DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment WASp and Was

DIOPT Version :9

Sequence 1:	NP_001263045.1	Gene:	WASp / 43402	FlyBaseID:	FBgn0024273	Length:	527	Species:	Drosophila melanogaster
Sequence 2:	XP_038955700.1	Gene:	Was / 317371	RGDID:	1563567	Length:	503	Species:	Rattus norvegicus

Alignment Length:	585	Identity:	207/585 - (35%)
Similarity:	261/585 - (44%)	Gaps:	141/585 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSSGM---RS--QDGPRAKVNAASTLLTQEENEAVFKLLGKKCQTLNTAVVQIYKTEGSAHAHWK 60
            ||||.   ||  :.||..:.|..|.||...||:.:|:|||:||.||.|||||:|........||.
  Rat     1 MSSGPVGGRSGGRGGPAVQQNIPSNLLQDHENQRLFELLGRKCWTLATAVVQLYLALPPGAEHWT 65

  Fly    61 KRHTGVVCFVKDSAIRSYFMRAYCLIKNELIWEHEIYDGMEVVKSRPFLLTFEGSDGHVGLNFVS 125
            ..|.|.||||||:..:|||:|.|.|....|:||.|:|..:..:...||..||.|.|..|||||..
  Rat    66 MEHCGAVCFVKDNPQKSYFIRLYGLQAGRLLWEQELYSQLVYLTPTPFFHTFAGDDCQVGLNFSD 130

  Fly   126 EEECDSFFRIVDATIETRNRKRQEKRNRQKSQQAPNAPLPQVQRE----PARPP----------- 175
            |.|..:|..:|...|:.||:::..:|     :|.|..|.|..:..    |..||
  Rat   131 ESEAQAFRALVQEKIQKRNQRQSGER-----RQLPLTPAPTNEERRGGLPPVPPHPGGDHGGPSG 190

  Fly   176 -PMQGGLSSTDGVQLRNNKINSVTLTPAPAPAQSKNFLSSSFGLGNNAKDKKR----KVTKADIS 235
             |:..||.:.|   ::|..|.|......|||             |....||||    |::||||.
  Rat   191 GPLSLGLVTVD---IQNPDITSSRYRGLPAP-------------GPGPTDKKRSGKKKISKADIG 239

  Fly   236 RPTNFVHLSHVGWDAQKGFDLAGNENDEVLNEFFVKAGVSEVELKDRDTRAFIYDFIQSNNVLAS 300
            .|:.|.|:||||||.|.|||:  |..|..|...|.:||:||.:|.|.:|...|||||:....|.:
  Rat   240 APSGFKHVSHVGWDPQNGFDV--NNLDPDLRSLFSRAGISEAQLTDAETSKLIYDFIEDQGGLEA 302

  Fly   301 VKQYSVESPTETAAPMPPPV-------PTRHPSNGNQRTAPPLPPARQ---PPPAVPVTVPGAAR 355
            |:|    .......|.|||.       |.|.|...|:....||||...   |||..|       |
  Rat   303 VRQ----EMRRQEPPPPPPCRGGGGSQPLRPPVGSNKGRCGPLPPVPMGGAPPPPTP-------R 356

  Fly   356 APPPPNR-----PPPIST---APPPPPV---SAPVVAPPPPPPPPPAAVPP---PPPPPMPVGEI 406
            .||||.|     |||.:|   .|||||:   ..|:..|||||||||..|.|   |.|||:|
  Rat   357 VPPPPGRGGPPPPPPPATGRSGPPPPPLPGAGGPLAPPPPPPPPPPPPVCPGSGPAPPPLP---- 417

  Fly   407 PVITTTHAPTQAARPAAPAAPDP---RNALMDAIRKGTQLKKVDTTALSTGSGDSRSDLMKDIRQ 468
                    ||    |.:...|.|   |.||:|.||:|.||.|..
  Rat   418 --------PT----PVSGVGPAPGGGRGALLDQIRQGIQLNKTP--------------------- 449

  Fly   469 GTVLKPAKERELGSQRNSDSGA---GTDALADALRRALAARGNAIHSD---EDETESSDNEGEWD 527
                        |:..||...|   .::.|..||...:..|...|||.   ||:|...:.:.|||
  Rat   450 ------------GAMENSVPQALPQQSEGLVGALMHVMQKRSKVIHSSDEGEDQTGEDEEDDEWD 502

Fly 528 527
Rat 503 502

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
WASp	NP_001263045.1	WH1	31..140	CDD:144235	50/108 (46%)
		PBD	233..291	CDD:279166	28/57 (49%)
		WH2	<433..453	CDD:280384	8/19 (42%)
Was	XP_038955700.1	WH1	36..145	CDD:395450	50/108 (46%)
		PBD	237..294	CDD:395634	29/58 (50%)
		WH2	<435..449	CDD:425359	8/13 (62%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	102	1.000	Domainoid score	I6683
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	303	1.000	Inparanoid score	I2584
OMA	1	1.010	-	-		QHG55182
OrthoDB	1	1.010	-	-		D1407277at2759
OrthoFinder	1	1.000	-	-		FOG0001481
OrthoInspector	1	1.000	-	-		otm44654
orthoMCL	1	0.900	-	-		OOG6_104030
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2034
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	12	11.840