DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment spg and Dock9

DIOPT Version :9

Sequence 1:	NP_733258.4	Gene:	spg / 43404	FlyBaseID:	FBgn0264324	Length:	2187	Species:	Drosophila melanogaster
Sequence 2:	XP_006518407.1	Gene:	Dock9 / 105445	MGIID:	106321	Length:	2142	Species:	Mus musculus

Alignment Length:	1599	Identity:	289/1599 - (18%)
Similarity:	522/1599 - (32%)	Gaps:	555/1599 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   455 CLWGASGMESQPQYR----SMILYHQNAPSWNEMLRLSVPIDKFSTAHVRFEFRH--C--STRDK 511
            |::|..|   .|.:.    :.:|:||..|.:.:.:::.:|.......|:.|.|.|  |  ||:..
Mouse   692 CIYGRPG---GPVFTRSALAAVLHHQQNPEFYDEIKIELPAQLHERHHLLFTFFHVSCDNSTKGS 753

  Fly   512 TEPK-----LFAFSFARLMDTGGATLGDGLHELYVYKCEDPAKLQV-ANYLRLQ----CRPRDAQ 566
            |:.|     ...||:..|:..|.....    |.::     |....: :.||..|    .|....:
Mouse   754 TKKKDAVETQVGFSWLPLLKDGRVLTS----EQHI-----PVSANLPSGYLGYQELGMGRHYGPE 809

  Fly   567 AKMDCGGCFSRSSKEVFVLRSLLCSTKLTQNADLLSLLQWRTYPETIQDSLTGVLRLNDEELVK- 630
            .|...||      |.:..:.:.|.||..||:..|.:..|:      .|.:.:|. :.:..||||
Mouse   810 VKWVEGG------KPLLKISTHLVSTVYTQDQHLHNFFQY------CQKTESGA-QASGSELVKY 861

  Fly   631 --------------FLQDVLDALFAMFS----------------------NEEG----------- 648
                          ||..:|:.||.:.:                      :|||
Mouse   862 LKSLHAMEGHVMIAFLPTILNQLFRVLTRATQEEVAVNVTRVIIHVVAQCHEEGLESHLRSYVKF 926

  Fly   649 -----------NSTQHSGL---VFHVLVSIFSLLQSNKFQHF---------RPVMNEYIENH--- 687
                       ..|.|..|   :..:|......|.|||...:         :.:....|||:
Mouse   927 AYKAEPYVASEYKTVHEELTKSMTTILKPSADFLTSNKLLKYSWFFFDVLIKSMAQHLIENNKVK 991

  Fly   688 ------FAAALVYKGLITSVEHMAV-FMTKAEHPDP-------------FQKCFGSLE--YIFKL 730
                  |.|:  |...:.:|.:|.: .:|:....:|             .::||..::  ::||.
Mouse   992 LLRNQRFPAS--YHHAVETVVNMLMPHITQKFRDNPEASKNANHSLAVFIKRCFTFMDRGFVFKQ 1054

  Fly   731 LIQSRKLFARA---TGGQYEDSFKRDL--HSLFTALNGMLAVP--------------SYDVIIPT 776
            :......||..   |..:|:..|.|.:  |..:..||  |.:|              .|.:   |
Mouse  1055 INNYISCFAPGDPKTLFEYKFEFLRVVCNHEHYIPLN--LPMPFGKGRIQRYQDLQLDYSL---T 1114

  Fly   777 QE---------ALLNSTGVVLEQLKD--------------------------------TLPAPEL 800
            .|         .||...|..|::.::                                ||..|..
Mouse  1115 DEFCRNHFLVGLLLREVGTALQEFREVRVIAISMLKNLLIKHSFDDRYNSRSHQARIATLYLPLF 1179

  Fly   801 GMLARNMLD----------------------AIPRGAPI------RLIQAKLHAVKDL---VSGE 834
            |:|..|:..                      |:|.|.|:      ..:...||  |||   :||.
Mouse  1180 GLLIENVQRINVRDVSPFPVNPGSIVKDEALAVPAGNPLMTPQKGNTLDHSLH--KDLLGAISGI 1242

  Fly   835 LFHEDDSRTVVLSVACKHLRMHLSRRDELRLCAEILSEILSQLYDLQKEQREKVTNTLQHDLDSL 899
            ......|...:.||.....|..|           |.::..:.|.|...|:    :|:|.....|
Mouse  1243 ASPYTASTPNINSVRNADSRGSL-----------ISTDSGNSLPDRNPEK----SNSLDKQQQS- 1291

  Fly   900 CKNILGILIRTISIIMEGSNAVLPQLVSCLLGLLQLLDETHYKRYWDELSPNKDPRDLKEFLSKS 964
                 |:|..::....:...:.:..|:.|.|.:|:.:.:.....||::.|    ..:|.:|.:.|
Mouse  1292 -----GMLGNSVVRCDKLDQSEIKSLLMCFLYVLKSMSDDALFTYWNKAS----TAELMDFFTIS 1347

  Fly   965 LLVYEELLTQDWHVFPNDWLVMKLAANDVLRMSLEEFAKPLVYR---FLGPQAFD--SQLWWSYF 1024
                                       :|.....:...|..:.|   .|||...|  ||
Mouse  1348 ---------------------------EVCLHQFQYMGKRYIARNQEGLGPIGHDRKSQ------ 1379

  Fly  1025 SLAVAFLTQPSLQLEQYREPKRLKIL----------HSHGDMRV-----------------LMGF 1062
                   |.|..:........||:.|          ||:|....                 |...
Mouse  1380 -------TLPVSRNRTGMMHARLQQLGSLDNSVTFNHSYGHSEADVVHQSLLEANIATEVCLTAL 1437

