DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment spg and DOCK2

DIOPT Version :9

Sequence 1:NP_733258.4 Gene:spg / 43404 FlyBaseID:FBgn0264324 Length:2187 Species:Drosophila melanogaster
Sequence 2:NP_004937.1 Gene:DOCK2 / 1794 HGNCID:2988 Length:1830 Species:Homo sapiens


Alignment Length:1980 Identity:701/1980 - (35%)
Similarity:1055/1980 - (53%) Gaps:273/1980 - (13%)


- Green bases have known domain annotations that are detailed below.


  Fly     8 KYGVAIHNWHGDVRFGLALDVGDSVDIVEECKHWYRGSCPRKSRAVGLFPKTYIHIKDLSKID-- 70
            ::||||:|:.|.....|:|.:||.|.|.|.|..||||...:.....|:|||::||||::: ::  
Human    11 RHGVAIYNFQGSGAPQLSLQIGDVVRIQETCGDWYRGYLIKHKMLQGIFPKSFIHIKEVT-VEKR 74

  Fly    71 -----------PVVAECTQVLREWSEIWKRLYVDREAYKFQTLRKVMFSILESRRELLSATMTQD 124
                       |:..|.|..|.||..|||:|||..:..:|..::.:|:.::|.|.:|||.|:.:|
Human    75 RNTENIIPAEIPLAQEVTTTLWEWGSIWKQLYVASKKERFLQVQSMMYDLMEWRSQLLSGTLPKD 139

  Fly   125 QTLELQMVVVSKIDWGNRKLGLDLVPR-EGPLAVDPHGIGIVKLYNVHVSSADN----------- 177
            :..||:..|.||||:||:.|.|||:.| |....:||....::.|::.|..:.|.           
Human   140 ELKELKQKVTSKIDYGNKILELDLIVRDEDGNILDPDNTSVISLFHAHEEATDKITERIKEEMSK 204

  Fly   178 --------AKASSSRGTLRRKTQRKILTHHLYFCMRDFGHRIGGDDAEVYFFLYDGSHMRPLSER 234
                    ::.|||.            ||.||..:|:|..|| |:|||::..|||.:....:||.
Human   205 DQPDYAMYSRISSSP------------THSLYVFVRNFVCRI-GEDAELFMSLYDPNKQTVISEN 256

  Fly   235 FLVKISKDGFSNYIERLHSNCTVFTDLGAADLN-EELHLVAVVMRVGKIIQSDSIKKIEKSGTLG 298
            :||:....||...||.|::...||||||..||| ::::|:..::||||:...|:..|....|   
Human   257 YLVRWGSRGFPKEIEMLNNLKVVFTDLGNKDLNRDKIYLICQIVRVGKMDLKDTGAKKCTQG--- 318

  Fly   299 HGPTFRRPFGVGVLSLGDIAHFDSSLEQSSDEREYNFKLFQ--CEEKDFHLLPELIIKKSSGKYS 361
                .||||||.|:.:.||.    ..:..|||.:.:|..|.  ..|.||  |..|:     ||..
Human   319 ----LRRPFGVAVMDITDII----KGKAESDEEKQHFIPFHPVTAENDF--LHSLL-----GKVI 368

  Fly   362 PIQASQGTQGIVVSLKLLHGGLGQARQEQPMLFQGST-ITRKMGFPDVIMPGDVRNDLFLNLERG 425
            ..:...|.||:.|::|:|.|.:.|.|::.|.|...:| :.||:|||::|||||||||:::.|.:|
Human   369 ASKGDSGGQGLWVTMKMLVGDIIQIRKDYPHLVDRTTVVARKLGFPEIIMPGDVRNDIYITLLQG 433

  Fly   426 EFERGGKNTGKNILVTVVVLDVAGNVLTDCLWGASGMESQPQYRSMILYHQNAPSWNEMLRLSVP 490
            :|::..|.|.:|:.|.:.|....|..|.:.:...:|.:...:|||::.|....|.|.|.::::||
Human   434 DFDKYNKTTQRNVEVIMCVCAEDGKTLPNAICVGAGDKPMNEYRSVVYYQVKQPRWMETVKVAVP 498

  Fly   491 IDKFSTAHVRFEFRHCS---TRDKTEPKLFAFSFARLMDTGGATLGDGLHELYVYKCEDPAKLQV 552
            |:.....|:||.|||.|   ::||.| |.||.|:.:||...|.||.||.|:|.|.| .|..|::.
Human   499 IEDMQRIHLRFMFRHRSSLESKDKGE-KNFAMSYVKLMKEDGTTLHDGFHDLVVLK-GDSKKMED 561

  Fly   553 AN-YLRLQCRPRDAQAKMDCGGCFSR----------SSKEVFVLRSLLCSTKLTQNADLLSLLQW 606
            |: ||.|.......:.|   |...||          ||::||.:.:|:||||||||..||.||:|
Human   562 ASAYLTLPSYRHHVENK---GATLSRSSSSVGGLSVSSRDVFSISTLVCSTKLTQNVGLLGLLKW 623

