DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment spg and DOCK1

DIOPT Version :9

Sequence 1:NP_733258.4 Gene:spg / 43404 FlyBaseID:FBgn0264324 Length:2187 Species:Drosophila melanogaster
Sequence 2:NP_001364472.1 Gene:DOCK1 / 1793 HGNCID:2987 Length:1919 Species:Homo sapiens


Alignment Length:2184 Identity:737/2184 - (33%)
Similarity:1096/2184 - (50%) Gaps:411/2184 - (18%)


- Green bases have known domain annotations that are detailed below.


  Fly     2 WIPS--NNKYGVAIHNWHGDVRFGLALDVGDSVDIVEECKHWYRGSCPRKSRAVGLFPKTYIHIK 64
            |:|:  ..|||||.:|:.......|:|.:||:|.|:|..:.||||...||....|:||.:|||:|
Human     4 WVPTKREEKYGVAFYNYDARGADELSLQIGDTVHILETYEGWYRGYTLRKKSKKGIFPASYIHLK 68

  Fly    65 ----------------DLSKIDPVVAECTQVLREWSEIWKRLYVDREAYKFQTLRKVMFSILESR 113
                            ||    |::.|.|..|||||.||::|||......|:::|.:::.::|.|
Human    69 EAIVEGKGQHETVIPGDL----PLIQEVTTTLREWSTIWRQLYVQDNREMFRSVRHMIYDLIEWR 129

  Fly   114 RELLSATMTQDQTLELQMVVVSKIDWGNRKLGLDLVPR-EGPLAVDPHGIGIVKLYNVHVSSADN 177
            .::||.|:.||:..||:..|.:|||:|||.|.||||.| |....:||.....:.|:..|..::..
Human   130 SQILSGTLPQDELKELKKKVTAKIDYGNRILDLDLVVRDEDGNILDPELTSTISLFRAHEIASKQ 194

  Fly   178 A-----KASSSRGTLRRKTQRKIL---THHLYFCMRDFGHRIGGDDAEVYFFLYDGSHMRPLSER 234
            .     :..|.:..:....|.|..   :..|:..:::...:| |:||||...|||....:.:||.
Human   195 VEERLQEEKSQKQNIDINRQAKFAATPSLALFVNLKNVVCKI-GEDAEVLMSLYDPVESKFISEN 258

  Fly   235 FLVKISKDGFSNYIERLHSNCTVFTDLGAADL-NEELHLVAVVMRVGKI-IQSDSIKKIEKSGTL 297
            :||:.|..|....|:|||:...||||||:.|| .|::..|..::|||:: ::.::.:|:    |.
Human   259 YLVRWSSSGLPKDIDRLHNLRAVFTDLGSKDLKREKISFVCQIVRVGRMELRDNNTRKL----TS 319

  Fly   298 GHGPTFRRPFGVGVLSLGDIAHFDSSLEQSSDEREYNFKLFQ--CEEKDFHLLPELIIKKSSGKY 360
            |    .||||||.|:.:.||.:     .:..||.:.:|..||  ..|.||  |..:|.|..:.| 
Human   320 G----LRRPFGVAVMDVTDIIN-----GKVDDEDKQHFIPFQPVAGENDF--LQTVINKVIAAK- 372

  Fly   361 SPIQASQGTQGIVVSLKLLHGGLGQARQEQPMLFQGST-ITRKMGFPDVIMPGDVRNDLFLNLER 424
               :.:...||:.|:||||.|.:.|.|:|.|.|...:| :.||.|||::|||||||||:::.|.:
Human   373 ---EVNHKGQGLWVTLKLLPGDIHQIRKEFPHLVDRTTAVARKTGFPEIIMPGDVRNDIYVTLVQ 434

  Fly   425 GEFERGGKNTGKNILVTVVVLDVAGNVLTDCLWGASGMESQPQYRSMILYHQNAPSWNEMLRLSV 489
            |:|::|.|.|.||:.|||.|.|..|..|...::..:|.|:..:|:|:|.|....|.|.|.:::::
Human   435 GDFDKGSKTTAKNVEVTVSVYDEDGKRLEHVIFPGAGDEAISEYKSVIYYQVKQPRWFETVKVAI 499

