Protein Alignment spg and dock2

DIOPT Version :9

• Sequence 1: NP_733258.4
• Gene: spg / 43404
• FlyBaseID: FBgn0264324
• Length: 2187
• Species: Drosophila melanogaster
• Sequence 2: XP_031754648.1
• Gene: dock2 / 100497849
• XenbaseID: XB-GENE-990617
• Length: 1831
• Species: Xenopus tropicalis
• Alignment Length: 2044
• Identity: 704/2044 - (34%)
• Similarity: 1071/2044 - (52%)
• Gaps: 284/2044 - (13%)

  Fly     8 KYGVAIHNWHGDVRFGLALDVGDSVDIVEECKHWYRGSCPRKSRAVGLFPKTYIHIKDL------ 66
            :|||||.|:..:....::|.:||.|.|.|.|:.||:|...|:....|:|||::|||||:
 Frog    11 RYGVAICNFKSNGVPQISLQIGDVVHIQESCEDWYKGYLVRQRTLEGIFPKSFIHIKDVTVQRKR 75

  Fly    67 -------SKIDPVVAECTQVLREWSEIWKRLYVDREAYKFQTLRKVMFSILESRRELLSATMTQD 124
                   ::| |:|.|.|..||||..|||:||...:..||:.::.:|:.::|.|.:|||.|:.:|
 Frog    76 NMENIVPAEI-PLVREVTTTLREWGNIWKQLYASGKTEKFKQVQSMMYDLMEWRSQLLSGTLPKD 139

  Fly   125 QTLELQMVVVSKIDWGNRKLGLDLVPR-EGPLAVDPHGIGIVKLYNVH------VSSADNAKASS 182
            :..||:..|.||||:||:.|.|||:.| |....:||....::.|::.|      ::.....:.:.
 Frog   140 ELKELKQKVTSKIDYGNKILELDLIVRDEDGNILDPDKTSVISLFHAHNEATEKITERIKEEMAQ 204

  Fly   183 SRGTLR-RKTQRKILTHHLYFCMRDFGHRIGGDDAEVYFFLYDGSHMRPLSERFLVKISKDGFSN 246
            :..||. |.|...  ||.||..:|:|..|| |:|||::..|||......:||.:||:....||..
 Frog   205 NEYTLHGRITSSP--THGLYVFVRNFVCRI-GEDAELFMSLYDPLKQTIISENYLVRWGSKGFPK 266

  Fly   247 YIERLHSNCTVFTDLGAADLN-EELHLVAVVMRVGKIIQSDS-IKKIEKSGTLGHGPTFRRPFGV 309
            .|:.|::...||||||..||| |:::||..::|:|::...|| :||..:.        .||||||
 Frog   267 EIDMLNNLKVVFTDLGNKDLNREKIYLVCQIVRIGRMDLKDSNLKKYTQG--------LRRPFGV 323

  Fly   310 GVLSLGDIAHFDSSLEQSSDEREYNFKLFQ--CEEKDFHLLPELIIKKSSGKYSPIQASQGTQGI 372
            .|:.:.|:  ....:|  |||.:.:|..|.  ..|.||  |..|:.|.:|.|     ...|.||:
 Frog   324 AVMDITDV--IKGKIE--SDEEKQHFIPFHPVVAENDF--LHSLLTKVTSSK-----GDSGGQGL 377

  Fly   373 VVSLKLLHGGLGQARQEQPMLFQGST-ITRKMGFPDVIMPGDVRNDLFLNLERGEFERGGKNTGK 436
            .|::|:|.|...|.|::.|.|...:| :.||:|||::|||||||||:::.|.:|:|:|.   |.:
 Frog   378 WVTVKMLVGDSVQIRKDYPHLVDRTTVVARKLGFPEIIMPGDVRNDIYVTLLQGDFDRA---TQR 439

