DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG1647 and Zfp655

DIOPT Version :9

Sequence 1:	NP_651636.1	Gene:	CG1647 / 43401	FlyBaseID:	FBgn0039602	Length:	1222	Species:	Drosophila melanogaster
Sequence 2:	NP_082574.1	Gene:	Zfp655 / 72611	MGIID:	1919861	Length:	541	Species:	Mus musculus

Alignment Length:	677	Identity:	116/677 - (17%)
Similarity:	203/677 - (29%)	Gaps:	251/677 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 GKVPILLPNEEDTIDLDEPRMSQKIYELVGFTVSVDDKMPQTICSQCVDKINDFYEFREMCYATN 93
            |..||..|:     .:.|.....::::|       :.|..:.|...|.|.     |.||
Mouse    45 GGFPISKPD-----GISEREQDLQVFDL-------ESKNREVIRGDCSDG-----ETRE------ 86

  Fly    94 KQTRNLLGLKQIEPARLIDLKRIVKEERPISGAVGKRGR-------KRKGEESWPKNNNVKPQVK 151
                        |...||..::|.:|.......|||..:       .|:..:|..:...::..::
Mouse    87 ------------ENKLLIPKRKISEEVHSYKVRVGKFKQDIAQVPETREVYKSEDRLERLQEILR 139

  Fly   152 KESFV-------------WHKKQKLQPSQITSLVSKREPEIK------DEPAEQDTSLKGPPKKA 197
            |..|:             :..::..:|.:..||.|..:.:.:      .:.::.|.:....|...
Mouse   140 KFLFLEREFRQITISKKTFSSEKNTEPEKSFSLDSTLDTDQRVLRIQTTDDSKYDMNFNQNPAVG 204

  Fly   198 GRKSICSVCGEKFLSKELADEHKSLVH------VPSIPR-YICNACNQTHHNQSDIRAHQLWHKL 255
            .::.|...  |.|.|.:..:....|.|      :|:..| |.|:.|.:|.|..|.:..||..|..
Mouse   205 EQEPINLT--ENFQSTDYKESLMDLSHLNKWESMPTTDRSYKCDTCGKTFHQASALTRHQRIHTR 267

  Fly   256 SKTPYKCPLCESSVANAYAFTRHLREHTPPTPVQLLVLDRECPLCKKTFVTNFFYNTHR---CAI 317
            .| ||||..||.|.:.:.:.:||.|.||.....:....|:.|....|:...:.....|:   ...
Mouse   268 EK-PYKCKECEKSFSQSSSLSRHKRIHTREKSYKCEASDKSCDAPDKSCSQSSDVLQHKKGHAKA 331

  Fly   318 RKRKCGGCSRTLNTEAAYMRHAPTCPKIYLNHSKHIMPQVVTNEAQMLIKNEIEEELLGLPPATT 382
            :..|||.|.|..:......:|..|                   ...|..|            .|.
Mouse   332 KSYKCGTCERVFSRSVHLTQHQRT-------------------HKDMSCK------------CTV 365

  Fly   383 VPPDFVIDEGMQPVVVLERLSSPLLRSSSGTDQLVAAKSKNSDRVSARNYLKRVDQLLKNTINTL 447
            ...||                                                        .:|.
Mouse   366 CGSDF--------------------------------------------------------CHTS 374

  Fly   448 VSIKHEPEVHINDTGPPRGQAESDPEPERNEEHPSFGDDIQAANDECQECQPETESDKISVAACD 512
            ..::|:...|                .|::.|:           |||            .:|
Mouse   375 YLVEHQRLHH----------------QEKSYEY-----------DEC------------GLA--- 397

  Fly   513 DIPSVSVKQEPEYDGYEKQTGVKQEPLKLKLKITKNHGKLNSSLID-----------DLDEAGQA 566
                           |.||.|::.:.............:|||.||.           :.:|.|::
Mouse   398 ---------------YVKQQGIRFQEKPYSCNECGKDFRLNSHLIQHQRIHTGEKLHECNECGKS 447

  Fly   567 FGRSSKKKKKRKHKEREKEASNETENCRTESQNQPAIKIKQEPVDYAPEATVMTTIPMTQ--FES 629
            |.::|  ...:.||...||.|.|..|             .:|...::.:.|:...:|:.:  |:.
Mouse   448 FSQTS--CLIQHHKMHRKEKSYEYNN-------------YEESFSHSSDLTLQQEVPIRERVFDC 497

  Fly   630 SL---NESERSEEVDEAMIQSQEDVKP 653
            ..   |.|:|:..:....:.::|  ||
Mouse   498 DAWEENFSQRAHLIQHERVHTKE--KP 522

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1647	NP_651636.1	zf-AD	19..99	CDD:285071	13/69 (19%)
		C2H2 Zn finger	203..224	CDD:275368	4/20 (20%)
		C2H2 Zn finger	233..253	CDD:275368	7/19 (37%)
		C2H2 Zn finger	262..282	CDD:275368	7/19 (37%)
		C2H2 Zn finger	297..314	CDD:275368	2/16 (13%)
Zfp655	NP_082574.1	COG5048	237..>316	CDD:227381	27/79 (34%)
		C2H2 Zn finger	245..265	CDD:275368	7/19 (37%)
		C2H2 Zn finger	273..293	CDD:275368	7/19 (37%)
		C2H2 Zn finger	301..356	CDD:275368	11/73 (15%)
		zf-C2H2	334..356	CDD:395048	7/40 (18%)
		C2H2 Zn finger	363..383	CDD:275368	5/75 (7%)
		COG5048	400..>468	CDD:227381	17/69 (25%)
		C2H2 Zn finger	413..433	CDD:275368	5/19 (26%)
		C2H2 Zn finger	441..461	CDD:275368	6/21 (29%)
		C2H2 Zn finger	497..517	CDD:275368	3/19 (16%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S5489
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.950