Protein Alignment spg and dock5

DIOPT Version :9

• Sequence 1: NP_733258.4
• Gene: spg / 43404
• FlyBaseID: FBgn0264324
• Length: 2187
• Species: Drosophila melanogaster
• Sequence 2: XP_004912607.1
• Gene: dock5 / 100488768
• XenbaseID: XB-GENE-490920
• Length: 1849
• Species: Xenopus tropicalis
• Alignment Length: 1909
• Identity: 666/1909 - (34%)
• Similarity: 1017/1909 - (53%)
• Gaps: 218/1909 - (11%)

  Fly     2 WIPS-NNKYGVAIHNWHGDVRFGLALDVGDSVDIVEECKHWYRGSCPRKSRAVGLFPKTYIHIKD 65
            |||: ..|:||||:|:.......|:|.|||:|.|:|..:.||||...|.....|:||.||:|:|:
 Frog     4 WIPTKREKFGVAIYNFQVTHEEELSLQVGDTVQILETYEGWYRGFTLRNKSKKGIFPSTYVHVKE 68

  Fly    66 LSKID-----------PVVAECTQVLREWSEIWKRLYVDREAYKFQTLRKVMFSILESRRELLSA 119
            :::..           |:|.|.|..||||..:|..|:|.....:|..::::||.::|.|.::||.
 Frog    69 VTEDKGLHDQAVPSELPLVQELTATLREWGNLWHSLFVHNSRLQFSQIQEMMFLLMEWRSQILSG 133

  Fly   120 TMTQDQTLELQMVVVSKIDWGNRKLGLDLVPR-EGPLAVDPHGIGIVKLYNVHVSSAD--NAKAS 181
            |:.:|...||:..|.:|||:|||.||||||.| |....:||....|:.||..|.|::.  :.:..
 Frog   134 TLPKDDLAELRKKVTAKIDYGNRILGLDLVVRDENGNILDPDETSIITLYRSHESASRRIDERIQ 198

  Fly   182 SSRGTLRRKTQRK--IL----THHLYFCMRDFGHRIGGDDAEVYFFLYDGSHMRPLSERFLVKIS 240
            ..:..|:....|.  ||    |:.||..:::|...: |:|||:...|||....|.:||.|||:..
 Frog   199 EEKSQLQPLDSRSSAILHMAHTYSLYVNLKNFVCNM-GEDAELLMSLYDPDDSRFISENFLVRWG 262

  Fly   241 KDGFSNYIERLHSNCTVFTDLGAADL-NEELHLVAVVMRVGKIIQSDSIKKIEKSGTLGHGPTFR 304
            ..|....||:|::...|||||..:|| ...:.||..::|||.:...|.     |..|.|    .|
 Frog   263 SSGMPKDIEKLNNLPAVFTDLSCSDLIRPRISLVCQIVRVGHMELKDG-----KKHTCG----LR 318

  Fly   305 RPFGVGVLSLGDIAHFDSSLEQSSDEREYNFKLFQCEEKDFHLLPELIIKKSSGKYSPIQASQGT 369
            |||||.|:.:.|:.|     .:..||.:.:|..||...|      |.:|.:.....||:.||:..
 Frog   319 RPFGVAVMDISDVIH-----GKVDDEEKQHFIPFQQMNK------ENLISQRQLIMSPLMASRAI 372

  Fly   370 -----------------------QGIVVSLKLLHGGLGQARQEQPMLF-QGSTITRKMGFPDVIM 410
                                   ||:.:|||||.|.|.|.::|...|. :.|.:.||||||::|:
 Frog   373 AENEPLTAIYNKVIAAKEVNHKGQGLWISLKLLPGDLAQVQKEYSHLVDRSSAVARKMGFPEIIL 437

  Fly   411 PGDVRNDLFLNLERGEFERGGKNTGKNILVTVVVLDVAGNVLTDCLWGASGMESQPQYRSMILYH 475
            |||||||:::.|.:|||::|.|.|.||:.||:.|.|..|.::...:...:|.|...:|:|::.|.
 Frog   438 PGDVRNDIYITLIQGEFDKGKKKTPKNVEVTLSVHDPDGALIEKAIHPGAGHEGLTEYKSVVYYQ 502

  Fly   476 QNAPSWNEMLRLSVPIDKFSTAHVRFEFRHCS---TRDKTEPKLFAFSFARLMDTGGATLGDGLH 537
            ...|.|.|.:::|:||:..|..|:||.|||.|   :|||:| |:|...|.|||:..|.||.|.:|
 Frog   503 VKQPCWYETVKVSIPIEDVSHCHLRFTFRHRSSQESRDKSE-KVFGMGFVRLMNPDGTTLRDRIH 566

  Fly   538 ELYVYKCE----DPAKLQVANYLRL--QCRPRDAQAKMDCGGCFS-RSSKEVFVLRSLLCSTKLT 595
            :|.:||.:    |.|||    ||.|  .....|...:...|...| ..:|:.|.:.:|:||||||
 Frog   567 DLIIYKGDSKKSDDAKL----YLLLPGTKEEEDEDGRSQRGHSASITPTKDSFQIGTLICSTKLT 627

