DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment spg and ced-5

DIOPT Version :9

Sequence 1:NP_733258.4 Gene:spg / 43404 FlyBaseID:FBgn0264324 Length:2187 Species:Drosophila melanogaster
Sequence 2:NP_501938.1 Gene:ced-5 / 177942 WormBaseID:WBGene00000419 Length:1781 Species:Caenorhabditis elegans


Alignment Length:1868 Identity:466/1868 - (24%)
Similarity:811/1868 - (43%) Gaps:272/1868 - (14%)


- Green bases have known domain annotations that are detailed below.


  Fly    24 LALDVGDSVDIVEECKHW-YRGSCPRKSRAVGLFPKTYIHIKDLSKIDP------VVAECTQVLR 81
            |.|.:||.:.:..:...| |......|:...|:||..|:.|...|....      ||.|.::|:.
 Worm    27 LELFIGDRICVYGQHGEWGYGRKFDEKNGKCGIFPLAYVQ
IVQKSMFVSTSDGYLVVDEISRVIN 91

  Fly    82 EWSEIWKRLYVDREAY-KFQTLRKVMFSILESRRELLSATMTQDQTLELQMVVVSKIDWGNRKLG 145
            ||....|.|.|:.... .|:.|......:|..:.::.|..:..::..:|::.|...:|.||..||
 Worm    92 EWWTKIKELMVETTRIGSFEDLMDSFNELLIIKTKIESGGIPIEELSKLRLRVSKLVDRGNTILG 156

  Fly   146 LDLVPR-EGPLAVDPHGIGIVKLYNVHVSSADNAKASSSRGTLRRK---------------TQRK 194
            .|:|.| |..:.:|...:.:::.|..|:||....      |:|.|:               :.:.
 Worm   157 QDVVIRNEEGVPLDVESLSLLRTYEAHISSKGRV------GSLMREKPENVTINDSFSLLLSIKS 215

  Fly   195 ILTHHLYFCMRDFGHRIGGDDAEVYFFLYDGSHMRPLSERFLVKISKDGFSNYIERLHSNC---T 256
            :..|..|.|             |:...|||      |.::.....|.....|.....|::.   .
 Worm   216 VELHCKYSC-------------EISISLYD------LDKKMFTTDSYTFLWNSGSGKHTDLNLKA 261

  Fly   257 VFTDLGAADLNEELHLVAVVMRVGKIIQSDSIKKIEKSGTLGHG-------PTF--RRPFGVGVL 312
            :|||....|:.::..:|..|:.|..|..|::..:       .||       .||  |:.:...::
 Worm   262 LFTDFAKEDIQKKYLMVTRVVHVSPIESSNATMR-------KHGHHEATIPKTFYCRQSYASDIM 319

  Fly   313 SLGDIAHFDSSLEQSSDEREYNFKLFQCEEKDFHLLPELIIKKSSGKYSPIQASQGTQGI----- 372
            .:..|  |.:.:...:.||    .:|...|      |||.:.        ::|...|..|     
 Worm   320 EMSSI--FLAGVGHEAKER----VIFLNRE------PELPLS--------LKAYHATNRIPKNLS 364

  Fly   373 -------VVSLKLLHGGLGQARQEQPMLFQ--GSTITRKMGFPDVIMPGDVRNDLFLNLERGEFE 428
                   ::|.:|:.|.:.|.:...|.||.  .:.|.|:.....|.:. |.||::::.|.:.|. 
 Worm   365 NDMETKLLISTQLVPGNVSQIKARHPHLFS
RCPAAILRRADRTAVSIE-DSRNEMYITLMQAEL- 427

  Fly   429 RGGKNTGKNILVTVVVLDVAGNVLTDCL--WGASGMESQPQYRSMILYHQNAPSWNEMLRLSVPI 491
             .||::.:||...:.|::..|:|:.:..  ...:|.:....|:|:::||.:.|.|.|.:::::|.
 Worm   428 -SGKSSDRNIEARLHVVESNGHVMENVFETISVTGSQLSTVYKSIVVYHTDKPMWTEPIKIALPS 491

  Fly   492 DKFSTAHVRFEFRHCSTRDKTEPKLFAFSFARL-MDTGGATLGDGLHELYVYKCEDP-AKLQVAN 554
            ......::|..|......||.:|:...|:.|.: :....|.|.||.|:|.|||.::| :....:|
 Worm   492 CASHDVYLRILFYSKKAYDKPKPEKGPFAIAHVQLIRSSALLCDGEHDLAVYKIDNPGSHFDESN 556

  Fly   555 --YLRLQCRPRD-----AQAKMDCGGCFSRSSKEVFVLRSLLCSTKLTQNADLLSLLQWRTYPET 612
              |:.|....|.     ..||....| ||.|.|...::.:..||:.||||..||::|:||.....
 Worm   557 VHYMNLPDTRRTLKESIGSAKPHSQG-FSLSDKSFVMISTHSCSSMLTQNEHLLNVLRWRVNCVN 620

