DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment spg and dock9b

DIOPT Version :9

Sequence 1:	NP_733258.4	Gene:	spg / 43404	FlyBaseID:	FBgn0264324	Length:	2187	Species:	Drosophila melanogaster
Sequence 2:	XP_021332715.1	Gene:	dock9b / 100151488	ZFINID:	ZDB-GENE-090916-2	Length:	2095	Species:	Danio rerio

Alignment Length:	1901	Identity:	357/1901 - (18%)
Similarity:	636/1901 - (33%)	Gaps:	597/1901 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   186 TLRRKTQRKILT--------------HHLYFCMRDFGHRIGGDDAE-------------VYFFLY 223
            ||...|||..|:              ..:..|..|....:....||             |...|:
Zfish   350 TLDPDTQRLDLSGIEPDVKQFEEKFGKRVLVCCNDLSFNLQSCVAENEEGPTTNVEPFFVVLSLF 414

  Fly   224 DGSHMRPLSERFLVKISKDGFSNYI--ERLHSNCTVFTDLGAADLNE---ELHL----------- 272
            |..:.|.:|..|.|.::.....:.|  ..:..|..|.|..|...|:|   .||.
Zfish   415 DVQNSRKISADFHVDLNHPLVRSLIPSPSMQINGGVDTPHGETLLSELQGMLHYPKKGVFSVTCP 479

  Fly   273 ---VAVVMRVGKIIQ-------------SDSIKKIEK--------SGTLGHGPTFRRPFGVGVL- 312
               :.:|.|:.|::|             |||.|..:|        ...||.   :|.||.....
Zfish   480 HPDIFLVARIEKVLQGGITHCAEPYMKSSDSSKVAQKVLKNAKMACSRLGQ---YRMPFAWAARP 541

  Fly   313 -------SLGDIAHFDSSLEQSSDE--REYNFKL---FQCEEKDFHLLPELI------------- 352
                   :|...|.|.:...|.|::  .|..|||   |:..|| ...||.::
Zfish   542 VFKDASGTLDKSARFSALYRQDSNKLSEEDLFKLLADFRKPEK-MAKLPVILGNLDVTIDNVPPD 605

  Fly   353 ----IKKSSGKYSPIQASQGTQGIVVSLKLLHGGLGQARQEQPMLFQGSTITRKMGFPDVIMPGD 413
                :..|.....|.:::....|:::.::.....:  |:..||.....:.:        .:.|..
Zfish   606 MANCVTPSYIPVRPFESNGPNDGVLLEVEEFVPCI--AKCSQPFTTYNNHL--------YVYPKH 660

  Fly   414 VRNDLFLNLERGEFERGGKNTGKNILVTVVV--LDVAGNVLTDCLWGASG--MESQPQYRSMILY 474
            ::.|     .:..|.:     .:||.|.|..  .|........|::|..|  :.::..| :.:|:
Zfish   661 LKYD-----NQKSFAK-----ARNIAVCVEFRESDEEDAQALKCIYGRPGGPVFTKHAY-AAVLH 714

  Fly   475 HQNAPSWNEMLRLSVPIDKFSTAHVRFEFRHCSTRDKTEPKLFAFSFARLMDT--GGA---TLGD 534
            ||..|.:.:.:::.:|.......|:.|.|.|.|....|:.:       .:::|  |.|   .|.|
Zfish   715 HQQNPEFYDEIKIELPTQLHEKHHLLFTFYHISCDSSTKKR-------DIVETPVGSAWLPLLKD 772

  Fly   535 G---LHELYVYKCEDPAKLQVANYL---RLQCRPRDAQAKMDCGGCFSRSSKEV---------FV 584
            |   :.|.::         .||:.|   .|.|:.          |....||.|:         |.
Zfish   773 GRVVMSEQHI---------SVASNLPNGYLSCQE----------GVSKHSSPEIKWVDGGRPLFR 818

  Fly   585 LRSLLCSTKLTQNADLLSLLQWRTYPETIQDSLTGVLRLNDEELVK---------------FLQD 634
            :.:.|.||..||:..|      ..:........:|..|..:.||||               ||..
Zfish   819 VSTHLVSTIYTQDQHL------HNFFHHFHSMQSGAPRPTEGELVKYLKSLHAMEGHVMINFLPT 877

