Protein Alignment spg and DOCK3

DIOPT Version :9

• Sequence 1: NP_733258.4
• Gene: spg / 43404
• FlyBaseID: FBgn0264324
• Length: 2187
• Species: Drosophila melanogaster
• Sequence 2: XP_005264971.1
• Gene: DOCK3 / 1795
• HGNCID: 2989
• Length: 2071
• Species: Homo sapiens
• Alignment Length: 2203
• Identity: 818/2203 - (37%)
• Similarity: 1200/2203 - (54%)
• Gaps: 299/2203 - (13%)

  Fly     1 MWIPS-NNKYGVAIHNWHGDVRFGLALDVGDSVDIVEECKHWYRGSCPRKSRAVGLFPKTYIHIK 64
            ||.|: ..||||.|.::.|.|..||.|::|::|.|:|:|:.||||...:|....|:||..|||:|
Human     1 MWTPTEEEKYGVVICSFRGSVPQGLVLEIGETVQILEKCEGWYRGVSTKKPNVKGIFPANYIHLK 65

  Fly    65 D------------LSKIDPVVAECTQVLREWSEIWKRLYVDREAYKFQTLRKVMFSILESRRELL 117
            .            :...|.:|.|.|..|:||:.:||:|||..:...|..||.||..:::.||:||
Human    66 KAIVSNRGQYETVVPLEDSIVTEVTATLQEWASLWKQLYVKHKVDLFYKLRHVMNELIDLRRQLL 130

  Fly   118 SATMTQDQTLELQMVVVSKIDWGNRKLGLDLVPREGPLAVDPHGIGIVKLYNVHVSSADNAKASS 182
            |..:||||..|::..:..::||||..||||||||:....||...|.:..||.:|:||..:.:.|:
Human   131 SGHLTQDQVREVKRHITVRLDWGNEHLGLDLVPRKDFEVVDSDQISVSDLYKMHLSSRQSVQQST 195

  Fly   183 SR-GTLRRK---TQRKILTHHLYFCMRDFGHRIGGDDAEVYFFLYDGSHMRPLSERFLVKISKDG 243
            |: .|:|.:   |.|..:.||.:..::.|.:...|:|.:|:|.|||....:.:||||||:::|:|
Human   196 SQVDTMRPRHGETCRMPVPHHFFLSLKSFTYNTIGEDTDVFFSLYDMREGKQISERFLVRLNKNG 260

  Fly   244 FSNYIERLHSNCTVFTDLGAADLNEELHLVAVVMRVGKIIQSDSIKKIEKSGTLGHGPT---FRR 305
            .....|::...|.:||||.:.|:..:|::||.|:|:|:::.:||.|          ||.   :||
Human   261 GPRNPEKIERMCALFTDLSSKDMKRDLYIVAHVIRIGRMLLNDSKK----------GPPHLHYRR 315

  Fly   306 PFGVGVLSLGDIAHFDSSLEQSSDEREYNFKLFQC-EEKDFHLLPELIIKKSSGKYSPIQASQGT 369
            |:|..|||:.|:.   .||.:..:|:::..|::.| .|.::..:.|.||:|||.|||   |...:
Human   316 PYGCAVLSILDVL---QSLTEVKEEKDFVLKVYTCNNESEWSQIHENIIRKSSAKYS---APSAS 374

  Fly   370 QGIVVSLKLLHGGLGQARQEQPMLF-QGSTITRKMGFPDVIMPGDVRNDLFLNLERGEFERGGKN 433
            .|:::||:||.|.:.|.|:|.||:| :|..||||:||||||||||:||||:|.||:|:||||||:
Human   375 HGLIISLQLLRGDMEQIRRENPMIFNRGLAITRKLGFPDVIMPGDIRNDLYLTLEKGDFERGGKS 439

  Fly   434 TGKNILVTVVVLDVAGNVLTDCLWGASGMESQPQYRSMILYHQNAPSWNEMLRLSVPIDKFSTAH 498
            ..|||.||:.||...|.:|.||:...||..::..|.|.:|||.|:|.|.|:::|.:|||:|..:|
Human   440 VQKNIEVTMYVLYADGEILKDCISLGSGEPNRSSYHSFVLYHSNSPRWGEIIKLPIPIDRFRGSH 504

