DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment WASp and VRP1

DIOPT Version :9

Sequence 1:	NP_001263045.1	Gene:	WASp / 43402	FlyBaseID:	FBgn0024273	Length:	527	Species:	Drosophila melanogaster
Sequence 2:	NP_013441.1	Gene:	VRP1 / 851051	SGDID:	S000004329	Length:	817	Species:	Saccharomyces cerevisiae

Alignment Length:	487	Identity:	121/487 - (24%)
Similarity:	182/487 - (37%)	Gaps:	175/487 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   156 SQQAPNAPLPQVQREPARPPPMQGGLSSTDGVQLRNNKINSVTLTPAPAPAQSKNFLSSSFGLGN 220
            |..||  |:|.|...||.|.|    ||.....::..|:.:..::.||....|.|   ||:..|.:
Yeast   162 SSAAP--PIPIVPSSPAPPLP----LSGASAPKVPQNRPHMPSVRPAHRSHQRK---SSNISLPS 217

  Fly   221 NAKDKKRKVTKADI---SRPTNFVHLSH------------VGWDAQKGFDLAGNENDEVLNEFFV 270
                    |:...:   |.||   |:|:            :|.|: |......|......:|  |
Yeast   218 --------VSAPPLPSASLPT---HVSNPPQAPPPPPTPTIGLDS-KNIKPTDNAVSPPSSE--V 268

  Fly   271 KAG----VSEVELKDRDTRAFIYDFIQSNNVLASVKQYSVESPTETAAPMP---PPVPTRHPSNG 328
            .||    ::|:..: |..|..:       ..::|.|..:....:.:..|:|   ||:||.|
Yeast   269 PAGGLPFLAEINAR-RSERGAV-------EGVSSTKIQTENHKSPSQPPLPSSAPPIPTSH---- 321

  Fly   329 NQRTAPPLPPARQPPPAVP--VTVP---GAARAPPPPNRPPPIST-------APPPPPVSAP--- 378
                ||||||...|||::|  .:.|   .:|.|||||..|..:|:       |.|.||..||
Yeast   322 ----APPLPPTAPPPPSLPNVTSAPKKATSAPAPPPPPLPAAMSSASTNSVKATPVPPTLAPPLP 382

  Fly   379 ------------VVAPPPPPPPPPAA----------------VPPPPPP---------PMPVGEI 406
                        :.||||||||||.|                :||||||         |.|
Yeast   383 NTTSVPPNKASSMPAPPPPPPPPPGAFSTSSALSASSIPLAPLPPPPPPSVATSVPSAPPP---- 443

  Fly   407 PVITTTHAPTQAARPA-----------APAAPDPRNALMDAIRKGTQLKKVDTTALSTGSGDSRS 460
            |...||:.|:.:::.:           .|..|.|   .:..|:|    |:.|...:...:|.:..
Yeast   444 PPTLTTNKPSASSKQSKISSSSSSSAVTPGGPLP---FLAEIQK----KRDDRFVVGGDTGYTTQ 501

  Fly   461 DLMKD---------IRQGTV---LKPAK-------------ERELGSQRNSDS----GAGTDALA 496
            |..:|         :|...:   :.|.|             |.:|..|.:|::    ...|||:|
Yeast   502 DKQEDVIGSSKDDNVRPSPISPSINPPKQSSQNGMSFLDEIESKLHKQTSSNAFNAPPPHTDAMA 566

  Fly   497 DALRRAL-----------AARGNAIHSDEDET 517
            ..|..:.           .|.|:...:|:.||
Yeast   567 PPLPPSAPPPPITSLPTPTASGDDHTNDKSET 598

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
WASp	NP_001263045.1	WH1	31..140	CDD:144235
		PBD	233..291	CDD:279166	16/76 (21%)
		WH2	<433..453	CDD:280384	4/19 (21%)
VRP1	NP_013441.1	WH2_WAS_WASL	27..55	CDD:409207
VRP1	NP_013441.1	PRK14951	<109..>240	CDD:237865	26/97 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.000