DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment WASp and waslb

DIOPT Version :9

Sequence 1:	NP_001263045.1	Gene:	WASp / 43402	FlyBaseID:	FBgn0024273	Length:	527	Species:	Drosophila melanogaster
Sequence 2:	NP_957353.2	Gene:	waslb / 394034	ZFINID:	ZDB-GENE-040426-718	Length:	518	Species:	Danio rerio

Alignment Length:	568	Identity:	202/568 - (35%)
Similarity:	284/568 - (50%)	Gaps:	103/568 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 GP----RAKVNAASTLLTQEENEAVFKLLGKKCQTLNTAVVQIYKTEGSAHAHWKKRHTGVVCFV 70
            ||    |..:|..|.|||.:|||.:|..|||||.:|::||||:|..:  .::.|.|:..||.|.|
Zfish     3 GPPSNRRPALNVGSILLTHQENEVLFNHLGKKCISLSSAVVQVYAAD--RNSSWVKKCCGVACLV 65

  Fly    71 KDSAIRSYFMRAYCLIKNELIWEHEIYDGMEVVKSRPFLLTFEGSDGHVGLNFVSEEECDSFFRI 135
            ||:..|||::|...:...:.::|.|:|:...:..|||:.:||.|.:..:||||.:|||...|...
Zfish    66 KDNTQRSYYIRVIDMKDGKTLFEQEMYNNFSINCSRPYFITFSGDNCQIGLNFANEEEAKRFRSA 130

  Fly   136 VDATIETRNRKRQEKRNRQKSQQAPNAPLPQVQREPARPP-PMQGGLSSTD--GVQLRNNKINSV 197
            :...:..::|:.:::|      :.||.  |.|...|:.|. ||    ::.|  ..::.|.:.::.
Zfish   131 IGELVGRKSRRTEKRR------EPPNG--PSVSSGPSGPALPM----ATVDIKNPEITNQRYHNN 183

  Fly   198 TLTPAPAPAQSKNFLSSSFGLGNNAKD--------KKRKVTKADISRPTNFVHLSHVGWDAQKGF 254
            |         ..|.|.|:|   |.|||        ||:|::||:|..|:||.|:.|||||...||
Zfish   184 T---------QMNNLQSNF---NRAKDKSKGKNNNKKKKISKAEIGTPSNFRHVGHVGWDPNTGF 236

  Fly   255 DLAGNENDEVLNEFFVKAGVSEVELKDRDTRAFIYDFIQSNNVLASVKQYSVESPTETAAPMPPP 319
            ||  |..|..|.:.|...|:||.||||::|...|||.|:....:.:||     :.....|| |||
Zfish   237 DL--NNLDPDLKKLFDMCGISEDELKDKETSKVIYDLIEKQGGVEAVK-----NEMRRQAP-PPP 293

  Fly   320 VPTR----HPSNGNQRTAPPLPPAR---QPPPAVPVTVPGAARAPPPPNRPPPISTAPPPPPVSA 377
            .|:|    .|...:....||.||:|   .|||..|...|.:|..||||:||...:..|||||...
Zfish   294 PPSRGGAPPPPPPHNSAPPPPPPSRGRGAPPPPPPSRAPTSAPPPPPPSRPGMGAPPPPPPPSRG 358

  Fly   378 PVVAPPPPPPP------PPA------AVPPPPPPPMPVGEIPVITTTHAPTQAARPAAPAA---- 426
            |..||||||||      |||      |.|||||||.|.|..|             |..|.|
Zfish   359 PTQAPPPPPPPHSASISPPAPPSIGGAPPPPPPPPPPPGPPP-------------PGPPPAQDVD 410

  Fly   427 ----PDPRNALMDAIRKGTQLKKVDTT---ALSTGSGDSRSDLMKDIRQGTVLKPAKERELGSQR 484
                |..|:|.:|.||:|.||||||..   .:|||   .|..|:..||||..||...:   ..:.
Zfish   411 SGDSPGGRSAFLDQIREGAQLKKVDQNNKPPVSTG---GRGALLDQIRQGIQLKTVTD---APES 469

  Fly   485 NSDSGAGTDALADALRRALAARGNAIH-----SDEDETESSDNEGEWD 527
            ...|.|.:|.:..||..|:..|...||     .|:|:.:..:::.:|:
Zfish   470 PPPSLAPSDGIVGALMEAMKNRSKVIHCSDDDDDDDDVDDFEDDEDWE 517

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
WASp	NP_001263045.1	WH1	31..140	CDD:144235	41/108 (38%)
		PBD	233..291	CDD:279166	28/57 (49%)
		WH2	<433..453	CDD:280384	10/22 (45%)
waslb	NP_957353.2	EVH1_WASP-like	37..131	CDD:269916	35/95 (37%)
		PBD	215..270	CDD:279166	27/56 (48%)
		WH2	415..438	CDD:280384	13/22 (59%)
		WH2	444..469	CDD:280384	10/30 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	67	1.000	Domainoid score	I9788
eggNOG	1	0.900	-	-		E1_KOG3671
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	305	1.000	Inparanoid score	I2622
OMA	1	1.010	-	-		QHG55182
OrthoDB	1	1.010	-	-		D1407277at2759
OrthoFinder	1	1.000	-	-		FOG0001481
OrthoInspector	1	1.000	-	-		otm25776
orthoMCL	1	0.900	-	-		OOG6_104030
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2034
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	11	10.830