DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG1647 and ZNF276

DIOPT Version :9

Sequence 1:	NP_651636.1	Gene:	CG1647 / 43401	FlyBaseID:	FBgn0039602	Length:	1222	Species:	Drosophila melanogaster
Sequence 2:	NP_001106997.1	Gene:	ZNF276 / 92822	HGNCID:	23330	Length:	614	Species:	Homo sapiens

Alignment Length:	260	Identity:	48/260 - (18%)
Similarity:	87/260 - (33%)	Gaps:	71/260 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   120 ERPISGAVGKRGRKRKGEESWPKNNNVKPQVKKESFV---WHKKQKLQPSQITSL---------- 171
            ||.:||...:....:|.||         |:::|:...   |.||.:.:..::.::
Human   388 ERKVSGKKSESKEAKKSEE---------PRIRKKPGPKPGWKKKLRCEREELPTIYKCPYQGCTA 443

  Fly   172 -----------VSKREPEIKDEPAEQDTSLKGPPKKAGRKSICSVCGEKFLSKELADEHKSLVHV 225
                       :.:...|:::.|.....                 |.:.|:.......|..|:|.
Human   444 VYRGADGMKKHIKEHHEEVRERPCPHPG-----------------CNKVFMIDRYLQRHVKLIHT 491

  Fly   226 PSIPRYICNACNQTHHNQSDIRAHQLWHKLSKTPYKCPLCESSVANAYAFTRHLREHTPPTPVQL 290
             .:..|||:.|.||...:..:..||:.|..:| |.:|.:|........:...|:.:|...|.
Human   492 -EVRNYICDECGQTFKQRKHLLVHQMRHSGAK-PLQCEVCGFQCRQRASLKYHMTKHKAETE--- 551

  Fly   291 LVLDRECPLCKKTFVTNFFYNTHRCAIR--------------KRKCGGCSRTLNTEAAYMRHAPT 341
              ||..|..|.:.|......|.|...:.              :...|..|.::.||...::..||
Human   552 --LDFACDQCGRRFEKAHNLNVHMSMVHPLTQTQDKALPLEAEPPPGPPSPSVTTEGQAVKPEPT 614

Fly 342 341
Human 615 614

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1647	NP_651636.1	zf-AD	19..99	CDD:285071
		C2H2 Zn finger	203..224	CDD:275368	4/20 (20%)
		C2H2 Zn finger	233..253	CDD:275368	6/19 (32%)
		C2H2 Zn finger	262..282	CDD:275368	3/19 (16%)
		C2H2 Zn finger	297..314	CDD:275368	4/16 (25%)
ZNF276	NP_001106997.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..50
		zf-AD	79..155	CDD:285071
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	268..420		9/40 (23%)
		C2H2 Zn finger	470..490	CDD:275368	4/36 (11%)
		zf-C2H2	496..518	CDD:278523	8/21 (38%)
		C2H2 Zn finger	498..518	CDD:275368	6/19 (32%)
		C2H2 Zn finger	526..546	CDD:275368	3/19 (16%)
		C2H2 Zn finger	556..573	CDD:275368	4/16 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	583..614		4/30 (13%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24406
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.100