Protein Alignment spg and dock6

DIOPT Version :9

• Sequence 1: NP_733258.4
• Gene: spg / 43404
• FlyBaseID: FBgn0264324
• Length: 2187
• Species: Drosophila melanogaster
• Sequence 2: XP_031755292.1
• Gene: dock6 / 100216257
• XenbaseID: XB-GENE-992620
• Length: 2111
• Species: Xenopus tropicalis
• Alignment Length: 2173
• Identity: 402/2173 - (18%)
• Similarity: 691/2173 - (31%)
• Gaps: 697/2173 - (32%)

  Fly    30 DSVDIVEECKHWYRGSCPRKSRAVGLFPKTYIHIKDLSKIDPVVAECTQV-LREWSEIWKRLYVD 93
            |.::|:.|         ||:.|.:.  |..    .:..|:|..|.|..:| :.:|..:.:|....
 Frog    81 DDIEILYE---------PRECRTIE--PAA----PEEGKLDARVREALKVYMHDWVLVQRRSQEL 130

  Fly    94 REAYKFQTLRKVMFSILESRREL---LSATMTQ-DQTLELQMVVVSKIDWGNRKLGLDLVPREGP 154
            ..||...|        ||.:|:|   ||..:.: |:..|.:.....:.|.....:.:|..||
 Frog   131 STAYSPIT--------LERQRQLQRGLSRHLYEVDEAEEERAAQEEQEDKKRASVSMDDTPR--- 184

  Fly   155 LAVDPHGIGIVKLYNVHVSSADN------AKASSSRGTLRRKTQRKILTHHLYFCM--------- 204
                  |.....::::..||.|.      .:|.|.......:.||:...|.....:
 Frog   185 ------GSWASSIFDLKNSSPDPLLPGLLERAPSEETDQINQEQRREGRHPQILALYSAPDEDEA 243

  Fly   205 -----------RDFGHRIGGDDAEVYF-----------FLYDGSHMRPLSERFLVKISKDGFSNY 247
                       ..||.|:......:.|           .|||....|.:||.|...::.|...|.
 Frog   244 VERSSIPEVPKEHFGFRLLVKFLSLKFEIEIEPIFGVMALYDAKEKRKISEGFHFDLNSDSVKNM 308

  Fly   248 IERL--HSNCTVFTDLGAADLNEELHLVAVVMRVGKIIQ----------------SDSIKKIEKS 294
            :...  |...:.........:......:.:::::.|::|                ||.:|..||.
 Frog   309 LRSQGGHQAPSTLARSAIFSITYPSPDIYLIIKLEKVLQQGDIGECCEPYMVLKESDGMKNKEKV 373

  Fly   295 GTL-GHGPTF-------RRPFGVGVLSLGDIAHFDSSLEQSSD---ER-----EYNFKLFQ---- 339
            ..| |....|       |.||....:.|.:|.....::|:.||   ||     |...|.|:
 Frog   374 DKLRGQADQFCSRLGRYRMPFAWTAIHLMNIVSSVGAVERDSDSDSERKGTWNERKRKAFERLSV 438

  Fly   340 ----C-----------------EEKDFHLLPELIIKKSSGKYSPIQASQGTQGIVVSLKLLHGGL 383
                |                 :|.| .|..|.:.|..:....|..|.:..:.:...||:   .:
 Frog   439 GDETCGLHTFRPATLTVTNFFKQEGD-RLSDEDLYKFLADMRRPSTALRRLRPVTAQLKI---DV 499

  Fly   384 GQARQEQPMLFQGSTITRKMGFPD----------------VIMP-GDVRNDLF-----LNLERGE 426
            ..| .|.|.......:.....:||                |.:| ...||.||     |||.
 Frog   500 SPA-PENPQFCLTPELRHVKPYPDPRVRPTKEVLEFPSREVYVPHTSYRNLLFVYPRSLNLS--- 560

  Fly   427 FERGGKNTGKNILVTVVVLDVAG---NVLTDCLWGASG-MESQPQYRSMILYHQNAPSWNEMLRL 487
             .|.|  :.:||.|.|..:  ||   |.....::|.|. .|...:..:.::||..:|.:.|..::
 Frog   561 -SRQG--SVRNIAVKVQFM--AGEDPNQALSVIFGKSSCSEFCSEAYTPVVYHNKSPDFYEEFKM 620

  Fly   488 SVPIDKFSTAHVRFEFRHCSTRDKTEPKL---FAFSFARLMDTGGATLGDGLHELYVYKCEDPAK 549
            .:|.:.....|:.|.|.|.|.|......:   ..:::..||..|  .|..|...|.|...:.|..
 Frog   621 KIPGNLTENHHLLFTFYHVSCRPNQSSAVETPAGYTWIPLMQHG--RLQTGSFSLPVSVEKLPPS 683

