DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment spg and dock2-like

DIOPT Version :9

Sequence 1:	NP_733258.4	Gene:	spg / 43404	FlyBaseID:	FBgn0264324	Length:	2187	Species:	Drosophila melanogaster
Sequence 2:	XP_021336757.1	Gene:	dock2-like / 100330200	-ID:	-	Length:	969	Species:	Danio rerio

Alignment Length:	1003	Identity:	332/1003 - (33%)
Similarity:	527/1003 - (52%)	Gaps:	116/1003 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 WIPSN-NKYGVAIHNWHGDVRFGLALDVGDSVDIVEECKHWYRGSCPRKSRAVGLFPKTYIHIKD 65
            |..:| .:|||...|:.......|:|.:||:|.|.|.|:.|::|...:.....|.||.::|.:|:
Zfish     4 WTKTNTERYGVVKWNFIAKAEKQLSLVIGDAVYIEESCEGWFKGYTVKNKERKGAFPASFIELKE 68

  Fly    66 ------------LSKIDPVVAECTQVLREWSEIWKRLYV-DREAYKFQTLRKVMFSILESRRELL 117
                        :|...|:|.|.|..||||..|||.||| ..:..:|..::::|:.::|.|.:||
Zfish    69 VIIEKRGDEEIIMSAEMPLVKEVTTTLREWGSIWKHLYVLSSKKERFVQVQRLMWDLMEWRSQLL 133

  Fly   118 SATMTQDQTLELQMVVVSKIDWGNRKLGLDLVPRE--GPLAVDPHGIGIVKLYNVHVSSA----- 175
            |.|:..|:..||:..|.||||:||:.|.||:|.|:  |.: :||....::.|:..|..:.
Zfish   134 SGTLPSDEFKELKQKVTSKIDYGNKILELDVVVRDVNGNI-LDPERASVISLFRAHEDATAKITE 197

  Fly   176 ------DNAKASSSRGTLRRKTQRKILTHHLYFCMRDFGHRIGGDDAEVYFFLYDGSHMRPLSER 234
                  .|.:..||..:.|.:...   ||.||..:|:|..|| |:|:|::..|||.:....:||.
Zfish   198 RIKEEQSNVQMESSGVSARIQLSP---THSLYVFVRNFVCRI-GEDSELFMSLYDPNKQTNISEN 258

  Fly   235 FLVKISKDGFSNYIERLHSNCTVFTDLGAADLN-EELHLVAVVMRVGKIIQSDSIKKIEKSGTLG 298
            :||:....|....||.|::...||||||..||| |:::|:..::|||::...|:   ..|..|:|
Zfish   259 YLVRWGDKGLPKDIEMLNNLKVVFTDLGNKDLNREKIYLICQIVRVGRMELKDN---NNKKCTMG 320

  Fly   299 HGPTFRRPFGVGVLSLGDIAHFDSSLEQSSDEREYNFKLFQ--CEEKDF-HLLPELIIKKSSGKY 360
                .||||||.|:.:.||.   ....:..:|::| |..|.  ..|.|| |.|        ..|.
Zfish   321 ----LRRPFGVAVMDISDII---KGKTECDEEKQY-FIPFHPVIAENDFLHTL--------LNKV 369

  Fly   361 SPIQASQGTQGIVVSLKLLHGGLGQARQEQPMLFQGST-ITRKMGFPDVIMPGDVRNDLFLNLER 424
            :..:...|.||:.|::|.|.|.:.|.|:|.|.|...|| :.||:|||::|||||:|||::|.|..
Zfish   370 TTTRGDSGGQGLWVTMKALVGDIVQIRKEYPHLVDRSTVVARKLGFPEIIMPGDIRNDIYLTLHS 434

  Fly   425 GEFERGGKNTGKNILVTVVVLDVAGNVLTDCLWGASGMESQPQYRSMILYHQNAPSWNEMLRLSV 489
            |:|::..|.|.||:.|.::|.|..|.|:.:.:...:|.....:|:|:|.|....|.|.|..::::
Zfish   435 GDFDKYNKTTQKNVEVIMLVCDEDGKVVPNSICLGAGDRPVNEYKSVIYYQIKQPRWMETFKVAI 499

