Protein Alignment spg and DOCK2

DIOPT Version :10

• Sequence 1: NP_733258.4
• Gene: spg / 43404
• FlyBaseID: FBgn0264324
• Length: 2187
• Species: Drosophila melanogaster
• Sequence 2: NP_004937.1
• Gene: DOCK2 / 1794
• HGNCID: 2988
• Length: 1830
• Species: Homo sapiens
• Alignment Length: 1980
• Identity: 702/1980 - (35%)
• Similarity: 1055/1980 - (53%)
• Gaps: 273/1980 - (13%)

  Fly     8 KYGVAIHNWHGDVRFGLALDVGDSVDIVEECKHWYRGSCPRKSRAVGLFPKTYIHIKDL------ 66
            ::||||:|:.|.....|:|.:||.|.|.|.|..||||...:.....|:|||::||||::
Human    11 RHGVAIYNFQGSGAPQLSLQIGDVVRIQETCGDWYRGYLIKHKMLQGIFPKSFIHIKEVTVEKRR 75

  Fly    67 -------SKIDPVVAECTQVLREWSEIWKRLYVDREAYKFQTLRKVMFSILESRRELLSATMTQD 124
                   ::| |:..|.|..|.||..|||:|||..:..:|..::.:|:.::|.|.:|||.|:.:|
Human    76 NTENIIPAEI-PLAQEVTTTLWEWGSIWKQLYVASKKERFLQVQSMMYDLMEWRSQLLSGTLPKD 139

  Fly   125 QTLELQMVVVSKIDWGNRKLGLDLVPR-EGPLAVDPHGIGIVKLYNVHVSSADN----------- 177
            :..||:..|.||||:||:.|.|||:.| |....:||....::.|::.|..:.|.
Human   140 ELKELKQKVTSKIDYGNKILELDLIVRDEDGNILDPDNTSVISLFHAHEEATDKITERIKEEMSK 204

  Fly   178 --------AKASSSRGTLRRKTQRKILTHHLYFCMRDFGHRIGGDDAEVYFFLYDGSHMRPLSER 234
                    ::.|||.            ||.||..:|:|..|| |:|||::..|||.:....:||.
Human   205 DQPDYAMYSRISSSP------------THSLYVFVRNFVCRI-GEDAELFMSLYDPNKQTVISEN 256

  Fly   235 FLVKISKDGFSNYIERLHSNCTVFTDLGAADLN-EELHLVAVVMRVGKIIQSDSIKKIEKSGTLG 298
            :||:....||...||.|::...||||||..||| ::::|:..::||||:...|:..|....|
Human   257 YLVRWGSRGFPKEIEMLNNLKVVFTDLGNKDLNRDKIYLICQIVRVGKMDLKDTGAKKCTQG--- 318

  Fly   299 HGPTFRRPFGVGVLSLGDIAHFDSSLEQSSDEREYNFKLFQ--CEEKDFHLLPELIIKKSSGKYS 361
                .||||||.|:.:.||.    ..:..|||.:.:|..|.  ..|.||  |..|:     ||..
Human   319 ----LRRPFGVAVMDITDII----KGKAESDEEKQHFIPFHPVTAENDF--LHSLL-----GKVI 368

  Fly   362 PIQASQGTQGIVVSLKLLHGGLGQARQEQPMLFQGST-ITRKMGFPDVIMPGDVRNDLFLNLERG 425
            ..:...|.||:.|::|:|.|.:.|.|::.|.|...:| :.||:|||::|||||||||:::.|.:|
Human   369 ASKGDSGGQGLWVTMKMLVGDIIQIRKDYPHLVDRTTVVARKLGFPEIIMPGDVRNDIYITLLQG 433

  Fly   426 EFERGGKNTGKNILVTVVVLDVAGNVLTDCLWGASGMESQPQYRSMILYHQNAPSWNEMLRLSVP 490
            :|::..|.|.:|:.|.:.|....|..|.:.:...:|.:...:|||::.|....|.|.|.::::||
Human   434 DFDKYNKTTQRNVEVIMCVCAEDGKTLPNAICVGAGDKPMNEYRSVVYYQVKQPRWMETVKVAVP 498

  Fly   491 IDKFSTAHVRFEFRHCS---TRDKTEPKLFAFSFARLMDTGGATLGDGLHELYVYKCEDPAKLQV 552
            |:.....|:||.|||.|   ::||.| |.||.|:.:||...|.||.||.|:|.|.| .|..|::.
Human   499 IEDMQRIHLRFMFRHRSSLESKDKGE-KNFAMSYVKLMKEDGTTLHDGFHDLVVLK-GDSKKMED 561

  Fly   553 AN-YLRLQCRPRDAQAKMDCGGCFSR----------SSKEVFVLRSLLCSTKLTQNADLLSLLQW 606
            |: ||.|.......:.|   |...||          ||::||.:.:|:||||||||..||.||:|
Human   562 ASAYLTLPSYRHHVENK---GATLSRSSSSVGGLSVSSRDVFSISTLVCSTKLTQNVGLLGLLKW 623

