DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG1647 and Rp1

DIOPT Version :9

Sequence 1:	NP_651636.1	Gene:	CG1647 / 43401	FlyBaseID:	FBgn0039602	Length:	1222	Species:	Drosophila melanogaster
Sequence 2:	XP_008761780.1	Gene:	Rp1 / 681377	RGDID:	1596713	Length:	2150	Species:	Rattus norvegicus

Alignment Length:	1341	Identity:	254/1341 - (18%)
Similarity:	438/1341 - (32%)	Gaps:	420/1341 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   146 VKPQVKKESFVWHKKQKLQPSQITSLVSKREPEIKDEPAEQDTSLKGPPKKAGRKSICSVCGEKF 210
            |:.::|:|:..|           |:.|::.:....||.::..:.   |.|...|.|...:.....
  Rat   361 VRFKIKEETVKW-----------TTTVNRADLSNDDEKSKISSY---PGKTEDRSSSLKLVVPCS 411

  Fly   211 LSKELAD--EHKSLVHVPSIPRYICNACNQTHHNQSDIRAHQLWHKLSKTPYKCPLCESSVANAY 273
            ||:::.|  :..||....:         .|....|:...:...|...|        .|..:..:.
  Rat   412 LSEDITDTTQQGSLTEEEN---------TQMTEQQALSSSSAGWENAS--------MEVGIQGSQ 459

  Fly   274 AFTRHLREHTPPTP-----------VQLLVLDRECPLCKKTF----------VTNFFYNTHRCAI 317
            ...:|.  :.||||           :..:.:..|..:.:|.|          .:.:...||.|:
  Rat   460 KQVKHF--YRPPTPGPRRMRQKKSVIGTVTVVSETEVQEKQFSYREEREVGEKSKYHMFTHSCS- 521

  Fly   318 RKRKCGGCSRTL-------NTEAAYMRHAPTCPKIYLNHSKHIMPQVVTNE--AQMLIKNEIEEE 373
               |....|..|       ..|:|..|...:.|  ..:|:.:.....:|::  .:|...|.:
  Rat   522 ---KMSSVSNKLVQISSDDERESALERTKESGP--LKSHAINAGAIEITSQRVLKMCHNNAL--- 578

  Fly   374 LLGLPPATTVPPDFVIDEGMQPVVVLERLSSPLLRSSSGTDQLVAAKSKNSDRVSARNYLKRVDQ 438
                  |:|||.:.|::||.....:..:.:....|:....:...::.:.::...|.
  Rat   579 ------ASTVPENSVVEEGTDDSAISGKATIKHFRTCGNANDSFSSTTADTTLTSG--------- 628

  Fly   439 LLKNTINTLVSIKHEPEVHINDTGPP---RGQAESDPEPERNE-------EHPSFGDDIQA--AN 491
               |....:.:|...|.|     |.|   .|..        ||       |||..|..|.:  |:
  Rat   629 ---NNCPNVRTISEVPSV-----GSPVLTTGLV--------NEFAHCGLTEHPGNGRQISSPFAS 677

  Fly   492 DECQECQPE--TESDKISVAACDDIPS-----------VSVKQEPEYDGYEKQTGVKQEPLKLKL 543
            .:.::.|..  |..||..|.....||:           ..|....:..|.:|:..|::|.|....
  Rat   678 KKKKKSQQRMITSKDKKKVIETKGIPNKVGKIHRAGTIAQVVLLQDSGGLDKEGRVREEELDTSP 742

  Fly   544 KITKNHGKLNSSLIDDLDEAGQAFGRSSKKKKKRKHKEREKEASN-ETENCRTESQNQPAIKIKQ 607
            .:.::|               ..|.:.:.|..|..||.:.....| :|:....:.:::| :|||.
  Rat   743 MVIESH---------------DIFPKGNSKFSKNFHKNKLNTVQNPKTQKLLAKRKSRP-LKIKS 791

  Fly   608 EPVDYAPEATVMTTIPMTQFESSLNESERS-----------EEVDEAMIQSQEDVK--------- 652
            .. :...:.|..........||.|.||...           ||..:|:.:||..|:
  Rat   792 IG-ELRKQETGQEDKVFLHSESKLCESNLEKQSLLHVFSSLEEDQKALHRSQSQVETVTENWKGM 855

  Fly   653 ------PNRMELDRMMQISNVTSGVDMAEEAMALER--AEEACPEDSLHKV--------KSVKS- 700
                  |...:|...::......||.:...|...|:  |..|.|..||.|.        .||||
  Rat   856 TKKSLVPKVNDLHVTVRNQRKQKGVKLKSGATVSEQHIATRADPLASLKKPDLTEGIPHHSVKSY 920

