DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment WASp and wasl

DIOPT Version :9

Sequence 1:	NP_001263045.1	Gene:	WASp / 43402	FlyBaseID:	FBgn0024273	Length:	527	Species:	Drosophila melanogaster
Sequence 2:	NP_001001206.1	Gene:	wasl / 407864	XenbaseID:	XB-GENE-1017182	Length:	511	Species:	Xenopus tropicalis

Alignment Length:	566	Identity:	206/566 - (36%)
Similarity:	271/566 - (47%)	Gaps:	99/566 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 MRSQDGP--------RAKVNAASTLLTQEENEAVFKLLGKKCQTLNTAVVQIYKTEGSAHAHWKK 61
            |.:..||        :...|:.|.|||.:|||::|..|||||.|:.:||||::.::  .::.|.|
Frog     1 MSNNIGPNNNNNRQTKRVTNSGSILLTAQENESLFSYLGKKCVTMTSAVVQVFLSD--RNSMWVK 63

  Fly    62 RHTGVVCFVKDSAIRSYFMRAYCLIKNELIWEHEIYDGMEVVKSRPFLLTFEGSDGHVGLNFVSE 126
            :..||||.|||:..||||:|.|.:.:...:.|.|:|........||:..||.|....:||||.||
Frog    64 KCCGVVCLVKDNPQRSYFIRVYDIKEGRQLHEQELYYNFVYNSPRPYFHTFPGDTCQIGLNFASE 128

  Fly   127 EECDSFFRIVDATIETRNRKRQEKRNRQKSQQAPNAP-LPQVQREPARPPPMQGGLSSTDGVQLR 190
            ||...|.:.....|..|.||..:||      :.||.| ||....:...|.......:..:.:..:
Frog   129 EEAKRFRKATTDLISRRPRKPDKKR------EPPNGPSLPMATVDIKNPEITNRYNAQVNNIPYK 187

  Fly   191 NNKINSVTLTPAPAPAQSKNFLSSSFGLGNNAKDKKRKVTKADISRPTNFVHLSHVGWDAQKGFD 255
            |:|                          ...|.||:|:|||||..|:||.|:.|||||...|||
Frog   188 NDK--------------------------KKGKTKKKKLTKADIGTPSNFQHIGHVGWDPNTGFD 226

  Fly   256 LAGNENDEVLNEFFVKAGVSEVELKDRDTRAFIYDFIQSNNVLASVK-----QYSVESPTETAAP 315
            :  |..|..|.:.|...|:||.:|||::|...|||||:....:.:||     |.....|.....|
Frog   227 V--NNLDPELKKLFDLCGISEAQLKDKETSKVIYDFIEKTGGVEAVKNELRRQAPPPPPPSRGGP 289

  Fly   316 MPPPVPTRH---------PSNGNQRTAPPLPPARQP---PPAVPVTVPGAARAPPPPNRPPPIST 368
            .|||.|  |         |:.|  |.|||.||:|.|   ||..|...||.:..||||||     .
Frog   290 PPPPPP--HSSGPPPPPPPARG--RGAPPPPPSRAPTTAPPPPPPIRPGQSGPPPPPNR-----M 345

  Fly   369 APPPPP---VSAPVVAPPPPPPPPP-----AAVPPPPPPPMPVGEIPVITT---THAPTQAARPA 422
            .|||||   .||| .:|||||||||     ||.|||||||.|.|..|..:|   .|:....|.
Frog   346 YPPPPPGHTSSAP-SSPPPPPPPPPSSGFGAAAPPPPPPPPPPGPPPDFSTENDNHSAVSGAN-- 407

  Fly   423 APAAPDPRNALMDAIRKGTQLKKVDTTALSTGSGDSRSDLMKDIRQGTVLKPAKERELGSQRNSD 487
                   ::||:|.||.|..|:|||.......|...|..|:..||||..||...: |..:..::.
Frog   408 -------KSALLDQIRGGATLRKVDNRESRPTSTSGRDALLDQIRQGIQLKSVPD-ESDTVASTP 464

  Fly   488 SGAGTDALADALRRALAARGNAIHS-----DEDETESSDNE-GEWD 527
            :.|.|..:..||...:..|..||||     ||||.|..|:| .||:
Frog   465 APAPTTGIVGALMEVMKKRSKAIHSSDSDEDEDEEEDFDDEDDEWE 510

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
WASp	NP_001263045.1	WH1	31..140	CDD:144235	43/108 (40%)
		PBD	233..291	CDD:279166	27/57 (47%)
		WH2	<433..453	CDD:280384	9/19 (47%)
wasl	NP_001001206.1	EVH1_WASP-like	44..142	CDD:269916	37/99 (37%)
		PBD	204..259	CDD:334253	26/56 (46%)
		WH2	409..424	CDD:128542	7/14 (50%)
		WH2	436..453	CDD:128542	8/16 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	85	1.000	Domainoid score	I8094
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	269	1.000	Inparanoid score	I2955
OMA	1	1.010	-	-		QHG55182
OrthoDB	1	1.010	-	-		D1407277at2759
OrthoFinder	1	1.000	-	-		FOG0001481
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2175
SonicParanoid	1	1.000	-	-		X2034
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	9.010