  Fly   607 RTYPETIQDSLTGVLRLNDEELVKFLQDVLDALFAMFSNEEGNSTQHSGLVFHVLVSIFSLLQSN 671
            |..|:.:|::|..:..::.||:||||||.|||||.:.. |...|.::..|||..|:.|..|:...
Human   624 RMKPQLLQENLEKLKIVDGEEVVKFLQDTLDALFNIMM-EHSQSDEYDILVFDALIYIIGLIADR 687

  Fly   672 KFQHFRPVMNEYIENHFAAALVYKGLITSVEHMAVFMTKAEHPDPFQKCFGSLEYIFKLLIQSRK 736
            |||||..|:..||:.||:|.|.||.|:|.::......::.|..:|..:...:|||:||.:::||.
Human   688 KFQHFNTVLEAYIQQHFSATLAYKKLMTVLKTYLDTSSRGEQCEPILRTLKALEYVFKFIVRSRT 752

  Fly   737 LFARATGGQYEDSFKRDLHSLFTALNGMLAVPSYDVIIPTQEALLNSTGVVLEQLKDTLPAPELG 801
            ||::...|:.:..|:..:..||.::|.::. ..|...|..|.|.|.....||..::....|..|.
Human   753 LFSQLYEGKEQMEFEESMRRLFESINNLMK-SQYKTTILLQVAALKYIPSVLHDVEMVFDAKLLS 816

  Fly   802 MLARNMLDAIPRGAPIRLIQAKLHAVKDLVSGELFHEDDSRTVVLSVACKHLRMHLSRRDEL--- 863
            .|.......||   |::|.:.|:.::.::|...||.:.:.|.::|.|..|.|:..|.::|::
Human   817 QLLYEFYTCIP---PVKLQKQKVQSMNEIVQSNLFKKQECRDILLPVITKELKELLEQKDDMQHQ 878

  Fly   864 ----RLCAEILSEILSQLYDLQKEQREKVTNTLQHDLDSLCKNILGILIRTIS---IIMEGSNAV 921
                :.|.|:|:.||..|      ..:....|..|     .:.|:..|:||::   |.|...:.:
Human   879 VLERKYCVELLNSILEVL------SYQDAAFTYHH-----IQEIMVQLLRTVNRTVITMGRDHIL 932

  Fly   922 LPQLVSCLLGLLQLLDETHYKRYWDELSPNKDPRDLKEFLSKSLLVYEELLTQDWHVFPNDWLVM 986
            :...|:|:..:|..:.:.||..|.:....:.   :|.:||.::.:::::|:.:  :|:|.||:.|
Human   933 ISHFVACMTAILNQMGDQHYSFYIETFQTSS---ELVDFLMETFIMFKDLIGK--NVYPGDWMAM 992

  Fly   987 KLAANDVLRMSLEEFAKPLVYRFLGPQAFDSQLWWSYFSLAVAFLTQPSLQLEQYREPKRLKILH 1051
            .:..|.|...::.:||:.:..:||....|:.|||.:||.|||||:||.||||||:...|..|||:
Human   993 SMVQNRVFLRAINKFAETMNQKFLEHTNFEFQLWNNYFHLAVAFITQDSLQLEQFSHAKYNKILN 1057

  Fly  1052 SHGDMRVLMGFQILSMWSQLGEQKLHFIPSMVGPFLEVTLVPEPALRKATLSVFYDMMQCEQAAR 1116
            .:||||.|:||.|..||.:||:.|:.|||.||||.||:||:||..|||||:.:|:|||.||....
Human  1058 KYGDMRRLIGFSIRDMWYKLGQNKICFIPGMVGPILEMTLIPEAELRKATIPIFFDMMLCEYQRS 1122

  Fly  1117 GSFRLVESELIDKLDLLISENKGDDEYRELFSTILLEKVQVENPNWKEAGIAFIASVTRLLERLL 1181
            |.|:..|:|:|.|||..:...:||::|.:|..:||:| ...|:|...::...|:..|..|||:||
Human  1123 GDFKKFENEIILKLDHEVEGGRGDEQYMQLLESILME-CAAEHPTIAKSVENFVNLVKGLLEKLL 1186

  Fly  1182 DYRSVMQGEENRDKRMTCTVNLLNFYKNEINRKEMYLRYIYKLHNLHLQAENYTEAGFTLKLYAS 1246
            |||.||. :|::|.||:||||||||||:. ||:|||:||:|||.:|||..:|||||.:||.|:..
Human  1187 DYRGVMT-DESKDNRMSCTVNLLNFYKDN-NREEMYIRYLYKLRDLHLDCDNYTEAAYTLLLHTW 1249

  Fly  1247 MLSWDRETQSFAPFDNSGQ--PEWQR--KERLYHEILKYFDKGKCWEKGIPLCKELAHLYETRRF 1307
            :|.|..| |..:....:||  |:..|  ||.||..|:.||||||.||:.|.||||||..||...|
Human  1250 LLKWSDE-QCASQVMQTGQQHPQTHRQLKETLYETIIGYFDKGKMWEEAISLCKELAEQYEMEIF 1313