  Fly   499 VRFEFRHCSTRDKTEPKLFAFSFARLMDTGGATLGDGLHELYVYKCEDPAKL-QVANYLRLQCRP 562
            :|||||||||:||.|.|||.|:|:.||...|.||.|.:||||||||::.:.. ..|.||.|.|
Human   505 LRFEFRHCSTKDKGEKKLFGFAFSTLMRDDGTTLSDDIHELYVYKCDENSTFNNHALYLGLPC-- 567

  Fly   563 RDAQAKMDCGGC--------FSRSSKEVFVLRSLLCSTKLTQNADLLSLLQWRTYPETIQDSLTG 619
                .|.|..||        |.||:||.|.:.:.|.|||||||.|||:||:|:.:|:.|.|.|..
Human   568 ----CKEDYNGCPNIPSSLIFQRSTKESFFISTQLSSTKLTQNVDLLALLKWKAFPDRIMDVLGR 628

  Fly   620 VLRLNDEELVKFLQDVLDALFAMFSNEEGNSTQHSGLVFHVLVSIFSLLQSNKFQHFRPVMNEYI 684
            :..::.||:||||||:||.||.:.   :.|:.::..|||..||.|.:||:..|:.||||||:.||
Human   629 LRHVSGEEIVKFLQDILDTLFVIL---DDNTEKYGLLVFQSLVFIINLLRDIKYFHFRPVMDTYI 690

  Fly   685 ENHFAAALVYKGLITSVEHMAVFMTKAEHPDPFQKCFGSLEYIFKLLIQSRKLFARATGGQYEDS 749
            :.|||.||.||.||..::.......:....|..|:...:|||:||.::|||.|::|||.|..|:.
Human   691 QKHFAGALAYKELIRCLKWYMDCSAELIRQDHIQEAMRALEYLFKFIVQSRILYSRATCGMEEEQ 755

  Fly   750 FKRDLHSLFTALNGMLAVPS--YDVIIPTQEALLNSTGVVLEQLKDTLPAPELGMLARNMLDAIP 812
            |:..:..||.::..:|::.|  .:.::.||.|||||...:.::|.......|:....|..|.::|
Human   756 FRSSIQELFQSIRFVLSLDSRNSETLLFTQAALLNSFPTIFDELLQMFTVQEVAEFVRGTLGSMP 820

  Fly   813 RGAPIRLIQA----KLHAVKDLVSGELFHEDDSRTVVLSVACKHLRMHLSRRDELRLCAEILSEI 873
              :.:.:.|:    ||.::...|...||...:||.::|.|...|:.:||.::.||.:|:.||..|
Human   821 --STVHIGQSMDVVKLQSIARTVDSRLFSFSESRRILLPVVLHHIHLHLRQQKELLICSGILGSI 883

  Fly   874 LSQLYDLQKEQREKVTNTLQHD----LDSLCKNILGILIRTISIIMEGSNA-------------- 920
            .|.:          .|::|:.|    ::.:.:::|.:|::|:..||..|:|
Human   884 FSIV----------KTSSLEADVMEEVEMMVESLLDVLLQTLLTIMSKSHAQEAVRGQRCPQCTA 938

  Fly   921 -VLPQLVSCLLGLLQLLDETHYKRYWDELSPNKDPRDLKEFLSKSLLVYEELLTQDWHVFPNDWL 984
             :..:.|||||.||:.:.:||::...|... :||  :|||||.|...|:..|:...  |||.||:
Human   939 EITGEYVSCLLSLLRQMCDTHFQHLLDNFQ-SKD--ELKEFLLKIFCVFRNLMKMS--VFPRDWM 998

  Fly   985 VMKLAANDVLRMSLEEFAKPLVYRFLGPQAFDSQLWWSYFSLAVAFLTQPSLQLEQYREPKRLKI 1049
            ||:|..::::..:::..:..|...|.... ||.::|.|||||||.|:.|||||||.....||.||
Human   999 VMRLLTSNIIVTTVQYLSSALHKNFTETD-FDFKVWNSYFSLAVLFINQPSLQLEIITSAKRKKI 1062

  Fly  1050 LHSHGDMRVLMGFQILSMWSQLGEQKLHFIPSMVGPFLEVTLVPEPALRKATLSVFYDMMQCEQA 1114
            |..:|||||:|.:::.|||..|||.|:||||.|:||||.|||||:|.:|...:.:|:|||..||.
Human  1063 LDKYGDMRVMMAYELFSMWQNLGEHKIHFIPGMIGPFLGVTLVPQPEVRNIMIPIFHDMMDWEQR 1127