  Fly   437 NILVTVVVLDVAGNVLTDCLWGASGMESQPQYRSMILYHQNAPSWNEMLRLSVPIDKFSTAHVRF 501
            |:.|.:.|.|..|.::.:.:...:|.:...:|||::.|....|.|.|.::::|||::....|:||
 Frog   440 NVEVIMCVCDEEGKIIPNAICSGAGDKPVSEYRSVLYYQIKQPRWMETIKVAVPIEEMQRIHLRF 504

  Fly   502 EFRHCS---TRDKTEPKLFAFSFARLMDTGGATLGDGLHELYVYKCEDPAKLQVANYLRLQCRPR 563
            .|||.|   ::||.| :.||.:|.|||...|.||.||.|:|.|.|.:.......:.||..   |.
 Frog   505 MFRHRSSQESKDKGE-RNFAMAFVRLMKEDGTTLHDGNHDLVVLKGDSKKMEDGSTYLHF---PF 565

  Fly   564 DAQAKMDCGGCFSR----------SSKEVFVLRSLLCSTKLTQNADLLSLLQWRTYPETIQDSLT 618
            ..|...:.|..|||          ||::.|.:.:|:||||||||..||.||:|||.||.:|::|.
 Frog   566 TRQQMDNKGSTFSRNSSSSGGLSVSSRDAFSISTLVCSTKLTQNVGLLGLLKWRTKPEHLQENLE 630

  Fly   619 GVLRLNDEELVKFLQDVLDALFAMFSNEEGNSTQHSGLVFHVLVSIFSLLQSNKFQHFRPVMNEY 683
            .:..::.||:||||||.|||||.:.. |...:.::..|||..|:.|..|:...|||||..|:..|
 Frog   631 KLKIVDGEEVVKFLQDTLDALFNIMM-ENSQTEKYDILVFDALIYIIGLIADRKFQHFNTVLEAY 694

  Fly   684 IENHFAAALVYKGLITSVEHMAVFMTKAEHPDPFQKCFGSLEYIFKLLIQSRKLFARATGGQYED 748
            |:.||:|.|.||.|:..::......::.|..:|..:...:|||:||.:::||.||::...|:.::
 Frog   695 IKQHFSATLAYKKLMCVLKKYLDISSRGEQCEPILRTLKALEYVFKFIVRSRTLFSQLYEGKEQN 759

  Fly   749 SFKRDLHSLFTALNGMLAVPSYDVIIPTQEALLNSTGVVLEQLKDTLPAPELGMLARNMLDAIPR 813
            .|:..:.:||.::|.::.. .:...|..|.|.|.....||..::....|..|..|.......||
 Frog   760 EFEESMRNLFESINNLMEC-EHKTTILLQVAALKYLPSVLHDVETVFDARLLSQLLYEFYTCIP- 822

  Fly   814 GAPIRLIQAKLHAVKDLVSGELFHEDDSRTVVLSVACKHLR--MHLSRRD-----ELRLCAEILS 871
              |::|.|.|:.::.::|...||.:.:.|.::|.:..|.|:  :...|:|     |.:.|.::|:
 Frog   823 --PVKLQQQKVQSMIEIVRSNLFKKQECRDILLPMITKELKDWLEQGRQDASHGKEKKFCVDLLN 885

  Fly   872 EILSQLYDLQKEQREKVTNTLQHDLDSLCKNILGILIRTISIIMEGSNAVLPQLVSCLLGLLQLL 936
            .|| ::...|.|.      :..|.:..:...:|..:|||: |:::....:....|:|:..:|..:
 Frog   886 NIL-EVLSCQDEA------STYHHIQEITIQLLRTVIRTV-IMLDREQDLTSHFVACMTAILNQM 942

  Fly   937 DETHYKRYWDELSPNKDPRDLKEFLSKSLLVYEELLTQDWHVFPNDWLVMKLAANDVLRMSLEEF 1001
            ...||..|.:....|   .||.:||.::.:::::|:.:  :|:|.||:.|.:..|.|...::.:|
 Frog   943 TNQHYTVYIETFKSN---YDLVDFLMETFIMFKDLIGK--NVYPCDWITMSMVQNRVFLRAINKF 1002