  Fly   607 RTYPETIQDSLTGVLRLNDEELVKFLQDVLDALFAMFSNEEGNSTQHSGLVFHVLVSIFSLLQSN 671
            |..|:.:|::|..:..::.||:||||||.|||||.:.. |...|.::..|||..|:.|..|:...
Human   624 RMKPQLLQENLEKLKIVDGEEVVKFLQDTLDALFNIMM-EHSQSDEYDILVFDALIYIIGLIADR 687

  Fly   672 KFQHFRPVMNEYIENHFAAALVYKGLITSVEHMAVFMTKAEHPDPFQKCFGSLEYIFKLLIQSRK 736
            |||||..|:..||:.||:|.|.||.|:|.::......::.|..:|..:...:|||:||.:::||.
Human   688 KFQHFNTVLEAYIQQHFSATLAYKKLMTVLKTYLDTSSRGEQCEPILRTLKALEYVFKFIVRSRT 752

  Fly   737 LFARATGGQYEDSFKRDLHSLFTALNGMLAVPSYDVIIPTQEALLNSTGVVLEQLKDTLPAPELG 801
            ||::...|:.:..|:..:..||.::|.::. ..|...|..|.|.|.....||..::....|..|.
Human   753 LFSQLYEGKEQMEFEESMRRLFESINNLMK-SQYKTTILLQVAALKYIPSVLHDVEMVFDAKLLS 816

  Fly   802 MLARNMLDAIPRGAPIRLIQAKLHAVKDLVSGELFHEDDSRTVVLSVACKHLRMHLSRRDEL--- 863
            .|.......||   |::|.:.|:.::.::|...||.:.:.|.::|.|..|.|:..|.::|::   
Human   817 QLLYEFYTCIP---PVKLQKQKVQSMNEIVQSNLFKKQECRDILLPVITKELKELLEQKDDMQHQ 878

  Fly   864 ----RLCAEILSEILSQLYDLQKEQREKVTNTLQHDLDSLCKNILGILIRTIS---IIMEGSNAV 921
                :.|.|:|:.||..|      ..:....|..|     .:.|:..|:||::   |.|...:.:
Human   879 VLERKYCVELLNSILEVL------SYQDAAFTYHH-----IQEIMVQLLRTVNRTVITMGRDHIL 932

  Fly   922 LPQLVSCLLGLLQLLDETHYKRYWDELSPNKDPRDLKEFLSKSLLVYEELLTQDWHVFPNDWLVM 986
            :...|:|:..:|..:.:.||..|.:....:.   :|.:||.::.:::::|:.:  :|:|.||:.|
Human   933 ISHFVACMTAILNQMGDQHYSFYIETFQTSS---ELVDFLMETFIMFKDLIGK--NVYPGDWMAM 992

  Fly   987 KLAANDVLRMSLEEFAKPLVYRFLGPQAFDSQLWWSYFSLAVAFLTQPSLQLEQYREPKRLKILH 1051
            .:..|.|...::.:||:.:..:||....|:.|||.:||.|||||:||.||||||:...|..|||:
Human   993 SMVQNRVFLRAINKFAETMNQKFLEHTNFEFQLWNNYFHLAVAFITQDSLQLEQFSHAKYNKILN 1057

  Fly  1052 SHGDMRVLMGFQILSMWSQLGEQKLHFIPSMVGPFLEVTLVPEPALRKATLSVFYDMMQCEQAAR 1116
            .:||||.|:||.|..||.:||:.|:.|||.||||.||:||:||..|||||:.:|:|||.||....
Human  1058 KYGDMRRLIGFSIRDMWYKLGQNKICFIPGMVGPILEMTLIPEAELRKATIPIFFDMMLCEYQRS 1122

  Fly  1117 GSFRLVESELIDKLDLLISENKGDDEYRELFSTILLEKVQVENPNWKEAGIAFIASVTRLLERLL 1181
            |.|:..|:|:|.|||..:...:||::|.:|..:||:| ...|:|...::...|:..|..|||:||
Human  1123 GDFKKFENEIILKLDHEVEGGRGDEQYMQLLESILME-CAAEHPTIAKSVENFVNLVKGLLEKLL 1186

  Fly  1182 DYRSVMQGEENRDKRMTCTVNLLNFYKNEINRKEMYLRYIYKLHNLHLQAENYTEAGFTLKLYAS 1246
            |||.||. :|::|.||:||||||||||:. ||:|||:||:|||.:|||..:|||||.:||.|:..
Human  1187 DYRGVMT-DESKDNRMSCTVNLLNFYKDN-NREEMYIRYLYKLRDLHLDCDNYTEAAYTLLLHTW 1249

  Fly  1247 MLSWDRETQSFAPFDNSGQ--PEWQR--KERLYHEILKYFDKGKCWEKGIPLCKELAHLYETRRF 1307
            :|.|..| |..:....:||  |:..|  ||.||..|:.||||||.||:.|.||||||..||...|
Human  1250 LLKWSDE-QCASQVMQTGQQHPQTHRQLKETLYETIIGYFDKGKMWEEAISLCKELAEQYEMEIF 1313