  Fly   550 LQVANYLRLQCRPRDAQAKMDCGGCFSRSSKEVFVLRSLLCSTKLTQNA------DLLSLLQWRT 608
            ..|..        .|.|..   |..:..:.|.||.:..:..|:..||:.      .|:.||:.::
 Frog   684 YSVLT--------PDVQLP---GMKWVDNHKPVFSVDLVAASSVHTQDPHLDKFFTLVQLLEEQS 737

  Fly   609 YPETIQD--------------SLTGVLRLNDEELVKFLQDVLDALFAMFSNEE---GNSTQHSGL 656
            :|..::|              |:..:|:......|.|...:||.|..:.....   |........
 Frog   738 FPFRLKDVIITESNVESELRNSMVNLLQAALGPAVCFCHPLLDKLILLIVRPPIIGGQIVNLGRA 802

  Fly   657 VFHVLVSIFSLL----QSNKFQHFRPVMNEYIENHFAAALVY------------KGLITSVE--- 702
            .|.|:..:...:    :..:.||.|        |...|:.:|            ..:.||..
 Frog   803 AFEVMAKLVGHIHRDVEVGQDQHGR--------NSLLASYLYYAFHLPSDMPAQLNMATSTSTAS 859

  Fly   703 --HMAVFMTKA-----------------EHPD-----------PFQKCFGS-------------- 723
              |.|. |::|                 .:||           ..|:..|.
 Frog   860 SLHSAT-MSRATGRPSSYTLARCKSISNSNPDLTSIPGSTDDEEVQRILGGKGIDRSHSWVNSAY 923

  Fly   724 ---------------------------------------------------------LEYI---- 727
                                                                     |:::
 Frog   924 GPGGPKSVQRRTQPNSNTELRQNVERSPNRISSYMEGGASSVQPRPTAKKLLHEELVLQWVVSSA 988

  Fly   728 -------------FKLLIQSRKLFARAT-------GGQYEDSFKRDLHSL--------------- 757
                         |:|:.:|..|....:       ..::.:.|..|:.:|
 Frog   989 AVREAAMSQAWFFFQLMTKSMTLHLHMSERLDAPRRQRFPERFVDDISALVCNVCSEITSRYLKD 1053

  Fly   758 --FT-ALNGMLA------------------VPSYDVIIPTQEALLNSTGVVLEQLKDTL------ 795
              || .||..||                  :.||...:..:.:...:...::....|.:
 Frog  1054 PEFTERLNSSLAFFLNDLLSLMDRGFVFNLIRSYYKQVNNKLSTAQNPNALISMRMDLIRIVCSQ 1118

  Fly   796 ------------------PAPELGMLA------------RNMLDAIPRGAPIR-------LIQAK 823
                              |.|.:....            |.:.:......|.|       ||..:
 Frog  1119 EHYVSLNLPCGTLTPPNSPTPSISSTTSQSSVFSSPAQDRTITNMFELSVPFRQQHFLAGLILTE 1183

  Fly   824 LHAVKDL-VSGELFHEDDSRTVVLSVACKH-----LRMHLSRRDELRLCAEILSEILS---QLYD 879
            |..:.:. |.|..|.:..|.:.:.::.|.|     ....|.:....||...::..||.   ||||
 Frog  1184 LSLILEPDVEGVFFLQKKSISTLHNLICSHDTDPRYAEPLVKESVARLYLPLIGVILENLPQLYD 1248

  Fly   880 LQKEQREKVTN--TLQHDLDSLCKNILGILIR-TISIIMEGSNAVLPQ----------------- 924
            .......:|.|  .|..::||     .|..|. |:::.:.||....||
 Frog  1249 FTDPHAHRVRNVSALVDEVDS-----DGTTINPTVAMAIAGSPLPAPQKTNNFPLPPPPARAGST 1308

  Fly   925 --------LVSCLLGLLQLLDETHYKRYWDELSPNKDPRDLKEFLS--------KSLLVYEEL-- 971
                    |:.|.|.:|:..:.....|::..|:..:..| |.|.||        |....:|.:
 Frog  1309 LSADASRNLLVCALWVLKNAERDLLHRWFSNLTVLQLTR-LLELLSLCVSCFQYKGKKAFERINS 1372

  Fly   972 LTQDWHVFPNDWLVMKL-----------AANDVLRMSLEEFAKPLVYRFLGPQAFDSQLWWSYFS 1025
            ||     |... |.||.           |..|:::.|.|.          ||......:.|.
 Frog  1373 LT-----FKKS-LDMKARLEEAILGTIGARQDMVKRSRER----------GPFGNQENVRWR--- 1418

  Fly  1026 LAVAFLTQ---PSLQLEQYREPKRLKI-----LHSHGDMRVLMGFQILSMWSQLGEQKLHFIPSM 1082
               ..:||   .|.:.|:.:..:.|:|     :.:..:|.||...:|:.....:.|.|...:..:
 Frog  1419 ---KNITQWRPTSEKTEKTQAERELEIIVDGNMATEANMVVLDTLEIVVQTVMMSELKESILAGV 1480