  Fly  1002 AKPLVYRFLGPQAFDSQLWWSYFSLAVAFLTQPSLQLEQYREPKRLKILHSHGDMRVLMGFQILS 1066
            |:.:..:||....|:.|||.:||.|||||:||.|||||.:...||.:||:.:||||.|:||.|..
 Frog  1003 AETMNQKFLENMNFEVQLWNNYFHLAVAFITQDSLQLENFSHDKRNEILNKYGDMRCLIGFAIRD 1067

  Fly  1067 MWSQLGEQKLHFIPSMVGPFLEVTLVPEPALRKATLSVFYDMMQCEQAARGSFRLVESELIDKLD 1131
            ||.:||:.|:.|||.||||.||:||:||..||::|:.:|:|||.||....|.||..|:|:|.|||
 Frog  1068 MWYKLGQNKICFIPGMVGPILEMTLIPEVELRRSTIPIFFDMMLCEYHHSGDFRKFENEIILKLD 1132

  Fly  1132 LLISENKGDDEYRELFSTILLEKVQVENPNWKEAGIAFIASVTRLLERLLDYRSVMQGEENRDKR 1196
            ..:...:||.:|.:||..|||: ..:.:....:|...|:..:..|||||||||:|:. :|::|.|
 Frog  1133 HEVEGGRGDWQYMQLFEAILLD-YSINHSYIFKAIETFVILIKGLLERLLDYRAVVT-DESKDNR 1195

  Fly  1197 MTCTVNLLNFYKNEINRKEMYLRYIYKLHNLHLQAENYTEAGFTLKLYASMLSWDRE---TQSFA 1258
            |:|||||||||| :|||:.||:||:|||.:|||..||||||.:||.|:..:|.|..|   .|...
 Frog  1196 MSCTVNLLNFYK-DINREAMYIRYLYKLRDLHLDCENYTEAAYTLLLHTRLLKWSDEQCSPQVMQ 1259

  Fly  1259 PFDNSGQPEWQRKERLYHEILKYFDKGKCWEKGIPLCKELAHLYETRRFDYNKLSEILIQEAKFF 1323
            ....|.|.....||.||..|:.||||||.||:.|.|||:||..||...|||..||:.|.|:|||:
 Frog  1260 TEFQSSQTYRHLKETLYGVIIGYFDKGKMWEEAIALCKQLADQYEMEVFDYELLSQCLTQQAKFY 1324

  Fly  1324 QNILTQLRPEPEYFRVGFYGMGLPLFVRNKQFVYRGLEYERIGAFTQRLQTEFPSAQILGNNSPP 1388
            :||:..|||:|:||.||:||.|.|.|:|||.|:|||.||||...|..:|..:||.::.|...|.|
 Frog  1325 ENIMKILRPKPDYFAVGYYGQGFPTFLRNKVFIYRGKEYERREDFLAQLMAQFPFSEKLNTTSSP 1389

  Fly  1389 DNAILNAPDQYIQISNVRPVGDAQALKTAMVPVPEKIARFYEVNDVTRFIYDRPMYKGTVDKDNE 1453
            ...|.|:|.||||...|:||.:.|. :....|||::|..||:.|.|.||.|.:|:.||::|.:||
 Frog  1390 GEDITNSPGQYIQCFTVQPVLEEQT-RFKNKPVPDQILNFYKSNYVQRFHYSKPVRKGSIDPENE 1453

  Fly  1454 FKSLWIERTILEIASPLPGILRWYEVKQKTMQELTPVEYACEIISNAGKELSELIVQYKRDPKRN 1518
            |.|:|||||....|..|||||||:||...:...::|:|.|.|.:|...:::..||.||:.|....
 Frog  1454 FASMWIERTTFFTAYRLPGILRWFEVTSMSHATISPLENAIETMSATNEKILMLINQYQSDENLP 1518