  Fly   613 IQDSLTGVLRL---NDEELVKFLQDVLDALFAMFSNEEGNSTQHSGLVFHVLVSIFSLLQSNK-F 673
            :..||..:.:.   .:.|:::|...:|||||.::.:.|.:..    :||.|:|::..:.:..: :
 Worm   621 LTSSLVALAQPIGDTEHEMIRFFSHLLDALFEIWHDRETSEK----VVFDVIVAVLRICEEPRHY 681

  Fly   674 QHFRPVMNEYIENHFAAALVYKGLITSVEHMAVFMTKAEHPDPFQK---CFGSLEYIFKLLIQSR 735
            .....:...|::.....:...| ::..:.|..:    ::..|..:|   .|..:..:|||::.|:
 Worm   682 PQAAKIFEVYLKRFSFTSAALK-ILKCLNHYVI----SDSEDSNEKARNAFKVMGPLFKLVVVSK 741

  Fly   736 KLFAR--------ATGGQYEDSFKRDLHSLFTALNGMLAVPSYDV-IIPTQEALLNSTGVVLEQL 791
            |...:        .|..||...|.:.|.:|.:.....:.|.:..: .|||...|||.:..|    
 Worm   742 KCGIKFEEFDDFEKTYKQYLREFMKSLVALMSEKKAKMTVQNTALKSIPTIIDLLNESDSV---- 802

  Fly   792 KDTLPAPELGMLARNMLDAIPRGAPIRLIQAKLHAVKDLVSGELFHEDDSRTVVLSVACKHLRMH 856
                 :||  .|...::|.:.......:.:.:|:.:..:|....|.....|..:| :.|..:.:.
 Worm   803 -----SPE--NLCGFIVDLMNNFGSNIVTRERLNFIAQIVETRFFSLSICREQLL-IPCLQIALD 859

  Fly   857 LSRRDELRL-----------CAEILSEILSQLYDLQKEQREKVTNTLQHDLDSLCKNILGILIRT 910
            :.:.|.:..           ||.|::.||.:|:...|.........|...:..:.:.::..:||.
 Worm   860 IIQIDNMATEKGEFADRAAECASIIAAILERLFADAKSGEGNAERELTSFILMVYRPLVQAMIRV 924

  Fly   911 ISIIMEGSNAVLPQLVSCLLGLLQLLDETHYKRYWDELSPNKDPRDLKEFLSKSLLVYEELLTQD 975
            |.......:.......|.:|.||..:....:..|.:|.|.:.|.||   ||.:.:.:..:||.: 
 Worm   925 IHDDKHTDDDARGHFFSVILALLDKMSAQMFSEYVEERSSDIDKRD---FLMEMVQMIRDLLNR- 985

  Fly   976 WHVFPNDWLVMKLAANDVLRMSLEEFAKPLVYRFLGPQAFDSQLWWSYFSLAVAFLTQPSLQLEQ 1040
             :.||:.|..|.:..|.|:..|| .|....|..|.....|..::|..|....|:|:||..|    
 Worm   986 -NAFPSTWKDMIMLQNKVIHKSL-RFVMSAVQTFFSNDKFCVEMWREYMVTVVSFVTQEGL---- 1044

  Fly  1041 YREPKRLKILHSHGDMRVLM----GFQILSMWSQL-GEQKLHFIPSMVGPFLEVTLVPEPALRKA 1100
              ..|...:.:...|||:.:    ...:.|||.:| ..|||::||||:|.||:|:||.:...|:|
 Worm  1045 --NSKHEWMKNEDEDMRIQLRKAAAKDLRSMWFRLTPSQKLNYIPSMIGSFLKVSLVDDDETREA 1107

  Fly  1101 TLSVFYDMMQCE--QAARGSFRLVESELIDKLDLLISENKGDDEYRELFSTILLEKVQVENPNWK 1163
            |:.:|:||||.|  .:|..||....|||:.:||..:.::.....::|.|..:.:...|.:.....
 Worm  1108 TIPIFFDMMQTEYNTSASRSFTEFASELVSQLDTNVDQHSATKGFKEHFRQLSITLCQSDKELMA 1172

  Fly  1164 EAGIAFIASVTRLLERLLDYRSVMQGE--ENRDKRMTCTVNLLNFYKNEINRKEMYLRYIYKLHN 1226
            ..|...|..:.|||..|::|..|....  |..|..|:.||.|:.:| |:.:.||:|::|||||::
 Worm  1173 NGGEELIERIDRLLTALIEYHEVASKSLVECVDSLMSRTVQLMRYY-NQYSHKELYVKYIYKLYD 1236

  Fly  1227 LHLQAENYTEAGFTLKLYASMLSWDRETQSFAPFDNSGQPEW--------------QRKERLYHE 1277
            ||....|..||..||..:|:||:          ||:...|:|              |.||.|..|
 Worm  1237 LHTSYGNKIEAAKTLLRHATMLT----------FDDDALPQWLIARSLNRHRELHRQLKEDLMEE 1291

