DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment WASp and AgaP_AGAP001081

DIOPT Version :9

Sequence 1:	NP_001263045.1	Gene:	WASp / 43402	FlyBaseID:	FBgn0024273	Length:	527	Species:	Drosophila melanogaster
Sequence 2:	XP_317970.5	Gene:	AgaP_AGAP001081 / 1278391	VectorBaseID:	AGAP001081	Length:	306	Species:	Anopheles gambiae

Alignment Length:	299	Identity:	132/299 - (44%)
Similarity:	182/299 - (60%)	Gaps:	26/299 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 AKVNAASTLLTQEENEAVFKLLGKKCQTLNTAVVQIYKTEGSAHAHWKKRHTGVVCFVKDSAIRS 77
            :|.|..|||||.:||:.:|:|||::||:|:|||||:|.|:..|||.|.||.||.:||:||:..:|
Mosquito    19 SKANRPSTLLTNDENDQLFRLLGRRCQSLSTAVVQLYTTQSPAHASWVKRCTGALCFIKDNIRKS 83

  Fly    78 YFMRAYCLIKNELIWEHEIYDGMEVVKSRPFLLTFEGSDGHVGLNFVSEEECDSFFRIVDATIET 142
            |:.|.|||..|:::||.|:|:.:||.:.:|:|:||||.||.|..||.:|:|..:.......||..
Mosquito    84 YYFRLYCLKANQMVWEQELYEKIEVTQPKPYLITFEGQDGIVAFNFATEDEAAAVMNTTLTTIHN 148

  Fly   143 RNRKRQEKRNRQKSQQAPNAPLPQVQREPARPPPMQ----GGLSSTD-----GVQLRNNK--INS 196
            |||:|.|:..|..:::.|         .||||||:|    ||..|..     ||..||.:  .:.
Mosquito   149 RNRRRDERIKRNNTRKDP---------PPARPPPLQTIPGGGTGSNIPDADLGVTYRNKQPPFSG 204

  Fly   197 VTLTPAPAPAQSKNFLSSSFGLGNNAKDKK----RKVTKADISRPTNFVHLSHVGWDAQKGFDLA 257
            ..:.|....||....::.|.|...:.|.:|    .|:.|:||..|:||.|::|||||...||||.
Mosquito   205 PAVPPMQQGAQPLAAVAPSLGSALHQKPRKVKGMGKLQKSDIGSPSNFKHVTHVGWDPHSGFDLI 269

  Fly   258 GNENDEVLNEFFVKAGVSEVELKDRDTRAFIYDFIQSNN 296
            |.:  |.|..|..||||.:..||||||.||||||||:||
Mosquito   270 GAQ--ESLKPFLEKAGVGDQHLKDRDTCAFIYDFIQTNN 306

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
WASp	NP_001263045.1	WH1	31..140	CDD:144235	52/108 (48%)
		PBD	233..291	CDD:279166	33/57 (58%)
		WH2	<433..453	CDD:280384
AgaP_AGAP001081	XP_317970.5	EVH1_WASP-like	46..146	CDD:269916	46/99 (46%)
AgaP_AGAP001081	XP_317970.5	PBD	245..301	CDD:279166	33/57 (58%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	127	1.000	Domainoid score	I10753
eggNOG	1	0.900	-	-		E1_KOG3671
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H136714
Inparanoid	1	1.050	247	1.000	Inparanoid score	I5626
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1407277at2759
OrthoFinder	1	1.000	-	-		FOG0001481
OrthoInspector	1	1.000	-	-		oto106321
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2034
TreeFam	1	0.960	-	-
	11	10.830