  Fly  1519 INPFSMRLQGTIDANVMGGISKYQEAFFSEQFLKSPQGAGQQANVQRLKVLILEQIQILEQALEL 1583
            |||.||.|.|.:|..||||.:||::|||::::::......::.|  |||.||..|..:|...:.:
 Frog  1519 INPLSMCLNGIVDPAVMGGFAKYEKAFFTDEYIQEHPEDNEKLN--RLKDLIAWQTPLLGAGIRI 1581

  Fly  1584 HGQLAPSGVQPLHNRLLERFSQLKQSLSGMGRLKRQHSESIVNTPLPPLPTEQRVAPATASSSLN 1648
            |.:.....::|.|:|:.|.|..||.      ::::|:.       :..||
 Frog  1582 HEKRVTDDLRPFHDRMEECFKSLKI------KVEKQYG-------VRELP--------------- 1618

  Fly  1649 ANAHSNYVYDLDEIYTRPGDTVRPVDPLSSYQTLSKESLSIPLEDTAAPPVPNRPRSQNFIGNGS 1713
                     |.|:     |...||...|.||:.:|..|:|....|...|.   :|.:::|    .
 Frog  1619 ---------DFDD-----GRVGRPRSMLRSYRQMSIISMSSVGSDCFTPV---KPANESF----E 1662

  Fly  1714 MDSPEVPPKRQPT-LNSPNAPPLPP----RGITPDKRASNPLIFNDFGSGDAVGRRHSQQQQQHG 1773
            :|.|....|.|.| .||......|.    |....:||:|  ::|.:..||
 Frog  1663 LDVPVPKAKHQETETNSSQGTAEPEVKLRRSKKKNKRSS--VVFTEEISG--------------- 1710

  Fly  1774 QKYSVVDISYDDPEADQQPHSLPPNFQDGSGGHLSVCFAPNDFRDSGISTTSSRELNHMNLNNLS 1838
                        ||                               |.:|...||:...|:..|||
 Frog  1711 ------------PE-------------------------------SSLSKRLSRKHEFMSDTNLS 1732

  Fly  1839 EDSSSISTITVQHREHCRISSNGSLDYNAAASMNITQRESSTSSFDVEDFPVPPPPIPPKSLAVS 1903
            |.:                       .|..|...:.|...::.|.         |.||..:|:|
 Frog  1733 EHT-----------------------VNQQAPSVLKQMSFASRSM---------PTIPALTLSV- 1764

  Fly  1904 SNGVNFSLDEAHSPHPSTQANTTQLNHIQNPNQNHSTNSHHHLQQQQN----GDGDGYSTLQHPM 1964
            :||            ||::.        |:|:|..|         |||    |:||..:..::.:
 Frog  1765 ANG------------PSSEE--------QSPSQKMS---------QQNLFSTGEGDKRTLKKNKV 1800

  Fly  1965 NGLGLPTLPPPPSAVESPMPASAIASSTS 1993
            |.. ..|:.|...|.:...|:...|...|
 Frog  1801 NQF-FRTMRPYKQAEDGKAPSDQHAEKLS 1828

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
spg	NP_733258.4	SH3_DOCK_AB	9..64	CDD:212805	23/54 (43%)
		DOCK_N	67..406	CDD:292790	125/351 (36%)
		C2_Dock-B	414..600	CDD:176077	70/198 (35%)
		DHR2_DOCK	1215..1610	CDD:297424	177/397 (45%)
dock2	XP_031754648.1	SH3_DOCK2_A	12..67	CDD:212983	23/54 (43%)
		DOCK_N	71..412	CDD:406558	125/363 (34%)
		C2	420..612	CDD:417471	70/198 (35%)
		DHR2_DOCK	1195..1615	CDD:414667	193/436 (44%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D102580at2759
OrthoFinder	1	1.000	-	-		FOG0000433
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X372
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.010