DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment WASp and CEL

DIOPT Version :9

Sequence 1:	NP_001263045.1	Gene:	WASp / 43402	FlyBaseID:	FBgn0024273	Length:	527	Species:	Drosophila melanogaster
Sequence 2:	NP_001798.3	Gene:	CEL / 1056	HGNCID:	1848	Length:	753	Species:	Homo sapiens

Alignment Length:	449	Identity:	110/449 - (24%)
Similarity:	149/449 - (33%)	Gaps:	165/449 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   116 DGHV-----------GLNFVSEEECDSFFRIVDATIETRNRKRQE---------------KRNRQ 154
            |||:           |...|:||:   |:::|.....|:..:..:               :.|::
Human   340 DGHIFASIDMPAINKGNKKVTEED---FYKLVSEFTITKGLRGAKTTFDVYTESWAQDPSQENKK 401

  Fly   155 K-------------------SQQAPNAPLPQVQ----REPARPP--PMQGGLSSTDGVQLRNNKI 194
            |                   :|...||...:..    ..|:|.|  |...|....|.:|....|
Human   402 KTVVDFETDVLFLVPTEIALAQHRANAKSAKTYAYLFSHPSRMPVYPKWVGADHADDIQYVFGK- 465

  Fly   195 NSVTLTPAPAPAQSKNFLSSSFGLGNNAKDKKRKVTKADISRPTNFVHLS--HVG-------WDA 250
                  |...|.            |...:|  |.|:||.|:..|||....  ::|       |:.
Human   466 ------PFATPT------------GYRPQD--RTVSKAMIAYWTNFAKTGDPNMGDSAVPTHWEP 510

  Fly   251 QKGFDLAGNENDEVLNEFFVKAGVSEVE--LKDRDTRAFIYDFIQSNNVLASVKQYSVESPT--E 311
            ..      .||...| |...|.|.|.::  |:....|.:...::....|  :.::.:...||  .
Human   511 YT------TENSGYL-EITKKMGSSSMKRSLRTNFLRYWTLTYLALPTV--TDQEATPVPPTGDS 566

  Fly   312 TAAPMPP-------PVPTRHPSNGNQRTAPPLPPARQ--PPPAVPVTVPGAARAPP------PPN 361
            .|.|:||       |||....|.     |||:||...  .||..|....||...||      ||.
Human   567 EATPVPPTGDSETAPVPPTGDSG-----APPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPV 626

  Fly   362 RP------PPI-----STAPPPPPV---SAPVVAP------PPPPPPPPAAVPPPPP------PP 400
            .|      ||:     |.|||.||.   .||.|.|      ||.||...|..||.||      ||
Human   627 PPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDAGPPPVPPTGDSGAPP 691

  Fly   401 MP----VGEIPVITTTHAPTQAARP----------------AAPAAP--DPRNALMDAI 437
            :|    .|..||..|..:.|....|                |||..|  |.:.|.|.|:
Human   692 VPPTGDSGAPPVTPTGDSETAPVPPTGDSGAPPVPPTGDSEAAPVPPTDDSKEAQMPAV 750

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
WASp	NP_001263045.1	WH1	31..140	CDD:144235	9/34 (26%)
		PBD	233..291	CDD:279166	15/68 (22%)
		WH2	<433..453	CDD:280384	2/5 (40%)
CEL	NP_001798.3	Heparin-binding	21..121
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	555..753		63/201 (31%)
		17 X 11 AA tandem repeats, glycodomain, O-linked (mucin type)	559..745		60/190 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910