DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment spg and DOCK11

DIOPT Version :9

Sequence 1:	NP_733258.4	Gene:	spg / 43404	FlyBaseID:	FBgn0264324	Length:	2187	Species:	Drosophila melanogaster
Sequence 2:	XP_005262425.1	Gene:	DOCK11 / 139818	HGNCID:	23483	Length:	2086	Species:	Homo sapiens

Alignment Length:	2017	Identity:	370/2017 - (18%)
Similarity:	696/2017 - (34%)	Gaps:	602/2017 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 VDIVEECKHWYRGSCPRKSRAVGLFPKTYIHIKDLSKIDP----VVAECTQVLREWSEIWKRLYV 92
            :|:|:         ||:..|          |..:|..:|.    :.||..|.:.||
Human   227 IDVVQ---------CPKMRR----------HAFELKMLDKYSHYLAAETEQEMEEW--------- 263

  Fly    93 DREAYKFQTLRKVM----FSILESRRELLSATMTQDQT------------LELQMVVVSKIDWGN 141
                  ..||:|::    .|:::.::|.:. |...|:|            ||..| ....:.:|.
Human   264 ------LITLKKIIQINTDSLVQEKKETVE-TAQDDETSSQGKAENIMASLERSM-HPELMKYGR 320

  Fly   142 RKLGLDLVPREGPLAVDPHGIGIVKLYNV--HVSSADNAKASSSRGTLRRKTQRKILT--HHLYF 202
            ....|:.:.|         |.|...|::.  .|...|.:...........|..::.|.  |.|.|
Human   321 ETEQLNKLSR---------GDGRQNLFSFDSEVQRLDFSGIEPDIKPFEEKCNKRFLVNCHDLTF 376

  Fly   203 CMRDFGHRIG--GDDA-------EVYFF---LYDGSHMRPLSERFLV----------------KI 239
                  :.:|  ||:|       |.:|.   |:|..:...:|..|.|                ::
Human   377 ------NILGQIGDNAKGPPTNVEPFFINLALFDVKNNCKISADFHVDLNPPSVREMLWGSSTQL 435

  Fly   240 SKDGF------SNYIERLHSNCTVFTDLGAADLNEELHLVAVVMRVGKIIQ-------------S 285
            :.||.      .:||..:..:...:...|...:......:.:|.|:.|::|             |
Human   436 ASDGSPKGSSPESYIHGIAESQLRYIQQGIFSVTNPHPEIFLVARIEKVLQGNITHCAEPYIKNS 500

  Fly   286 DSIKKIEK--------SGTLGHGPTFRRPFG----------VGVLSL----GDIAHFDSSLEQSS 328
            |.:|..:|        ...||.   :|.||.          .|.|.|    ..:...|||...|.
Human   501 DPVKTAQKVHRTAKQVCSRLGQ---YRMPFAWAARPIFKDTQGSLDLDGRFSPLYKQDSSKLSSE 562

  Fly   329 DEREYNFKLFQCEEKDFHLLP-ELIIKKS----------SGKYSPIQA-SQGTQGIVVSLKLLHG 381
            |..:...:..:.|:....::| :|.|...          :..|.|::. .:..|.|.|
Human   563 DILKLLSEYKKPEKTKLQIIPGQLNITVECVPVDLSNCITSSYVPLKPFEKNCQNITV------- 620

  Fly   382 GLGQARQEQPMLFQGSTITRKMGFPDVIMPGDVRNDLF---LNLERGEFERGGKNTGKNILVTVV 443
               :..:..|.:       .|..:|..|    .:|.|:   |.|:....:...|  .:||.|.|.
Human   621 ---EVEEFVPEM-------TKYCYPFTI----YKNHLYVYPLQLKYDSQKTFAK--ARNIAVCVE 669

  Fly   444 VLDVAGNVLTD--------CLWG--ASGMESQPQYRSMILYHQNAPSWNEMLRLSVPIDKFSTAH 498
            ..|      :|        |::|  |..:.:...| :::.:|...|.:.:.:::.:||......|
Human   670 FRD------SDESDASALKCIYGKPAGSVFTTNAY-AVVSHHNQNPEFYDEIKIELPIHLHQKHH 727

  Fly   499 VRFEFRHCSTRDKTEPKLFAFSFARLMDTGGATLG--------DGLHELYVYKCEDPAKLQV-AN 554
            :.|.|.|.|....|:      ...:..||....:|        ||  .:..::.:.|....: ..
Human   728 LLFTFYHVSCEINTK------GTTKKQDTVETPVGFAWVPLLKDG--RIITFEQQLPVSANLPPG 784