  Fly   635 VLDALFAMF---SNEE--GNSTQHSGLVFHVLVSIFSLLQSNKFQHFRPVMNEYIENHFAAALVY 694
            :|:.:..:.   :||:  .|:|:       |:|.|.:.......:|:   :..|::..|......
Zfish   878 ILNQMIHVLTSATNEDVAVNTTR-------VMVHIVAQCHEEGLEHY---LRSYVKYVFKTESYS 932

  Fly   695 KGLITSV-EHMAVFMTKAEHPD----PFQKCFGSLEYIFKLLIQSRKLFARATG-------GQYE 747
            .|...:| |.:|..||....|.    ...|......|.|:.|::|...:...:|       .::.
Zfish   933 NGNSKTVHEELAKAMTSILKPSTDFLTSNKLLKYSWYFFEALVKSMAQYLMESGKVKLSRNQRFT 997

  Fly   748 DSFKRDLHSLFTALNGMLAVPSYDVIIP--TQ------EALLNST----------------GVVL 788
            .||.   |::.|.:|         :::|  ||      :|..|:.                |.|.
Zfish   998 ASFH---HAVETLVN---------MLMPHITQKYKDNLDAARNANHSLAVFIKRCFTFMDRGFVF 1050

  Fly   789 EQLKD--TLPAP-----------ELGMLARNMLDAIPRGAPIRLIQAKLHAVKDL---------- 830
            :|:.:  |...|           |...:|.|....:|...|:...:.::...:||
Zfish  1051 KQINNYITCFVPGDPKTLYEFKFEFLRVACNHEHYVPLNLPMPFGKGRIQRFQDLQLDYSLTDDF 1115

  Fly   831 -------------VSGELFHEDDSRTVVL----SVACKHL--RMHLSRRDELRLCAEILSEILSQ 876
                         |.|.|....:.|.:.:    |:..||.  ..::|:..:.||....|     .
Zfish  1116 CRNHFLVGLLLREVCGALQEFGEVRQIAIQVLKSLMIKHTFDDRYVSKSQQARLATLYL-----P 1175

  Fly   877 LYDLQKEQREKVT-------NTLQHDLD--------------------SLCKNILGILIRTI--- 911
            |:.|.:|...::.       ||.|:..|                    ||.|::.|::..|.
Zfish  1176 LFGLLQENVHRLNVRDASNFNTNQNGRDEHLASIPSATPQKPVGNLDNSLHKDVFGVISGTASPH 1240

  Fly   912 ----------------SIIMEGSNAVLP-----------------------------------QL 925
                            |:|...|...||                                   .|
Zfish  1241 TSTPNIGSVRHADSRGSLISTDSGNSLPDKTNEKTGSLEKTQSASALGSSMLRCDKLDREEIKNL 1305

  Fly   926 VSCLLGLLQLLDETHYKRYWDELSPNK--DPRDL------------KEFLSKS------LLVYEE 970
            :.|.|.:|:.:.|.....||::.:.::  |...|            |.|:::|      ::...:
Zfish  1306 LMCFLHVLKSMSEDALFTYWNKATTSELMDFFTLVEVCLHQFRYMGKRFIARSQDGVGFMVPDRK 1370

  Fly   971 LLT---------------------QDWHVFPNDWL-----VMKLAAN----------DVLRMSLE 999
            .||                     ::.|.|.:.:.     ...|.||          |.|.:.:.
Zfish  1371 SLTLPVSRNRGSVMHTRLHQLGSLENSHTFNHTYCHADADACLLEANISTEVCLTVLDTLSVFIM 1435

  Fly  1000 EFAKPLVYRFLGPQAFDSQLWWSYFSLAVAFLTQP-----------SLQLEQYREPKRLKILHSH 1053
            .| |..:...||    .:.|....|.:.:.||..|           ||:...|:.|  .......
Zfish  1436 GF-KTQLCADLG----HNPLMKKVFQVHLCFLQIPQSETALKQVFTSLRTFIYKFP--CTFFDGR 1493

  Fly  1054 GDMRVLMGFQILSMWSQLGEQKLHFIPSMVGPFLEVTLVPEPALRKATLSVFYDMMQC--EQAAR 1116
            .||...:.::||...:    .||                  .::|.....:.|.:|:.  |...|
Zfish  1494 ADMCACLCYEILKCCN----SKL------------------SSIRSDAAHLLYFLMKSNFEYNGR 1536

  Fly  1117 GSFRLVESELIDKLDLLISE--NKGDDEYRELFSTILLEKVQVENPNWKEAGIAFIASVTRLLER 1179
            .||.....:::..:..||::  ..|...:::..|.|    ....|.:......||.:.|..|.:|
Zfish  1537 KSFVRTHLQVVIAVSQLIADVIGIGGTRFQQSLSII----NNCANSDKTVKHTAFPSDVKDLTKR 1597