  Fly  1063 QILSMWSQLGEQKL---HFIPSMVGPFLEVTLV------PEPALRKA------------------ 1100
            ..||:::...:.:|   |....::....:|.|.      .|.||:..
Mouse  1438 DTLSLFTLAFKNQLLADHGHNPLMKKVFDVYLCFLQKHQSEMALKNVFTALRSLIYKFPSAFYEG 1502

  Fly  1101 ----TLSVFYDMMQCEQAARGSFRLVESELIDKLDLLISENKGDDEYRELF-----------STI 1150
                ..|:.|::::|..:...|.|...|:|:    ..:..|..|...::.|           |.:
Mouse  1503 RADMCASLCYEVLKCCNSKLSSIRTEASQLL----YFLMRNNFDYTGKKSFVRTHLQVIISVSQL 1563

  Fly  1151 LLEKVQVENPNWKEA---------------GIAFIASVTRLLERLLDYRSVMQG-----EENRDK 1195
            :.:.|.:....::::               ..:|.:.|..|.:|:   |:|:..     |...|.
Mouse  1564 IADVVGIGGTRFQQSLSIINNCANSDRIIKHTSFSSDVKDLTKRI---RTVLMATAQMKEHENDP 1625

  Fly  1196 RMTCTVNLLNFYKNEINRKEMYLRYIYKLHNLHLQAENYTEAGFT-----------LKLYASMLS 1249
            .|...:. .:..|:..:..|:...::..:..:|::..:.:||...           |....:.|:
Mouse  1626 EMLVDLQ-YSLAKSYASTPELRKTWLDSMARIHVKNGDLSEAAMCYVHVTALVAEYLTRKEADLA 1689

  Fly  1250 WDRETQSFAPFDNSGQPEWQRK------------------------------------------- 1271
            ..||..:| |:.:|   ..|||
Mouse  1690 LQREPPAF-PYSHS---TCQRKSWGGMFRQGCTAFRVITPNIDEEASMMEDVGMQDVHFNEDVLM 1750

  Fly  1272 -------------ER------LYHEILKYFDKGKCWEKGIPLCKELAHLYETRRFDYNKLSEILI 1317
                         ||      :|..|:..::|.:.:|:       |||||:|....|:|::|::.
Mouse  1751 ELLEQCADGLWKAERYELIADIYKLIIPIYEKRRDFER-------LAHLYDTLHRAYSKVTEVMH 1808

  Fly  1318 QEAKFFQNILTQLRPEPEYFRVGFYGMGLPL-----------FVRN---KQFVYRGLEYERIGAF 1368
            ...:....          ||||.|:|.....           |..:   |:::|:..:...:...
Mouse  1809 SGRRLLGT----------YFRVAFFGQAAQYQFTDSETDVEGFFEDEDGKEYIYKEPKLTPLSEI 1863

  Fly  1369 TQRL----QTEFPSAQI-----LGNNSPPDNAILNAPDQYIQISNVRPVGDAQALKTAMVPVPEK 1424
            :|||    ..:|.|..:     .|..:|.|   |::...|||:::|.|..|.:.|:       |:
Mouse  1864 SQRLLKLYSDKFGSENVKMIQDSGKVNPKD---LDSKFAYIQVTHVTPFFDEKELQ-------ER 1918

  Fly  1425 IARFYEVNDVTRFIYDRPMYKGTVDKDNEFKSLWIERTILEIASPLPGILRWYEVKQKTMQELTP 1489
            ...|...:::.||:::.| :..|..:....:.....||||......|.:.:...|..:...:|.|
Mouse  1919 RTEFERCHNIRRFMFEMP-FTQTGKRQGGVEEQCKRRTILTAIHCFPYVKKRIPVMYQHHTDLNP 1982

  Fly  1490 VEYACEIISNAGKELSELIVQYKRDPKRNINPFSMRLQGTIDANVMGGISKYQEAFFSEQFLKS- 1553
            :|.|.:.:|....||.:|....:.|    :....::|||::...|..|...|..||..:...|.
Mouse  1983 IEVAIDEMSKKVAELRQLCSSAEVD----MIKLQLKLQGSVSVQVNAGPLAYARAFLDDTNTKRY 2043

  Fly  1554 PQGAGQQANVQRLKVLILEQIQILEQALELHGQLAPSGVQPLHNRLLERFSQLKQSLSGMGR--- 1615
            |..     .|:.||.:..:.::...|||.::.:|...........:...:.::.:.||.:.|
Mouse  2044 PDN-----KVKLLKEVFRQFVEACGQALAVNERLIKEDQLEYQEEMKANYREMAKELSDIMREQI 2103

  Fly  1616 --LKRQ-----HSESIVNTPLPPLPTEQRVAPATASSSL 1647
              |:.:     :|..|.|. :...||...|...|:|||:
Mouse  2104 CPLEEKTSVLPNSLHIFNA-ISGTPTSTVVQGLTSSSSV 2141

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
spg	NP_733258.4	SH3_DOCK_AB	9..64	CDD:212805
		DOCK_N	67..406	CDD:292790
		C2_Dock-B	414..600	CDD:176077	37/162 (23%)
		DHR2_DOCK	1215..1610	CDD:297424	92/491 (19%)
Dock9	XP_006518407.1	DUF3398	57..167	CDD:371776
		PH_DOCK-D	181..304	CDD:270087
		C2_Dock-D	648..837	CDD:176079	37/162 (23%)
		DHR2_DOCK9	1644..2098	CDD:212571	94/494 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1997
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810