  Fly  1308 DYNKLSEILIQEAKFFQNILTQLRPEPEYFRVGFYGMGLPLFVRNKQFVYRGLEYERIGAFTQRL 1372
            ||..||:.|||:|||:::|:..|||:|:||.||:||.|.|.|:|||.|:|||.||||...|..:|
Human  1314 DYELLSQNLIQQAKFYESIMKILRPKPDYFAVGYYGQGFPSFLRNKVFIYRGKEYERREDFQMQL 1378

  Fly  1373 QTEFPSAQILGNNSPPDNAILNAPDQYIQISNVRPVGDAQALKTAMVPVPEKIARFYEVNDVTRF 1437
            .|:||:|:.:...|.|.:.:.|||.||||...|:||.|... :....|||::|..||:.|.|.||
Human  1379 MTQFPNAEKMNTTSAPGDDVKNAPGQYIQCFTVQPVLDEHP-RFKNKPVPDQIINFYKSNYVQRF 1442

  Fly  1438 IYDRPMYKGTVDKDNEFKSLWIERTILEIASPLPGILRWYEVKQKTMQELTPVEYACEIISNAGK 1502
            .|.||:.:||||.:|||.|:|||||....|..|||||||:||...:...::|:|.|.|.:|.|.:
Human  1443 HYSRPVRRGTVDPENEFASMWIERTSFVTAYKLPGILRWFEVVHMSQTTISPLENAIETMSTANE 1507

  Fly  1503 ELSELIVQYKRDPKRNINPFSMRLQGTIDANVMGGISKYQEAFFSEQFLKS-PQGAGQQANVQRL 1566
            ::..:|.||:.|....|||.||.|.|.:|..||||.:||::|||:|::::. |:   .|..:..|
Human  1508 KILMMINQYQSDETLPINPLSMLLNGIVDPAVMGGFAKYEKAFFTEEYVRDHPE---DQDKLTHL 1569

  Fly  1567 KVLILEQIQILEQALELHGQLAPSGVQPLHNRLLERFSQLKQSLSGMGRLKRQHSESIVNTPLPP 1631
            |.||..||..|...:::|.:.....::|.|:|:.|.|..||        :|.:....:...|
Human  1570 KDLIAWQIPFLGAGIKIHEKRVSDNLRPFHDRMEECFKNLK--------MKVEKEYGVREMP--- 1623

  Fly  1632 LPTEQRVAPATASSSLNANAHSNYVYDLDEIYTRPGDTVRPVDPLSSYQTLSKESLSIPLEDTAA 1696
                                      |.|:  .|.|   ||...|.||:.:|..||:....|.:
Human  1624 --------------------------DFDD--RRVG---RPRSMLRSYRQMSIISLASMNSDCS- 1656

  Fly  1697 PPVPNRPRSQNFIGNGSMDSPEVPPKRQPTLNSPNAPPLPPRGITPDKRASNPLIFNDFGSGDAV 1761
              .|::|.|::|  :..:.||:.|...|       ..|:.|....|:                 |
Human  1657 --TPSKPTSESF--DLELASPKTPRVEQ-------EEPISPGSTLPE-----------------V 1693

  Fly  1762 GRRHSQQQQQHGQKYSVVDISYDDPEADQQPHSLPPNFQDGSGGHLSVCFAPNDFRDSGISTTSS 1826
            ..|.|:::.   ::.|||   :.|.:|                      .|.:|.:      ..|
Human  1694 KLRRSKKRT---KRSSVV---FADEKA----------------------AAESDLK------RLS 1724

  Fly  1827 RELNHMNLNNLSEDSSSISTITVQHREHCRISSNGSLDYNAAASMNITQRESSTSSFDVEDFPVP 1891
            |:...|:..|||              ||..|....|:              .|..||..:..|..
Human  1725 RKHEFMSDTNLS--------------EHAAIPLKASV--------------LSQMSFASQSMPTI 1761

  Fly  1892 PPPIPPKSLAVSSNGVNFSLDEAH-SPHPS 1920
            |      :||:|..|:. .||||: ||..|
Human  1762 P------ALALSVAGIP-GLDEANTSPRLS 1784

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
spg	NP_733258.4	SH3_DOCK_AB	9..64	CDD:212805	24/54 (44%)
		DOCK_N	67..406	CDD:465040	122/362 (34%)
		C2_Dock-B	414..600	CDD:176077	73/199 (37%)
		DHR2_DOCK	1215..1610	CDD:471388	185/399 (46%)
DOCK2	NP_004937.1	SH3_DOCK2_A	12..67	CDD:212983	24/54 (44%)
		DOCK_N	77..414	CDD:465040	122/368 (33%)
		C2	422..617	CDD:472691	73/199 (37%)
		Interaction with CRKL. /evidence=ECO:0000269|PubMed:12393632	939..1476		256/546 (47%)
		DHR2_DOCK2	1200..1620	CDD:212579	200/433 (46%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1651..1704		15/84 (18%)