  Fly   490 PIDKFSTAHVRFEFRHCS---TRDKTEPKLFAFSFARLMDTGGATLGDGLHELYVYKCEDPAKLQ 551
            ||:..:.:|:||.|||.|   ::||:| |:||.:|.:||...|.||.||.|:|.|||.|......
Human   500 PIEDVNRSHLRFTFRHRSSQDSKDKSE-KIFALAFVKLMRYDGTTLRDGEHDLIVYKAEAKKLED 563

  Fly   552 VANYLRLQCRPRDAQAK---------MDCGGCFSRSSKEVFVLRSLLCSTKLTQNADLLSLLQWR 607
            .|.||.|.....:.:.|         ...|.|  ..||:.|.:.:|:||||||||.|||.||:||
Human   564 AATYLSLPSTKAELEEKGHSATGKSMQSLGSC--TISKDSFQISTLVCSTKLTQNVDLLGLLKWR 626

  Fly   608 TYPETIQDSLTGVLRLNDEELVKFLQDVLDALF-AMFSNEEGNSTQHSGLVFHVLVSIFSLLQSN 671
            :....:|.:|..:::::..|:||||||.||||| .|..|.|  |.....|||..||.|..|:...
Human   627 SNTSLLQQNLRQLMKVDGGEVVKFLQDTLDALFNIMMENSE--SETFDTLVFDALVFIIGLIADR 689

  Fly   672 KFQHFRPVMNEYIENHFAAALVYKGLITSVEHMAVFMTKAEHP---DPFQKCFGSLEYIFKLLIQ 733
            |||||.||:..||:.||:|.|.|..|...:::   ::..||.|   :...|...:||.|||.:::
Human   690 KFQHFNPVLETYIKKHFSATLAYTKLTKVLKN---YVDGAEKPGVNEQLYKAMKALESIFKFIVR 751

  Fly   734 SRKLFARATGGQYEDSFKRDLHSLFTALNGMLAVPSYDVIIPTQEALLNSTGVVLEQLKDTLPAP 798
            ||.||.:....:.|..|...|..||.::|.|::..| |..:..:.|.|.....::..:|......
Human   752 SRILFNQLYENKGEADFVESLLQLFRSINDMMSSMS-DQTVRVKGAALKYLPTIVNDVKLVFDPK 815

  Fly   799 ELGMLARNMLDAIPRGAPIRLIQAKLHAVKDLVSGELFHEDDSRTVVLSVACKHLRMHLSRRDEL 863
            ||..:....:..:|.|  :..|| ||:.:.::|..:||.:.|.|.::|.:....|:.||.|:::|
Human   816 ELSKMFTEFILNVPMG--LLTIQ-KLYCLIEIVHSDLFTQHDCREILLPMMTDQLKYHLERQEDL 877

  Fly   864 RLCAEILSEILSQLYDLQKEQREKVTNTLQHDLDSLCKNILGILIRTIS---IIMEGSNAVLPQL 925
            ..|.::||.||..||      |:.|..|.:|     .:.|:..|:||::   |.|...:.::...
Human   878 EACCQLLSHILEVLY------RKDVGPTQRH-----VQIIMEKLLRTVNRTVISMGRDSELIGNF 931

  Fly   926 VSCLLGLLQLLDETHY----KRYWDELSPNKDPRDLKEFLSKSLLVYEELLTQDWHVFPNDWLVM 986
            |:|:..:|:.:::.||    |.:      .|...|:.:||.::.::::.|:.:  :|:|.||::|
Human   932 VACMTAILRQMEDYHYAHLIKTF------GKMRTDVVDFLMETFIMFKNLIGK--NVYPFDWVIM 988

  Fly   987 KLAANDVLRMSLEEFAKPLVYRFLGPQAFDSQLWWSYFSLAVAFLTQPSLQLEQYREPKRLKILH 1051
            .:..|.|...::.::|..|..:||....|:.|||.:||.||||||||.|||||.:...||.|||:
Human   989 NMVQNKVFLRAINQYADMLNKKFLDQANFELQLWNNYFHLAVAFLTQESLQLENFSSAKRAKILN 1053

