Protein Alignment spg and dock3

DIOPT Version :9

• Sequence 1: NP_733258.4
• Gene: spg / 43404
• FlyBaseID: FBgn0264324
• Length: 2187
• Species: Drosophila melanogaster
• Sequence 2: XP_031756989.1
• Gene: dock3 / 100216191
• XenbaseID: XB-GENE-855883
• Length: 2032
• Species: Xenopus tropicalis
• Alignment Length: 2134
• Identity: 814/2134 - (38%)
• Similarity: 1187/2134 - (55%)
• Gaps: 268/2134 - (12%)

  Fly     1 MWIPS-NNKYGVAIHNWHGDVRFGLALDVGDSVDIVEECKHWYRGSCPRKSRAVGLFPKTYIHIK 64
            ||.|: ..||||.|.::.|.|..||.|::|::|.|:|:|:.||||:..:.....|:||...||:|
 Frog     1 MWTPTEEEKYGVVICSFRGSVPQGLTLELGEAVHILEKCEGWYRGASIKNPNIKGIFPVNIIHLK 65

  Fly    65 D------------LSKIDPVVAECTQVLREWSEIWKRLYVDREAYKFQTLRKVMFSILESRRELL 117
            .            :...||:|.|.|..|:||:.:||:|||..:...|..||.||..:::.||:||
 Frog    66 KATVSNRGQYETVVPAEDPLVTEVTSTLQEWASLWKQLYVKHKVDLFYKLRHVMNEVIDLRRQLL 130

  Fly   118 SATMTQDQTLELQMVVVSKIDWGNRKLGLDLVPREGPLAVDPHGIGIVKLYNVHVSSADNAKASS 182
            |..:||||..|::..:..::||||..||||||||:..:|.|...|.:..||.:|:||..:.:.|:
 Frog   131 SGHLTQDQVREVKRHLTVRLDWGNEHLGLDLVPRKEFVAADSDQISVSDLYKMHLSSRHSVQQST 195

  Fly   183 SRG-TLRR--KTQRKILTHHLYFCMRDFGHRIGGDDAEVYFFLYDGSHMRPLSERFLVKISKDGF 244
            ::. |||:  |..|..:.|||...::.|.|...|:|.:::|.|||....|.:||||:|:::|:|.
 Frog   196 NQADTLRQRHKESRAPVPHHLLLNLKSFTHTNIGEDVDLFFSLYDMREARQISERFMVRLNKNGG 260

  Fly   245 SNYIERLHSNCTVFTDLGAADLNEELHLVAVVMRVGKIIQSDSIKKIEKSGTLGHGPT---FRRP 306
            ....|:|...|.:||||.:.|:..:||||..|:|:|:::.:||.|          ||.   :|||
 Frog   261 PKNPEKLERLCALFTDLSSKDVKRDLHLVVHVIRIGRMLLNDSRK----------GPPHVHYRRP 315

  Fly   307 FGVGVLSLGDIAHFDSSLEQSSDEREYNFKLFQC-EEKDFHLLPELIIKKSSGKYSPIQASQGTQ 370
            :|..|||||::.   ..|.:..||:::..|::.| .|.:::...|.||:|:|.|||   ......
 Frog   316 YGCAVLSLGEVL---PVLCEHRDEKDFVLKVYMCNNENEWYQTHENIIRKTSTKYS---TPSSNY 374

  Fly   371 GIVVSLKLLHGGLGQARQEQPMLF-QGSTITRKMGFPDVIMPGDVRNDLFLNLERGEFERGGKNT 434
            |::|||:||.|.:.|.|:|..:|| :|:.:|||:||||||:|||:||||::.||||:||||||:.
 Frog   375 GLMVSLQLLRGDMEQIRRENQLLFNRGAAVTRKLGFPDVILPGDIRNDLYVTLERGDFERGGKSV 439

  Fly   435 GKNILVTVVVLDVAGNVLTDCLWGASGMESQPQYRSMILYHQNAPSWNEMLRLSVPIDKFSTAHV 499
            .|||.||:.||...|..|.||:...:|...:.||.|.:|||.|:|.|.|:::|.:|||:|..:|:
 Frog   440 QKNIEVTMHVLYADGENLRDCVSLGTGEPPRTQYHSFVLYHNNSPRWGELIKLPIPIDRFRGSHL 504

