DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment spg and Dock3

DIOPT Version :9

Sequence 1:	NP_733258.4	Gene:	spg / 43404	FlyBaseID:	FBgn0264324	Length:	2187	Species:	Drosophila melanogaster
Sequence 2:	XP_011241171.1	Gene:	Dock3 / 208869	MGIID:	2429763	Length:	2071	Species:	Mus musculus

Alignment Length:	2236	Identity:	824/2236 - (36%)
Similarity:	1204/2236 - (53%)	Gaps:	332/2236 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MWIPS-NNKYGVAIHNWHGDVRFGLALDVGDSVDIVEECKHWYRGSCPRKSRAVGLFPKTYIHIK 64
            ||.|: ..||||.|.::.|.|..||.|::|::|.|:|:|:.||||...:|....||||..|||:|
Mouse     1 MWTPTEEEKYGVVICSFRGSVPQGLVLEIGETVQILEKCEGWYRGVSTKKPNVKGLFPANYIHLK 65

  Fly    65 D------------LSKIDPVVAECTQVLREWSEIWKRLYVDREAYKFQTLRKVMFSILESRRELL 117
            .            :...|.:|.|.|..|:||:.:||:|||..:...|..||.||..:::.||:||
Mouse    66 KAIVSNRGQYETVVPLEDSIVTEVTTTLQEWASLWKQLYVKHKVDLFYKLRHVMNELIDLRRQLL 130

  Fly   118 SATMTQDQTLELQMVVVSKIDWGNRKLGLDLVPREGPLAVDPHGIGIVKLYNVHVSSADNAKASS 182
            |..:||||..|::..:..::||||..||||||||:....||...|.:..||.:|:||..:.:.|:
Mouse   131 SGHLTQDQVREVKRHITVRLDWGNEHLGLDLVPRKDFEVVDSDQISVSDLYKMHLSSRQSVQQST 195

  Fly   183 SR-GTLRRK---TQRKILTHHLYFCMRDFGHRIGGDDAEVYFFLYDGSHMRPLSERFLVKISKDG 243
            |: .|:|.:   |.|..:.||.:|.::.|.:...|:|::|:|.|||....:.:||||||:::|:|
Mouse   196 SQVDTMRPRHGETCRMPVPHHFFFSLKSFTYNTIGEDSDVFFSLYDMREGKQISERFLVRLNKNG 260

  Fly   244 FSNYIERLHSNCTVFTDLGAADLNEELHLVAVVMRVGKIIQSDSIKKIEKSGTLGHGPT---FRR 305
            .....|::...|.:||||.:.|:..:|::||.|:|:|:::.:||.|          ||.   :||
Mouse   261 GPRNPEKIERMCALFTDLSSKDMKRDLYIVAHVIRIGRMLLNDSKK----------GPAHLHYRR 315

  Fly   306 PFGVGVLSLGDIAHFDSSLEQSSDEREYNFKLFQC-EEKDFHLLPELIIKKSSGKYSPIQASQGT 369
            |:|..|||:.|:.   .||.:..:|:::..|::.| .|.::..:.|.||:|||.|||   |...:
Mouse   316 PYGCAVLSILDVL---QSLTELKEEKDFVLKVYTCNNESEWTQIHENIIRKSSTKYS---APSAS 374

  Fly   370 QGIVVSLKLLHGGLGQARQEQPMLF-QGSTITRKMGFPDVIMPGDVRNDLFLNLERGEFERGGKN 433
            .|:::||:|..|.:.|.|:|.||:| :|..||||:||||||||||:||||:|.||:|:||||||:
Mouse   375 HGLIISLQLFRGDMEQIRRENPMIFNRGLAITRKLGFPDVIMPGDIRNDLYLTLEKGDFERGGKS 439

  Fly   434 TGKNILVTVVVLDVAGNVLTDCLWGASGMESQPQYRSMILYHQNAPSWNEMLRLSVPIDKFSTAH 498
            ..|||.||:.||...|.:|.||:...||..::..|.|.:|||.|:|.|.|:::|.:|||:|..:|
Mouse   440 VQKNIEVTMYVLYADGEILKDCISLGSGEPNRSSYHSFVLYHSNSPRWGEIIKLPIPIDRFRGSH 504