  Fly   701 --------------TARKSTG-GAERKTYSPPRTNTLPQ--IVAVVSGESAFNMISIKPEPRNLG 748
                          ..|||.. |.:|.......:|..|:  :....|...:|.|.|.|.:.:|..
  Rat   921 IQRWLQNINPYPDFEHRKSAPLGQDRSNVVNYNSNGFPENNLPTTSSKGKSFLMESNKRKTKNAN 985

  Fly   749 Y-GDEEPEDQRETTEEIN------HNDMMEEEK---EYIGSL----DLSDVSVKQERELDIC--- 796
            : |::..|..:....:.|      |:...::|.   .|:|.|    .||..|:.     |.|
  Rat   986 WKGNKNQETSKSLVVKDNGEQPNKHSCESQDESLYDSYLGPLHDNCTLSQTSIN-----DPCTKS 1045

  Fly   797 ---------EIDAVH--------RNGLEKSDEDDDDGN---EDSASSADEAEEAMERDTEERIYR 841
                     |:..|:        |..||.:.:.|..|.   :|..:...:..||...:.::....
  Rat  1046 HLSTEKSRPEVKLVYQEMNFSTKRQTLEVAIQVDTMGENVPKDLLALLLQHLEAFIPNNQKHQNG 1110

  Fly   842 EIELP--------PLELQNESS------------RKDLESERMDTEVSTALPASETPSQTRDVLG 886
            ..:||        |..:.|.|:            ::::.|          ...|:.|..|.
  Rat  1111 ISQLPGSLAEVVFPSAIYNSSTNLLLAWLLVLNLKRNMNS----------FCQSDAPKTTS---- 1161

  Fly   887 VEKSEASAFSLVITNIC-SQAVPQPSAACSNDIE----CSIGPS-------PSTTNEPHSHTV-- 937
             ..||.:|...|:.::. ::......||.:|.:|    || |||       |:.......|:|
  Rat  1162 -RSSETAALLDVLKHVAITEEADDLKAAVANLVESTKTCS-GPSGREQDTAPANCIAASLHSVDK 1224

  Fly   938 --ENVQSPANDLQTSAQVAIAAQSQPDPCIVSQPAAS----SESQADTKDLPP------------ 984
              ||..:..:.|...  .::.....|:.|::...:.|    ||....:...||
  Rat  1225 CKENKSTQKSLLDEG--YSVRGDCGPELCVLEMVSKSNNTPSEGHTVSMTYPPKGVNNQNDALFT 1287

  Fly   985 -----AASQIQTFN----------TESLPIHVHSETEDNSIE----NDASYLESRAQVDC----- 1025
                 ..||..|.|          |:||..|.....:||..|    :|.:::..|   ||
  Rat  1288 SNDSSTMSQRSTHNASFLGEACLLTDSLCSHKACAQKDNIYEAACLSDETHIPIR---DCKTIEF 1349

  Fly  1026 ----QSAGTENPSVVLEQNESLPSGSCVSPIPENPSPGNSPPQHDESESLDKPE----------- 1075
                ::..|:|    ||..|.:.:   |..:|::        .:..::|:||.|
  Rat  1350 VNSKENKCTDN----LELTEEIKT---VDKVPKD--------LNILADSIDKNESDISTSSQNVN 1399

  Fly  1076 MAAGSAYCLATVSLDAPKDTEALA----LPPCDAAIIDSNYTSD-------EEQQNVLNHELSEQ 1129
            ..:.....|:...||:.||...|.    .||........:.:||       ||.:::.|...|.:
  Rat  1400 KLSSQGIFLSKTHLDSDKDYSPLEEFQNCPPKKIVNKKKSVSSDKEDSRTSEEPRSITNSVTSSE 1464

  Fly  1130 QLAIMEHR-------------QLLVHEEQPAL-------------LEVIPPGLSSRPIEETENRI 1168
            :.|..|..             .:.|..|:.|.             ||:|  .:|.|.|.|...|.
  Rat  1465 RNATSELESFEESESQDTGIFNMKVRTEEKAAKESMQKESEARMSLELI--NISGRNIIEQGRRN 1527

  Fly  1169 NEQQQDLEQGEERPPRFQANDDSNINEIAENNNNANIEREL 1209
            ....:...:|:..||......||          |.|.|:|:
  Rat  1528 TAFLETTGRGQVTPPSLVFCYDS----------NKNTEKEM 1558

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1647	NP_651636.1	zf-AD	19..99	CDD:285071
		C2H2 Zn finger	203..224	CDD:275368	5/22 (23%)
		C2H2 Zn finger	233..253	CDD:275368	2/19 (11%)
		C2H2 Zn finger	262..282	CDD:275368	2/19 (11%)
		C2H2 Zn finger	297..314	CDD:275368	3/26 (12%)
Rp1	XP_008761780.1	DCX	60..135	CDD:176357
Rp1	XP_008761780.1	DCX	182..257	CDD:176357
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1181
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900