  Fly   555 YLRLQCRPRDAQAKMDCGGCFS--RSSKEVFVLRSLLCSTKLTQNADL------LSLLQ--WRTY 609
            ||.|    .||:::..|.....  ..:|.:..::|.|.||..||:..:      ..|:|  .:..
Human   785 YLNL----NDAESRRQCNVDIKWVDGAKPLLKIKSHLESTIYTQDLHVHKFFHHCQLIQSGSKEV 845

  Fly   610 PETIQDSLTGVLRLNDEELVKFLQDVLDALFAMFSN---EEGNSTQHSGLVFHVL-----VSIFS 666
            |..:...|..:..:..:.:::||..:|..||.:.:|   |:......:.::.|::     ..:.|
Human   846 PGELIKYLKCLHAMEIQVMIQFLPVILMQLFRVLTNMTHEDDVPINCTMVLLHIVSKCHEEGLDS 910

  Fly   667 LLQSNKFQHFRPVMNEYIENHFA--AALVYKGLITSVEHMAVFMTKAEHPDPFQKCFGSLEY--- 726
            .|:|.....|||      |...|  |.|:::.|.|::  :|:....|:    |......|:|
Human   911 YLRSFIKYSFRP------EKPSAPQAQLIHETLATTM--IAILKQSAD----FLSINKLLKYSWF 963

  Fly   727 IFKLLIQSRKLF-------ARATGGQYEDSFKRDLHSLFTALNGMLAVPSYDV---IIPTQEALL 781
            .|:::.:|...:       ....|.::.:::...||||..|:     :|...:   .||.:...:
Human   964 FFEIIAKSMATYLLEENKIKLPRGQRFPETYHHVLHSLLLAI-----IPHVTIRYAEIPDESRNV 1023

  Fly   782 NSTGVVLEQLKDTLPAPELGMLARNMLDAIPRGAPIRLIQAKLHAVKDLVSGELFHEDDSRTVV- 845
            |.:               |....:..|..:.||....||       .|.:||  |...|.:.:.
Human  1024 NYS---------------LASFLKRCLTLMDRGFIFNLI-------NDYISG--FSPKDPKVLAE 1064

  Fly   846 -----LSVACKH-----LRMHLS-RRDELRLCAEILSEILSQLYDLQKEQREKVTNTLQHDL-DS 898
                 |...|.|     |.:.:: .:.:|:...:..|..:.:|        ..|.:.|::.| |.
Human  1065 YKFEFLQTICNHEHYIPLNLPMAFAKPKLQRVQDFFSFAVDRL--------TSVDSNLEYSLSDE 1121

  Fly   899 LCKN--ILGILIRTISIIMEGSNAVLPQLVSCLLGLL-QLLDETHYKR----------------- 943
            .||:  ::|:|:|..||.::.:..:....:|.:..|| :...:|.|:.
Human  1122 YCKHHFLVGLLLRETSIALQDNYEIRYTAISVIKNLLIKHAFDTRYQHKNQQAKIAQLYLPFVGL 1186

  Fly   944 --------------YWDELSPNKDPRD-------------------------------LKEFLSK 963
                          |.....||...||                               :|...|:
Human  1187 LLENIQRLAGRDTLYSCAAMPNSASRDEFPCGFTSPANRGSLSTDKDTAYGSFQNGHGIKREDSR 1251

  Fly   964 SLLVYEELLTQDWHVFPND----------------------------------WLVMKLAANDVL 994
            ..|:.|....     ||:.                                  ..::|:.:.|.|
Human  1252 GSLIPEGATG-----FPDQGNTGENTRQSSTRSSVSQYNRLDQYEIRSLLMCYLYIVKMISEDTL 1311

  Fly   995 -----RMSLEEFAKPLV--------YRFLGPQ--AFDSQLWWS-YFSLAVAFLTQPSLQLEQYRE 1043
                 ::|.:|....|:        :|::|.:  |.....|.| :|.:.....|.|:|:......
Human  1312 LTYWNKVSPQELINILILLEVCLFHFRYMGKRNIARVHDAWLSKHFGIDRKSQTMPALRNRSGVM 1376

  Fly  1044 PKRLKILHS------------------------HGDMRVLMGFQIL---SMWSQLGEQKL----- 1076
            ..||:.|.|                        .|:....:...:|   |.::|..:.:|
Human  1377 QARLQHLSSLESSFTLNHSSTTTEADIFHQALLEGNTATEVSLTVLDTISFFTQCFKTQLLNNDG 1441

  Fly  1077 HFIPSMVGPF-----------LEVTLVPEPALRKATLSVF----------------YDMMQC--- 1111
            | .|.|...|           .||:|....|..:|.:|.|                |::::|
Human  1442 H-NPLMKKVFDIHLAFLKNGQSEVSLKHVFASLRAFISKFPSAFFKGRVNMCAAFCYEVLKCCTS 1505