  Fly   499 VRFEFRHCSTRDKTEPKLFAFSFARLMDTGGATLGDGLHELYVYKCEDPAKL-QVANYLRLQCRP 562
            :|||||||||:||.|.|||.|:|:.||...|.||.|.:||||||||::.:.. ..|.||.|.|
Mouse   505 LRFEFRHCSTKDKGEKKLFGFAFSPLMRDDGTTLSDDIHELYVYKCDENSTFNNHALYLGLPC-- 567

  Fly   563 RDAQAKMDCGGC--------FSRSSKEVFVLRSLLCSTKLTQNADLLSLLQWRTYPETIQDSLTG 619
                .|.|..||        |.||:||.|.:.:.|.|||||||.|||:||:|:.:|:.|.|.|..
Mouse   568 ----CKEDYNGCPNIPSSLIFQRSAKESFFISTQLSSTKLTQNVDLLALLKWKAFPDRIMDILGR 628

  Fly   620 VLRLNDEELVKFLQDVLDALFAMFSNEEGNSTQHSGLVFHVLVSIFSLLQSNKFQHFRPVMNEYI 684
            :..::.||:||||||:||.||.:.   :.|:.::..|||..||.|.:||:..|:.||||||:.||
Mouse   629 LRHVSGEEIVKFLQDILDTLFVIL---DDNTEKYGLLVFQSLVFIINLLRDIKYFHFRPVMDTYI 690

  Fly   685 ENHFAAALVYKGLITSVEHMAVFMTKAEHPDPFQKCFGSLEYIFKLLIQSRKLFARATGGQYEDS 749
            :.|||.||.||.||..::.......:....|..|:...:|||:||.::|||.|::|||.|..|:.
Mouse   691 QKHFAGALAYKELIRCLKWYMDCSAELIRQDHIQEAMRALEYLFKFIVQSRILYSRATCGMEEEQ 755

  Fly   750 FKRDLHSLFTALNGMLAVPS--YDVIIPTQEALLNSTGVVLEQLKDTLPAPELGMLARNMLDAIP 812
            |:..:..||.::..:|::.|  .:.::.||.|||||...:.::|.......|:....|..|.::|
Mouse   756 FRSSIQELFQSIRFVLSLDSRNSETLLFTQAALLNSFPTIFDELLQMFTVQEVAEFVRGTLGSMP 820

  Fly   813 RGAPIRLIQA----KLHAVKDLVSGELFHEDDSRTVVLSVACKHLRMHLSRRDELRLCAEILSEI 873
              :.:.:.|:    ||.::...|...||...:||.::|.|...|:.:||.::.||.:|:.||..|
Mouse   821 --STVHIGQSMDVVKLQSIARTVDSRLFSFSESRRILLPVVLHHIHLHLRQQKELLICSGILGSI 883

  Fly   874 LSQLYDLQKEQREKVTNTLQHD----LDSLCKNILGILIRTISIIMEGSNA-------------- 920
            .|.:          .|::|:.|    ::.:.:::|.:|::|:..||..|:|
Mouse   884 FSIV----------KTSSLEADVMEEVEMMVESLLDVLLQTLLTIMSKSHAQEAVRGQRCPQCTA 938

  Fly   921 -VLPQLVSCLLGLLQLLDETHYKRYWDELSPNKDPRDLKEFLSKSLLVYEELLTQDWHVFPNDWL 984
             :..:.|||||.||:.:.:||::...|... :||  :|||||.|...|:..|:...  |||.||:
Mouse   939 EITGEYVSCLLSLLRQMCDTHFQHLLDNFQ-SKD--ELKEFLLKIFCVFRNLMKMS--VFPRDWM 998

  Fly   985 VMKLAANDVLRMSLEEFAKPLVYRFLGPQAFDSQLWWSYFSLAVAFLTQPSLQLEQYREPKRLKI 1049
            ||:|..::::..:::..:..|...|.... ||.::|.|||||||.|:.|||||||.....||.||
Mouse   999 VMRLLTSNIIVTTVQYLSSALHKNFTETD-FDFKVWNSYFSLAVLFINQPSLQLEIITSAKRKKI 1062

  Fly  1050 LHSHGDMRVLMGFQILSMWSQLGEQKLHFIPSMVGPFLEVTLVPEPALRKATLSVFYDMMQCEQA 1114
            |..:|||||:|.:::.|||..||:.|:||||.|:||||.|||||:|.:|...:.:|:|||..||.
Mouse  1063 LDKYGDMRVMMAYELFSMWQNLGDHKIHFIPGMIGPFLGVTLVPQPEVRNIMIPIFHDMMDWEQR 1127

