Protein Alignment WASp and LAS17

DIOPT Version :9

• Sequence 1: NP_001263045.1
• Gene: WASp / 43402
• FlyBaseID: FBgn0024273
• Length: 527
• Species: Drosophila melanogaster
• Sequence 2: NP_014824.1
• Gene: LAS17 / 854353
• SGDID: S000005707
• Length: 633
• Species: Saccharomyces cerevisiae
• Alignment Length: 704
• Identity: 161/704 - (22%)
• Similarity: 229/704 - (32%)
• Gaps: 271/704 - (38%)

  Fly    21 LLTQEENEAVFKLLGKKC-QTLNTAVVQIY-----KTEGSAHAHWKKRHTGV---VCFVKDSAIR 76
            ||...:.|.:.:.|.|.. :.::..|.::|     |.|      |  ::||:   :..|.|....
Yeast     3 LLNSSDKEIIKRALPKASNKIIDVTVARLYIAYPDKNE------W--QYTGLSGALALVDDLVGN 59

  Fly    77 SYFMRAYCLIKNE-LIWEHEIYDGMEVVKSRPFLLTFEGSDGHVGLNFVSEEECDSFFRIVDATI 140
            ::|::...:..:. :||:.|:|...|..:.|.|..|||..:...||.||...|...|.:.|....
Yeast    60 TFFLKLVDINGHRGVIWDQELYVNFEYYQDRTFFHTFEMEECFAGLLFVDINEASHFLKRVQKRE 124

  Fly   141 ETRNRK----------RQEKRNRQKSQ--QAPNA-----------------PLPQVQREPARPPP 176
            ...|||          .::.|..||||  ..|..                 .:|..:.:...|||
Yeast   125 RYANRKTLLNKNAVALTKKVREEQKSQVVHGPRGESLIDNQRKRYNYEDVDTIPTTKHKAPPPPP 189

  Fly   177 MQGGLSSTDGVQLRNNKINSVT----LTPAPA--------------PAQSKNFLSSSFG------ 217
            .......:|.....:: |||.|    .|||||              |..|...|.:.|.
Yeast   190 PTAETFDSDQTSSFSD-INSTTASAPTTPAPALPPASPEVRKEETHPKHSLPPLPNQFAPLPDPP 253

  Fly   218 -----LGNNAKDKKRKVTKADISRPTNFVHLSHVGWDAQKGFDLAGNENDEVLNEFFVKAGVSEV 277
                 ..|||..:.:       |.|..|                                .:.|:
Yeast   254 QHNSPPQNNAPSQPQ-------SNPFPF--------------------------------PIPEI 279

  Fly   278 ELKDRDTRAFIY-----DFIQSNNVLASVKQYS---VESPTETAAPMPPPVPTRHPSNGN--QRT 332
            ......|..|.:     .|.|:.::  .:.|.:   .:.|.....|:|||.|.|..:.|:  :..
Yeast   280 PSTQSATNPFPFPVPQQQFNQAPSM--GIPQQNRPLPQLPNRNNRPVPPPPPMRTTTEGSGVRLP 342

  Fly   333 APPLPPARQPPPAVP----VT------------VPGA----ARAPPPP---NRPPPIST------ 368
            |||.||.|.|.|..|    ||            :|.|    ..|||||   :||.|..|
Yeast   343 APPPPPRRGPAPPPPPHRHVTSNTLNSAGGNSLLPQATGRRGPAPPPPPRASRPTPNVTMQQNPQ 407

  Fly   369 ------------------APPPPPV--------------------------------SAPVVAPP 383
                              :||||||                                :.||..||
Yeast   408 QYNNSNRPFGYQTNSNMSSPPPPPVTTFNTLTPQMTAATGQPAVPLPQNTQAPSQATNVPVAPPP 472

  Fly   384 PP----------------------------PPPPPA----------AVPPPPPPPMPVGEIPVIT 410
            ||                            ||||||          |..|||||.||.      |
Yeast   473 PPASLGQSQIPQSAPSAPIPPTLPSTTSAAPPPPPAFLTQQPQSGGAPAPPPPPQMPA------T 531

  Fly   411 TTHAPTQAARPAAPAAPDPRNALMDAIRKG---TQLKKVDTTALSTGSGDSRSDLMKDIRQGTVL 472
            :|......|.....|.   |:||:.:||..   ..|:|||.:.|     |..|.|:::.|..:..
Yeast   532 STSGGGSFAETTGDAG---RDALLASIRGAGGIGALRKVDKSQL-----DKPSVLLQEARGESAS 588

  Fly   473 KPAKERELGSQRNSDSGAGTDALADALRRALAARGNAIHSDEDETESSDNEGEW 526
            .||.....|:     .|....:|||||..||..|...:.:.:|    .||..:|
Yeast   589 PPAAAGNGGT-----PGGPPASLADALAAALNKRKTKVGAHDD----MDNGDDW 633

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
WASp	NP_001263045.1	WH1	31..140	CDD:144235	29/118 (25%)
		PBD	233..291	CDD:279166	6/62 (10%)
		WH2	<433..453	CDD:280384	8/22 (36%)
LAS17	NP_014824.1	EVH1_WASP-like	23..123	CDD:269916	27/107 (25%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3671
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	76	1.000	Inparanoid score	I1653
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001481
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_104030
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2175
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	7	6.840