  Fly  1115 ARGSFRLVESELIDKLDLLISENKGDDEYRELFSTI---------LLEKVQVENPNWKEAGIAFI 1170
            ..|:|:.||:|||||||.::||.|||:.||||||.:         |||||:.|  .|:|.||:|:
Human  1128 KNGNFKQVEAELIDKLDSMVSEGKGDESYRELFSLLTQLFGPYPSLLEKVEQE--TWRETGISFV 1190

  Fly  1171 ASVTRLLERLLDYRSVMQGEENRDKRMTCTVNLLNFYKNEINRKEMYLRYIYKLHNLHLQAENYT 1235
            .|||||:|||||||..|:|||..:|::.|||||:||||:|||::|||:|||:||.::||||||||
Human  1191 TSVTRLMERLLDYRDCMKGEETENKKIGCTVNLMNFYKSEINKEEMYIRYIHKLCDMHLQAENYT 1255

  Fly  1236 EAGFTLKLYASMLSW-DRETQSFAPFDNSGQPEWQRKERLYHEILKYFDKGKCWEKGIPLCKELA 1299
            ||.|||.||..:|.| ||..:.|..:.:  |.||||||.|..:|:.||:|||.||.|||||:|||
Human  1256 EAAFTLLLYCELLQWEDRPLREFLHYPS--QTEWQRKEGLCRKIIHYFNKGKSWEFGIPLCRELA 1318

  Fly  1300 HLYETRRFDYNKLSEILIQEAKFFQNILTQLRPEPEYFRVGFYGMGLPLFVRNKQFVYRGLEYER 1364
            ..||: .:||..||.|...||.::.||:.|.|.|||:|||||||...|.|:|||::|.||.:|||
Human  1319 CQYES-LYDYQSLSWIRKMEASYYDNIMEQQRLEPEFFRVGFYGRKFPFFLRNKEYVCRGHDYER 1382

  Fly  1365 IGAFTQRLQTEFPSAQILGNNSPPDNAILNAPDQYIQISNVRPVGD-AQALKTAMVPVPEKIARF 1428
            :.||.||:.:|||.|..:.:.:.||:|||....||:||..|.|:.| ...|:  |..||:::..|
Human  1383 LEAFQQRMLSEFPQAVAMQHPNHPDDAILQCDAQYLQIYAVTPIPDYVDVLQ--MDRVPDRVKSF 1445

  Fly  1429 YEVNDVTRFIYDRPMYKGTVDKDNEFKSLWIERTILEIASPLPGILRWYEVKQKTMQELTPVEYA 1493
            |.||:|.:|.||||.:||..||:|||||||||||.|.:...||||.||:||:::.:.|::|:|.|
Human  1446 YRVNNVRKFRYDRPFHKGPKDKENEFKSLWIERTTLTLTHSLPGISRWFEVERRELVEVSPLENA 1510

  Fly  1494 CEIISNAGKELSELIVQYK-RDPKRNINPFSMRLQGTIDANVMGGISKYQEAFFSEQFL-KSPQG 1556
            .:::.|..:||..||.||: :....|||..||.|.|.|||.|.|||::||||||.:.:: |.|
Human  1511 IQVVENKNQELRSLISQYQHKQVHGNINLLSMCLNGVIDAAVNGGIARYQEAFFDKDYINKHP-- 1573

  Fly  1557 AGQQANVQRLKVLILEQIQILEQALELHGQLAPSGVQPLHNRLLERFSQLKQSL----------- 1610
             |....:.:||.|:.||:.:|...|.:|.:.....::|||.:|:::|..::.||
Human  1574 -GDAEKITQLKELMQEQVHVLGVGLAVHEKFVHPEMRPLHKKLIDQFQMMRASLYHEFPGLDKLS 1637

  Fly  1611 ---SG----MGRLKRQHSESIVNTPLPP--LPTEQRVAPAT-------ASSSLNANAHS---NYV 1656
               ||    .|.:...||      |:.|  :....|.:|..       :||||:::|.|   |.|
Human  1638 PACSGTSTPRGNVLASHS------PMSPESIKMTHRHSPMNLMGTGRHSSSSLSSHASSEAGNMV 1696