  Fly  1115 ARGSFRLVESELIDKLDLLISENKGDDEYRELFSTI---------LLEKVQVENPNWKEAGIAFI 1170
            ..|:|:.||:|||||||.::||.|||:.|||||..:         |||||:.|  .|:|.||:|:
Mouse  1128 KNGNFKQVEAELIDKLDSMVSEGKGDESYRELFGLLTQLFGPYPSLLEKVEQE--TWRETGISFV 1190

  Fly  1171 ASVTRLLERLLDYRSVMQGEENRDKRMTCTVNLLNFYKNEINRKEMYLRYIYKLHNLHLQAENYT 1235
            .|||||:|||||||..|:|||..:|::.|||||:||||:|||::|||:|||:||.::||||||||
Mouse  1191 TSVTRLMERLLDYRDCMKGEETENKKVGCTVNLMNFYKSEINKEEMYIRYIHKLCDMHLQAENYT 1255

  Fly  1236 EAGFTLKLYASMLSW-DRETQSFAPFDNSGQPEWQRKERLYHEILKYFDKGKCWEKGIPLCKELA 1299
            ||.|||.||..:|.| ||..:.|..:.:  |.||||||.|..:|:.||:|||.||.|||||:|||
Mouse  1256 EAAFTLLLYCELLQWEDRPLREFLHYPS--QTEWQRKEGLCRKIIHYFNKGKSWEFGIPLCRELA 1318

  Fly  1300 HLYETRRFDYNKLSEILIQEAKFFQNILTQLRPEPEYFRVGFYGMGLPLFVRNKQFVYRGLEYER 1364
            ..||: .:||..||.|...||.::.||:.|.|.|||:|||||||...|.|:|||::|.||.:|||
Mouse  1319 CQYES-LYDYQSLSWIRKMEASYYDNIIEQQRLEPEFFRVGFYGRKFPFFLRNKEYVCRGHDYER 1382

  Fly  1365 IGAFTQRLQTEFPSAQILGNNSPPDNAILNAPDQYIQISNVRPVGD-AQALKTAMVPVPEKIARF 1428
            :.||.||:.:|||.|..:.:.:.||:|||....||:||..|.|:.| ...|:  |..||:::..|
Mouse  1383 LEAFQQRMLSEFPQAVAMQHPNHPDDAILQCDAQYLQIYAVTPIPDYVDVLQ--MDRVPDRVKSF 1445

  Fly  1429 YEVNDVTRFIYDRPMYKGTVDKDNEFKSLWIERTILEIASPLPGILRWYEVKQKTMQELTPVEYA 1493
            |.||:|.:|.||||.:||..||||||||||||||.|.:...||||.||:||:::.:.|::|:|.|
Mouse  1446 YRVNNVRKFRYDRPFHKGPKDKDNEFKSLWIERTTLTLTHSLPGISRWFEVERRELVEVSPLENA 1510

  Fly  1494 CEIISNAGKELSELIVQYK-RDPKRNINPFSMRLQGTIDANVMGGISKYQEAFFSEQFL-KSPQG 1556
            .:::.|..:||..||.||: :....|||..||.|.|.|||.|.|||::||||||.:.:: |.|
Mouse  1511 IQVVENKNQELRALISQYQHKQVHGNINLLSMCLNGVIDAAVNGGIARYQEAFFDKDYITKHP-- 1573

  Fly  1557 AGQQANVQRLKVLILEQIQILEQALELHGQLAPSGVQPLHNRLLERFSQLKQSLSGMGRLKRQHS 1621
             |....:.:||.|:.||:.:|...|.:|.:.....::|||.:|:::|..::.||        .|.
Mouse  1574 -GDAEKISQLKELMQEQVHVLGVGLAVHEKFVHPEMRPLHKKLIDQFQMMRASL--------YHE 1629

  Fly  1622 ESIVNTPLPPLPTEQRVAPATASSSLNANAHSNYVYDLDEIYTRPGDTVRPVDPLSSYQTLSKES 1686
                      .|...:::||.:.:|                 |..|:.      |:|:..:|.|:
Mouse  1630 ----------FPGLDKLSPACSGTS-----------------TPRGNV------LASHSPMSPEN 1661