  Fly  1052 SHGDMRVLMGFQILSMWSQLGEQKLHFIPSMVGPFLEVTLVPEPALRKATLSVFYDMMQCEQAAR 1116
            .:||||..:||:|..||..||:.|:.|||.||||.||:||:||..|||||:.:|:||||||..:.
Human  1054 KYGDMRRQIGFEIRDMWYNLGQHKIKFIPEMVGPILEMTLIPETELRKATIPIFFDMMQCEFHST 1118

  Fly  1117 GSFRLVESELIDKLDLLISENKGDDEYRELFSTILLEKVQVENPNWKEAGIAFIASVTRLLERLL 1181
            .||::.|:|:|.|||..:...:||::|:.||..||||..: ::....:.|..|:..|.||:||||
Human  1119 RSFQMFENEIITKLDHEVEGGRGDEQYKVLFDKILLEHCR-KHKYLAKTGETFVKLVVRLMERLL 1182

  Fly  1182 DYRSVMQGEENRDKRMTCTVNLLNFYKNEINRKEMYLRYIYKLHNLHLQAENYTEAGFTLKLYAS 1246
            |||::|. :||::.||:||||:||||| ||.|:|||:||:|||.:||.:.:|||||.:||.|:|.
Human  1183 DYRTIMH-DENKENRMSCTVNVLNFYK-EIEREEMYIRYLYKLCDLHKECDNYTEAAYTLLLHAK 1245

  Fly  1247 MLSWDRE------TQSFAPFDN-SGQPEWQRKERLYHEILKYFDKGKCWEKGIPLCKELAHLYET 1304
            :|.|..:      ||.    |. ....:.|.||:||.||:.||||||.||:.|.|.||||..||.
Human  1246 LLKWSEDVCVAHLTQR----DGYQATTQGQLKEQLYQEIIHYFDKGKMWEEAIALGKELAEQYEN 1306

  Fly  1305 RRFDYNKLSEILIQEAKFFQNILTQLRPEPEYFRVGFYGMGLPLFVRNKQFVYRGLEYERIGAFT 1369
            ..|||.:|||:|.::|:|::||:..:||:|:||.||:||.|.|.|:|.|.|:|||.||||...|.
Human  1307 EMFDYEQLSELLKKQAQFYENIVKVIRPKPDYFAVGYYGQGFPTFLRGKVFIYRGKEYERREDFE 1371

  Fly  1370 QRLQTEFPSAQILGNNSPPDNAILNAPDQYIQISNVRP--------------------------- 1407
            .||.|:||:|:.:...|||.:.|.|:|.||||...|:|                           
Human  1372 ARLLTQFPNAEKMKTTSPPGDDIKNSPGQYIQCFTVKPKLDLPPKFHRPVSEQIVRGLKQIVTLR 1436

  Fly  1408 -------------------------VGDAQAL---KTAMVPVPEKIARFYEVNDVTRFIYDRPMY 1444
                                     |....||   |..:||.|..   ||.||:|.||.|.||:.
Human  1437 AFSDAVVSFAVEACLHFSAGEKSVSVSPRPALCMRKACLVPRPRS---FYRVNEVQRFEYSRPIR 1498

  Fly  1445 KGTVDKDNEFKSLWIERTILEIASPLPGILRWYEVKQKTMQELTPVEYACEIISNAGKELSELIV 1509
            ||..:.||||.::||||||...|..|||||||:|||...|.|::|:|.|.|.:.....:::.::.
Human  1499 KGEKNPDNEFANMWIERTIYTTAYKLPGILRWFEVKSVFMVEISPLENAIETMQLTNDKINSMVQ 1563