  Fly  1657 YDLDEIYTRPGDTVRPVDPLSSYQTLSKESLSIPLEDTAAPPVPNRPRSQNFIGNGSMDSPEVPP 1721
                    ..||......|...|..:   .|:.|           .||.|..:.|.|:.|.....
Human  1697 --------MLGDGSMGDAPEDLYHHM---QLAYP-----------NPRYQGSVTNVSVLSSSQAS 1739

  Fly  1722 KRQPTLNSPNAPPLPPRGITPDKRASNPLIFNDFGSGDAVGRRHSQQQQQHGQKYSVVDISYDDP 1786
            ....:|:|.::.|.......|.....:|.:.:.:        ||:::.......|.      |.|
Human  1740 PSSSSLSSTHSAPSQMITSAPSSARGSPSLPDKY--------RHAREMMLLLPTYR------DRP 1790

  Fly  1787 EADQQPHSL-----PPNFQ----DGSGGHLSVCFAPNDFRDSGISTTSSRELNHMNLNNLSEDSS 1842
            .:...|.::     |||||    ....|....|..||
Human  1791 SSAMYPAAILENGQPPNFQRALFQQVVGACKPCSDPN---------------------------- 1827

  Fly  1843 SISTITVQHREHCRISSNGSLDYNAAASMNITQRESSTSSFDVEDFPVPPPPIPPKSLAVSSNGV 1907
                ::|..:......|:.|||..|..:..........         :..||:||:||......:
Human  1828 ----LSVAEKAVPAAPSSWSLDSGAQEAQPFLSAHMGR---------ILAPPVPPRSLLHGHYSL 1879

  Fly  1908 NFSLDEAHSP------------------HPSTQANTTQLNHIQNPNQNHSTNSHHHLQQQQNGDG 1954
            :|  |..|.|                  ||...:.|:..:.:...|...|.::...:......:
Human  1880 HF--DAFHHPLGDTPPALPARTLRKSPLHPIPASPTSPQSGLDGSNSTLSGSASSGVSSLSESN- 1941

  Fly  1955 DGYSTLQHPMNGL--GLPT--------LPPPPSAVESPMPASAIASSTSSHQHDGGTFXVTICRC 2009
            .|:|:...|....  .:|:        |.||...|...:..||:..|..:..          ||.
Human  1942 FGHSSEAPPRTDTMDSMPSQAWNADEDLEPPYLPVHYSLSESAVLDSIKAQP----------CRS 1996

  Fly  2010 H------------HPPDQPHQPHKPSSSTSTSDSTATDTASESTESSSSTHSMTPPPP 2055
            |            .||..|.:|:.|.......|...  ...|.||.....|...|.||
Human  1997 HSAPGCVIPQDPMDPPALPPKPYHPRLPALEHDEGV--LLREETERPRGLHRKAPLPP 2052

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
spg	NP_733258.4	SH3_DOCK_AB	9..64	CDD:212805	25/54 (46%)
		DOCK_N	67..406	CDD:292790	131/347 (38%)
		C2_Dock-B	414..600	CDD:176077	96/194 (49%)
		DHR2_DOCK	1215..1610	CDD:297424	191/398 (48%)
DOCK3	XP_005264971.1	SH3_DOCK3_B	10..65	CDD:212981	25/54 (46%)
		DOCK_N	69..412	CDD:292790	131/358 (37%)
		C2_Dock-B	420..609	CDD:176077	96/194 (49%)
		DHR2_DOCK3	1235..1626	CDD:212577	191/398 (48%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	490	1.000	Domainoid score	I376
eggNOG	1	0.900	-	-		E1_KOG1997
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H21030
Inparanoid	1	1.050	1308	1.000	Inparanoid score	I154
Isobase	1	0.950	-	0	Normalized mean entropy	S4615
OMA	1	1.010	-	-		QHG54452
OrthoDB	1	1.010	-	-		D102580at2759
OrthoFinder	1	1.000	-	-		FOG0000433
OrthoInspector	1	1.000	-	-		otm40333
orthoMCL	1	0.900	-	-		OOG6_100636
Panther	1	1.100	-	-	LDO	PTHR45653
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2355
SonicParanoid	1	1.000	-	-		X372
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.820