat  1482 LKNVFTALRS-LIYKFPSTFYEGRADMCASLCYEVLKCCNSKLSSIRTEASQLLYFLMRNNFDYT 1545

  Fly  1166 G--------IAFIASVTRLL------------------------ERLLDYRSVMQGEENRDKRMT 1198
            |        :..|.||::|:                        :||:.:.|.....::..||:.
  Rat  1546 GKKSFVRTHLQVIISVSQLIADVVGIGGTRFQQSLSIINNCANSDRLIKHTSFSSDVKDLTKRIR 1610

  Fly  1199 CTVNLLNFYKNEINRKEMYLRYIYKL------------------HNLHLQAENYTEAGFT----- 1240
            ..:......|...|..||.:...|.|                  ..:|::..:.:||...
  Rat  1611 TVLMATAQMKEHENDPEMLVDLQYSLAKSYASTPELRKTWLDSMARIHVKNGDLSEAAMCYVHVT 1675

  Fly  1241 ------LKLYASMLSWDRETQSFAPFDNSGQPEWQRKER-------------------------- 1273
                  |....:.|:..||...| |:.::   ..|||.|
  Rat  1676 ALVAEYLTRKEADLALQREPPVF-PYSHT---SCQRKSRGGMFRQGCTAFRVITPNIDEEASMME 1736

  Fly  1274 ------------------------------------LYHEILKYFDKGKCWEKGIPLCKELAHLY 1302
                                                :|..|:..::|.:.:|:       |||||
  Rat  1737 DVGMQDVHFNEDVLMELLEQCADGLWKAERYELIADIYKLIIPIYEKRRDFER-------LAHLY 1794

  Fly  1303 ETRRFDYNKLSEILIQEAKFFQNILTQLRPEPEYFRVGFYGMGLPL-----------FVRN---K 1353
            :|....|:|::|::....:....          ||||.|:|.....           |..:   |
  Rat  1795 DTLHRAYSKVTEVMHSGRRLLGT----------YFRVAFFGQAAQYQFTDSETDVEGFFEDEDGK 1849

  Fly  1354 QFVYRGLEYERIGAFTQRL----QTEFPSAQI-----LGNNSPPDNAILNAPDQYIQISNVRPVG 1409
            :::|:..:...:...:|||    ..:|.|..:     .|..:|.|   |::...|||:::|.|..
  Rat  1850 EYIYKEPKLTPLSEISQRLLKLYSDKFGSENVKMIQDSGKVNPKD---LDSKFAYIQVTHVTPFF 1911

  Fly  1410 DAQALKTAMVPVPEKIARFYEVNDVTRFIYDRPMYKGTVDKDNEFKSLWIERTILEIASPLPGIL 1474
            |.:.|:       |:...|...:::.||:::.| :..|..:....:.....||||......|.:.
  Rat  1912 DEKELQ-------ERKTEFERCHNIRRFMFEMP-FTQTGKRQGGVEEQCKRRTILTAIHCFPYVK 1968

  Fly  1475 RWYEVKQKTMQELTPVEYACEIISNAGKELSELIVQYKRDPKRNINPFSMRLQGTIDANVMGGIS 1539
            :...|..:...:|.|:|.|.:.:|....||.:|....:.|    :....::|||::...|..|..
  Rat  1969 KRIPVMYQHHTDLNPIEVAIDEMSKKVAELRQLCSSAEVD----MIKLQLKLQGSVSVQVNAGPL 2029

  Fly  1540 KYQEAFFSEQFLKS-PQGAGQQANVQRLKVLILEQIQILEQALELHGQLAPSGVQPLHNRLLERF 1603
            .|..||..:...|. |..     .|:.||.:..:.::...|||.::.:|...........:...:
  Rat  2030 AYARAFLDDTNTKRYPDN-----KVKLLKEVFRQFVEACGQALAVNERLIKEDQLEYQEEMKANY 2089

  Fly  1604 SQLKQSLSGMGR-----LKRQ-----HSESIVNTPLPPLPTEQRVAPATASSSL 1647
            .::.:.||.:.|     |:.:     :|..|.|. :...||...|...|:|||:
  Rat  2090 REMAKELSDIMREQICPLEEKTSVLPNSLHIFNA-ISGTPTSTVVQGLTSSSSV 2142

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
spg	NP_733258.4	SH3_DOCK_AB	9..64	CDD:212805
		DOCK_N	67..406	CDD:292790
		C2_Dock-B	414..600	CDD:176077	37/162 (23%)
		DHR2_DOCK	1215..1610	CDD:297424	93/509 (18%)
Dock9	XP_006252543.1	DUF3398	74..165	CDD:288711
		PH_DOCK-D	181..304	CDD:270087
		PH	186..291	CDD:278594
		C2_Dock-D	648..837	CDD:176079	37/162 (23%)
		DHR2_DOCK9	1645..2099	CDD:212571	91/494 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1997
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810