  Fly  1112 ---------------------EQAARGSFRLVESELIDKLDLLISE--NKGDDEYRELFSTILLE 1153
                                 |...|.:|.....::|..:..||::  ..|...::|  |..::.
Human  1506 KISSTRNEASALLYLLMRNNFEYTKRKTFLRTHLQIIIAVSQLIADVALSGGSRFQE--SLFIIN 1568

  Fly  1154 KVQVENPNWKEAGIAFIASVTRLLERLLDYRSVMQG-----EENRDKRMTCTVNLLNFYKNEINR 1213
              ...|.:......||.|.|..|.:|:   |:|:..     |..:|..|...:. .:..|:..:.
Human  1569 --NFANSDRPMKATAFPAEVKDLTKRI---RTVLMATAQMKEHEKDPEMLIDLQ-YSLAKSYAST 1627

  Fly  1214 KEMYLRYIYKLHNLHLQAENYTEAGFTLKLYASMLSWDRETQSFAP------------------- 1259
            .|:...::..:..:|::..:::||.......|::::.....:...|
Human  1628 PELRKTWLDSMAKIHVKNGDFSEAAMCYVHVAALVAEFLHRKKLFPNGCSAFKKITPNIDEEGAM 1692

  Fly  1260 FDNSGQPEWQRKERLYHEILKY----FDKGKCWEKGIPLCKELAHLYETRRFDYNKLSEILIQEA 1320
            .:::|..:....|.:..|:|:.    ..|.:.:|....:.|.:..:||.|| ::.||:::.....
Human  1693 KEDAGMMDVHYSEEVLLELLEQCVDGLWKAERYEIISEISKLIVPIYEKRR-EFEKLTQVYRTLH 1756

  Fly  1321 KFFQNIL----TQLRPEPEYFRVGFYGMGLPLFVRNKQFVYR-----GL---EYERIGAFTQRLQ 1373
            ..:..||    |:.|....:|||.|||.........|:::|:     ||   ....:..:.::..
Human  1757 GAYTKILEVMHTKKRLLGTFFRVAFYGQSFFEEEDGKEYIYKEPKLTGLSEISLRLVKLYGEKFG 1821

  Fly  1374 TEFPSAQILGNNSPPDNAILNAPDQYIQISNVRPVGDAQALKTAMVPVPEKIARFYEVNDVTRFI 1438
            ||  :.:|:.::...:...|:....:||::.|:|..|.:.|       .|:...|...::::||:
Human  1822 TE--NVKIIQDSDKVNAKELDPKYAHIQVTYVKPYFDDKEL-------TERKTEFERNHNISRFV 1877

  Fly  1439 YDRPMYKGTVDKDNEFKSLWIERTILEIASPLPGILRWYEVKQKTMQELTPVEYACEIISNAGKE 1503
            ::.| |..:..|....:.....||||..::..|.:.:...:..:....|.|::.|.:.|.:...|
Human  1878 FEAP-YTLSGKKQGCIEEQCKRRTILTTSNSFPYVKKRIPINCEQQINLKPIDVATDEIKDKTAE 1941

  Fly  1504 LSELIVQYKRDPKRNINPFSMRLQGTIDANVMGGISKYQEAFFSE-QFLKSPQGAGQQANVQRLK 1567
            |.:|......|    :....::|||.:...|..|...|..||.:: |..|.|     ...|..||
Human  1942 LQKLCSSTDVD----MIQLQLKLQGCVSVQVNAGPLAYARAFLNDSQASKYP-----PKKVSELK 1997

  Fly  1568 VLILEQIQILEQALELHGQLAPSGVQPLHNRLLERFSQLKQSLSGMGRLKRQ-------HSESIV 1625
            .:..:.||....||||:.:|........|..|...|..:.:.||.:  :..|       ||..:.
Human  1998 DMFRKFIQACSIALELNERLIKEDQVEYHEGLKSNFRDMVKELSDI--IHEQILQEDTMHSPWMS 2060

  Fly  1626 NT 1627
            ||
Human  2061 NT 2062

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
spg	NP_733258.4	SH3_DOCK_AB	9..64	CDD:212805	6/31 (19%)
		DOCK_N	67..406	CDD:292790	78/443 (18%)
		C2_Dock-B	414..600	CDD:176077	44/209 (21%)
		DHR2_DOCK	1215..1610	CDD:297424	87/430 (20%)
DOCK11	XP_005262425.1	DUF3398	54..145	CDD:288711
		PH_DOCK-D	161..284	CDD:270087	17/90 (19%)
		PH	166..271	CDD:278594	16/77 (21%)
		C2_Dock-D	639..828	CDD:176079	44/209 (21%)
		DHR2_DOCK11	1628..2040	CDD:212573	87/431 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1997
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810