  Fly  1687 LSIPLEDTAAPPVPNRPRSQNFIGNGSMDSPEVPPKRQPTLNSPNAPPLPPRGITPDKRASNPLI 1751
            :.          :.:|....|.:|.|...|..:         |.:|          ...|.|.::
Mouse  1662 IK----------MTHRHSPMNLMGTGRHSSSSL---------SSHA----------SSEAGNMMM 1697

  Fly  1752 FNDFGSGDA-VGRRHSQQQQQHGQKY-------SVVDISYDDPEAD--QQPHSLPPNFQDGSGGH 1806
            ..|...|:| ....|..|...|..:|       ||:..|...|.:.  ...||.|...
Mouse  1698 MGDNSMGEAPEDLYHHMQLAYHNPRYQGSVTNVSVLSSSQASPSSSSLSSTHSAPSQM------- 1755

  Fly  1807 LSVCFAPNDFRDSGISTTSSRELNHMNLNNLSEDSSSISTITVQHREHCRISSNGSLDYNAAASM 1871
              :..||:..|.|.......|....|.|            :...||:.     ..|..|.||...
Mouse  1756 --ITSAPSSTRGSPSLPDKYRHAREMML------------LLPTHRDR-----PSSAMYPAAILE 1801

  Fly  1872 NITQRESSTSSFDVEDF--------PVPPPPIPPKSLAVSSNGVNFSLDE-AHSPHPSTQANTTQ 1927
            |     ....:|....|        |...|.:.....||.:...::|||. |....|...|   .
Mouse  1802 N-----GQPPNFQRALFQQVVGACKPCSDPNLSMAEKAVPAAPSSWSLDSGAQEAQPFLSA---L 1858

  Fly  1928 LNHIQNPNQNHSTNSHHHLQQQQNGDGDGYSTLQHPMNGLGLPTLPPPPSAVESPMPASAIASST 1992
            :.||..|.....:..|.|....       :....||:.       ..||:     :||..:..|.
Mouse  1859 MGHIMVPPVPPRSLLHGHYSLH-------FDAFHHPLG-------DTPPA-----LPARTLRKSP 1904

  Fly  1993 SSHQHDGGTFXVTICRCHHPPDQPHQPHKPSSSTSTSDSTATDTASESTESSSST---HSMTPPP 2054
            .                 ||  .|..|..|.|....|:||.:.:||....|.|.:   ||...||
Mouse  1905 L-----------------HP--IPASPTSPQSGLDGSNSTLSGSASSGVSSLSESNFGHSSEAPP 1950

  Fly  2055 -------------------PPPPPPSSFTHLHHQMAAT------------THYCQDCL--SSPSP 2086
                               .||..|     :|:.::.:            :|....|:  ..|..
Mouse  1951 RTDTMDSMPSQAWNGDEDLEPPYLP-----VHYSLSESAVLDAIKSQPCRSHSAPGCVLPQDPMD 2010

  Fly  2087 PPTIITEQAQVHPTPGSTSAQPHIEH 2112
            ||.:  .....||      ..|.:||
Mouse  2011 PPAL--PPKPYHP------RLPALEH 2028

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
spg	NP_733258.4	SH3_DOCK_AB	9..64	CDD:212805	26/54 (48%)
		DOCK_N	67..406	CDD:292790	131/347 (38%)
		C2_Dock-B	414..600	CDD:176077	96/194 (49%)
		DHR2_DOCK	1215..1610	CDD:297424	192/398 (48%)
Dock3	XP_011241171.1	SH3_DOCK3_B	10..65	CDD:212981	26/54 (48%)
		DOCK_N	69..412	CDD:374409	131/358 (37%)
		C2_Dock-B	420..609	CDD:176077	96/194 (49%)
		DHR2_DOCK3	1235..1626	CDD:212577	192/398 (48%)
		Atrophin-1	1751..>2058	CDD:367360	70/363 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	488	1.000	Domainoid score	I378
eggNOG	1	0.900	-	-		E1_KOG1997
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H21030
Inparanoid	1	1.050	1302	1.000	Inparanoid score	I159
Isobase	1	0.950	-	0	Normalized mean entropy	S4615
OMA	1	1.010	-	-		QHG54452
OrthoDB	1	1.010	-	-		D102580at2759
OrthoFinder	1	1.000	-	-		FOG0000433
OrthoInspector	1	1.000	-	-		otm42399
orthoMCL	1	0.900	-	-		OOG6_100636
Panther	1	1.100	-	-	LDO	PTHR45653
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2355
SonicParanoid	1	1.000	-	-		X372
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	15	14.820