  Fly   490 PIDKFSTAHVRFEFRHCS---TRDKTEPKLFAFSFARLMDTGGATLGDGLHELYVYKCEDPAKLQ 551
            |:::....|:||.|||.|   ::||:| :.||.:|.|||...|..|.||:|:|.|:|.:.....:
Zfish   500 PLEEMPRIHLRFMFRHRSSQESKDKSE-RNFAMAFVRLMKEDGTVLRDGIHDLTVFKGDSKRMEE 563

  Fly   552 VANYLRLQCRPRDAQAKMDC-------------GGCFSRSSKEVFVLRSLLCSTKLTQNADLLSL 603
            |:.||.|    ...::..||             || .|.||:::|.:.:|:||||||||..||.|
Zfish   564 VSMYLPL----ASERSTSDCHKGSTLMRSSSSVGG-LSVSSRDIFTISTLVCSTKLTQNVGLLGL 623

  Fly   604 LQWRTYPETIQDSLTGVLRLNDEELVKFLQDVLDALFAMFSNEEGNSTQHSGLVFHVLVSIFSLL 668
            |:|||.||.::.:|..:..::.||:||||||.|||||.:.. |...:..:..|||..|:.|..|:
Zfish   624 LKWRTRPEMLKKNLQELKLIDGEEVVKFLQDTLDALFNIMM-EHSQTDDYDILVFDALIYIIGLI 687

  Fly   669 QSNKFQHFRPVMNEYIENHFAAALVYKGLITSVEHMAVFMTKAEHPDPFQKCFGSLEYIFKLLIQ 733
            ...|||||..|:..||:.||:|.|.||.|::.::......::.|..:|..:...:||||||.:::
Zfish   688 ADRKFQHFNTVLEAYIKQHFSATLAYKKLMSVLKTYLDVSSRGEACEPILRTLKALEYIFKFIVR 752

  Fly   734 SRKLFARATGGQYEDSFKRDLHSLFTALNGMLAVPSYDVIIPTQEALLNSTGVVLEQLKDTLPAP 798
            ||.|:::...|:.:..|:..|.|||.::|.::. ..|...:..|.|.|.....||:.::....|.
Zfish   753 SRMLYSQLYEGKEQAEFEESLKSLFESINNLMK-SDYTTTLLQQVAALKYLPTVLQDVETVFNAK 816

  Fly   799 ELGMLARNMLDAIPRGAPIRLIQAKLHAVKDLVSGELFHEDDSRTVVLSVACKHLRMHLS----R 859
            .|..|..:....||   |.:|.:.|:.::.::|...|||..|.|.|:|.:..:.|...|:    .
Zfish   817 LLSKLLYDFYTCIP---PDKLQKHKVSSMTEIVGSRLFHRQDCRDVLLPMMLRELAGGLALMEGL 878

  Fly   860 RDELRLCAEILSEILSQLYDLQKEQREKVTNTLQHDLDSLCKNILGILIRTIS------------ 912
            :||.:...|:|:.||..|      .|..|.:|.||     .::|:..|:|||:
Zfish   879 QDEKKNSIELLNNILEVL------SRSDVGDTFQH-----IQDIVSSLLRTINRTVITMGREHTL 932

  Fly   913 ------IIMEGSNAVLPQLVSCLLGLLQ 934
                  :|:..:.::.|.|||..|.|::
Zfish   933 IVSYTHLILSIAFSLAPFLVSLSLWLIK 960

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
spg	NP_733258.4	SH3_DOCK_AB	9..64	CDD:212805	18/54 (33%)
		DOCK_N	67..406	CDD:292790	123/357 (34%)
		C2_Dock-B	414..600	CDD:176077	70/201 (35%)
		DHR2_DOCK	1215..1610	CDD:297424
dock2-like	XP_021336757.1	SH3	12..67	CDD:327375	18/54 (33%)
		DOCK_N	71..416	CDD:318415	123/368 (33%)
		C2	424..620	CDD:326325	70/201 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D102580at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.920