Protein Alignment WASp and waslb

DIOPT Version :10

• Sequence 1: NP_651637.1
• Gene: WASp / 43402
• FlyBaseID: FBgn0024273
• Length: 527
• Species: Drosophila melanogaster
• Sequence 2: NP_957353.2
• Gene: waslb / 394034
• ZFINID: ZDB-GENE-040426-718
• Length: 518
• Species: Danio rerio
• Alignment Length: 568
• Identity: 202/568 - (35%)
• Similarity: 284/568 - (50%)
• Gaps: 103/568 - (18%)

  Fly    10 GP----RAKVNAASTLLTQEENEAVFKLLGKKCQTLNTAVVQIYKTEGSAHAHWKKRHTGVVCFV 70
            ||    |..:|..|.|||.:|||.:|..|||||.:|::||||:|..:  .::.|.|:..||.|.|
Zfish     3 GPPSNRRPALNVGSILLTHQENEVLFNHLGKKCISLSSAVVQVYAAD--RNSSWVKKCCGVACLV 65

  Fly    71 KDSAIRSYFMRAYCLIKNELIWEHEIYDGMEVVKSRPFLLTFEGSDGHVGLNFVSEEECDSFFRI 135
            ||:..|||::|...:...:.::|.|:|:...:..|||:.:||.|.:..:||||.:|||...|...
Zfish    66 KDNTQRSYYIRVIDMKDGKTLFEQEMYNNFSINCSRPYFITFSGDNCQIGLNFANEEEAKRFRSA 130

  Fly   136 VDATIETRNRKRQEKRNRQKSQQAPNAPLPQVQREPARPP-PMQGGLSSTD--GVQLRNNKINSV 197
            :...:..::|:.:::|      :.||.  |.|...|:.|. ||    ::.|  ..::.|.:.::.
Zfish   131 IGELVGRKSRRTEKRR------EPPNG--PSVSSGPSGPALPM----ATVDIKNPEITNQRYHNN 183

  Fly   198 TLTPAPAPAQSKNFLSSSFGLGNNAKD--------KKRKVTKADISRPTNFVHLSHVGWDAQKGF 254
            |         ..|.|.|:|   |.|||        ||:|::||:|..|:||.|:.|||||...||
Zfish   184 T---------QMNNLQSNF---NRAKDKSKGKNNNKKKKISKAEIGTPSNFRHVGHVGWDPNTGF 236

  Fly   255 DLAGNENDEVLNEFFVKAGVSEVELKDRDTRAFIYDFIQSNNVLASVKQYSVESPTETAAPMPPP 319
            ||  |..|..|.:.|...|:||.||||::|...|||.|:....:.:||     :.....|| |||
Zfish   237 DL--NNLDPDLKKLFDMCGISEDELKDKETSKVIYDLIEKQGGVEAVK-----NEMRRQAP-PPP 293

  Fly   320 VPTR----HPSNGNQRTAPPLPPAR---QPPPAVPVTVPGAARAPPPPNRPPPISTAPPPPPVSA 377
            .|:|    .|...:....||.||:|   .|||..|...|.:|..||||:||...:..|||||...
Zfish   294 PPSRGGAPPPPPPHNSAPPPPPPSRGRGAPPPPPPSRAPTSAPPPPPPSRPGMGAPPPPPPPSRG 358

  Fly   378 PVVAPPPPPPP------PPA------AVPPPPPPPMPVGEIPVITTTHAPTQAARPAAPAA---- 426
            |..||||||||      |||      |.|||||||.|.|..|             |..|.|
Zfish   359 PTQAPPPPPPPHSASISPPAPPSIGGAPPPPPPPPPPPGPPP-------------PGPPPAQDVD 410

  Fly   427 ----PDPRNALMDAIRKGTQLKKVDTT---ALSTGSGDSRSDLMKDIRQGTVLKPAKERELGSQR 484
                |..|:|.:|.||:|.||||||..   .:|||   .|..|:..||||..||...:   ..:.
Zfish   411 SGDSPGGRSAFLDQIREGAQLKKVDQNNKPPVSTG---GRGALLDQIRQGIQLKTVTD---APES 469

  Fly   485 NSDSGAGTDALADALRRALAARGNAIH-----SDEDETESSDNEGEWD 527
            ...|.|.:|.:..||..|:..|...||     .|:|:.:..:::.:|:
Zfish   470 PPPSLAPSDGIVGALMEAMKNRSKVIHCSDDDDDDDDVDDFEDDEDWE 517

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
WASp	NP_651637.1	WH1	31..140	CDD:395450	41/108 (38%)
		PBD	233..294	CDD:395634	30/60 (50%)
		WH2	<433..453	CDD:460490	10/22 (45%)
waslb	NP_957353.2	EVH1_WASP-like	37..131	CDD:269916	35/95 (37%)
		PBD	215..272	CDD:395634	29/58 (50%)
		WH2_N-WASP_r1	416..440	CDD:409217	12/23 (52%)
		actin-binding sequence	431..434	CDD:409217	2/2 (100%)
		WH2_hN-WASP_r2_like	442..466	CDD:409218	11/29 (38%)