DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG1647 and AIP5

DIOPT Version :9

Sequence 1:	NP_651636.1	Gene:	CG1647 / 43401	FlyBaseID:	FBgn0039602	Length:	1222	Species:	Drosophila melanogaster
Sequence 2:	NP_116671.1	Gene:	AIP5 / 850570	SGDID:	S000001912	Length:	1233	Species:	Saccharomyces cerevisiae

Alignment Length:	941	Identity:	196/941 - (20%)
Similarity:	321/941 - (34%)	Gaps:	294/941 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   409 SSSGTDQLVAAKSKNSDRVSARNYLKRVD-QLLKNTINTLVSIKHEPEVHINDTGPPRGQAES-D 471
            :....|:..:....|.:...|.:.|.|.: ::|........|.||:.|.|..:.|...|||.: |
Yeast   271 NKDNVDETSSKSENNINEEKAEHTLPREENEILNVNEGNAASFKHQLEPHGLEAGDENGQASTKD 335

  Fly   472 PEPE----------RNE-EHPSFGDDIQAANDECQECQPETESDKISVAACDDIPSVSVKQEPEY 525
            .|.|          .|| :|...|:            :.:||||:..::     |||..|.:.|.
Yeast   336 VESESLTKNGFNFKENESKHLKAGE------------KQQTESDRDGIS-----PSVLAKNQKET 383

  Fly   526 D-GYEKQTGVK--QEPLKLKLKITKNH-----GKLNSSLIDDL-----------DEAGQAFGRSS 571
            : |.|.....:  :|..|.:.:::.||     ...|::..|.:           ||......|.|
Yeast   384 EIGKEDHVFEQKDKEDEKCRKELSVNHENNMSHNFNAAGSDSIIPPETERETYDDETMGPTKRIS 448

  Fly   572 KKKKKRKH------KEREKEASNETENCRTESQNQPAIKIKQEPVDYAPEATVMTTIPMTQFESS 630
            ..:|..:|      .|.|||...|.|    |.:|....|:|:|.|....||.....:..|:.||
Yeast   449 DNEKNLQHGTNDISVEVEKEEEEEEE----EEENSTFSKVKKENVTGEQEAVRNNEVSGTEEES- 508

  Fly   631 LNESERSEEV---DEAMIQSQEDVKPNRMELDRMMQISNVTSGVDMAEEAMALERAEEACPEDSL 692
               :.:.||:   ||.  ||:...|.:      :::|....:...::::.:.||...||
Yeast   509 ---TSKGEEIMGGDEK--QSEAGEKSS------IIEIEGSANSAKISKDNLVLEDEAEA------ 556

  Fly   693 HKVKSVKSTARKSTGGAERKTYSPPRTNTLPQIVAVVSGESAFNMISIKPEPRNLGYGDEEPEDQ 757
                                   |.:.|...::|    ||     |.|...||          |.
Yeast   557 -----------------------PTQENKPTEVV----GE-----IDIPDAPR----------DD 579

  Fly   758 RETTEEINHNDMMEEEKEYIGSLDLSDVSVKQERELDICEIDAVHRNGLEKSDEDDDDGNEDSAS 822
            .|..|.:..| ::.|:.| :...|.....||.:..:...:.|.:...|.|...||.....|.:|
Yeast   580 VEIVEAVEKN-IIPEDLE-VAKEDQEGEQVKLDEPVKAMKDDKIAMRGAESISEDMKKKQEGTA- 641

  Fly   823 SADEAEEAMERDTEERIYREIELPPLELQNESSRKDLESERMDTEVSTALPASETPSQTRDVLGV 887
                                      ||.||.::|:::               ||..::.:.:.|
Yeast   642 --------------------------ELSNEKAKKEVD---------------ETARESAEGVEV 665

  Fly   888 EKSEASAFSLVITNICSQAVPQPSAACSNDIECSIGPSPSTTNEPHSHTV-ENVQSPANDLQTSA 951
            |||:......|:.. |:...|:       |::         .||.....: |:|:.|..|::...
Yeast   666 EKSKTPESPKVVKR-CTSGRPE-------DLQ---------INERDPEVLKEDVRVPDEDVKPEI 713

  Fly   952 QVAIAAQSQPDPCIVSQPAASSESQADT--KDLPPAASQIQTFNTESLP---------------- 998
            ...|....:.||  .||....|..||:|  ||:....| ..:|..|..|
Yeast   714 ATTIENSEEEDP--KSQRVQISTEQAETTQKDMGDVGS-TTSFKEEEKPKRFEITQEGDKITGKD 775

  Fly   999 -IHVHSETEDNSIENDAS--------YL-----------ESRAQVDCQSAGTENPSVVLE-QNES 1042
             .|.|.|..:.:.||..:        |:           |..|:|: .|..||...|..| :|..
Yeast   776 TNHEHGEATEAASENSKASDVGTAEKYIEPSSESVKKDTEEDAEVE-NSEKTEFIKVKAELENLD 839

  Fly  1043 LPSGSCVSP--IPENPSPGNSPPQHDESESLDKPEMAAGSAYCLATVSLDAPKDTEALA------ 1099
            .|..:.|:.  ..||........:..|.|:.:|.|.....|   ...:|||||:.|..|
Yeast   840 APKEAEVTAELNKENEDVEVDTEEDAEVENSEKTEFIKVKA---ELGNLDAPKEAEVTAELNKEN 901

  Fly  1100 -----------------LPPCDAAIIDSNYTSDE-----------EQQNVLNHELSEQQLAI--- 1133
                             ..|.:..|.|...|..|           |.:|:.|.:::|....:
Yeast   902 EDVEVAATSKEDIETKCSEPAETPIEDGTCTEAEVSKKDAEAVTKEDENMENSKIAEALKDVTGD 966

  Fly  1134 MEHRQLLVHEEQPALLEVIPPGLSSRPI------------EET-----------ENRINEQQQDL 1175
            .|...:.:.:|....:|:  |.|..:.|            |||           |..|.|::.::
Yeast   967 QEIDDINISDEFQRTVEL--PELEKQDIKDNKGEDKELEVEETEKETSLPDLVVEENITEEKNEI 1029

  Fly  1176 EQGEERPPRFQANDDSNINEIAENNNNANIE 1206
            :|.||...:...|:..:|::.|.||:....|
Yeast  1030 KQEEEEVSQLDFNETESISKEAPNNDENGFE 1060

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1647	NP_651636.1	zf-AD	19..99	CDD:285071
		C2H2 Zn finger	203..224	CDD:275368
		C2H2 Zn finger	233..253	CDD:275368
		C2H2 Zn finger	262..282	CDD:275368
		C2H2 Zn finger	297..314	CDD:275368
AIP5	NP_116671.1	2A1904	<271..>528	CDD:273344	68/283 (24%)
AIP5	NP_116671.1	PTZ00121	<482..1082	CDD:173412	143/709 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1181
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900