Protein Alignment WASp and Was

DIOPT Version :10

• Sequence 1: NP_651637.1
• Gene: WASp / 43402
• FlyBaseID: FBgn0024273
• Length: 527
• Species: Drosophila melanogaster
• Sequence 2: NP_001385676.1
• Gene: Was / 317371
• RGDID: 1563567
• Length: 503
• Species: Rattus norvegicus
• Alignment Length: 585
• Identity: 207/585 - (35%)
• Similarity: 261/585 - (44%)
• Gaps: 141/585 - (24%)

  Fly     1 MSSGM---RS--QDGPRAKVNAASTLLTQEENEAVFKLLGKKCQTLNTAVVQIYKTEGSAHAHWK 60
            ||||.   ||  :.||..:.|..|.||...||:.:|:|||:||.||.|||||:|........||.
  Rat     1 MSSGPVGGRSGGRGGPAVQQNIPSNLLQDHENQRLFELLGRKCWTLATAVVQLYLALPPGAEHWT 65

  Fly    61 KRHTGVVCFVKDSAIRSYFMRAYCLIKNELIWEHEIYDGMEVVKSRPFLLTFEGSDGHVGLNFVS 125
            ..|.|.||||||:..:|||:|.|.|....|:||.|:|..:..:...||..||.|.|..|||||..
  Rat    66 MEHCGAVCFVKDNPQKSYFIRLYGLQAGRLLWEQELYSQLVYLTPTPFFHTFAGDDCQVGLNFSD 130

  Fly   126 EEECDSFFRIVDATIETRNRKRQEKRNRQKSQQAPNAPLPQVQRE----PARPP----------- 175
            |.|..:|..:|...|:.||:::..:|     :|.|..|.|..:..    |..||
  Rat   131 ESEAQAFRALVQEKIQKRNQRQSGER-----RQLPLTPAPTNEERRGGLPPVPPHPGGDHGGPSG 190

  Fly   176 -PMQGGLSSTDGVQLRNNKINSVTLTPAPAPAQSKNFLSSSFGLGNNAKDKKR----KVTKADIS 235
             |:..||.:.|   ::|..|.|......|||             |....||||    |::||||.
  Rat   191 GPLSLGLVTVD---IQNPDITSSRYRGLPAP-------------GPGPTDKKRSGKKKISKADIG 239

  Fly   236 RPTNFVHLSHVGWDAQKGFDLAGNENDEVLNEFFVKAGVSEVELKDRDTRAFIYDFIQSNNVLAS 300
            .|:.|.|:||||||.|.|||:  |..|..|...|.:||:||.:|.|.:|...|||||:....|.:
  Rat   240 APSGFKHVSHVGWDPQNGFDV--NNLDPDLRSLFSRAGISEAQLTDAETSKLIYDFIEDQGGLEA 302

  Fly   301 VKQYSVESPTETAAPMPPPV-------PTRHPSNGNQRTAPPLPPARQ---PPPAVPVTVPGAAR 355
            |:|    .......|.|||.       |.|.|...|:....||||...   |||..|       |
  Rat   303 VRQ----EMRRQEPPPPPPCRGGGGSQPLRPPVGSNKGRCGPLPPVPMGGAPPPPTP-------R 356

  Fly   356 APPPPNR-----PPPIST---APPPPPV---SAPVVAPPPPPPPPPAAVPP---PPPPPMPVGEI 406
            .||||.|     |||.:|   .|||||:   ..|:..|||||||||..|.|   |.|||:|
  Rat   357 VPPPPGRGGPPPPPPPATGRSGPPPPPLPGAGGPLAPPPPPPPPPPPPVCPGSGPAPPPLP---- 417

  Fly   407 PVITTTHAPTQAARPAAPAAPDP---RNALMDAIRKGTQLKKVDTTALSTGSGDSRSDLMKDIRQ 468
                    ||    |.:...|.|   |.||:|.||:|.||.|..
  Rat   418 --------PT----PVSGVGPAPGGGRGALLDQIRQGIQLNKTP--------------------- 449

  Fly   469 GTVLKPAKERELGSQRNSDSGA---GTDALADALRRALAARGNAIHSD---EDETESSDNEGEWD 527
                        |:..||...|   .::.|..||...:..|...|||.   ||:|...:.:.|||
  Rat   450 ------------GAMENSVPQALPQQSEGLVGALMHVMQKRSKVIHSSDEGEDQTGEDEEDDEWD 502

  Fly   528  527
              Rat   503  502

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
WASp	NP_651637.1	WH1	31..140	CDD:395450	50/108 (46%)
		PBD	233..294	CDD:395634	31/60 (52%)
		WH2	<433..453	CDD:460490	8/19 (42%)
Was	NP_001385676.1	WH1	36..145	CDD:395450	50/108 (46%)
		PBD	237..294	CDD:395634	29/58 (50%)
		WH2	<435..449	CDD:425359	8/13 (62%)