  Fly  1278 ILKYFDKGKCWEKGIPLCKELAHLYETRRFDYNKLSEILIQEAKFFQNILTQLRPEPEYFRVGFY 1342
            ....|.||:.||..:.:..:|..:|:....||:||:.:|.:.|:.:.:|....|....|:.|.||
 Worm  1292 AGNLFSKGEDWEDALIVYNQLVPVYQNIIMDYDKLAGLLQKIAQLYTSISRTERAYFYYYLVAFY 1356

  Fly  1343 GMGLPLFVRNKQFVYRGLEYERIGAFTQRLQTEFPSAQILGNNSPPDNAILNAPDQYIQISNVRP 1407
            |.|.|.::...:||:|..:.|..|.|.||:...:.:.:.:....|..: ::::|.:|||:.|:.|
 Worm  1357 GQGFPAYLNGHKFVFRSEKLEMHGEFMQRIMKMYDNPEKIMKTDPCPH-LVDSPGRYIQVFNIDP 1420

  Fly  1408 VGDAQALKT--AMVPVPEKIARFYEVNDVTRFIY----DRPMYKGT-VDKDNEFKSLWIERTILE 1465
            :|...:.:.  .:.||.:|..|:|   ::..|.|    :|...|.| :|..:||...|:.|..::
 Worm  1421 IGTGCSFENNPEVKPVIKKYFRYY---NIQTFEYSKVEERKDTKWTSIDPSSEFMRNWLVRRRIK 1482

  Fly  1466 IASPLPGILRWYEVKQKTMQ-ELTPVEYACEIISNAGKELSELIVQYKRDPKRNINPFSMRLQGT 1529
            .|..||..||:.|:.:.:.. .:||::.|.|.:....|||:|.....:.:|..::...|..:.|.
 Worm  1483 TADSLPTDLRFTEIVELSDPIYVTPLQNAVEQMRKKNKELNETAASAESNPNFDLKLLSRDILGV 1547

  Fly  1530 IDANVMGGISKYQEAFFSEQFLKSPQGAGQQANVQRLKVLILEQIQILEQALELHGQLAPSGVQP 1594
            :.|.||||:..| |.||:|. .::....|:|:.:..|..||:||::|||....:|........:.
 Worm  1548 VSAAVMGGVKNY-EVFFTEA-CRNICECGEQSVIMELSSLIIEQVEILEYCCYVHASRCQGEARA 1610

  Fly  1595 LHNRLLERFSQLKQSLSGMGRLKRQHSESIVNTPLPPLPTEQRVAPAT-ASSSLN---------- 1648
            ::..|.:.|..           .|::.|.........|||...:..:: .|.|:|          
 Worm  1611 INTMLADSFDS-----------HRRYVEENFGKTRSRLPTHANIRLSSFDSDSINDGMMTMKSGK 1664

  Fly  1649 ----ANAHSNYVYDLDEIYTRPGDTVRPVDPLSSYQTLSKESLSIPLEDT------AAPPVPNRP 1703
                .||.:|.:|. ::..:.||..|.    |||....|.:::|..|..:      |.||.|..|
 Worm  1665 AAVLGNAVANLIYS-NKRSSGPGTPVN----LSSRSAPSFDNISSKLRSSLAISKLAPPPRPPNP 1724

  Fly  1704 RSQNFIGNGSMDSPEVPPKR----QPTLNSPN----APPLPPRGITPD 1743
            .|.  |..|...:.|....|    |.:..|.|    |||||||...||
 Worm  1725 ISP--INRGPSSNYEGIRMRAHSHQASTVSLNHMSVAPPLPPRPDRPD 1770

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
spgNP_733258.4 SH3_DOCK_AB 9..64 CDD:212805 11/40 (28%)
DOCK_N 67..406 CDD:292790 79/387 (20%)
C2_Dock-B 414..600 CDD:176077 54/196 (28%)
DHR2_DOCK 1215..1610 CDD:297424 119/416 (29%)
ced-5NP_501938.1 SH3 5..66 CDD:214620 11/38 (29%)
DOCK_N 82..394 CDD:292790 75/363 (21%)
C2_DOCK180_related 415..608 CDD:176061 54/195 (28%)
DHR2_DOCK 1225..1621 CDD:212566 119/411 (29%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 225 1.000 Domainoid score I1443
eggNOG 1 0.900 - - E1_KOG1997
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 566 1.000 Inparanoid score I586
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG54452
OrthoDB 1 1.010 - - D102580at2759
OrthoFinder 1 1.000 - - FOG0000433
OrthoInspector 1 1.000 - - otm14735
orthoMCL 1 0.900 - - OOG6_100636
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R2355
SonicParanoid 1 1.000 - - X372
SwiftOrtho 1 1.000 - -
TreeFam 1 0.960 - -
1413.770

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