  Fly   500 RFEFRHCSTRDKTEPKLFAFSFARLMDTGGATLGDGLHELYVYKCEDPAKL-QVANYLRLQCRPR 563
            |||||||||:||.|.|||.|||..||...|.||.|.:||||||||::.:.. ..|.||.|.|
 Frog   505 RFEFRHCSTKDKGEKKLFGFSFTPLMRDDGTTLSDDIHELYVYKCDENSTFNNHALYLGLPC--- 566

  Fly   564 DAQAKMDCGGC--------FSRSSKEVFVLRSLLCSTKLTQNADLLSLLQWRTYPETIQDSLTGV 620
               .|.|..||        |.||:||.|.:.:.|.|||||||.|||:||:|:.||:.|.|.|..:
 Frog   567 ---CKDDMSGCPNIPSSLIFQRSAKETFCISTQLSSTKLTQNVDLLALLKWKAYPDRILDILGRL 628

  Fly   621 LRLNDEELVKFLQDVLDALFAMFSNEEGNSTQHSGLVFHVLVSIFSLLQSNKFQHFRPVMNEYIE 685
            ..:|.||:||||||:||.||.:.   :.|:.::..|||..||.|.:||:.:|:.|||||::.||:
 Frog   629 RHVNGEEIVKFLQDILDTLFVIL---DENTEKYGLLVFQSLVFIINLLRDSKYYHFRPVLDSYIQ 690

  Fly   686 NHFAAALVYKGLITSVEHMAVFMTKAEHPDPFQKCFGSLEYIFKLLIQSRKLFARATGGQYEDSF 750
            .|||.||.|:.||..::............|..|:...:||.:||.:||||.||||:|.|..|:.|
 Frog   691 KHFAGALAYRELIRCLKWYMDRSADLVRQDHIQEAMRALEILFKFIIQSRLLFARSTAGLDEEPF 755

  Fly   751 KRDLHSLFTALNGMLAVP--SYDVIIPTQEALLNSTGVVLEQLKDTLPAPELGMLARNMLDAIPR 813
            :..:|.||.::..:|::.  |.|.::.||.|||:|...:.|:|.......|:....|..|.::|
 Frog   756 RCSIHELFQSMRFVLSLDTRSSDTLLFTQAALLSSFPAIFEELLPMFSVAEVAEFVRGTLSSLP- 819

  Fly   814 GAPIRLIQA----KLHAVKDLVSGELFHEDDSRTVVLSVACKHLRMHLSRRDELRLCAEILSEIL 874
             :.:.|.|:    ||.::...|...||...::|.::|.|...|:.:||.::.||.:|    |.||
 Frog   820 -STLHLGQSMDVVKLQSIGRTVDCRLFSYPEARRILLPVVLHHIHLHLRQQKELLVC----SGIL 879

  Fly   875 SQLYDLQKEQREKVTNTLQHDLDSLCKNILGILIRTISIIMEGSNA---------------VLPQ 924
            |.::.:.|....:|  .:..::..|.:::|.:|::|:.|||..|.|               :..:
 Frog   880 SSIFSIIKSSSTEV--DVGEEVQMLQESLLDVLLQTLLIIMSKSQAQEAARGQRCPQCTAEITGE 942

  Fly   925 LVSCLLGLLQLLDETHYKRYWDELSPNKDPRDLKEFLSKSLLVYEELLTQDWHVFPNDWLVMKLA 989
            .|||||.||:|:.:|||:..   |...:...:|||||.|...|:..||...  |||.||.||:|.
 Frog   943 YVSCLLSLLRLMSDTHYQHL---LHNFQSKEELKEFLLKIFCVFRNLLKLS--VFPPDWTVMRLL 1002

  Fly   990 ANDVLRMSLEEFAKPLVYRFLGPQAFDSQLWWSYFSLAVAFLTQPSLQLEQYREPKRLKILHSHG 1054
            |::|: ::..::..|.|::......||.::|.|||||||.|:.|||||||.:...||.:||..:|
 Frog  1003 ASNVI-VTTVQYVSPAVHKNFCDGDFDFKVWNSYFSLAVLFINQPSLQLENFAAAKRRRILDKYG 1066

