Protein Alignment WASp and WAS

DIOPT Version :9

• Sequence 1: NP_001263045.1
• Gene: WASp / 43402
• FlyBaseID: FBgn0024273
• Length: 527
• Species: Drosophila melanogaster
• Sequence 2: XP_016885275.1
• Gene: WAS / 7454
• HGNCID: 12731
• Length: 590
• Species: Homo sapiens
• Alignment Length: 569
• Identity: 197/569 - (34%)
• Similarity: 262/569 - (46%)
• Gaps: 129/569 - (22%)

  Fly     1 MSSG-MRSQDG----PRAKVNAASTLLTQEENEAVFKLLGKKCQTLNTAVVQIYKTEGSAHAHWK 60
            ||.| |..:.|    |..:.|..||||...||:.:|::||:||.||.|||||:|........||.
Human     1 MSGGPMGGRPGGRGAPAVQQNIPSTLLQDHENQRLFEMLGRKCLTLATAVVQLYLALPPGAEHWT 65

  Fly    61 KRHTGVVCFVKDSAIRSYFMRAYCLIKNELIWEHEIYDGMEVVKSRPFLLTFEGSDGHVGLNFVS 125
            |.|.|.||||||:..:|||:|.|.|....|:||.|:|..:......||..||.|.|...||||..
Human    66 KEHCGAVCFVKDNPQKSYFIRLYGLQAGRLLWEQELYSQLVYSTPTPFFHTFAGDDCQAGLNFAD 130

  Fly   126 EEECDSFFRIVDATIETRNRKRQEKRNRQKSQQAPNAPLP-QVQREPARPP-------------- 175
            |:|..:|..:|...|:.||:::...|     :|.|..|.| ..:|....||
Human   131 EDEAQAFRALVQEKIQKRNQRQSGDR-----RQLPPPPTPANEERRGGLPPLPLHPGGDQGGPPV 190

  Fly   176 -PMQGGLSSTDGVQLRNNKINSVTL----TPAPAPAQSKNFLSSSFGLGNNAKDKKRKVTKADIS 235
             |:..||::.|   ::|..|.|...    .|.|:||..|             :..|:|::||||.
Human   191 GPLSLGLATVD---IQNPDITSSRYRGLPAPGPSPADKK-------------RSGKKKISKADIG 239

  Fly   236 RPTNFVHLSHVGWDAQKGFDLAGNENDEVLNEFFVKAGVSEVELKDRDTRAFIYDFIQSNNVLAS 300
            .|:.|.|:||||||.|.|||:  |..|..|...|.:||:||.:|.|.:|...|||||:....|.:
Human   240 APSGFKHVSHVGWDPQNGFDV--NNLDPDLRSLFSRAGISEAQLTDAETSKLIYDFIEDQGGLEA 302

  Fly   301 VKQYSVESPTETAAPMPPPVPTRHPSN---------GNQRTAPPLPPAR---QPPPAVPVTVPGA 353
            |:|     ......|:|||.|.....|         ||:..:.||||..   .|||..|
Human   303 VRQ-----EMRRQEPLPPPPPPSRGGNQLPRPPIVGGNKGRSGPLPPVPLGIAPPPPTP------ 356

  Fly   354 ARAPPPPNR-----PPPISTA-----PPPPPVSA--PVVAPPPPPPPPPAAVPPPPPPPMPVGEI 406
             |.||||.|     |||.:|.     |||||.:.  |:..|||||||||::...|.|||:|
Human   357 -RGPPPPGRGGPPPPPPPATGRSGPLPPPPPGAGGPPMPPPPPPPPPPPSSGNGPAPPPLP---- 416

  Fly   407 PVITTTHAPTQAARPAAPAAP-DPRNALMDAIRKGTQLKKVDTTALSTGSGDSRSDLMKDIRQGT 470
            |.:.          ||...|| ..|.||:|.||:|.||.|      :.|:.:|           :
Human   417 PALV----------PAGGLAPGGGRGALLDQIRQGIQLNK------TPGAPES-----------S 454

  Fly   471 VLKPAKERELGSQRNSDSGAGTDALADALRRALAARGNAIHSDEDETES 519
            .|:|..:             .::.|..||...:..|..||||....:.|
Human   455 ALQPPPQ-------------SSEGLVGALMHVMQKRSRAIHSSGSRSVS 490

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
WASp	NP_001263045.1	WH1	31..140	CDD:144235	49/108 (45%)
		PBD	233..291	CDD:279166	28/57 (49%)
		WH2	<433..453	CDD:280384	8/19 (42%)
WAS	XP_016885275.1	None

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	103	1.000	Domainoid score	I6775
eggNOG	1	0.900	-	-		E1_KOG3671
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	304	1.000	Inparanoid score	I2661
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55182
OrthoDB	1	1.010	-	-		D1407277at2759
OrthoFinder	1	1.000	-	-		FOG0001481
OrthoInspector	1	1.000	-	-		oto88707
orthoMCL	1	0.900	-	-		OOG6_104030
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2175
SonicParanoid	1	1.000	-	-		X2034
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	13	12.770