  Fly  1180 LLDYRSVMQG-----EENRDKRMTCTV--NLLNFYKNEINRKEMYLRYIYKLH----NLHLQAEN 1233
            :   |:|:..     |..:|..|...:  :|...|.:....::.:|..:.|:|    :|...|..
Zfish  1598 I---RTVLMATEQMKEHEKDPEMLVDLQYSLAKSYTSTPELRKTWLDSMAKIHVKNGDLSEAAMC 1659

  Fly  1234 YTEAGFTLKLYASMLSWDRE------------TQSFAPFDNSGQPEWQRKERLYHEILKYFDKGK 1286
            |......:..|.......|:            .:..|..::.|..:....|.:..|:|:....|
Zfish  1660 YVHVAALVAEYLKRKGMFRQGCCAFRVITPNIDEEAAMMEDVGMQDVHFNEEVLMELLEACADG- 1723

  Fly  1287 CWEKG------------IPLCKE------LAHLYETRRFDYNKLSEILIQEAKFFQNILTQLRPE 1333
            .|:..            ||:.::      |||||:|....|.|:.|::....:....
Zfish  1724 LWKAERYELISDIYKLIIPIYEQRRDFEKLAHLYDTLHRAYTKVMEVMHSGKRLLGT-------- 1780

  Fly  1334 PEYFRVGFYGMGLPLF--VRNKQFVYRGLEYERIGAFTQRL---------QTEFPSAQILGNNSP 1387
              :|||.|:|.....|  ...|:::|:..::..:...:|||         |......|..|..:|
Zfish  1781 --FFRVAFFGQAAGFFEDEDGKEYIYKEPKFTPLSEISQRLLKLYSDKFGQENVKMIQDSGRVNP 1843

  Fly  1388 PDNAILNAPDQYIQISNVRPVGDAQALKTAMVPVPEKIARFYEVNDVTRFIYDRPMYK-----GT 1447
            .|   |.|...|||:::|.|..:.:.|:       |:...|...:::.||:::.|..:     |.
Zfish  1844 KD---LEAKFAYIQVTHVTPYLEEKELE-------ERKTDFERSHNIRRFVFETPFTESGKRHGG 1898

  Fly  1448 VDKDNEFKSLWIERTILEIASPLPGILRWYEVKQKTMQELTPVEYACEIISNAGKELSELIVQYK 1512
            |::..:      .||:|......|.:.:...|..:...:|:|:|.|.:.:|....||..|....:
Zfish  1899 VEEQCK------RRTVLTTTHCFPYVKKRIAVMYQHHTDLSPIEVAIDEMSGKVAELRALCATSE 1957

  Fly  1513 RDPKRNINPFSMRLQGTIDANVMGGISKYQEAFFSEQFLKS-PQGAGQQANVQRLKVLILEQIQI 1576
            .|..|    ..::|||:|...|..|...|..||..:...|. |..     .|::||.:..:.::.
Zfish  1958 VDMIR----LQLKLQGSISVQVNAGPLAYARAFLDDACAKKYPDN-----KVKQLKEVFRQFVEA 2013

  Fly  1577 LEQALELHGQLAPSGVQPLHNRLLERFSQLKQSLSGM---------GRLKRQHSESI-VNTPLPP 1631
            ..|||.::.:|.....|..|:.:...:..|.:.||.:         |..|...|:|: :...:..
Zfish  2014 CGQALAVNERLIKEDQQEYHDEMKASYRDLARELSNIMHEQISAVDGGTKSALSDSLHIFNAISG 2078

  Fly  1632 LPTEQRV--APATASS 1645
            .||...:  .|::||:
Zfish  2079 TPTSTTLHGMPSSAST 2094

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
spg	NP_733258.4	SH3_DOCK_AB	9..64	CDD:212805
		DOCK_N	67..406	CDD:292790	60/316 (19%)
		C2_Dock-B	414..600	CDD:176077	44/209 (21%)
		DHR2_DOCK	1215..1610	CDD:297424	93/445 (21%)
dock9b	XP_021332715.1	DUF3398	77..168	CDD:314708
		PH_DOCK-D	184..307	CDD:270087
		C2_Dock-D	650..832	CDD:176079	45/226 (20%)
		DHR2_DOCK9	1634..2050	CDD:212571	95/451 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1997
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810