  Fly  1055 DMRVLMGFQILSMWSQLGEQKLHFIPSMVGPFLEVTLVPEPALRKATLSVFYDMMQCEQAARGSF 1119
            ||||:|.:::.:||..|||.|.||||.|:||||.|:|||:|.:|...:.:|:|||.|||...|:|
 Frog  1067 DMRVMMTYELFNMWQNLGEHKYHFIPGMIGPFLGVSLVPQPEVRNIMIPIFHDMMDCEQRRNGNF 1131

  Fly  1120 RLVESELIDKLDLLISENKGDDEYRELFSTI---------LLEKVQVENPNWKEAGIAFIASVTR 1175
            :.||:|||||||.|:||.|||:.||||||.:         ||||::.|  .|:|.|.:|:.||||
 Frog  1132 KQVEAELIDKLDSLVSEGKGDENYRELFSLLSQLFGPYPSLLEKIEQE--TWREPGASFVTSVTR 1194

  Fly  1176 LLERLLDYRSVMQGEENRDKRMTCTVNLLNFYKNEINRKEMYLRYIYKLHNLHLQAENYTEAGFT 1240
            |:|||||||..|:|||..:|::.|||||:||||:|||::||::|||:||.:||||||:||||.||
 Frog  1195 LMERLLDYRDCMKGEEPENKKLGCTVNLMNFYKSEINKEEMFIRYIHKLCDLHLQAESYTEAAFT 1259

  Fly  1241 LKLYASMLSW-DRETQSFAPFDNSGQPEWQRKERLYHEILKYFDKGKCWEKGIPLCKELAHLYET 1304
            |.||..:|.| :|..:.|..:  ..|.||||||.|..:|:.||:||||||.|||||:|||..||
 Frog  1260 LLLYWELLQWEERPLREFLHY--PAQSEWQRKEGLSRKIIHYFNKGKCWEFGIPLCRELAAQYE- 1321

  Fly  1305 RRFDYNKLSEILIQEAKFFQNILTQLRPEPEYFRVGFYGMGLPLFVRNKQFVYRGLEYERIGAFT 1369
            :.:||..||.||..||.::.:|:.|.|.|||:|||||||...|.|:|||:||.||.:|||:.||.
 Frog  1322 KLYDYQSLSWILKMEASYYDHIMDQQRLEPEFFRVGFYGKKFPFFLRNKEFVCRGHDYERLEAFQ 1386

  Fly  1370 QRLQTEFPSAQILGNNSPPDNAILNAPDQYIQISNVRPVGDAQALKTAMVPVPEKIARFYEVNDV 1434
            ||:.:|||.|..:.:.:.||:.||.:..||:||..|.|:.|...: ..|..||::|..||.||:|
 Frog  1387 QRMLSEFPQAIAMQHLNHPDDTILQSDAQYLQIYAVTPLPDTPNI-LQMDQVPDRIKSFYRVNNV 1450

  Fly  1435 TRFIYDRPMYKGTVDKDNEFKSLWIERTILEIASPLPGILRWYEVKQKTMQELTPVEYACEIISN 1499
            .||.||||.::||.|||||||||||||:.|.::..||||..|:||:::.:.|::|:|.|.:::.|
 Frog  1451 RRFRYDRPFHRGTRDKDNEFKSLWIERSTLTLSHSLPGISCWFEVQKRELVEVSPLENALQVLGN 1515

  Fly  1500 AGKELSELIVQYK-RDPKRNINPFSMRLQGTIDANVMGGISKYQEAFFSEQFL-KSPQGAGQQAN 1562
            ..:||..||.||: .:...|||..||.|.|.|||.|.|||::||||||.:::: :.|:.|   ..
 Frog  1516 KTQELRALITQYQHHNLHGNINLLSMCLNGVIDAAVNGGITRYQEAFFDKEYITQHPEDA---EK 1577