  Fly  1083 VGPFLEVTLVPEPAL--------RKATLSVFYDMM--------------------QCEQAAR--- 1116
            :...|......:.||        ::|.:|.|.:|:                    .|..:.|
 Frog  1481 LKVILHSLGCSQSALYLQHCLASQRALVSKFPEMLFEDDTELCSDLCLRLLRHCSSCISSVRTQA 1545

  Fly  1117 ---------------GSFRLVESELIDKLDLLI--SENKGDDEYRELFSTILL---EKVQVENPN 1161
                           .:|..|:.::...|..|:  |:...::..|....|||.   |.:::.:..
 Frog  1546 SASLYLLMRQNFEIGNNFARVKMQVTMSLSSLVGTSQKFNEEHLRRSLKTILTYAEEDLEMRDTT 1610

  Fly  1162 WKEAGIAFIASVTRLL-------------ERLLD--YRSVMQGEENR-DKRMTCTVNLLNFYKNE 1210
            :.|.....:.::..:|             |.|:|  || :.:|.:|. |.|:|...|:...:...
 Frog  1611 FPEQVQDLVFNLHMILTDTVKMKEHQQDPEMLIDLMYR-IAKGYQNSPDLRLTWLQNMAAKHSER 1674

  Fly  1211 INRKEMYLRYIYKLHNLHLQAENYTEAGFTLKLYASMLSWDRE---------------TQSFAPF 1260
            .|:.|....::   |...|.||           |.|||...|.               .:..|..
 Frog  1675 GNQAEAAHCFV---HGAALVAE-----------YLSMLEDARHLPVGCVSFQNISSNILEESAVS 1725

  Fly  1261 DNSGQPEWQRKE--------------RLYHEILKYFDKGKCWEKGIPLCKELAHLYETRRFDYNK 1311
            |:...|:   :|              .|..:....|:.|..:|....:.|.|..:||..| ||.|
 Frog  1726 DDVVSPD---EEGICAGKYFTEAGLVGLLEQACASFNLGGLFEAVNEVYKILIPIYEASR-DYKK 1786

  Fly  1312 LSEILIQEAKFFQNILTQL----RPEPEYFRVGFYGMGLPLFVRNKQFVYRGLEYERIGAFTQRL 1372
            |:.:..:..:.|..|..|:    |....||||||||.... .:..::|||:.....::...:.||
 Frog  1787 LAVVHGKLQEVFSKITNQITSWERMFGTYFRVGFYGSKFG-DLDEQEFVYKEPSITKLAEISHRL 1850

  Fly  1373 QTEF-------PSAQILGNNSPPDNAILNAPDQYIQISNVRPVGDAQALKTAMVPVPEKIARFYE 1430
            : ||       .:.|::.:::..|.:.|:....||||:.|.|..|...||       :::..|.:
 Frog  1851 E-EFYTERFGEGTVQVVKDSNHVDKSKLDPNKAYIQITYVEPFFDTYELK-------DRVTYFDK 1907

  Fly  1431 VNDVTRFIYDRPMYKGTVD--KDNEFKSLWIERTILEIASPLPGILRWYEVKQKTMQELTPVEYA 1493
            ..::..|::..|.   |:|  ...|....:..:|:|..:...|.|.....|..:....|.|||.|
 Frog  1908 NYNLRTFLFCTPF---TLDGRAHGELHEQYKRKTVLTTSHAFPYIKTRINVLDREEVVLIPVEVA 1969

  Fly  1494 CEIISNAGKELSELIVQYKRDPKRNINPFSMRLQGTIDANVMGGISKYQEAFFSEQFLKSPQGAG 1558
               |.:..|:..||.....:|| .:.....|.|||.:...|..|..:..:.|.||    .|:...
 Frog  1970 ---IEDMQKKTQELAFATHQDP-ADAKMLQMVLQGCVGTTVNQGPLEVAQVFLSE----IPEDPR 2026

  Fly  1559 QQANVQRLKVLILEQIQILEQALELHGQLAPSGVQPLHNRLLERFSQLKQSLSGMGRLKRQHSES 1623
            ......:|::...:..:..|.||:.:..|.....:..|..|...:.:|:::|:   .|..:....
 Frog  2027 LYRLHNKLRLCFRDFTKRCEDALKKNKTLIGPDQREYHRELERNYQRLREALA---PLTSRRIPQ 2088

  Fly  1624 IVNTPLPPLPTEQRVAPATASSSLNANA 1651
            :.|..||         ..||..|||.::
 Frog  2089 LYNDLLP---------HTTARDSLNRSS 2107

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
spg	NP_733258.4	SH3_DOCK_AB	9..64	CDD:212805	7/33 (21%)
		DOCK_N	67..406	CDD:292790	81/439 (18%)
		C2_Dock-B	414..600	CDD:176077	48/203 (24%)
		DHR2_DOCK	1215..1610	CDD:297424	98/436 (22%)
dock6	XP_031755292.1	DUF3398	48..157	CDD:403173	23/98 (23%)
		C2_Dock-C	546..723	CDD:176078	48/197 (24%)
		DHR2_DOCK	1656..2078	CDD:414667	103/459 (22%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910