  Fly  1308 DYNKLSEILIQEAKFFQNILTQLRPEPEYFRVGFYGMGLPLFVRNKQFVYRGLEYERIGAFTQRL 1372
            ||..||:.|||:|||:::|:..|||:|:||.||:||.|.|.|:|||.|:|||.||||...|..:|
Human  1314 DYELLSQNLIQQAKFYESIMKILRPKPDYFAVGYYGQGFPSFLRNKVFIYRGKEYERREDFQMQL 1378

  Fly  1373 QTEFPSAQILGNNSPPDNAILNAPDQYIQISNVRPVGDAQALKTAMVPVPEKIARFYEVNDVTRF 1437
            .|:||:|:.:...|.|.:.:.|||.||||...|:||.|... :....|||::|..||:.|.|.||
Human  1379 MTQFPNAEKMNTTSAPGDDVKNAPGQYIQCFTVQPVLDEHP-RFKNKPVPDQIINFYKSNYVQRF 1442

  Fly  1438 IYDRPMYKGTVDKDNEFKSLWIERTILEIASPLPGILRWYEVKQKTMQELTPVEYACEIISNAGK 1502
            .|.||:.:||||.:|||.|:|||||....|..|||||||:||...:...::|:|.|.|.:|.|.:
Human  1443 HYSRPVRRGTVDPENEFASMWIERTSFVTAYKLPGILRWFEVVHMSQTTISPLENAIETMSTANE 1507

  Fly  1503 ELSELIVQYKRDPKRNINPFSMRLQGTIDANVMGGISKYQEAFFSEQFLKS-PQGAGQQANVQRL 1566
            ::..:|.||:.|....|||.||.|.|.:|..||||.:||::|||:|::::. |:   .|..:..|
Human  1508 KILMMINQYQSDETLPINPLSMLLNGIVDPAVMGGFAKYEKAFFTEEYVRDHPE---DQDKLTHL 1569

  Fly  1567 KVLILEQIQILEQALELHGQLAPSGVQPLHNRLLERFSQLKQSLSGMGRLKRQHSESIVNTPLPP 1631
            |.||..||..|...:::|.:.....::|.|:|:.|.|..||        :|.:....:...|   
Human  1570 KDLIAWQIPFLGAGIKIHEKRVSDNLRPFHDRMEECFKNLK--------MKVEKEYGVREMP--- 1623

  Fly  1632 LPTEQRVAPATASSSLNANAHSNYVYDLDEIYTRPGDTVRPVDPLSSYQTLSKESLSIPLEDTAA 1696
                                      |.|:  .|.|   ||...|.||:.:|..||:....|.: 
Human  1624 --------------------------DFDD--RRVG---RPRSMLRSYRQMSIISLASMNSDCS- 1656

  Fly  1697 PPVPNRPRSQNFIGNGSMDSPEVPPKRQPTLNSPNAPPLPPRGITPDKRASNPLIFNDFGSGDAV 1761
              .|::|.|::|  :..:.||:.|...|       ..|:.|....|:                 |
Human  1657 --TPSKPTSESF--DLELASPKTPRVEQ-------EEPISPGSTLPE-----------------V 1693

  Fly  1762 GRRHSQQQQQHGQKYSVVDISYDDPEADQQPHSLPPNFQDGSGGHLSVCFAPNDFRDSGISTTSS 1826
            ..|.|:::.   ::.|||   :.|.:|                      .|.:|.:      ..|
Human  1694 KLRRSKKRT---KRSSVV---FADEKA----------------------AAESDLK------RLS 1724

  Fly  1827 RELNHMNLNNLSEDSSSISTITVQHREHCRISSNGSLDYNAAASMNITQRESSTSSFDVEDFPVP 1891
            |:...|:..|||              ||..|....|:              .|..||..:..|..
Human  1725 RKHEFMSDTNLS--------------EHAAIPLKASV--------------LSQMSFASQSMPTI 1761

  Fly  1892 PPPIPPKSLAVSSNGVNFSLDEAH-SPHPS 1920
            |      :||:|..|:. .||||: ||..|
Human  1762 P------ALALSVAGIP-GLDEANTSPRLS 1784

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
spgNP_733258.4 SH3_DOCK_AB 9..64 CDD:212805 24/54 (44%)
DOCK_N 67..406 CDD:292790 121/375 (32%)
C2_Dock-B 414..600 CDD:176077 73/199 (37%)
DHR2_DOCK 1215..1610 CDD:297424 185/399 (46%)
DOCK2NP_004937.1 SH3_DOCK2_A 12..67 CDD:212983 24/54 (44%)
DOCK_N 71..414 CDD:292790 121/373 (32%)
C2 422..617 CDD:301316 73/199 (37%)
Interaction with CRKL. /evidence=ECO:0000269|PubMed:12393632 939..1476 256/546 (47%)
DHR2_DOCK2 1200..1620 CDD:212579 200/433 (46%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1651..1704 15/84 (18%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG54452
OrthoDB 1 1.010 - - D102580at2759
OrthoFinder 1 1.000 - - FOG0000433
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100636
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X372
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
76.830

Return to query results.
Submit another query.