  Fly  1510 QYKRDPKRNINPFSMRLQGTIDANVMGGISKYQEAFFSEQFLKSPQGAGQQANVQRLKVLILEQI 1574
            |:..||...|||.||.|.|.:|..||||.:.|::|||::::|:....|.::  :::||.||..||
Human  1564 QHLDDPSLPINPLSMLLNGIVDPAVMGGFANYEKAFFTDRYLQEHPEAHEK--IEKLKDLIAWQI 1626

  Fly  1575 QILEQALELHGQLAPSGVQPLHNRLLERFSQLKQSLSGMGRLKRQHSESIVNTPLPPLPTEQRVA 1639
            ..|.:.:.:||......::|.|.|:...|.|||:      ::::::.              .|:.
Human  1627 PFLAEGIRIHGDKVTEALRPFHERMEACFKQLKE------KVEKEYG--------------VRIM 1671

  Fly  1640 PATASSSLNANAHSNYVYDLDEIYTRPGDTVRPVDPLSSYQTLSKESLSIPLEDTAAPPVPNRPR 1704
            |    |||:           |...:||...||.....||.:.||..|:|....|:    .|:||.
Human  1672 P----SSLD-----------DRRGSRPRSMVRSFTMPSSSRPLSVASVSSLSSDS----TPSRPG 1717

  Fly  1705 SQNFIGNGSMDSPEVPPKRQPTLNSPNAPPLPPRGITPDKRASNPLIFNDFGSGDAVGRRHSQQQ 1769
            |..|    ::: |.:|.|    ::|.:...|....:..:|:....            .:|:|:.|
Human  1718 SDGF----ALE-PLLPKK----MHSRSQDKLDKDDLEKEKKDKKK------------EKRNSKHQ 1761

  Fly  1770 QQHGQKYSVVDISYDDPEA-----------DQQPHSLPPNFQDGSGGHLSVCFAPNDFRDSGIST 1823
            :...:::...|||....||           .|:|.|...|. .||....||  :|          
Human  1762 EIFEKEFKPTDISLQQSEAVILSETISPLRPQRPKSQVMNV-IGSERRFSV--SP---------- 1813

  Fly  1824 TSSRELNHMNLNNLSEDSSSISTITVQHREHCRISSNGSLDYNAAASMNITQRESSTSSFDVEDF 1888
                          |..||..:...|..|.....|...||:.|            ..:..||.|.
Human  1814 --------------SSPSSQQTPPPVTPRAKLSFSMQSSLELN------------GMTGADVADV 1852

  Fly  1889 PVPPPPIPPKSLAVSSNGVNFSLDEAHSPHPSTQANTTQLNHIQNPNQNHSTNSHHHLQQQQNGD 1953
               |||:|.|                                                     |.
Human  1853 ---PPPLPLK-----------------------------------------------------GS 1861

  Fly  1954 GDGYSTLQHPMNGLGLPTLPPPPSAVESPMPASAIASSTSSHQHDGGTFXVTICRCHHPPDQPHQ 2018
            ...|..|....:.||.||.||||                                       |||
Human  1862 VADYGNLMENQDLLGSPTPPPPP---------------------------------------PHQ 1887

  Fly  2019 PHKPSSSTSTSDSTATDTASESTESSSSTHSMTPPPPPP 2057
            .|.|                      ....|.|||||||
Human  1888 RHLP----------------------PPLPSKTPPPPPP 1904

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
spgNP_733258.4 SH3_DOCK_AB 9..64 CDD:212805 24/54 (44%)
DOCK_N 67..406 CDD:292790 119/352 (34%)
C2_Dock-B 414..600 CDD:176077 76/197 (39%)
DHR2_DOCK 1215..1610 CDD:297424 182/456 (40%)
DOCK1NP_001364472.1 SH3_DOCK1_5_A 13..68 CDD:212984 24/54 (44%)
DOCK_N 72..416 CDD:406558 121/367 (33%)
C2_Dock-A 424..619 CDD:176076 76/197 (39%)
DHR2_DOCK 1214..1666 CDD:414667 182/466 (39%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1997
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG54452
OrthoDB 1 1.010 - - D102580at2759
OrthoFinder 1 1.000 - - FOG0000433
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100636
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R2355
SonicParanoid 1 1.000 - - X372
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
98.760

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