DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment WASp and Wasl

DIOPT Version :9

Sequence 1:	NP_001263045.1	Gene:	WASp / 43402	FlyBaseID:	FBgn0024273	Length:	527	Species:	Drosophila melanogaster
Sequence 2:	XP_038964277.1	Gene:	Wasl / 682507	RGDID:	735144	Length:	507	Species:	Rattus norvegicus

Alignment Length:	570	Identity:	207/570 - (36%)
Similarity:	281/570 - (49%)	Gaps:	107/570 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSSGMRSQDGPRAKVNAASTLLTQEENEAVFKLLGKKCQTLNTAVVQIYKTEGSAHAHWKKRHTG 65
            ||||   |..||...|..|.|||.:|||::|..|||||.|:::||||:|..:  .:..|.|:.:|
  Rat     1 MSSG---QQPPRRVTNVGSLLLTPQENESLFSFLGKKCVTMSSAVVQLYAAD--RNCMWSKKCSG 60

  Fly    66 VVCFVKDSAIRSYFMRAYCLIKNELIWEHEIYDGMEVVKSRPFLLTFEGSDGHVGLNFVSEEECD 130
            |.|.|||:..||||:|.:.:...:|:||.|:|:.......|.:..||.|....|.|||.:|||..
  Rat    61 VACLVKDNPQRSYFLRIFDIKDGKLLWEQELYNNFVYNSPRGYFHTFAGDTCQVALNFANEEEAK 125

  Fly   131 SFFRIVDATIETRNRKRQEKRNRQKSQQAPNAP-LPQVQREPARPPPMQGGLSSTDGVQLRNNK- 193
            .|.:.|...:..|.||.:::|:      |||.| ||....:...|             ::..|:
  Rat   126 KFRKAVTDLLGRRQRKSEKRRD------APNGPNLPMATVDIKNP-------------EITTNRF 171

  Fly   194 ----INSVTLTPAPAPAQSKNFLSSSFGLGNNAKDKKRKVTKADISRPTNFVHLSHVGWDAQKGF 254
                :|:::.|...                ...|.||:::|||||..|:||.|:.|||||...||
  Rat   172 YGSQVNNISHTKEK----------------KKGKAKKKRLTKADIGTPSNFQHIGHVGWDPNTGF 220

  Fly   255 DLAGNENDEVLNEFFVKAGVSEVELKDRDTRAFIYDFIQSNNVLASVK-QYSVESPTETAAPMPP 318
            ||  |..|..|...|...|:||.:||||:|...|||||:....:.:|| :...:.|.:.:|| ||
  Rat   221 DL--NNLDPELKNLFDMCGISEAQLKDRETSKVIYDFIEKTGGVEAVKNELRRQGPPQWSAP-PP 282

  Fly   319 PVPTR----------H-------PSNGNQRTAPPLPPARQP---PPAVPVTVPGAARAPPPPNR- 362
            |.|:|          |       |:.|  |.|||.||:|.|   ||..|.:.||....||||||
  Rat   283 PPPSRGGPPPPPPPPHSSGPPPPPARG--RGAPPPPPSRAPTAAPPPPPPSRPGVVVPPPPPNRM 345

  Fly   363 ---PPPI------STAPPPPPVS-APVVAPPPPPPPPPAAVPPPPPPPMPVGEIPVITTTHAPTQ 417
               |||.      |..|||||:| |...||||||||||...|||||.....|:..|
  Rat   346 YPPPPPALPSSAPSGPPPPPPLSMAGSTAPPPPPPPPPPPGPPPPPGLPSDGDHQV--------- 401

  Fly   418 AARPAAPAAPDPRNALMDAIRKGTQLKKVDTTALSTGSGDSRSDLMKDIRQGTVLKPAKERELGS 482
                  ||:...:.||:|.||:|.|||||:..:... |...|..|:..||||..||...:   |.
  Rat   402 ------PASSGNKAALLDQIREGAQLKKVEQNSRPV-SCSGRDALLDQIRQGIQLKSVSD---GQ 456

  Fly   483 QRNSDSGAGTDALADALRRALAARGNAIHS-----DEDETESSDNEGEWD 527
            :....:.|.|..:..||...:..|..||||     |:|:.|..:::.||:
  Rat   457 ESTPPTPAPTSGIVGALMEVMQKRSKAIHSSDEDEDDDDEEDFEDDDEWE 506

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
WASp	NP_001263045.1	WH1	31..140	CDD:144235	43/108 (40%)
		PBD	233..291	CDD:279166	29/57 (51%)
		WH2	<433..453	CDD:280384	10/19 (53%)
Wasl	XP_038964277.1	WH1	28..135	CDD:395450	43/108 (40%)
		PBD	199..256	CDD:395634	30/58 (52%)
		WH2_N-WASP_r1	404..430	CDD:409217	11/25 (44%)
		WH2_hN-WASP_r2_like	431..455	CDD:409218	9/27 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	102	1.000	Domainoid score	I6683
eggNOG	1	0.900	-	-		E1_KOG3671
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	303	1.000	Inparanoid score	I2584
OMA	1	1.010	-	-		QHG55182
OrthoDB	1	1.010	-	-		D1407277at2759
OrthoFinder	1	1.000	-	-		FOG0001481
OrthoInspector	1	1.000	-	-		otm44654
orthoMCL	1	0.900	-	-		OOG6_104030
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2034
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	12	11.780