  Fly  1563 VQRLKVLILEQIQILEQALELHGQLAPSGVQPLHNRLLERFSQLKQSLSGMGRLKRQHSESIVNT 1627
            :.:||.|:.||:.:|...|.:|.:.....::|||.:|:::|..::.||     .:...:...:|.
 Frog  1578 ISQLKELMQEQVHVLGVGLAVHERCVHPEMRPLHKKLVDQFQVMRSSL-----YQEFPTMEKMNL 1637

  Fly  1628 PLPPLPTEQRV---APATASSSLNANAHSNYVYDLDEIYTRPGDTVRPVDPLSSYQTLSKESLSI 1689
            ..|||.....:   .|.:|.|....:.||                  |:..|:|.:..|....|.
 Frog  1638 SCPPLSRSNILLAHGPMSADSVRLLHRHS------------------PLVVLNSVRHSSSSLSSH 1684

  Fly  1690 PLEDTAAPP----------------VPNRPRSQNFIGNGSMDSPEVPPKRQPTLNSPNAP----- 1733
            ...||...|                :|:...:.:.....::.|....|......::.:||
 Frog  1685 ASSDTGTTPTAGDSENEDPYSMQMLLPHSLHAGSITNVSALSSSYTSPSSSSLSSTHSAPSQLVN 1749

  Fly  1734 --PLPPRG--ITPDK-RASNPLIFNDFGSGDAVGRRHSQQQQQHGQKYSVVDISYDDPEADQQPH 1793
              |...||  ..||| |.|..|:.......|.......|....:||:.             ..|.
 Frog  1750 SAPSSTRGSPSLPDKYRHSRDLVMLLPAPRDRPSSAMYQTSTDNGQRC-------------MYPR 1801

  Fly  1794 SLPPNFQDGSGGHLSVCFAPN-DFRDSGISTTSSRELNHMNLNNLSEDSSSISTITVQHREHCRI 1857
            :|   ||... |....|..|| ...:..::..||..|:.....:|...:|.|.::         :
 Frog  1802 AL---FQQVL-GPCKPCSDPNLSVAEKVLTAPSSWSLDSGTRESLPFMASHIGSV---------L 1853

  Fly  1858 SSNGSLDYNAAASMNITQRESSTSSFDV------EDFP-------------VPPPPIPPKSLAVS 1903
            :..|:       :..:||...|. .||.      |..|             :|..|..|:|....
 Frog  1854 TPTGT-------TRGLTQGHYSL-HFDAFHPAMGEGAPLPTRSLRKSPLHTIPASPTSPQSCLDG 1910

  Fly  1904 SN---------GVNFSLDEAH---SPHPSTQANTTQLNHIQNPNQNHSTNSHHHLQQQQNGDGDG 1956
            ||         ||: ||.|.:   .|.|::..:       ....:||:....|:...:
 Frog  1911 SNSPLSGSASSGVS-SLSEGNLSGCPDPASATD-------PRTEENHTGGFQHYPPVR------- 1960

  Fly  1957 YSTLQHPMNGLGLPTLPPP----------PSAVESPMPASAIASSTSSHQHDGG 2000
            || |..| ||     |.||          ||.|..|       .|.|..|.:||
 Frog  1961 YS-LSDP-NG-----LEPPKFQGCRSHSAPSGVTPP-------RSPSGEQEEGG 2000

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
spg	NP_733258.4	SH3_DOCK_AB	9..64	CDD:212805	23/54 (43%)
		DOCK_N	67..406	CDD:292790	133/346 (38%)
		C2_Dock-B	414..600	CDD:176077	97/194 (50%)
		DHR2_DOCK	1215..1610	CDD:297424	189/397 (48%)
dock3	XP_031756989.1	SH3_DOCK3_B	10..65	CDD:212981	23/54 (43%)
		DOCK_N	69..411	CDD:406558	133/357 (37%)
		C2_Dock-B	419..608	CDD:176077	97/194 (50%)
		DHR2_DOCK	1234..1625	CDD:414667	189/397 (48%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	486	1.000	Domainoid score	I392
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H21030
Inparanoid	1	1.050	1299	1.000	Inparanoid score	I157
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D102580at2759
OrthoFinder	1	1.000	-	-		FOG0000433
OrthoInspector	1	1.000	-	-		otm47508
Panther	1	1.100	-	-	LDO	PTHR45653
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X372
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	9.160