DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment WASp and C31C9.6

DIOPT Version :9

Sequence 1:	NP_001263045.1	Gene:	WASp / 43402	FlyBaseID:	FBgn0024273	Length:	527	Species:	Drosophila melanogaster
Sequence 2:	NP_872049.2	Gene:	C31C9.6 / 259475	WormBaseID:	WBGene00007840	Length:	932	Species:	Caenorhabditis elegans

Alignment Length:	675	Identity:	166/675 - (24%)
Similarity:	232/675 - (34%)	Gaps:	261/675 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 STLLTQEENEAVFKLLGKKCQTLNTAVVQIYKTEGSAHAHWKKRHTG--VVCFVKDSAIRSYFMR 81
            |..|...|.|:|.:.:....:.|::.:.|....|   :..|:|...|  |..|:|:|..|.|
Worm     7 SDFLEINEKESVLRGISASDKILSSGICQFLVAE---NGQWRKPDEGAAVALFLKNSTERYY--- 65

  Fly    82 AYCLIKNELI---------WEHEI-YDGM------EVVKSRPFLLTFEGSDGHVGLNFVSEEECD 130
                   .:|         ||..| :|.:      |.::....||.||....::||||...:||:
Worm    66 -------RIIVMEPSADPDWEPTIQFDFLIRDKRFETIQEHARLLVFEAESRYIGLNFYDSKECE 123

  Fly   131 SFFRIVDATIETRNRKRQ-----EKRNRQKSQQAPNAPL-----PQVQREPARPPPMQ--GGLSS 183
            :|...| ...:||:..:.     |.:.::||....| |.     |:.|.|...|...:  .||..
Worm   124 NFHNSV-CKRQTRSTDKAKQPALEGKKKKKSSFYHN-PFKSHKEPRKQVEFGAPIDFRHVDGLKL 186

  Fly   184 TD-----GVQLR-----NN-------------------------KINSVTLTPAPAPAQSKNFLS 213
            ||     .:|:|     ||                         |..|.|:.......:.|...|
Worm   187 TDVQEDLYMQVRSRLNVNNPEEEEEIVKQLIVRNEDHIRQSLMVKKESQTVKGVKDKHKDKVKTS 251

  Fly   214 SSFGLGNNAKDKKRKVTKADISRP-------------------TNFVHLSH----------VGWD 249
            .|| .|.|    |.||  .|:|:|                   |:|.| ||          ..|:
Worm   252 KSF-FGRN----KPKV--EDVSQPIVPVITGDPLNPDWTVTAATSFKH-SHTFAAIDPIKTTDWE 308

  Fly   250 AQKGFDLAGNENDEVLNEFFVKAGVSEVELKDRDTRAFIYDFIQSNNVLASVKQ-YSVE------ 307
            ..:. |..|:.|......                    ||.|.|.:     |:| |.:|
Worm   309 TPRK-DTYGSTNQRQPQN--------------------IYKFEQEH-----VEQTYQIEKIEVDD 347

  Fly   308 SPTETAA---------------------------------------PMPPPVPTRHPSNGNQ--- 330
            :|||..:                                       ..|||.|.. ||:.:|
Worm   348 TPTELPSRGASRNPEDQMTRGGLSTPRIPTHRDSYRWATKPDTVPKQTPPPTPNA-PSHSHQVDQ 411

  Fly   331 -------------RTAPPLPPARQPPPAVPV---------TVPGAAR-APPPPNRPPPISTAPPP 372
                         |.|||.||:..|....|:         |.|...: |||||:|.|..|.:|.|
Worm   412 FAEFKLVEPKTPTRVAPPPPPSAPPTIKFPISTGTSYSSTTPPTTPKPAPPPPSRIPNPSPSPQP 476

  Fly   373 PPVSAPVVAPPPPPPPPPAAVP---PPPPPPMPVGEIPVITTTHAPTQAARPAAPAAPDPRNALM 434
            ..||.   :||||||.||.|.|   ||||||.|..|..:    ..|......|.|.:...|.:||
Worm   477 AEVSK---SPPPPPPLPPIATPSSVPPPPPPPPALEQEI----SGPPTVRLTAVPESNSDRRSLM 534

  Fly   435 DAIR---KGTQLKKVDTTALSTGSGDSRSDLMKDIRQGTVLKPAKERELGSQRNSDSGAGTDALA 496
            |.||   :...|:||..|              .|.|| :|..|.              :||  :.
Worm   535 DQIRSIDRSQVLRKVSDT--------------PDTRQ-SVPSPT--------------SGT--IV 568

  Fly   497 DALRRALAARGNAIH-SDEDETESS 520
            |.::..|.||.:.|: ||.:|:|.|
Worm   569 DQIQNFLDARRSGINPSDSEESEYS 593

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
WASp	NP_001263045.1	WH1	31..140	CDD:144235	30/126 (24%)
		PBD	233..291	CDD:279166	14/86 (16%)
		WH2	<433..453	CDD:280384	9/22 (41%)
C31C9.6	NP_872049.2	PH-like	23..133	CDD:388408	30/123 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	110	1.000	Inparanoid score	I3450
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	2	2.010