  Fly   596 QNADLLSLLQWRTYPETIQDSLTGVLRLNDEELVKFLQDVLDALFAMFSNEEGNSTQHSGLVFHV 660
            ||.|||.||.||:....:..:|..::.::..|::|||||.|||||.:.. |..:......|||..
 Frog   628 QNVDLLGLLNWRSNSRPVSQALRKLMEVDGGEIMKFLQDTLDALFNIMM-ETPDKESCDVLVFDA 691

  Fly   661 LVSIFSLLQSNKFQHFRPVMNEYIENHFAAALVYKGLITSVEHMAVFMTKAEHPDPFQKCFGSL- 724
            ||.|.||:...|||||.||:..||..||:..|.|:.||   :.::.::..|:.|...:..|.||
 Frog   692 LVFIISLIADIKFQHFNPVLETYITKHFSTTLAYERLI---KVLSWYVRSADDPCRQEMLFSSLK 753

  Fly   725 --EYIFKLLIQSRKLFARATG-GQYEDSFKRDLHSLFTALNGMLAVPSYDVIIPTQEALLNSTGV 786
              :|:|:.::|||.|:.|..| |:..|.|...:..||.:||.::..| .|..:..:.|.|.....
 Frog   754 AIKYLFRFIVQSRILYLRFYGQGEGRDQFNDSIRQLFLSLNELMDRP-LDKAVKIKAAALKYLPG 817

  Fly   787 VLEQLKDTLPAPELGMLARNMLDAIPRGAPIRLIQAKLHAVKDLVSGELFHEDDSRTVVLSVACK 851
            ::..||......||.:|....:.::|..   :|:...|..:..:|..:||.:.:.|..:..:...
 Frog   818 IINDLKTVFDPVELSVLFAKFVQSVPAD---QLVHQTLTCMSKVVESDLFLQPECRDALQPLLID 879

  Fly   852 HLRMHLS---RRDELRLCAEILSEILSQLYDLQKEQREKVTNTLQHDLDSLCKNILGILIRTISI 913
            .|...|.   .:.:...|..:||.|:..|      |.::|..|..|     .:.|:..|:|.|:.
 Frog   880 QLSGQLDDNYAKPDHEACGHLLSNIIEVL------QSKEVGETSLH-----IQLIMERLLRRINR 933

  Fly   914 IMEGSNAVLPQL---VSCLLGLLQLLDETHYKRYWDELSPNKDPRDLKEFLSKSLLVYEELLTQD 975
            .:.|.:...|.:   |:|:..||:.:|:.||..|   :|..:..:|:.:||.::.:::::|:.:
 Frog   934 TVIGMSRQSPHIGCFVACMTALLRQMDDYHYDYY---ISTFRTRQDIIDFLMETFILFKDLIGK- 994

  Fly   976 WHVFPNDWLVMKLAANDVLRMSLEEFAKPLVYRFLGPQAFDSQLWWSYFSLAVAFLTQPSLQLEQ 1040
             .|:|.||::|.:..|.|...::..||..|...||...:|:.|||.::|.|||:|||..||||.:
 Frog   995 -RVYPKDWMLMTMTQNKVFLRAMTRFAAVLNKLFLDESSFELQLWNNFFHLAVSFLTHESLQLHR 1058

  Fly  1041 YREPKRLKILHSHGDMRVLMGFQILSMWSQLGEQKLHFIPSMVGPFLEVTLVPEPALRKATLSVF 1105
            :.|.||.|||..:||||..:|.:|..||..||..|:.||||||||.|||||.||..|||||:.:|
 Frog  1059 FSEEKRKKILSKYGDMRKEIGLKIRDMWYNLGPHKIKFIPSMVGPILEVTLTPETDLRKATIPIF 1123

  Fly  1106 YDMMQCEQ--AARGSFRLVESELIDKLDLLISENKGDDEYRELFSTILLEKVQVENPNWKEAGIA 1168
            :||||.|.  :..|.|.:.|:|||.:||..:...:||.:|::|...:|||..: ::.....:|..
 Frog  1124 FDMMQHEHNFSGSGHFHMFENELITRLDQEVEGGRGDRQYKDLLERLLLENCR-KHKYLSGSGEV 1187

  Fly  1169 FIASVTRLLERLLDYRSVMQGEENRDKRMTCTVNLLNFYKNEINRKEMYLRYIYKLHNLHLQAEN 1233
            |...|:.|||.|||||:: ..:|:.:.||:|||||||||| |..|:::|:||:|||.:|||:.||
 Frog  1188 FTLLVSSLLENLLDYRTI-ANDESEENRMSCTVNLLNFYK-EKKREDIYIRYLYKLRDLHLRKEN 1250

  Fly  1234 YTEAGFTLKLYASMLSWDR--------ETQSFAPFDNSGQPEWQRKERLYHEILKYFDKGKCWEK 1290
            ||||.:.|.|:|.:|.|..        :..|:..:     .:.:.||||||||:.:|||||.||:
 Frog  1251 YTEAAYALLLHAELLQWSEKPCAPHLLQRDSYTVY-----TQQELKERLYHEIISFFDKGKMWEQ 1310

  Fly  1291 GIPLCKELAHLYETRRFDYNKLSEILIQEAKFFQNILTQLRPEPEYFRVGFYGMGLPLFVRNKQF 1355
            .|...|||..:||.:.|.|..||.:|.::|.|:|||:..||.:.|||.||:||.|.|.|:|||.|
 Frog  1311 AIIHSKELLDMYENQIFHYEALSVLLNKQAGFYQNIMRSLRLQSEYFAVGYYGQGFPSFLRNKIF 1375

  Fly  1356 VYRGLEYERIGAFTQRLQTEFPSAQILGNNSPPDNAILNAPDQYIQISNVRPVGDAQALKTAMVP 1420
            :|||.||||:..|...|..:||:.:.|.::|||.:.|.|:..||:|..:|:|:.:..:.....:
 Frog  1376 IYRGKEYERLEDFNLWLLNQFPNGEKLSSSSPPGDEIRNSTKQYVQCFSVKPLMNLPSRYKEKL- 1439

  Fly  1421 VPEKIARFYEVNDVTRFIYDRPMYKGTVDKDNEFKSLWIERTILEIASPLPGILRWYEVKQKTMQ 1485
            |||:|..:|..|:|.||.|.||..:|..|.||||.::|||||....|..|||||:|:|||....:
 Frog  1440 VPEQILGYYRYNEVQRFSYSRPFRRGEKDPDNEFATMWIERTTFTTAYKLPGILKWFEVKHFDTE 1504

  Fly  1486 ELTPVEYACEIISNAGKELSELIVQYKRDPKRNINPFSMRLQGTIDANVMGGISKYQEAFFSEQF 1550
            |::|::.|.|.:....:::|.|:.|::.|....::|.||.|.|.:|..||||.|.|::|||:|::
 Frog  1505 EISPLQNAIETMELTNEKISHLVQQHRADQSLPLHPLSMLLSGIVDPAVMGGFSNYEKAFFTERY 1569

  Fly  1551 LKS-PQGAGQQANVQRLKVLILEQIQILEQALELHGQLAPSGVQPLHNRLLERFSQLK---QSLS 1611
            |:. |.   .|..::.||.||..|:.:|.|.:.:||:.....::|||.||:..|..|:   :.|.
 Frog  1570 LQEHPM---DQDKLELLKQLIALQMPLLAQGIRIHGEKLTDNLRPLHERLVSCFKDLRSKVEKLY 1631

  Fly  1612 GMGRL-------KRQHSESIVNTPLPPLPTEQRVAPATASSSLNANA------------------ 1651
            |...|       |...:.|:| .|.....|.:|::..:.|||.::::
 Frog  1632 GTITLPASLTDRKLSRAGSVV-VPYITSATLRRLSSVSTSSSGSSSSRPGSEGSIPEPVPHRRAS 1695

  Fly  1652 ----HSNYVYDLDEI--------YTRPGDTVRPVDPLSSYQTLSK--ESLSIPLED------TAA 1696
                |.: :.|.||:        ::|....|.....::|...::|  ...|:.|.|      :|:
 Frog  1696 LISRHED-ISDRDEVDSRAMKFKHSREVSWVHNGGSVTSLSLVNKCQRPKSLQLTDGRLTLHSAS 1759

  Fly  1697 P----------PV-PNRPRSQNFIGNGS--------MDSPEVPPKR------QPTLNSPNAPPLP 1736
            |          |: |..||:.:|....|        :.||..||.:      ...|:...|||||
 Frog  1760 PVQGGTPLSPLPITPRTPRTHSFPSLSSHAETTAQILGSPPPPPPKCRSNEGSQRLSVEIAPPLP 1824

  Fly  1737 PR----GITPDKRASNPLIFNDFG 1756
            .|    ..||..:.....:.:|.|
 Frog  1825 KREEMKPPTPPPKVRKSSVIHDPG 1848

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
spg	NP_733258.4	SH3_DOCK_AB	9..64	CDD:212805	24/54 (44%)
		DOCK_N	67..406	CDD:292790	123/383 (32%)
		C2_Dock-B	414..600	CDD:176077	76/195 (39%)
		DHR2_DOCK	1215..1610	CDD:297424	166/406 (41%)
dock5	XP_004912607.1	SH3	12..67	CDD:388381	24/54 (44%)
		DOCK_N	71..433	CDD:374409	123/382 (32%)
		C2	441..632	CDD:387358	76/195 (39%)
		DHR2_DOCK5	1232..1631	CDD:212581	166/407 (41%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54452
OrthoDB	1	1.010	-	-		D102580at2759
OrthoFinder	1	1.000	-	-		FOG0000433
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X372
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.930